Professor Luke O'Neill

CURRICULUM VITAE Name: Luke A.J. O'Neill Title: Professor (Chair of Biochemistry) Affiliations: School of Biochemistry and Immunology Trinity College Dublin, Ireland Email: laoneill@tcd.ie EDUCATION AND QUALIFICATIONS 1985: Awarded B.A. (Mod.) in Natural Sciences (Biochemistry) Trinity College Dublin, Ireland. Class: I 1988: Awarded PhD in Pharmacology, University of London EMPLOYMENT 2011 Founder Director, Trinity Biomedical Sciences Institute 2007 Appointed to the Chair of Biochemistry, Trinity College Dublin 2005 Head, School of Biochemistry and Immunology, Trinity College Dublin Appointed Professor of Molecular Immunology 2004 Head of Department of Biochemistry, Trinity College Dublin Appointed Science Foundation Ireland Research Professor 2002 Visiting Professor, Monash University, Australia 1999 Visiting Professor, Millennium Pharmaceuticals, Cambridge MA 1999 Associate Professor of Biochemistry, Trinity College Dublin 1996 Fellow, Trinity College Dublin 1991 - 1999 Lecturer in Biochemistry, Trinity College Dublin 1988 - 1991 Medical Research Council Post-doctoral fellow, Strangeways Research Laboratory, Cambridge, UK AWARDS AND HONOURS 2005 Elected member of European Molecular Biology Organisation 2008 Appointed Chair of the European Research Council Infection and Immunity Panel 2009 Immunology 'Guru', National Institutes of Health Royal Dublin Society / Irish Times Boyle Medal for Scientific Excellence Science Foundation Ireland Researcher of the Year Award 2010 McGill University Dan Perry Award Lecture University of Oxford Jenner Institute Distinguished Lecturer Appointed Chair of the Programme Committee for Dublin European City of Science European Open Science Forum Conference 2011 European Research Council Advanced Grant awardee Appointed to Board of Reviewing Editors, Science President, International Cytokine Society 2012 Royal Irish Academy Gold Medal for Life Sciences 2014 European Federation of Immunology Societies Medal 2015 Listed in Thompson / Reuters top 1% of scientists (2002- 2012) in Immunology and Pharmacology/Toxicology based on citations Visiting Fellow, Christ's College Cambridge 2016 Visiting Professor, GlaxoSmithKline, Stevenage, UK Elected Fellow of the Royal Society (FRS) 2018 Milstein Award, International Cytokine and Interferon Society CURRENT RESEARCH Research Area: Molecular and Cellular basis to inflammation and innate immunity. Toll-like receptors. Pro-inflammatory cytokines. Signal transduction in the immune system. Molecular analysis of inflammatory and infectious diseases. Immunometabolism and Metabolic Reprogramming in Immunity

