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Professor John Reynolds

Adjunct Professor (Surgery)
      
Profile Photo

Professor John Reynolds

Adjunct Professor (Surgery)

 reynoljv@tcd.ie

 


  Anti-oxidants in inflammatory disease   Genetic polymorphisms in upper gastrointestinal cancer and Barrett's oesophagus   Liver and gut immune function in patients undergoing complex major surgery   Molecular predictors of response and resistance to chemotherapy and radiation therapy   Transcription factors in inflammation and neoplasia of the oesophagus   Upper gastrointestinal physiology
Details Date
Member, DMMC Inflammation, Immunity & Infection Principal Investigators, DMMC Principal Investigators leading research in inflammation, immunit and infection.
Member, Centre for Molecular Research in Cancer (Proposed), This consortium combines researchers with common interest in understanding cell cycle signaling and regulation with specific focus on two key cancer-related processes (cell cycle control, apoptosis) and/or three specific malignancy types (oesophageal, prostate and haematological).
Member, Colorectal & GI Cancer Research Group (Proposed), Speculative idea to cluster PI's around collaborative study on Upper GI and Colon Cancers.Deliberately wide selection of surgeons, pathologists and academic researchers based on stated interest or publication in fields of oesophageal or colorectal cancer.
Member, PHG Funded PI's and Researchers, All Researchers funded under Cycle 3 PRTLI - Programme for Human Genomics
O'Neill, Linda and Knapp, Peter and Doyle, Suzanne L. and Begic, Sanela and Smyth, Emily and Kearney, Neil and Grehan, Sophie and Parker, Adwoa and Browne, Peter and Segurado, Ricardo and Connolly, Deirdre and O'Sullivan, Jacintha and Reynolds, John V. and Guinan, Emer and Hussey, Juliette, Can a Public and Patient Involvement (PPI) Informed Participant Information Leaflet (PIL) Improve Trial Recruitment, Retention, and Quality of Decision Making? Results of a Randomised Controlled Double-Blind Study Within a Trial (SWAT), Health Expectations, 28, (3), 2025, Notes: [Cited by: 0], Journal Article, PUBLISHED  DOI
Ramjit, Sinead E. and Davey, Matthew G. and Keelan, Stephen and Herlihy, Emer and Dromey, Marie and Garvey, Chris and Nugent, Timothy S. and Fawaz, Aisling and O'Connell, Lauren and Cunningham, Melanie and Fahy, Matthew and Ryan, Eanna J. and Moran, Brendan and Aljohmani, Lylas and Narayanasamy, Jeyanthi and Kelly, Michael E. and Healy, Clara and Donohoe, Claire and Ravi, Narayansamy and Neary, Paul and Reynolds, John V. and Donlon, Noel E., Evaluating the use of absorbable sutures versus sTaples versus tIssue glue in laparoscopic port skin closure (STILS) trial: A prospective, multi-centre randomised clinical trial (RCT), Surgeon, 2025, Notes: [Cited by: 0], Journal Article, PUBLISHED  DOI
Owen, Richard and Chidambaram, Swathikan and Shamiyah, Khalid and Elliott, Jessie A and Hedberg, Jakob and Kamarajah, Sivesh and Klevebro, Frederik and Schneider, Marcel Andre and Fourie, Lana and Gutschow, Christian and Nilsson, Magnus and Griffiths, Ewen and Rosati, Ricardo and Sultan, Javed and Pera, Manuel and Grimminger, Peter and Piessen, Guillaume and Eveno, Clarisse and Ruurda, Jelle and van Hillegersberg, Richard and Reynolds, John V. and van Berge Henegouwen, Mark and Gisbertz, Suzanne and So, Jimmy B.Y. and Maynard, Nick and Markar, Sheraz and Peronace, Vanessa and Boyle, Ellen A. and Pang, Aileen and Yap, Candy and Chia, Daryl and Kim, Guowei and Shabbir, Asim and Youcef, Amina and Bhatti, Khalid and Keywani, Kammy and Calef, Ricardo and Uzun, Eren and Cero, Mariagiulia Dal and Halle-Smith, James and Bagnell, Tim and Triemstra, Lianne and Josef, Matthias and NeuschÃŒtz, Kerstin and Cossu, Andrea and Saunders, John, Prognostic impact of positive peritoneal cytology (POPEC) in gastric cancer: Multi-centre European retrospective cohort study, Surgical Oncology Insight, 2, (3), 2025, Notes: [Cited by: 0], Journal Article, PUBLISHED  DOI
