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Professor John Reynolds

Professor & Head of Department (Surgery)


  Anti-oxidants in inflammatory disease   Genetic polymorphisms in upper gastrointestinal cancer and Barrett's oesophagus   Liver and gut immune function in patients undergoing complex major surgery   Molecular predictors of response and resistance to chemotherapy and radiation therapy   Transcription factors in inflammation and neoplasia of the oesophagus   Upper gastrointestinal physiology
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Member, DMMC Inflammation, Immunity & Infection Principal Investigators, DMMC Principal Investigators leading research in inflammation, immunit and infection.
Member, Centre for Molecular Research in Cancer (Proposed), This consortium combines researchers with common interest in understanding cell cycle signaling and regulation with specific focus on two key cancer-related processes (cell cycle control, apoptosis) and/or three specific malignancy types (oesophageal, prostate and haematological).
Member, Colorectal & GI Cancer Research Group (Proposed), Speculative idea to cluster PI's around collaborative study on Upper GI and Colon Cancers.Deliberately wide selection of surgeons, pathologists and academic researchers based on stated interest or publication in fields of oesophageal or colorectal cancer.
Member, PHG Funded PI's and Researchers, All Researchers funded under Cycle 3 PRTLI - Programme for Human Genomics
Gillman A, Hayes M; Sheaf G, Walshe M, Reynolds JV, Regan J, Exercise-Based Dysphagia Rehabilitation for Adults with Oesophageal Cancer: a Systematic Review, BMC Cancer, 2022, Journal Article, PUBLISHED  TARA - Full Text  DOI  URL
Davern, M. and O†Brien, R.M. and McGrath, J. and Donlon, N.E. and Melo, A.M. and Buckley, C.E. and Sheppard, A.D. and Reynolds, J.V. and Lynam-Lennon, N. and Maher, S.G. and Lysaght, J., PD-1 blockade enhances chemotherapy toxicity in oesophageal adenocarcinoma, Scientific Reports, 12, (1), 2022, Notes: [cited By 0], Journal Article, PUBLISHED  DOI
Davern, M. and Donlon, N.E. and O†Connell, F. and Sheppard, A.D. and Hayes, C. and King, R. and Temperley, H. and Butler, C. and Bhardwaj, A. and Moore, J. and Bracken-Clarke, D. and Donohoe, C. and Ravi, N. and Reynolds, J.V. and Maher, S.G. and Conroy, M.J. and Lysaght, J., Cooperation between chemotherapy and immune checkpoint blockade to enhance anti-tumour T cell immunity in oesophageal adenocarcinoma, Translational Oncology, 20, (101406), 2022, Notes: [cited By 0], Journal Article, PUBLISHED  DOI
Davern M, Fitzgerald MC, Buckley CE, Heeran AB, Donlon NE, McGrath J, O'Connell F, Deshpande MR, Hayes C, MacDonald J, Sheppard AD, Reynolds JV, Maher SG, Lynam-Lennon N, Murphy B, Lysaght J, PD-1 and TIGIT blockade differentially affect tumour cell survival under hypoxia and glucose deprived conditions in oesophageal adenocarcinoma; implications for overcoming resistance to PD-1 blockade in hypoxic tumours, Cancer Letters, 2022, Journal Article, SUBMITTED
Bolger, J.C. and Donlon, N.E. and Butt, W. and Neary, C. and Al Azzawi, M. and Brett, O. and King, S. and Downey, E. and Arumugasamy, M. and Murphy, T. and Robb, W.B. and Collins, C.G. and Carroll, P.A. and Donohoe, C.L. and Ravi, N. and Reynolds, J.V., Successful maintenance of process and outcomes for oesophageal cancer surgery in Ireland during the first wave of the COVID-19 pandemic, Irish Journal of Medical Science, 191, (2), 2022, p831-837 , Notes: [cited By 1], Journal Article, PUBLISHED  DOI
Bolger, J.C. and Donohoe, C.L. and Lowery, M. and Reynolds, J.V., Advances in the curative management of oesophageal cancer, British Journal of Cancer, 126, (5), 2022, p706-717 , Notes: [cited By 1], Journal Article, PUBLISHED  DOI
