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Professor Luke O'Neill

Chair of Biochemistry(1960) (Biochemistry)

 Luke.ONeill@tcd.ie

 3531896 2439


Biography

CURRICULUM VITAE Name: Luke A.J. O'Neill Title: Professor (Chair of Biochemistry) Affiliations: School of Biochemistry and Immunology Trinity College Dublin, Ireland Email: laoneill@tcd.ie EDUCATION AND QUALIFICATIONS 1985: Awarded B.A. (Mod.) in Natural Sciences (Biochemistry) Trinity College Dublin, Ireland. Class: I 1988: Awarded PhD in Pharmacology, University of London EMPLOYMENT 2011 Founder Director, Trinity Biomedical Sciences Institute 2007 Appointed to the Chair of Biochemistry, Trinity College Dublin 2005 Head, School of Biochemistry and Immunology, Trinity College Dublin Appointed Professor of Molecular Immunology 2004 Head of Department of Biochemistry, Trinity College Dublin Appointed Science Foundation Ireland Research Professor 2002 Visiting Professor, Monash University, Australia 1999 Visiting Professor, Millennium Pharmaceuticals, Cambridge MA 1999 Associate Professor of Biochemistry, Trinity College Dublin 1996 Fellow, Trinity College Dublin 1991 - 1999 Lecturer in Biochemistry, Trinity College Dublin 1988 - 1991 Medical Research Council Post-doctoral fellow, Strangeways Research Laboratory, Cambridge, UK AWARDS AND HONOURS 2005 Elected member of European Molecular Biology Organisation 2008 Appointed Chair of the European Research Council Infection and Immunity Panel 2009 Immunology 'Guru', National Institutes of Health Royal Dublin Society / Irish Times Boyle Medal for Scientific Excellence Science Foundation Ireland Researcher of the Year Award 2010 McGill University Dan Perry Award Lecture University of Oxford Jenner Institute Distinguished Lecturer Appointed Chair of the Programme Committee for Dublin European City of Science European Open Science Forum Conference 2011 European Research Council Advanced Grant awardee Appointed to Board of Reviewing Editors, Science President, International Cytokine Society 2012 Royal Irish Academy Gold Medal for Life Sciences 2014 European Federation of Immunology Societies Medal 2015 Listed in Thompson / Reuters top 1% of scientists (2002- 2012) in Immunology and Pharmacology/Toxicology based on citations Visiting Fellow, Christ's College Cambridge 2016 Visiting Professor, GlaxoSmithKline, Stevenage, UK Elected Fellow of the Royal Society (FRS) 2018 Milstein Award, International Cytokine and Interferon Society CURRENT RESEARCH Research Area: Molecular and Cellular basis to inflammation and innate immunity. Toll-like receptors. Pro-inflammatory cytokines. Signal transduction in the immune system. Molecular analysis of inflammatory and infectious diseases. Immunometabolism and Metabolic Reprogramming in Immunity