Butterworth, J.W. and Boshier, P.R. and Mavroveli, S. and Reynolds, J.V. and Kim, Young-Woo and Hanna, G.B., A proposed framework of strategies to overcome challenges to surgical quality assurance in oncology trials (SQA-Onc.), European Journal of Surgical Oncology, 51, (5), 2025, Notes: [Cited by: 0], Journal Article, PUBLISHED  DOI
Zheng, Y. and Elliott, J.A. and Reynolds, J.V. and Markar, S.R. and Papie?, B.W. and study group, E.N.S.U.R.E., Deep Neural Networks for~Predicting Recurrence and~Survival in~Patients with~Esophageal Cancer After Surgery, Lecture Notes in Computer Science (including subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics), 15199 LNCS, 2025, p176-189 , Journal Article, PUBLISHED
Liu, David S. and Lee, Margaret M. and Hall, Katheryn and Watson, David I. and Ferri, Lorenzo and So, Jimmy and Donohoe, Claire L. and Michael, Michael and Tebbutt, Niall C. and Wong, Darren J. and Duong, Cuong P. and Bright, Tim and Aly, Ahmad and Gill, Sonia and Cheng, Chao and Goh, Su Kah and Read, Matthew and Tan, James and Stevens, Sean and Wong, Enoch and Ooi, Geraldine and Lam, Yick Ho and Lee, Eunice and Williams, David and Jackett, Louise and Chan, Kevin and Smith, Garett and Chan, David L. and Merrett, Neil and Gananadha, Sivakumar and Kanhere, Harsh and Kennedy, Lauren and Smithers, Mark and Thomas, Janine and Bozin, Michael and Chong, Lynn and Mori, Krinal and Johnson, Mary-Ann and Martin, Sarah A. and Usatoff, Val and Jacobs, Rod and Al-Habbal, Yahya and Liew, Chon Hann and Huynh, Fredrick and Bohmer, Robert and Pande, Girish and Daruwalla, Jurstine and Ballal, Mo and Lee, Deanna and Ranjan, Rukshan and Maccormick, Andrew D. and Wilkins, James and Pattison, Sharon and Evennett, Nicholas and Robertson, Jason and Pang, Mark and Gordon, Alexandra and Bann, Simon and Lim, Yu Kai and Samarasam, Inian and Gurunathan, Ramesh and Yeung, Jonathan and Allison, Frances and Siblini, Aya and Griffiths, Ewen A. and Phillips, Alexander W. and Prasad, Pooja and Markar, Sheraz and Chidambaram, Swathikan and Chan, David and Murphy, Thomas and Reynolds, John and Nilsson, Magnus and Klevebro, Fredrik and Piessen, Guillaume and Lerooy, Justine and Wijnhoven, Bas and Van Der Zijden, CharlÚne and Van Hillegersberg, Richard and Triemstra, Lianne and Ruurda, Jelle and Van Berge Henegouwen, Mark Ivo and Gisbertz, Suzanne Sarah and Lombardi, Pietro Maria and Edmondson, Aleksandra and Wei, Joe Q. and Lorenzo, Aldenb and Alhayo, Sam and Narendra, Aaditya and Rahim, Aadil and Ho, Rocita and Granger, Jeremy and Tran, Steven and Koullouros, Michalis and Nguyen, Alain and Mcveay, Christina and Gan, Siang Wei and Hopping, Eve and Thomson, Iain and Barbour, Andrew and Gotley, David and Frankel, Adam and Patel, Riteshkumar and Chew, Shaun Jin Hui and Lah, Kevin and Barnett, Stephen A. and Muralidharan, Vijayaragavan and Phillips, Samantha and Jamel, Wael and Ko, Bung-Kook and Joglekar, Shantanu and Rajagopalan, Ashray and Jaya, Joseph and Chung, Yat Cheung and Peeroo, Saania and Bak, Marek and Tiong, Jonathan and Zhou, Zhei and Crowe, Amy and Newbold, Ryan and Trainor, Bethanie and Pac Soo, Mei Lynn and Khandelwal, Vaibhavee and Eikelboom, Nicholas