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Dr. Lucy Norris

SENIOR EXP OFFICER OBS&GYN (P/T 17/8/06) (Obstetrics)
TRINITY CENTRE, S J H

 lnorris@tcd.ie

 3531896 2116


Biography

Lucy Norris MSc Mol. Med. PhD https://orcid.org/0000-0001-7862-3230. Lucy Norris graduated from Trinity College Dublin with an honours degree in Biochemistry. She was awarded a PhD in 1992 from TCD Dept of Obstetrics and Gynaecology based on her work investigating platelet activation in pregnancy, pre-eclampsia and oral contraception. She is the Principal Investigator of Coagulation Research group at the Department of obstetrics and Gynaecology and has over 25 years' experience in the area of haemostasis and thrombosis research. Her current research program focuses on the prediction of venous thrombosis in gynaecological cancer and the role of coagulation gene expression in the aetiology of ovarian cancer and has recieved independent funding from the HRB and the pharmaceutical industry. She has over 100 peer reviewed articles many as senior author(h-index:22, i10 index 33, Citations 1809). She is co-editor in chief of the journal "Thrombosis Update" and a member of the editorial board of Thrombosis Research and European Journal of Gynaecological Oncology.

Research Tags

  Biomedical sciences   Cardiovascular risk assessment and hormone replacement therapy   Clinical research, trials   Coagulation biochemistry and disorders   Cytokines, Nitric Oxide   Foetal, maternal and neonatal physiology   Haemotology   Hormone physiology and biochemistry   Inflammation and coagulation syndromes   Medical Sciences, Research   Menopause   Molecular haematology   Oral contaraceptives and haemostasis   Pre-eclampsia and intrauterine growth retardation   Prevention, treatment of thromboembolic complications in pregnancy   Reproduction, fertility and contraception   Thrombosis and haemostasis   Vascular Biology, Thrombosis

Research Projects

 Activated protein C pathway in ovarian cancer -a novel prognostic marker?
 Lymph node status and coagulation biomarkers as predictors of venous thromboembolism in gynaecological cancer
 A risk model for prediction of venous thromboembolism in gynaecological cancer patients post surgery
 Towards increased awareness and understanding of the risk of thrombosis in gynaecological cancers
 Interrogation of the Onco-metabolome in ovarian cancer

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Representations

Details Date
Co-Editor in Chief of Thrombosis Update 2019
Member of the Editorial board of Thrombosis Research
Member of International Society for Thrombosis and Haemostasis publications committee 2016-2020
Member Editorial Board European Journal of Gynaecological Oncology 2021

Languages

Language Skill Reading Skill Writing Skill Speaking
English Fluent Fluent Fluent

Memberships

Membership of Professional Institutions, Associations, Societies

Details Date From Date To
Member of International Society for Thrombosis and Haemostasis 2010 2020
Irish Society for Gynaecological Oncology 2016-present
Irish Association of Cancer Research 2015-present
Irish National Network for Ovarian Cancer Collaboration INNOVATION Founder member 2016 Present
Abu Saadeh F, Marchocki Z, O'Toole SA, Ibrahim N, Gleeson N, Norris LA. , Extended thromboprophylaxis post gynaecological cancer surgery; the effect of weight adjusted and fixed dose LMWH (Tinzaparin). , Thrombosis Research, 207, 2021, p25 - 32, Journal Article, PUBLISHED  DOI
Ibrahim, Elzahra, Norris, Lucy A., Abu Saadeh, Feras, Update on extended prophylaxis for venous thromboembolism following surgery for gynaecological cancers, Thrombosis Update, 2, 2021, p100038 , Journal Article, PUBLISHED  DOI
Ward, Mark P., Saadeh, Feras Abu, O'Toole, Sharon A., O'Leary, John J., Gleeson, Noreen, Norris, Lucy A., Procoagulant activity in high grade serous ovarian cancer patients following neoadjuvant chemotherapy-The role of the activated protein C pathway, Thrombosis Research, 200, 2021, p91 - 98, Journal Article, PUBLISHED  DOI
McKendry, Kate, Duff, Stephen, Huang, Yanmei, Redha, Mostafa, Scanlon, Áine, Abu Saadeh, Feras, Gleeson, Noreen, O"Leary, John, Norris, Lucy, O"Toole, Sharon, The value of HE4, D"dimer, and fibrinogen compared to CA125 alone in triaging women presenting with pelvic masses: a retrospective cohort study, Acta Obstetricia et Gynecologica Scandinavica, 2021, Journal Article, PUBLISHED  DOI
Ward, M.P., Kane, L.E., Norris, L.A et al. , Platelets, immune cells and the coagulation cascade; friend or foe of the circulating tumour cell?, Molecular Cancer, 20, 2021, p59-, Journal Article, PUBLISHED  DOI
Spillane CD, Cooke NM, Ward MP, Kenny D, Blackshields G, Kelly T, Bates M, Huang Y, Martin C, Skehan S, Canney A, Gallagher M, Smyth P, Brady N, Clarke A, Mohamed B, Norris L, Brooks DA, Brooks RD, Heatlie JK, Selemidis S, Hanniffy S, Dixon E, Sheils O, O'Toole SA, O'Leary JJ., The induction of a mesenchymal phenotype by platelet cloaking of cancer cells is a universal phenomenon., Translational oncology, 14, (12), 2021, p101229 , Journal Article, PUBLISHED  DOI
Papadakis E and Norris LA, Covid-19: "the end of the beginning", Thrombosis Update, 5, 2021, p100051 - 10051, Journal Article, PUBLISHED  DOI
E Ibrahim, SA O'Toole, F Abu Saadeh, LA Norris., Lymph node status as a predictor of venous thromboembolic risk postoperatively in gynae-oncology. , International Journal of Gynecologic Cancer, European Society For Gynae-Oncology (ESGO), 31, (Supplement 3), 2021, Poster, PUBLISHED
Norris LA, Ward MP, O'Toole SA, Marchocki Z, Ibrahim N, Khashan AS, Abu Saadeh F, Gleeson N. , A risk score for prediction of venous thromboembolism in gynecologic cancer: The Thrombogyn score. , Research Practice in Thrombosis and Haemostasis, 4, (5), 2020, p848 - 859, Journal Article, PUBLISHED  DOI
Norris, Lucy A., Papadakis, Emmanouil S., A new journal in a brave new world, Thrombosis Update, 1, 2020, p100019 , Journal Article, PUBLISHED  DOI
  

