Skip to main content

Trinity College Dublin, The University of Dublin

Menu Search

Trinity College Dublin By using this website you consent to the use of cookies in accordance with the Trinity cookie policy. For more information on cookies see our cookie policy.

Profile Photo

Professor Ross Mc Manus

Professor in Molecular Medicine (Clinical Medicine)

Professor in Molecular Medicine (Molecular Medicine Ireland)

  Autoimmunity   Chronic inflamation   Coeliac disease   GENE EXPRESSION ANALYSIS   GENE POLYMORPHISM   Genetic Analysis of Systemic Inflammatory Response Syndrome (SARS)   Genetic Mapping, Gene Sequence   Genetics   Genetics of inflammatory disease   Genomes, Genomics   Genomic structure and function, molecular approaches to gene function   Inflammatory bowel disease   Molecular Genetics   PSORIASIS   SEPSIS
 COVREs: Understanding the Host-Virus Response in Patients with Mild versus Serious Disease
  How immunology can help to address the COVID-19 epidemic in Ireland
  Protecting the ICU - A prognostic test to predict clinical course and direct therapy in patients infected with SARS-COV2
 Changing Landscapes in the Health and Life Sciences: Ethical Challenges of Big Data

Details Date
Member of Molecular Medicine Ireland (MMI)/Clinical Research Development Ireland (CRDI) Education Committee 2003 - 2020
Council member, Irish Society of Human Genetics 2004 - 2008
Member, Scientific Committee, FINBAR, all-Ireland genetic epidemiology study of oesophageal cancer 2003 - 2009
Member, PHG Funded PI's and Researchers, All Researchers funded under Cycle 3 PRTLI - Programme for Human Genomics
Member of LIPGENE WP1.1. Genetic association study of candidate genes in the Metabolic Syndrome in a large French cohort. 2004 - 2009
Member of Eurolife Network of European Universities in the Life Sciences Steering Committee 2005 - 2015
Chairperson of Eurolife Joint Educational Programme in Translational and Experimental Medicine 2008 - 2013
Coordinator, Eurolife Network 2009 - 2011
Details Date From Date To
American Society of Human Genetics 2003 present
Irish Society of Human Genetics 2001 present
European Society of Human Genetics 2005 present
Irish Society of Immunology 2008 present
Kenyon, M. and Maguire, S. and Rueda Pujol, A. and O†Shea, F. and McManus, R., The genetic backbone of ankylosing spondylitis: how knowledge of genetic susceptibility informs our understanding and management of disease, Rheumatology International, 42, (12), 2022, p2085-2095 , Notes: [cited By 0], Journal Article, PUBLISHED  DOI
Soomro, M. and Stadler, M. and Dand, N. and Bluett, J. and Jadon, D. and Jalali-najafabadi, F. and Duckworth, M. and Ho, P. and Marzo-Ortega, H. and Helliwell, P.S. and Ryan, A.W. and Kane, D. and Korendowych, E. and Simpson, M.A. and Packham, J. and McManus, R. and Gabay, C. and Lamacchia, C. and Nissen, M.J. and Brown, M.A. and Verstappen, S.M.M. and Van Staa, T. and Barker, J.N. and Smith, C.H. and Chalmers, R. and Flohr, C. and Watson, K. and Prieto-Merino, D. and Alabas, O. and Barker, J. and Becher, G. and Bewley, A. and Burden, D. and Morrison, S. and Laws, P. and Evans, I. and Griffiths, C. and Ahmed, S. and Kirby, B. and Kleyn, E. and Lawson, L. and Mackenzie, T. and McPherson, T. and McElhone, K. and Murphy, R. and Ormerod, A. and Owen, C. and Reynolds, N. and Rashid, A. and Smith, C. and Warren, R. and Burden, D. and Smith, C. and Siebert, S. and Brown, S. and McAteer, H. and Schofield, J. and Dand, N. and FitzGerald, O. and McHugh, N. and Warren, R.B. and Bowes, J. and Barton, A., Comparative Genetic Analysis of Psoriatic Arthritis and Psoriasis for the Discovery of Genetic Risk Factors and Risk Prediction Modeling, Arthritis and Rheumatology, 74, (9), 2022, p1535-1543 , Notes: [cited By 1], Journal Article, PUBLISHED  DOI
Shraim, R. and Macdonnchadha, C. and Vrbanic, L. and McManus, R. and Zgaga, L., Gene-Environment Interactions in Vitamin D Status and Sun Exposure: A Systematic Review with Recommendations for Future Research, Nutrients, 14, (13), 2022, Notes: [cited By 0], Journal Article, PUBLISHED  DOI
King, S. and Holleran, L. and Mothersill, D. and Patlola, S. and Rokita, K. and McManus, R. and Kenyon, M. and McDonald, C. and Hallahan, B. and Corvin, A. and Morris, D. and Kelly, J. and McKernan, D. and Donohoe, G., Early life Adversity, functional connectivity and cognitive performance in Schizophrenia: The mediating role of IL-6, Brain, Behavior, and Immunity, 98, 2021, p388-396 , Notes: [cited By 1], Journal Article, PUBLISHED  DOI
Mothersill, D. and King, S. and Holleran, L. and Dauvermann, M. and Patlola, S. and Rokita, K. and McManus, R. and Keynon, M. and McDonald, C. and Hallahan, B. and Corvin, A. and Morris, D. and Kelly, J. and McKernan, D. and Donohoe, G., Interleukin 6 predicts increased neural response during face processing in a sample of individuals with schizophrenia and healthy participants: A functional magnetic resonance imaging study, NeuroImage: Clinical, 32, (102851), 2021, Notes: [cited By 0], Journal Article, PUBLISHED  DOI
Castro P.D., Harkin G., Hussey M., Christopher B., Kiat C., Chin J.L., Trimble V., McNamara D., MacMathuna P., Egan B., Ryan B., Kevans D., Abuzakouk M., Farrell R., Feighery C., Byrnes V., Mahmud N., McManus R., Prevalence of coexisting autoimmune thyroidal diseases in coeliac disease is decreasing, United European Gastroenterology Journal, 8, (2), 2020, p148 - 156, Journal Article, PUBLISHED  DOI
Coakley J.D., Breen E., Moreno-Olivera A., Al-Harbi A., Melo A., O'Connell B., McManus R., Doherty D., Ryan T. , Innate lymphocyte Th1 and Th17 responses in elderly hospitalised patients with infection and sepsis., Vaccines, 8, (2), 2020, p311-, Journal Article, PUBLISHED  DOI  URL
Ní Chonchubhair H.M., Duggan S.N., Egan S.M., Kenyon M., O'Toole D., McManus R., Conlon K.C. , A high prevalence of genetic polymorphisms in idiopathic and alcohol-associated chronic pancreatitis patients in Ireland., HPB Journal, 2020, Journal Article, ACCEPTED
Romero-Ortuno R, Kenny RA, McManus R, Collagens and elastin genetic variations and their potential role in aging-related diseases and longevity in humans, Experimental Gerontology, 129, 2019, p110781 -, Journal Article, PUBLISHED  DOI  URL
Coakley JD, Breen EP, Moreno-Olivera A, Al-Harbi AI, Melo AM, O'Connell B, McManus R, Doherty DG, Ryan T., Dysregulated T helper type 1 (Th1) and Th17 responses in elderly hospitalised patients with infection and sepsis, PLoS One, 14, (10), 2019, pe0224276-, Journal Article, PUBLISHED  DOI

