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Dr. Lucy Norris

SENIOR EXP OFFICER OBS&GYN (P/T 17/8/06) (Obstetrics)
COOMBE WOMENS HOSPITAL

 lnorris@tcd.ie

 3531896 2116


Biography

Lucy Norris MSc Mol. Med. PhD https://orcid.org/0000-0001-7862-3230. Lucy Norris graduated from Trinity College Dublin with an honours degree in Biochemistry. She was awarded a PhD in 1992 from TCD Dept of Obstetrics and Gynaecology based on her work investigating platelet activation in pregnancy, pre-eclampsia and oral contraception. She is the Principal Investigator of Coagulation Research group at the Department of obstetrics and Gynaecology and has over 25 years' experience in the area of haemostasis and thrombosis research. Her current research program focuses on the prediction of venous thrombosis in gynaecological cancer and the role of coagulation gene expression in the aetiology of ovarian cancer and has received independent funding from the HRB and the pharmaceutical industry. She has over 100 peer reviewed articles many as senior author(h-index:24, i10 index 41, Citations 2188). She is co-editor in chief of the journal "Thrombosis Update" and a member of the editorial board of Thrombosis Research and European Journal of Gynaecological Oncology.

Research Tags

  Biomedical sciences   Cardiovascular risk assessment and hormone replacement therapy   Clinical research, trials   Coagulation biochemistry and disorders   Cytokines, Nitric Oxide   Foetal, maternal and neonatal physiology   Haemotology   Hormone physiology and biochemistry   Inflammation and coagulation syndromes   Medical Sciences, Research   Menopause   Molecular haematology   Oral contaraceptives and haemostasis   Pre-eclampsia and intrauterine growth retardation   Prevention, treatment of thromboembolic complications in pregnancy   Reproduction, fertility and contraception   Thrombosis and haemostasis   Vascular Biology, Thrombosis

Research Projects

 Thrombomodulin as a predictor for chemotherapy associated venous thromboembolism
 Activated protein C pathway in ovarian cancer -a novel prognostic marker?
 Lymph node status and coagulation biomarkers as predictors of venous thromboembolism in gynaecological cancer
 A risk model for prediction of venous thromboembolism in gynaecological cancer patients post surgery
 Towards increased awareness and understanding of the risk of thrombosis in gynaecological cancers

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Representations

Details Date
Co-Editor in Chief of Thrombosis Update 2019
Member of the Editorial board of Thrombosis Research
Member of International Society for Thrombosis and Haemostasis publications committee 2016-2020
Member Editorial Board European Journal of Gynaecological Oncology 2021

Languages

Language Skill Reading Skill Writing Skill Speaking
English Fluent Fluent Fluent

Memberships

Membership of Professional Institutions, Associations, Societies

Details Date From Date To
Member of International Society for Thrombosis and Haemostasis 2010 2020
Irish Society for Gynaecological Oncology 2016-present
Irish Association of Cancer Research 2015-present
Irish National Network for Ovarian Cancer Collaboration INNOVATION Founder member 2016 Present
Mohamed BM, Ward MP, Bates M, Spillane CD, Kelly T, Martin C, Gallagher M, Heffernan S, Norris L, Kennedy J, Saadeh FA, Gleeson N, Brooks DA, Brooks RD, Selemidis S, O'Toole S, O'Leary JJ., Ex vivo expansion of circulating tumour cells (CTCs)., Scientific reports, 13, (1), 2023, p3704 - 3704, Journal Article, PUBLISHED  DOI
O'Neill AM, Calpin GG, Norris L, Beirne JP., The impact of enhanced recovery after gynaecological surgery: A systematic review and meta-analysis. , Gynaecological Oncology, 168, 2023, p8 - 16, Journal Article, PUBLISHED  URL
Lucy A Norris, Feras Abu Saadeh, "Risk of venous thromboembolism and bleeding after major surgery for ovarian cancer: standard in-hospital versus extended duration of thromboprophylaxis": Comment . , Journal of Thrombosis and Haemostasis, 21, (6), 2023, p1681 - 1683, Journal Article, PUBLISHED
Batog, WI, Maguire P, O'Toole SA, Norris L, Abu Saadeh F, Identification of groin node metastasis in squamous vulval cancer using pre-operative [18F] FDG-PET/CT. Can unnecessary lymphadectomy be prevented?, International Journal of Gynaecological Cancer, European Society for Gynaecological Oncology, Berlin, October 2022, 32, (Supplement 2), 2022, pp1590 - 1590, Conference Paper, PUBLISHED  URL
Ward MP, Ibrahim E, O'Toole S, Gleeson N, Abu Saadeh F, O'Donnell D, Norris LA, Thrombomodulin as a marker for VTE following neoadjuvant chemotherapy, Thrombosis Research, International Congress on Issues in Thrombosis in Cancer , Bergamo, Italy, May 2022, 213, ((6) Supplement 2), Elsevier, 2022, ppS13 - S14, Conference Paper, PUBLISHED  URL
Ward MP, O'Toole SA, Abu Saadeh F, Marchocki Z, Ibrahim EM, Martin F, Gleeon N, O'leary JJ, Norris LA, Mechanisms of cancer associated thrombosis in gynaecological cancer patients- tumour or treatment effect?, Research Practice in Thrombosis and Haemostasis, International Society for Thrombosis and Haemostasis, London, July 2022, 6, (Supplement 2), Wiley, 2022, ppPB0752 - PB0752, Conference Paper, PUBLISHED  URL
Ward MP, Lochrin SE, Ovarere C, O'Gorman C, Kane LE, Mohamed BM, Bates M, Kelly TE, O'Connor R, Kennedy J, Cadoo K, Kamran W, Beirne J, Abu Saadeh F, Martin CM, Norris LA, O'Toole SA, O'leary JJ, Platelets and immune call cloaking of circulating tumour cells in breast and ovarian cancer, Research Practice in Thrombosis and Haemostasis, International Society for Thrombosis and Haemostasis, London, July 2022, 6, ((supplement 2)), Wiley, 2022, ppPB0931 - PB0931, Conference Paper, PUBLISHED  URL
Mark P Ward, Mark Bates, Bashir Mohamed, Tanya Kelly, Roisin O'Connor, Robert Brooks, Doug Brooks, Stavros Selemidis, Celine Ovaere, Jane Tully, Patrick Maguire, Catherine O'Gorman, Waseem Kamran, James Beirne, Feras Saadeh, Noreen Gleeson, Lucy Norris, Cara Martin, Sharon O'Toole, John O'Leary, Isolation and characterisation of circulating tumour cells from ovarian cancer patients, LABORATORY INVESTIGATION, March 2022, 102, (SUPPL 1), SPRINGER NATURE, 2022, Poster, PUBLISHED  DOI
Elzahra Ibrahim, Lucy Norris, Feras Abu Saadeh, Does the use of long-term Aspirin reduce risk of post operative VTE in Gynaecological cancer patients, International Journal of Gynecologic Cancer, 23rd ESGO, Berlin, Oct 2022, 32, 2022, Poster, PUBLISHED  URL
E Ibrahim, SA O'Toole, F Abu Saadeh, LA Norris., Lymph node status as a predictor of venous thromboembolic risk postoperatively in gynae-oncology. , International Journal of Gynecologic Cancer, European Society For Gynae-Oncology (ESGO), 31, (Supplement 3), 2021, Conference Paper, PUBLISHED
  