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Ibrahim E, O'Toole S, Ward M, Abu Saadeh F, Norris LA. , Factor VIIIc predicts venous thromboembolism in gynaecological cancer patients., Research. Practice in Thrombosis. and Haemostasis , 5, (Supplement 2), 2021, ppPB1096 - PB1096, Poster, PUBLISHED
M.P. Ward, F.A. Saadeh, J.J. O'Leary, N. Gleeson, S.A. O'Toole, L.A. Norris ., The Effect of Neoadjuvant Chemotherapy on the Activated Protein C (aPC) Pathway in High Grade Serous Ovarian Cancer Patients., Research Practice in Thrombosis and Haemostasis, International Society for Thrombosis and Haemostasis , Berlin, July 2017, 1, (1), Wiley, 2017, pp625 - 625, Published Abstract, PUBLISHED
Lucy Norris, Can we predict VTE in gynaecological cancer?, Irish Society for Gynae-Oncology (ISGO) annual scientific meeting 'TRANSLATION AND INNOVATION'., Dublin, December 1st , 2016, ISGO, Invited Talk, PRESENTED
Lucy Norris, Prediction and Prevention of venous thromboembolism in Gynaecological cancer. , Master class in Cancer and Thrombosis, Dublin, July 7, 2015, 87-, Invited Talk, PRESENTED
Ibrahim N, Norris L, O'Toole S, McHugh T, Gleeson N, Does extended thromboprophylaxis help reduce the incidence of venous thromboembolism in gynaecological cancer patients?, Thrombosis Research, 7th Internation Conference onal Thrombosis & Hemostatis Issues in Cancer,, Bergamo Italy, May 2014, edited by A Falanga, B. Brenner, F, Rickles , 133, (Suppl 2), Elsevier, 2014, Published Abstract, PUBLISHED
Lucy Norris, HRT and haemostasis, UCC Obstetrics and Gynaecology, research seminar, Cork, February, 2011, UCC, 87-, Invited Talk, PRESENTED
Abu Saadeh F, Norris L, O'Toole S, Gleeson N. , The role of tissue factor and tissue factor pathway inhibitor in ovarian cancer, Thrombosis Research, Womens Health Issues in Thrombosis and Haemostasis, Berlin, February 2011, 127, (Suppl 3), Elsevier, 2011, pp149 - 149, Meeting Abstract, PUBLISHED
SK Ismail, Norris LA, Muttukrishna S, Higgins JR, Effect of LMWH prophylaxis on thrombin generation post caesarean section, Thrombosis Research, Women's Health Issues in Thrombosis and Haemostasis, Berlin, February 2011, 127, (Suppl), 2011, ppS137 - S137, Meeting Abstract, PUBLISHED
Lynne Kelly, Shanthi Muttukrishna, Lucy Norris, John Higgins, Placental expression of haemostatic and angiogenic markers in preeclampsia, Hydrometallurgy, 1, (3), 2011, pp277-, Published Abstract, PUBLISHED
Lucy Norris, Hormones and the risk of thrombosis., Update on Coagulation, Dublin, March, 2010, National Centre for Coagulation and Hereditary disorders, 87-, Invited Talk, PRESENTED

  

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Awards and Honours

Award Date
Donegan Medal of best presentation (RAMI)-Runner up June 1987

Research Interests

Description Of Research Interests

The role of coagulation proteases and platelets in the aetiology of gynaecological cancers. Development of risk models for the prediction of thrombosis in gynaecological cancer patients. Aetiology of thrombosis risk in high risk pregnancy patients. Effects of oestrogens, progestogens and phytoestogens on coagulation gene expression and their role in thrombosis risk. The role of coagulation gene expression in the transition from endometriosis to clear cell cancer.