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Professor Padraic Fallon

Professor of Translational Immunology (Clinical Medicine)

 pfallon@tcd.ie

 3531896 3297

Interim IMM Director (Molecular Medicine Ireland)


Biography

Professor Padraic Fallon heads the Translational Immunology Group. Prof Fallon is Professor of Translational Immunology in the School of Medicine, TCD. Previously, Fallon was a Wellcome Trust Fellow in the University of Cambridge, UK, investigating immune modulation by schistosomes. Since returning to Ireland in 2001, he has continued his research, elucidating underlying mechanisms of aberrant immune function and novel therapeutic strategies for inflammatory diseases. The main diseases addressed are allergic lung inflammation (asthma), skin inflammation (eczema), inflammatory bowel disease (ulcerative colitis and Crohn's disease).as well as haemophilia. Since 2007, Prof Fallon has generated over €15 million of funding as Principal Investigator supporting research programmes on inflammatory diseases, clinical immunology and infections (helminths and COVID-19). The main diseases addressed are fibrotic disorders, allergic lung and skin inflammation, inflammatory bowel disease and haemophilia. The research on inflammatory diseases is across the human lifespan; from studies on skin diseases in infants, asthma in adults to the metabolic syndrome in the elderly. Prof Fallon has delivered a number of seminal discoveries across the field of immunology. He is an author of ~220 peer-reviewed publications in the leading scientifc journals. Fallon has been ranked in top 1% of scientists in the world by citations for publications from 2018-2022 in immunology (Clarivate Analytics).