Kroese, T.E. and van Hillegersberg, R. and Schoppmann, S. and Deseyne, P.R.A.J. and Nafteux, P. and Obermannova, R. and Nordsmark, M. and Pfeiffer, P. and Hawkings, M.A. and Smyth, E. and Markar, S. and Hanna, G.B. and Cheong, E. and Chaudry, A. and Elme, A. and Adenis, A. and Piessen, G. and Gani, C. and Bruns, C.J. and Moehler, M. and Liakakos, T. and Reynolds, J. and Morganti, A. and Rosati, R. and Castoro, C. and D'Ugo, D. and Roviello, F. and Bencivenga, M. and de Manzoni, G. and Jeene, P. and van Sandick, J.W. and Muijs, C. and Slingerland, M. and Nieuwenhuijzen, G. and Wijnhoven, B. and Beerepoot, L.V. and Kolodziejczyk, P. and Polkowski, W.P. and Alsina, M. and Pera, M. and Kanonnikoff, T.F. and Nilsson, M. and Guckenberger, M. and Monig, S. and Wagner, D. and Wyrwicz, L. and Berbee, M. and Gockel, I. and Lordick, F. and Griffiths, E.A. and Verheij, M. and van Rossum, P.S.N. and van Laarhoven, H.W.M. and Rosman, C. and RÃŒtten, H. and Gootjes, E.C. and Vonken, F.E.M. and van Dieren, J.M. and Vollebergh, M.A. and van der Sangen, M. and Creemers, G.-J. and Zander, T. and Schlöà er, H. and Cascinu, S. and Mazza, E. and Nicoletti, R. and Damascelli, A. and Slim, N. and Passoni, P. and Cossu, A. and Puccetti, F. and Barbieri, L. and Fanti, L. and Azzolini, F. and Ventoruzzo, F. and Szczepanik, A. and Visa, L. and Reig, A. and Roques, T. and Harrison, M. and CiseÅ', B. and PikuÅ'a, A. and Skórzewska, M. and Vanommeslaeghe, H. and Van Daele, E. and Pattyn, P. and Geboes, K. and Callebout, E. and Ribeiro, S. and van Duijvendijk, P. and Tromp, C. and Sosef, M. and Warmerdam, F. and Heisterkamp, J. and Vera, A. and Jordá, E. and López-Mozos, F. and Fernandez-Moreno, M.C. and Barrios-Carvajal, M. and Huerta, M. and de Steur, W. and Lips, I. and Diez, M. and Castro, S. and O'Neill, R. and Holyoake, D. and Hacker, U. and Denecke, T. and Kuhnt, T. and Hoffmeister, A. and Kluge, R. and Bostel, T. and Grimminger, P. and JedliÄ ka, V. and KŠístek, J. and Pospíšil, P. and Mourregot, A. and Maurin, C. and Starling, N. and Chong, I., Definitions and treatment of oligometastatic oesophagogastric cancer according to multidisciplinary tumour boards in Europe, European Journal of Cancer, 164, 2022, p18-29 , Notes: [cited By 3], Journal Article, PUBLISHED  DOI
Markar, S.R. and Zaninotto, G. and Castoro, C. and Johar, A. and Lagergren, P. and Elliott, J.A. and Gisbertz, S.S. and Mariette, C. and Alfieri, R. and Huddy, J. and Sounderajah, V. and Pinto, E. and Scarpa, M. and Klevebro, F. and Sunde, B. and Murphy, C.F. and Greene, C. and Ravi, N. and Piessen, G. and Brenkman, H. and Ruurda, J.P. and Van Hillegersberg, R. and Lagarde, S. and Wijnhoven, B. and Pera, M. and Roig, J. and Castro, S. and Matthijsen, R. and Findlay, J. and Antonowicz, S. and Maynard, N. and Mccormack, O. and Ariyarathenam, A. and Sanders, G. and Cheong, E. and Jaunoo, S. and Allum, W. and Van Lanschot, J. and Nilsson, M. and Reynolds, J.V. and Henegouwen, M.I.V.B. and Hanna, G.B., Lasting Symptoms After Esophageal Resection (LASER): European Multicenter Cross-sectional Study, Annals of Surgery, 275, (2), 2022, pE392-E400 , Notes: [cited By 11], Journal Article, PUBLISHED  DOI
Bennett, S. and Murphy, C.F. and Fanning, M. and Reynolds, J.V. and Doyle, S.L. and Donohoe, C.L., The impact of Nutrition and Gastrointestinal Symptoms on Health-related Quality of Life in Survivorship after Oesophageal Cancer Surgery, Clinical Nutrition Open Science, 41, 2022, p44-61 , Notes: [cited By 0], Journal Article, PUBLISHED  DOI
Noel E. Donlon, Maria Davern, Andrew D. Sheppard, Fiona O'Connell, Margaret R. Dunne, Conall Hayes, Eimear Mylod, Sinead Ramjit, Hugo Temperley, Michael Mac Lean, Gillian Cotter, Anshul Bhardwaj, Christine Butler, Melissa J. Conroy, Jacintha O'Sullivan, Narayanasamy Ravi, Claire L. Donohoe, John V. Reynolds and Joanne Lysaght, The Impact of Esophageal Oncological Surgery on Perioperative Immune Function; Implications for Adjuvant Immune Checkpoint Inhibition, Frontiers in Immunology, 2022, Journal Article, PUBLISHED  URL
  

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Gillman A, Hayes M; Sheaf G, Walshe M, Reynolds JV, Regan J, Exercise-Based Dysphagia Rehabilitation for Adults with Oesophageal Cancer: a Systematic Review, Dysphagia, 10th ESSD Congress, 2020, 2022, Poster, PUBLISHED

  

Anti-oxidants in inflammatory disease. Genetic polymorphisms in upper gastrointestinal cancer and Barrett's oesophagus. Liver and gut immune function in patients undergoing complex major surgery. Molecular predictors of response and resistance to chemotherapy and radiation therapy. Transcription factors in inflammation and neoplasia of the oesophagus. Upper gastrointestinal physiology.