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Norris Lucy A, Biomarkers for cancer associated venous thromboembolism, Hospital Professional News, 2023, Notes: [https://hospitalprofessionalnews.ie/2023/02/14/biomarkers-for-cancer-associated-venous-thromboembolism/], Review Article, PUBLISHED
Lucy Norris, Can we predict VTE in gynaecological cancer?, Irish Society for Gynae-Oncology (ISGO) annual scientific meeting 'TRANSLATION AND INNOVATION'., Dublin, December 1st , 2016, ISGO, Invited Talk, PRESENTED
Lucy Norris, Prediction and Prevention of venous thromboembolism in Gynaecological cancer. , Master class in Cancer and Thrombosis, Dublin, July 7, 2015, 87-, Invited Talk, PRESENTED
Ibrahim N, Norris L, O'Toole S, McHugh T, Gleeson N, Does extended thromboprophylaxis help reduce the incidence of venous thromboembolism in gynaecological cancer patients?, Thrombosis Research, 7th Internation Conference onal Thrombosis & Hemostatis Issues in Cancer,, Bergamo Italy, May 2014, edited by A Falanga, B. Brenner, F, Rickles , 133, (Suppl 2), Elsevier, 2014, Published Abstract, PUBLISHED
Lucy Norris, HRT and haemostasis, UCC Obstetrics and Gynaecology, research seminar, Cork, February, 2011, UCC, 87-, Invited Talk, PRESENTED
Abu Saadeh F, Norris L, O'Toole S, Gleeson N. , The role of tissue factor and tissue factor pathway inhibitor in ovarian cancer, Thrombosis Research, Womens Health Issues in Thrombosis and Haemostasis, Berlin, February 2011, 127, (Suppl 3), Elsevier, 2011, pp149 - 149, Meeting Abstract, PUBLISHED
SK Ismail, Norris LA, Muttukrishna S, Higgins JR, Effect of LMWH prophylaxis on thrombin generation post caesarean section, Thrombosis Research, Women's Health Issues in Thrombosis and Haemostasis, Berlin, February 2011, 127, (Suppl), 2011, ppS137 - S137, Meeting Abstract, PUBLISHED
Lynne Kelly, Shanthi Muttukrishna, Lucy Norris, John Higgins, Placental expression of haemostatic and angiogenic markers in preeclampsia, Hydrometallurgy, 1, (3), 2011, pp277-, Published Abstract, PUBLISHED
Lucy Norris, Hormones and the risk of thrombosis., Update on Coagulation, Dublin, March, 2010, National Centre for Coagulation and Hereditary disorders, 87-, Invited Talk, PRESENTED
Kelly L, O'Leary J, Wuttke W, Norris L. , Effects of Genistein versus Oestrogen on haemostatic gene expression in ovariectomised rats, Journal of Thrombosis and Haemostasis , International Society for Thrombosis and Haemostasis, Boston, July 2009, 7 , (Supplement 2), 2009, ppPP-WE-3731-, Meeting Abstract, PUBLISHED

  

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Research Interests

Description Of Research Interests

The role of coagulation proteases and platelets in the aetiology of gynaecological cancers. Development of risk models for the prediction of thrombosis in gynaecological cancer patients. The effect of chemotherapy in natural anticoagulant pathways. Aetiology of thrombosis risk in high risk pregnancy patients. Effects of oestrogens, progestogens and phytoestogens on coagulation gene expression and their role in thrombosis risk. The role of coagulation gene expression in the transition from endometriosis to clear cell cancer.