Research Tags

  Allergies   ALLERGY   Animal Models   ANIMAL-MODELS   Asthma   CYTOKINE RESPONSES   DISEASE MODELS   EXPERIMENTAL COLITIS   Helminths   Immunotherapies   INFECTION   Inflammatory Bowel Disease   MATERNAL-FETAL INTERFACE   Parasites   Transgenic Mice
Yin M, Wadhwa R, Marshall JE, Gillis CM, Kim RY, Dua K, Palsson-McDermott EM, Fallon PG, Hansbro PM, O'Neill LAJ., 4-Octyl Itaconate Alleviates Airway Eosinophilic Inflammation by Suppressing Chemokines and Eosinophil Development., Journal of immunology (Baltimore, Md. : 1950), 212, (1), 2024, p13-23 , Journal Article, PUBLISHED  DOI
Szeto ACH, Clark PA, Ferreira ACF, Heycock M, Griffiths EL, Jou E, Mannion J, Luan SL, Storrar S, Knolle MD, Kozik P, Jolin HE, Fallon PG, McKenzie ANJ., Mef2d potentiates type-2 immune responses and allergic lung inflammation., Science (New York, N.Y.), 384, (6703), 2024, peadl0370 , Journal Article, PUBLISHED  DOI
Tchen J, Simon Q, Chapart L, Thaminy MK, Vibhushan S, Saveanu L, Lamri Y, Saidoune F, Pacreau E, Pellefigues C, Bex-Coudrat J, Karasuyama H, Miyake K, Hidalgo J, Fallon PG, Papo T, Blank U, Benhamou M, Hanouna G, Sacre K, Daugas E, Charles N., PD-L1- and IL-4-expressing basophils promote pathogenic accumulation of T follicular helper cells in lupus., Nature communications, 15, (1), 2024, p3389 , Journal Article, PUBLISHED  DOI
Schneider AK, Domingos-Pereira S, Cesson V, Polak L, Fallon PG, Zhu J, Roth B, Nardelli-Haefliger D, Derré L., Type 2 innate lymphoid cells are not involved in mouse bladder tumor development, Frontiers in Immunology, 14, 2024, p1335326 , Notes: [DOI: 10.3389/fimmu.2023.1335326], Journal Article, PUBLISHED  DOI
Hawerkamp HC, Dyer AH, Patil ND, McElheron M, O'Dowd N, O'Doherty L, Mhaonaigh AU, George AM, O'Halloran AM, Reddy C, Kenny RA, Little MA, Martin-Loeches I, Bergin C, Kennelly SP, Donnelly SC, Bourke NM, Long A, Sui J, Doherty DG, Conlon N, Cheallaigh CN, Fallon PG., Characterisation of the pro-inflammatory cytokine signature in severe COVID-19., Frontiers in Immunology, 14, 2023, p1170012-, Journal Article, PUBLISHED  URL
Roberts J, Chevalier A, Hawerkamp HC, Yeow A, Matarazzo L, Schwartz C, Hams E, Fallon PG., Retinoic Acid-Related Orphan Receptor " Is Required for Generation of Th2 Cells in Type 2 Pulmonary Inflammation., Journal of immunology (Baltimore, Md. : 1950), 211, (4), 2023, p626-632 , Journal Article, PUBLISHED  DOI
Klement JD, Redd PS, Lu C, Merting AD, Poschel DB, Yang D, Savage NM, Zhou G, Munn DH, Fallon PG, Liu K., Tumor PD-L1 engages myeloid PD-1 to suppress type I interferon to impair cytotoxic T lymphocyte recruitment., Cancer cell, 41, (3), 2023, p620-636.e9 , Journal Article, PUBLISHED  DOI
Einas Elsheikh, Michelle Lavin, Lilian Antunes Heck, Niamh Larkin, Brendan Mullaney, Dearbhla Doherty, Megan Kennedy, Catriona Keenan, Thomas Guest, Brian O'Mahony, Judicael Fazavana, Padraic G. Fallon, Roger J.S. Preston, John Gormley, Kevin Ryan, Niamh M. O'Connell, Evelyn Singleton, Mary Byrne, Mark McGowan, Sheila Roche, Mairead Doyle, Maeve P. Crowley, Susan I. O'Shea, Birgit M. Reipert, Jill M. Johnsen, Steven W. Pipe, Jorge Di Paola, Peter L. Turecek, James S. O'Donnell, Heterogeneity in the half-life of factor VIII concentrate in patients with hemophilia A is due to variability in the clearance of endogenous von Willebrand factor, Journal of Thrombosis and Haemostasis, 2023, Journal Article, PUBLISHED  DOI
Ward SE, Guest T, Byrne C, Lopes P, O'Sullivan JM, Doherty D, O'Connell D, Gutierrez Llaneza S, Chion A, Fazavana J, Fallon PG, Preston RJS, Johnsen JM, Pipe SW, Turecek PL, O'Donnell JS, iPATH Study Group., Macrophage Galactose Lectin Contributes to the Regulation of FVIII (Factor VIII) Clearance in Mice-Brief Report., Arteriosclerosis, thrombosis, and vascular biology, 43, (4), 2023, p540-546 , Journal Article, PUBLISHED  DOI
Dietschmann A, Ruhl A, Murray PJ, Günther C, Becker C, Fallon P, Voehringer D., Th2-dependent disappearance and phenotypic conversion of mouse alveolar macrophages., European journal of immunology, 53, (10), 2023, pe2350475 , Journal Article, PUBLISHED  DOI
  

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Awards and Honours

Award Date
Member Royal Irish Academy (MRIA) 2014
Stokes Professorship from Science Foundation Ireland. 2008
Fellow Trinity College Dublin (FTCD) 2009

Research Interests

Description Of Research Interests

RESEARCH Research involves overlapping translational immunology themes. i. The use of mouse as models, transgenics and mutant strains, to study basic mechanisms of innate and adaptive immunity in inflammatory and infectious diseases. ii. Immune phenotyping of patients with inflammatory diseases such as atopic dermatitis, asthma and pulmonary fibrosis. iii. Research on inflammatory diseases of patients across the lifespan; from skin diseases in infants, asthma in adults to the metabolic syndrome in the elderly. Research aims to elucidate new mechanism of modulation of innate and adaptive cellular immunity that can alter inflammation and have therapeutic potential. The main diseases addressed are fibrotic disorders, allergic lung and skin inflammation and inflammatory bowel disease.