and Kim, Kyungchul and Moran, Emily and Hammerschlag, Joshua and Desmond, Brendan and D'souza, Joel and Lu, Jacky and Mclay-Barnes, Rachel and Gower, Alexandra and Choi, Jenny and Wood, Douglas and Whytock, Kate and Surendran, Suraj and Paul, Negine and Khan H, Feroz and Chia, Daryl KA and Leong, Eugene KF and Ijner, Tvisha and Lin, Yi-Tzu Linda and Liew, Mei Sien and Jaretzke, Helen and Dempster, Niall and Bhanot, Kunal and Mian, Areeb and Mastoridis, Sotiris and Gibbons, Ben and Owen-Smith, Sam and Walmsley, James and Al Azzawi, Mohammed and Doyle, Evin and Okamura, Yasuhiro and Keywani, Kammy and Ferrari, Giovanni and Gualtierotti, Monica and De Martini, Paolo and Bushati, Frida, Pathological response guides adjuvant 5-fluorouracil, leucovorin, oxaliplatin, and docetaxel (FLOT) chemotherapy in surgically resected gastro-oesophageal cancer (SPACE-FLOT): international cohort study, British Journal of Surgery, 112, (4), 2025, Notes: [Cited by: 3], Journal Article, PUBLISHED  DOI
Miyoshi, Jinsei and Mannucci, Alessandro and Scarpa, Marco and Gao, Feng and Toden, Shusuke and Whitsett, Timothy and Inge, Landon J. and Bremner, Ross M. and Takayama, Tetsuji and Cheng, Yulan and Bottiglieri, Teodoro and Nagetaal, Iris D. and Shrubsole, Martha J. and Zaidi, Ali H and Wang, Xin and Coleman, Helen G. and Anderson, Lesley A. and Meltzer, Stephen J and Goel, Ajay and Fassan, Matteo and Trevellin, Elisabetta and Scarpa, Melania and Murray, Liam J. and Johnston, B.T. and Watson, R.G.P. and Mcguigan, J. and Ferguson, H.R. and Murphy, S.J. and Reynolds, J.V. and Comber, H., Liquid biopsy to identify Barrett's oesophagus, dysplasia and oesophageal adenocarcinoma: the EMERALD multicentre study, Gut, 74, (2), 2025, p169 â€" 181 , Notes: [Cited by: 6], Journal Article, PUBLISHED  DOI
Hayes, Michelle and Gillman, Anna and Elliott, Jessie A. and Donohoe, Claire L. and Reynolds, John V. and Regan, Julie, The prevalence, nature and severity of oropharyngeal dysphagia in the acute post-operative phase following curative resection for esophageal cancer, Diseases of the Esophagus, 38, (4), 2025, Notes: [Cited by: 0], Journal Article, PUBLISHED  DOI
Fiona O"Connell, Eimear Mylod, Noel E. Donlon, Maria Davern, Christine Butler, Niamh O"Connor, Meghana Menon, Claire L. Donohoe, Narayanasamy Ravi, Derek G. Doherty, Margaret R. Dunne, John V. Reynolds, Helen M. Roche, Jacintha O"Sullivan, Adipose tissue from oesophageal adenocarcinoma patients is differentially affected by chemotherapy and chemoradiotherapy regimens altering immune cell phenotype and cancer cell metabolism, Translational Oncology, 53, 2025, p102302 - 102302, p102302-102302 , Journal Article, PUBLISHED  DOI
Elliott, J.A. and Reynolds, J.V., Insulin resistance, hyperinsulinemia, and cancer: pathogenic considerations and therapeutic opportunities, 2024, 285-314pp, Notes: [cited By 0], Book, PUBLISHED  DOI
  

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Cliona M Lorton, John V Reynolds, Joanne Lysaght, ASO Author Reflections: Can CRP and CRP-Based Scores Predict Survival in Operable Adenocarcinomas of the Esophagus and Esophago-Gastric Junction?, Annals of Surgical Oncology, 2021, Journal Article, PUBLISHED

  


Anti-oxidants in inflammatory disease. Genetic polymorphisms in upper gastrointestinal cancer and Barrett's oesophagus. Liver and gut immune function in patients undergoing complex major surgery. Molecular predictors of response and resistance to chemotherapy and radiation therapy. Transcription factors in inflammation and neoplasia of the oesophagus. Upper gastrointestinal physiology.