Research Tags

  3-DIMENSIONAL STRUCTURE   ACCEPTOR   ACIDIC SPHINGOMYELINASE   ACTIN-BASED MOVEMENT   ACTIVATED PROTEIN-KINASE   ACTIVATION   ACTIVATION PATHWAY   ADHESION MOLECULE   ADHESION MOLECULE-1   ALPHA   ANTIGEN   ANTINEOPLASTIC AGENTS   ANTIOXIDANTS   ATHEROSCLEROTIC LESION   Autoimmune Diseases (Multiple Sclerosis, Rheumatoid Arthritis)   BACTERIAL LIPOPOLYSACCHARIDE   BLOOD MONONUCLEAR-CELLS   CALCIUM CURRENTS   CALCIUM INFLUX   CASCADE   CATALYTIC ACTIVITY   CD18   CELL-FREE SYSTEM   CELLS   CELLULAR STRESSES   CERAMIDE   CHEMOKINE GENE-EXPRESSION   CHROMOSOMAL LOCATION   C-JUN   CLOSTRIDIUM-DIFFICILE   COMPLEX FACTOR ELK-1   CORD BLOOD   CRYSTAL-STRUCTURE   CUTTING EDGE   CYCLIC-AMP   CYTOKINES   DAUNORUBICIN-INDUCED APOPTOSIS   DENTATE GYRUS   DEPENDENT GENE-EXPRESSION   DEPENDENT MECHANISM   DEPENDENT TRANSCRIPTION   DIACYLGLYCEROL PRODUCTION   DISEASE   DISULFIDE   DNA-BINDING   DNA-BINDING ACTIVITY   DNA-BINDING SUBUNIT   DORSOVENTRAL POLARITY   DROSOPHILA   E-CADHERIN   EFFECTOR PATHWAYS   ENDOTHELIAL-CELL LINE   ENDOTHELIAL-CELLS   ENDOTOXIN   EXPRESSION   FACTOR INCREASE PHOSPHORYLATION   FACTOR-ALPHA   FACTOR-KAPPA-B   FAMILY   FAS-LIGAND   FIBROBLASTS   FUNCTIONAL-RESPONSES   GENE   GENE-EXPRESSION   Genetics   GROWTH-FACTOR-BETA   GTP-BINDING   GTP-BINDING PROTEINS   HIPPOCAMPAL SLICE   HIPPOCAMPAL SLICES   HIPPOCAMPAL-NEURONS   HIPPOCAMPUS   HL-60 CELLS   HL-60 LEUKEMIA-CELLS   HOST-DEFENSE   HUMAN-ENDOTHELIAL-CELLS   HUMAN-IMMUNODEFICIENCY-VIRUS   IDENTIFICATION   IL-1   IL-1 RECEPTOR   IL-1, Toll Receptors, NF-KappaB   IL-1/MAP KINASES   IL1HY1   IL-2 MESSENGER-RNA   Immune System   Immunomodulatory molecules as therapy for inflammatory or immune-mediated diseasesPro-inflammatory cytokines, Interleukin-1, Toll-like receptors, Toll-IL-1 receptor domain, Lipopolysaccharide   INDUCED APOPTOSIS   Inflammation   INHIBITORS   INTACT-CELLS   INTERLEUKIN-1   INTERLEUKIN-1 BETA   INTERLEUKIN-1 RECEPTOR ANTAGONIST   INTERLEUKIN-1 RECEPTORS   INTERLEUKIN-1-BETA   INTERLEUKIN-2   INTERLEUKIN-2 PROMOTER   INTERNALIN MULTIGENE FAMILY   IN-VITRO   KAPPA-B   KAPPA-B ACTIVATION   KINASE   LETHAL TOXIN   LEUKOCYTE ADHESION MOLECULES   LINE ECV304   LIPOPOLYSACCARIDE   LIPOPOLYSACCHARIDE   LONG-TERM POTENTIATION   Long-term potentiation & signal transduction mechanisms including MAP kinases   MAMMALIAN-CELLS   MAP KINASE   MECHANISMS   Medicines   MESSENGER-RNA   MESSENGERS   Molecular basis to inflammation and innate immunity   MOLECULE CD28   MONOCYTE   MULTIPLE-SCLEROSIS   MURINE MACROPHAGES   MUTATIONS   NECROSIS-FACTOR-ALPHA   NEONATAL T CELLS   NF-KAPPA-B   NITRIC-OXIDE SYNTHASE   ORGANIZATION   P50 SUBUNIT   PATHWAY   Pharmacology   PHOSPHATIDYLINOSITOL 3-KINASE   PHOSPHOINOSITIDE 3-KINASE   PHOSPHORYLATION   PROTEINS   RECEPTOR   RECEPTOR ANTAGONIST BINDS   RECEPTOR CD44   RECEPTOR SUPERFAMILY   RECOGNITION   RICH REPEAT REGION   SIGNAL TRANSDUCTION   Signal transduction in the immune system, NF-kappaB, T1/ST2, MAP kinases   SIGNAL-TRANSDUCTION   SIGNAL-TRANSDUCTION PATHWAYS   SUBSTRATE-SPECIFICITY   SUPERFAMILY   SUPEROXIDE   SURFACE PROTEIN   T LYMPHOCYTES   T-CELL ACTIVATION   TERM POTENTIATION   T-LYMPHOCYTE ACTIVATION   TRANSCRIPTION FACTOR   TRANSDUCTION   TUMOR-NECROSIS-FACTOR

