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Professor John Reynolds

Professor & Head of Department (Surgery)

 reynoljv@tcd.ie

 3531896 2189/3277


Research Tags

  Anti-oxidants in inflammatory disease   Genetic polymorphisms in upper gastrointestinal cancer and Barrett's oesophagus   Liver and gut immune function in patients undergoing complex major surgery   Molecular predictors of response and resistance to chemotherapy and radiation therapy   Transcription factors in inflammation and neoplasia of the oesophagus   Upper gastrointestinal physiology

Representations

Details Date
Member, DMMC Inflammation, Immunity & Infection Principal Investigators, DMMC Principal Investigators leading research in inflammation, immunit and infection.
Member, Centre for Molecular Research in Cancer (Proposed), This consortium combines researchers with common interest in understanding cell cycle signaling and regulation with specific focus on two key cancer-related processes (cell cycle control, apoptosis) and/or three specific malignancy types (oesophageal, prostate and haematological).
Member, Colorectal & GI Cancer Research Group (Proposed), Speculative idea to cluster PI's around collaborative study on Upper GI and Colon Cancers.Deliberately wide selection of surgeons, pathologists and academic researchers based on stated interest or publication in fields of oesophageal or colorectal cancer.
Member, PHG Funded PI's and Researchers, All Researchers funded under Cycle 3 PRTLI - Programme for Human Genomics
Kampan, N.C. and Kartikasari, A.E.R. and Deceneux, C. and Madondo, M.T. and McNally, O.M. and Flanagan, K.L. and Aziz, N.A. and Stephens, A.N. and Reynolds, J. and Quinn, M.A. and Plebanski, M., Combining TNFR2-Expressing Tregs and IL-6 as Superior Diagnostic Biomarkers for High-Grade Serous Ovarian Cancer Masses, Cancers, 15, (3), 2023, Notes: [cited By 0], Journal Article, PUBLISHED  DOI
McDonnell, S. and Breslin, T. and Mascan, B. and Shahruddin, N.S. and Elnour, M. and Fanning, M. and Galvin, A. and Moore, J. and Ravi, N. and Reynolds, J.V. and Donohoe, C.L., Translating evidence in a priority setting partnership: knowledge gaps between healthcare providers and oesophageal cancer patients, Supportive Care in Cancer, 31, (2), 2023, Notes: [cited By 0], Journal Article, PUBLISHED  DOI
Davern, M. and Bracken-Clarke, D. and Donlon, N.E. and Sheppard, A.D. and Connell, F.O. and Heeran, A.B. and Majcher, K. and Conroy, M.J. and Mylod, E. and Butler, C. and Donohoe, C. and Donnell, D.O. and Lowery, M. and Bhardwaj, A. and Ravi, N. and Melo, A.A. and Sullivan, J.O. and Reynolds, J.V. and Lysaght, J., Visceral adipose tissue secretome from early and late-stage oesophageal cancer patients differentially affects effector and regulatory T cells, Journal of Cancer Research and Clinical Oncology, 2023, Notes: [cited By 0], Journal Article, PUBLISHED  DOI
O'Brien, A., Brennan, L., O'Neill, L, Guinan, E., Connolly, D., Reynolds, JV., and Hussey, J., Patient Experiences of a Telehealth Multidisciplinary Cancer Rehabilitation Programme: Qualitative Findings from the ReStOre@Home Feasibility Study, 2023, Journal Article, PUBLISHED  DOI
Gillman A, Hayes M; Sheaf G, Walshe M, Reynolds JV, Regan J, Exercise-Based Dysphagia Rehabilitation for Adults with Oesophageal Cancer: a Systematic Review, BMC Cancer, 2022, Journal Article, PUBLISHED  TARA - Full Text  DOI  URL
Davern, M. and O†Brien, R.M. and McGrath, J. and Donlon, N.E. and Melo, A.M. and Buckley, C.E. and Sheppard, A.D. and Reynolds, J.V. and Lynam-Lennon, N. and Maher, S.G. and Lysaght, J., PD-1 blockade enhances chemotherapy toxicity in oesophageal adenocarcinoma, Scientific Reports, 12, (1), 2022, Notes: [cited By 0], Journal Article, PUBLISHED  DOI
Davern, M. and Donlon, N.E. and O†Connell, F. and Sheppard, A.D. and Hayes, C. and King, R. and Temperley, H. and Butler, C. and Bhardwaj, A. and Moore, J. and Bracken-Clarke, D. and Donohoe, C. and Ravi, N. and Reynolds, J.V. and Maher, S.G. and Conroy, M.J. and Lysaght, J., Cooperation between chemotherapy and immune checkpoint blockade to enhance anti-tumour T cell immunity in oesophageal adenocarcinoma, Translational Oncology, 20, (101406), 2022, Notes: [cited By 0], Journal Article, PUBLISHED  DOI
Davern M, Fitzgerald MC, Buckley CE, Heeran AB, Donlon NE, McGrath J, O'Connell F, Deshpande MR, Hayes C, MacDonald J, Sheppard AD, Reynolds JV, Maher SG, Lynam-Lennon N, Murphy B, Lysaght J, PD-1 and TIGIT blockade differentially affect tumour cell survival under hypoxia and glucose deprived conditions in oesophageal adenocarcinoma; implications for overcoming resistance to PD-1 blockade in hypoxic tumours, Cancer Letters, 2022, Journal Article, SUBMITTED
Bolger, J.C. and Donlon, N.E. and Butt, W. and Neary, C. and Al Azzawi, M. and Brett, O. and King, S. and Downey, E. and Arumugasamy, M. and Murphy, T. and Robb, W.B. and Collins, C.G. and Carroll, P.A. and Donohoe, C.L. and Ravi, N. and Reynolds, J.V., Successful maintenance of process and outcomes for oesophageal cancer surgery in Ireland during the first wave of the COVID-19 pandemic, Irish Journal of Medical Science, 191, (2), 2022, p831-837 , Notes: [cited By 1], Journal Article, PUBLISHED  DOI
Bolger, J.C. and Donohoe, C.L. and Lowery, M. and Reynolds, J.V., Advances in the curative management of oesophageal cancer, British Journal of Cancer, 126, (5), 2022, p706-717 , Notes: [cited By 1], Journal Article, PUBLISHED  DOI
  

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Cliona M Lorton, John V Reynolds, Joanne Lysaght, ASO Author Reflections: Can CRP and CRP-Based Scores Predict Survival in Operable Adenocarcinomas of the Esophagus and Esophago-Gastric Junction?, Annals of Surgical Oncology, 2021, Journal Article, PUBLISHED

  

Research Interests

Description Of Research Interests

Anti-oxidants in inflammatory disease. Genetic polymorphisms in upper gastrointestinal cancer and Barrett's oesophagus. Liver and gut immune function in patients undergoing complex major surgery. Molecular predictors of response and resistance to chemotherapy and radiation therapy. Transcription factors in inflammation and neoplasia of the oesophagus. Upper gastrointestinal physiology.