Page 1 of 14
Feighery CF, McManus R, Recent advances in the genetic understanding of coeliac disease, Proceedings of the Nutrition Society, 68, 2009, p1 - 5, Journal Article, PUBLISHED
Kelleher D, McManus R., Mechanisms of steroid action and resistance in inflammatory bowel disease , Falk Symposia, 2005, Journal Article, PUBLISHED
Kelleher D, Farrell R, McManus R, Pharmacogenetics of inflammatory bowel disease, in 'Inflammatory bowel disease - crossroads between microbes, epithelium and immune systems' , Novartis Foundation Symposium , 263, 2004, Journal Article, PUBLISHED
McManus R, Kelleher D. , Celiac disease - the villain unmasked? , New England Journal of Medicine, 348, 2003, p2573 - 2574, Journal Article, PUBLISHED
McManus R, Mechanisms of Steroid Action and Resistance in Inflammation and Disease., Journal of Endocrinology, 178, (1), 2003, p1-4 , Notes: [(Invited meeting review). PMID: 12844329 ], Journal Article, PUBLISHED


Award Date
Wellcome Trust / Health Research Board 'New Blood' Fellowship 1998
Science Foundation Ireland Principal Investigator 2010
Fellow, Trinity College Dublin 2009
I am interested in the genetics/genomics of common diseases with an inflammatory component, particularly coeliac disease, inflammatory bowel disease and sepsis. We currently also have programmes into the genetic basis of psoriasis and oesophageal cancers in conjunction with collaborators nationwide and in Europe.