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Professor Padraic Fallon

Professor of Translational Immunology (Clinical Medicine)

Interim IMM Director (Molecular Medicine Ireland)

Professor Padraic Fallon heads the Translational Immunology Group. Prof Fallon is the Science Foundation Ireland Stokes Professor in Translational Immunology in the School of Medicine, TCD. Previously, Fallon was a Wellcome Trust Fellow in the University of Cambridge, UK, investigating immune modulation by schistosomes. Since returning to Ireland in 2001, he has continued his research, elucidating underlying mechanisms of aberrant immune function and novel therapeutic strategies for inflammatory diseases. The main diseases addressed are allergic lung inflammation (asthma), skin inflammation (eczema) and inflammatory bowel disease (ulcerative colitis and Crohn's disease). Fallon is the Director of the Paediatric Research in Translational Immunology (PRiTI) Programme, a strategic partnership between Trinity College Dublin and the National Children's Research Centre The PRiTI programme bridges basic and clinician scientists and focuses on the underlying inflammatory processes associated with a number of childhood diseases. Prof Fallon is also the current Director of Research for the School of Medicine.
  Allergies   ALLERGY   Animal Models   ANIMAL-MODELS   Asthma   CYTOKINE RESPONSES   DISEASE MODELS   EXPERIMENTAL COLITIS   Helminths   Immunotherapies   INFECTION   Inflammatory Bowel Disease   MATERNAL-FETAL INTERFACE   Parasites   Transgenic Mice
Bidault G., Virtue S., Petkevicius K., Jolin H.E., Dugourd A., Guenantin A.-C., Leggat J., Mahler-Araujo B., Lam B.Y.H., Ma M.K., Dale M., Carobbio S., Kaser A., Fallon P.G., Saez-Rodriguez J., McKenzie A.N.J., Vidal-Puig A., SREBP1-induced fatty acid synthesis depletes macrophages antioxidant defences to promote their alternative activation, Nature Metabolism, 3, (9), 2021, p1150 - 1162, p1150-1162 , Journal Article, PUBLISHED  DOI
Lok L.S.C., Walker J.A., Jolin H.E., Scanlon S.T., Ishii M., Fallon P.G., McKenzie A.N.J., Clatworthy M.R., Group 2 Innate Lymphoid Cells Exhibit Tissue-Specific Dynamic Behaviour During Type 2 Immune Responses, Frontiers in Immunology, 12, 2021, Journal Article, PUBLISHED  DOI
Muhandes L., Chapsa M., Pippel M., Behrendt R., Ge Y., Dahl A., Yi B., Dalpke A., Winkler S., Hiller M., Boutin S., Beissert S., Jessberger R., Fallon P.G., Roers A., Low Threshold for Cutaneous Allergen Sensitization but No Spontaneous Dermatitis or Atopy in FLG-Deficient Mice, Journal of Investigative Dermatology, 141, (11), 2021, p2611 - 2619.e2, p2611-2619.e2 , Journal Article, PUBLISHED  DOI
Hams E., Roberts J., Bermingham R., Fallon P.G., Functions for Retinoic Acid-Related Orphan Receptor Alpha (ROR") in the Activation of Macrophages During Lipopolysaccharide-Induced Septic Shock, Frontiers in Immunology, 12, 2021, Journal Article, PUBLISHED  DOI
Giannoudaki E, Stefanska AM, Lawler H, Leon G, Hernandez Santana YE, Hassan N, Russell SE, Horan R, Sweeney C, Preston RS, Mantovani A, Garlanda C, Fallon PG, Walsh PT., SIGIRR Negatively Regulates IL-36-Driven Psoriasiform Inflammation and Neutrophil Infiltration in the Skin, Journal of Immunology, 207, (2), 2021, p651 - 660, Journal Article, PUBLISHED  DOI
Liam Townsend, Adam H Dyer, Aifric Naughton, Rachel Kiersey, Dean Holden, Mary Gardiner, Joanne Dowds, Kate O'Brien, Ciaran Bannan, Parthiban Nadarajan, Jean Dunne, Ignacio Martin-Loeches, Padraic Fallon, Colm Bergin, Cliona O'Farrelly, Cliona Ni Cheallaigh, Nollaig Bourke, Niall Conlon, Longitudinal analysis of COVID-19 patients shows age-associated T cell changes independent of ongoing ill-health, Frontiers In Immunology, 2021, Journal Article, PUBLISHED
Alí Alejo, Carolina Sánchez, Sylvie Amu, Padraic G. Fallon and Antonio Alcamí, Addition of a Viral Immunomodulatory Domain to Etanercept Generates a Bifunctional Chemokine and TNF Inhibitor, Journal of Clinical Medicine, 9, (1), 2020, p1-25 , Journal Article, PUBLISHED  TARA - Full Text  DOI
Sean P. Saunders, Achilleas Floudas, Tara Moran, Ciara M. Byrne, Michael D. Rooney, Caoimhe M.R. Fahy, Joan A. Geoghegan, Yoichiro Iwakura, Padraic G. Fallon, Christian Schwartz, Dysregulated skin barrier function in Tmem79 mutant mice promotes IL"17A"dependent spontaneous skin and lung inflammation., Allergy, 2020, Journal Article, PUBLISHED
Thyssen J.P., Jakasa I., Riethmuller C., Schon M.P., Braun A., Haftek M., Fallon P.G., Wroblewski J., Jakubowski H., Eckhart L., Declercq W., Koppes S., Engebretsen K.A., Bonefeld C., Irvine A.D., Keita-Alassane S., Simon M., Kawasaki H., Kubo A., Amagai M., Matsui T., Kezic S., Filaggrin Expression and Processing Deficiencies Impair Corneocyte Surface Texture and Stiffness in Mice, Journal of Investigative Dermatology, 140, (3), 2020, p615 - 623.e5, p615-623.e5 , Journal Article, PUBLISHED  DOI
Browning J, Rooney M, Hams E, Takahashi S, Mizuno S, Sugiyama F, Fallon PG, Kelly VP., Highly efficient CRISPR-targeting of the murine Hipp11 intergenic region supports inducible human transgene expression., Molecular biology reports, 2020, Journal Article, PUBLISHED  DOI

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Award Date
Member Royal Irish Academy (MRIA) 2014
Fellow Trinity College Dublin (FTCD) 2009
Stokes Professorship from Science Foundation Ireland. 2008
My research involves two overlapping translational immunology themes. i. The use of mouse models to study pathogen modulation of human inflammatory diseases. ii. Immune phenotyping of patients, in particular children, with inflammatory diseases such as atopic dermatitis and pulmonary fibrosis. Research aims to elucidate new mechanism of modulation of immunity that can alter inflammation and have therapeutic potential. Collaborative activity involves the phenotyping of new transgenic mice. The main diseases addressed are allergic lung and skin inflammation and inflammatory bowel disease. A growing emphasis is applying extensive expertise in animal models of human inflammatory diseases and general pathophysiology of inflammation to functional analysis of new therapeutic molecules/strategies with clinical collaborators and Pharma.