Research Projects

 Control of TLRs and NLRs by microRNAs
 Role of Nlrp3 in Type 2 diabetes
 . Novel proteins in the TLR and NLR systems
 Role of metabolism in innate immunity
 Circadian control of innate immunity

Representations

Details Date
External examiner for 40 PhD theses to date (Universities of Cambridge, London, Bath, Sheffield, Manchester, Liege, St. Andrews, Ulster, Melbourne, Sienna, University College Dublin, University College Cork, Queen's University Belfast).
External examiner for degree programme in Molecular Medicine, University of Wales
Section Editor for Journal of Leukocyte Biology
Chair of EU delegation to NSF/EU joint committee on Biotechnology of host defence
Member, DMMC Inflammation, Immunity & Infection Principal Investigators, DMMC Principal Investigators leading research in inflammation, immunit and infection.
Member, Centre for Research into Global Disease (Proposed), This consortium combines researchers with complementary interests in globally significant infectious disease. Interests include innate immunity, immune regulation, regional immunity, immune evasiob, vaccine & adjuvant development as well as drug & target development.
Member, Hepatitis C Focus Group Meeting, Focus group of investigators with Hepatitis C related research interests.Suggested themes : Immunogenomics of Hepatitis C or more broad theme
Member, Cycle 2 PI's & Researchers, All Cycle 2 Researchers & PI's
Member of the editorial boards of the Journal of Immunology (Section Editor), Trends in Immunology, Journal of Biological Chemistry, British Journal of Pharmacology and Cytokine
Member of board of external assessors for medical research at the Universities of Ghent and Melbourne (chairman of the latter)
Ad Hoc Member of Bacteriology and Mycology-2 Study Section, National Institutes of Health, USA
Ad Hoc Member of Cell and Molecular Immunology A Study Section, National Institutes of Health, USA
Member of Medical Research Council Advisory Board, UK
Member Avenir Committee INSERM, French National Insitute of Health
Member, Science Foundation Ireland Biotechnology Advisory Board
Chair, Scientific Advisory Board, Australian Co-operative Research Centre for Chronic Inflammatory Diseases
Member, Royal Irish Academy Life Sciences Committee
Member of the Pre-clinical committee, Irish Medicines Board
Member, Arthritis Foundation of Ireland academic advisory committee