  3-DIMENSIONAL STRUCTURE   ACCEPTOR   ACIDIC SPHINGOMYELINASE   ACTIN-BASED MOVEMENT   ACTIVATED PROTEIN-KINASE   ACTIVATION   ACTIVATION PATHWAY   ADHESION MOLECULE   ADHESION MOLECULE-1   ALPHA   ANTIGEN   ANTINEOPLASTIC AGENTS   ANTIOXIDANTS   ATHEROSCLEROTIC LESION   Autoimmune Diseases (Multiple Sclerosis, Rheumatoid Arthritis)   BACTERIAL LIPOPOLYSACCHARIDE   BLOOD MONONUCLEAR-CELLS   CALCIUM CURRENTS   CALCIUM INFLUX   CASCADE   CATALYTIC ACTIVITY   CD18   CELL-FREE SYSTEM   CELLS   CELLULAR STRESSES   CERAMIDE   CHEMOKINE GENE-EXPRESSION   CHROMOSOMAL LOCATION   C-JUN   CLOSTRIDIUM-DIFFICILE   COMPLEX FACTOR ELK-1   CORD BLOOD   CRYSTAL-STRUCTURE   CUTTING EDGE   CYCLIC-AMP   CYTOKINES   DAUNORUBICIN-INDUCED APOPTOSIS   DENTATE GYRUS   DEPENDENT GENE-EXPRESSION   DEPENDENT MECHANISM   DEPENDENT TRANSCRIPTION   DIACYLGLYCEROL PRODUCTION   DISEASE   DISULFIDE   DNA-BINDING   DNA-BINDING ACTIVITY   DNA-BINDING SUBUNIT   DORSOVENTRAL POLARITY   DROSOPHILA   E-CADHERIN   EFFECTOR PATHWAYS   ENDOTHELIAL-CELL LINE   ENDOTHELIAL-CELLS   ENDOTOXIN   EXPRESSION   FACTOR INCREASE PHOSPHORYLATION   FACTOR-ALPHA   FACTOR-KAPPA-B   FAMILY   FAS-LIGAND   FIBROBLASTS   FUNCTIONAL-RESPONSES   GENE   GENE-EXPRESSION   Genetics   GROWTH-FACTOR-BETA   GTP-BINDING   GTP-BINDING PROTEINS   HIPPOCAMPAL SLICE   HIPPOCAMPAL SLICES   HIPPOCAMPAL-NEURONS   HIPPOCAMPUS   HL-60 CELLS   HL-60 LEUKEMIA-CELLS   HOST-DEFENSE   HUMAN-ENDOTHELIAL-CELLS   HUMAN-IMMUNODEFICIENCY-VIRUS   IDENTIFICATION   IL-1   IL-1 RECEPTOR   IL-1, Toll Receptors, NF-KappaB   IL-1/MAP KINASES   IL1HY1   IL-2 MESSENGER-RNA   Immune System   Immunomodulatory molecules as therapy for inflammatory or immune-mediated diseasesPro-inflammatory cytokines, Interleukin-1, Toll-like receptors, Toll-IL-1 receptor domain, Lipopolysaccharide   INDUCED APOPTOSIS   Inflammation   INHIBITORS   INTACT-CELLS   INTERLEUKIN-1   INTERLEUKIN-1 BETA   INTERLEUKIN-1 RECEPTOR ANTAGONIST   INTERLEUKIN-1 RECEPTORS   INTERLEUKIN-1-BETA   INTERLEUKIN-2   INTERLEUKIN-2 PROMOTER   INTERNALIN MULTIGENE FAMILY   IN-VITRO   KAPPA-B   KAPPA-B ACTIVATION   KINASE   LETHAL TOXIN   LEUKOCYTE ADHESION MOLECULES   LINE ECV304   LIPOPOLYSACCARIDE   LIPOPOLYSACCHARIDE   LONG-TERM POTENTIATION   Long-term potentiation & signal transduction mechanisms including MAP kinases   MAMMALIAN-CELLS   MAP KINASE   MECHANISMS   Medicines   MESSENGER-RNA   MESSENGERS   Molecular basis to inflammation and innate immunity   MOLECULE CD28   MONOCYTE   MULTIPLE-SCLEROSIS   MURINE MACROPHAGES   MUTATIONS   NECROSIS-FACTOR-ALPHA   NEONATAL T CELLS   NF-KAPPA-B   NITRIC-OXIDE SYNTHASE   ORGANIZATION   P50 SUBUNIT   PATHWAY   Pharmacology   PHOSPHATIDYLINOSITOL 3-KINASE   PHOSPHOINOSITIDE 3-KINASE   PHOSPHORYLATION   PROTEINS   RECEPTOR   RECEPTOR ANTAGONIST BINDS   RECEPTOR CD44   RECEPTOR SUPERFAMILY   RECOGNITION   RICH REPEAT REGION   SIGNAL TRANSDUCTION   Signal transduction in the immune system, NF-kappaB, T1/ST2, MAP kinases   SIGNAL-TRANSDUCTION   SIGNAL-TRANSDUCTION PATHWAYS   SUBSTRATE-SPECIFICITY   SUPERFAMILY   SUPEROXIDE   SURFACE PROTEIN   T LYMPHOCYTES   T-CELL ACTIVATION   TERM POTENTIATION   T-LYMPHOCYTE ACTIVATION   TRANSCRIPTION FACTOR   TRANSDUCTION   TUMOR-NECROSIS-FACTOR

CURRENT RESEARCH: Research Area: Molecular and Cellular basis to inflammation and innate immunity. Toll-like receptors. Pro-inflammatory cytokines. Signal transduction in the immune system. Molecular analysis of inflammatory and infectious diseases. Inflammasomes. Immunometabolism.