Memberships

Membership of Professional Institutions, Associations, Societies

Details Date From Date To
International Cytokine Society (Councillor)
Biochemical Society
American Society for Biochemistry and Molecular Biology
Member Royal Irish Academy Life Sciences Committee
Member of the Pre-clinical committee, Irish Medicines Board
Member of MRC Advisory Board, UK
Member of Bacteriology and Mycology-2 Study Section, National Institutes of Health, USA
Hooftman A, Peace CG, Ryan DG, Day EA, Yang M, McGettrick AF, Yin M, Montano EN, Huo L, Toller-Kawahisa JE, Zecchini V, Ryan TAJ, Bolado-Carrancio A, Casey AM, Prag HA, Costa ASH, De Los Santos G, Ishimori M, Wallace DJ, Venuturupalli S, Nikitopoulou E, Frizzell N, Johansson C, Von Kriegsheim A, Murphy MP, Jefferies C, Frezza C, O'Neill LAJ., Macrophage fumarate hydratase restrains mtRNA-mediated interferon production. , Nature, 2023, p32 , Journal Article, PUBLISHED  TARA - Full Text  DOI
Pinkerton, J.W. and Kim, R.Y. and Brown, A.C. and Rae, B.E. and Donovan, C. and Mayall, J.R. and Carroll, O.R. and Khadem Ali, M. and Scott, H.A. and Berthon, B.S. and Baines, K.J. and Starkey, M.R. and Kermani, N.Z. and Guo, Y.-K. and Robertson, A.A.B. and O'Neill, L.A.J. and Adcock, I.M. and Cooper, M.A. and Gibson, P.G. and Wood, L.G. and Hansbro, P.M. and Horvat, J.C., Relationship between type 2 cytokine and inflammasome responses in obesity-associated asthma, Journal of Allergy and Clinical Immunology, 149, (4), 2022, p1270-1280 , Notes: [cited By 1], Journal Article, PUBLISHED  DOI
Ryan, T.A.J. and Preston, R.J.S. and O†Neill, L.A.J., Immunothrombosis and the molecular control of tissue factor by pyroptosis: prospects for new anticoagulants, Biochemical Journal, 479, (6), 2022, p731-750 , Notes: [cited By 0], Journal Article, PUBLISHED  DOI
Runtsch, M.C. and Angiari, S. and Hooftman, A. and Wadhwa, R. and Zhang, Y. and Zheng, Y. and Spina, J.S. and Ruzek, M.C. and Argiriadi, M.A. and McGettrick, A.F. and Mendez, R.S. and Zotta, A. and Peace, C.G. and Walsh, A. and Chirillo, R. and Hams, E. and Fallon, P.G. and Jayamaran, R. and Dua, K. and Brown, A.C. and Kim, R.Y. and Horvat, J.C. and Hansbro, P.M. and Wang, C. and O'Neill, L.A.J., Itaconate and itaconate derivatives target JAK1 to suppress alternative activation of macrophages, Cell Metabolism, 34, (3), 2022, p487-501.e8 , Notes: [cited By 0], Journal Article, PUBLISHED  DOI
Ryan, D.G. and Knatko, E.V. and Casey, A.M. and Hukelmann, J.L. and Dayalan Naidu, S. and Brenes, A.J. and Ekkunagul, T. and Baker, C. and Higgins, M. and Tronci, L. and Nikitopolou, E. and Honda, T. and Hartley, R.C. and O'Neill, L.A.J. and Frezza, C. and Lamond, A.I. and Abramov, A.Y. and Arthur, J.S.C. and Cantrell, D.A. and Murphy, M.P. and Dinkova-Kostova, A.T., Nrf2 activation reprograms macrophage intermediary metabolism and suppresses the type I interferon response, iScience, 25, (2), 2022, Notes: [cited By 0], Journal Article, PUBLISHED  TARA - Full Text  DOI
Williams, N.C. and Ryan, D.G. and Costa, A.S.H. and Mills, E.L. and Jedrychowski, M.P. and Cloonan, S.M. and Frezza, C. and O'Neill, L.A., Signaling metabolite L-2-hydroxyglutarate activates the transcription factor HIF-1α in lipopolysaccharide-activated macrophages, Journal of Biological Chemistry, 298, (2), 2022, Notes: [cited By 0], Journal Article, PUBLISHED  TARA - Full Text  DOI
Peace, C.G. and O†Neill, L.A.J., The role of itaconate in host defense and inflammation, Journal of Clinical Investigation, 132, (2), 2022, Notes: [cited By 2], Journal Article, PUBLISHED  TARA - Full Text  DOI
Toller-Kawahisa, J.E. and O†Neill, L.A.J., Creating ATP via creatine kinase B for NLRP3 activation, Nature Immunology, 2022, Notes: [cited By 0], Journal Article, PUBLISHED  DOI
Baldanti, F. and Ganguly, N.K. and Wang, G. and Möckel, M. and O†Neill, L.A. and Renz, H. and dos Santos Ferreira, C.E. and Tateda, K. and Van Der Pol, B., Choice of SARS-CoV-2 diagnostic test: challenges and key considerations for the future, Critical Reviews in Clinical Laboratory Sciences, 2022, Notes: [cited By 0], Journal Article, PUBLISHED  TARA - Full Text  DOI
Hooftman, A. and O'Neill, L.A.J., Nanoparticle asymmetry shapes an immune response, Nature, 601, (7893), 2022, p323-325 , Notes: [cited By 1], Journal Article, PUBLISHED  DOI
  

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O'Neill, LAJ (Chair) and organising committee, International Cytokine Society meeting, September, 2003, TCD, Notes: [ 550 delegates from 32 countries attended.], Meetings /Conferences Organised, PUBLISHED
O'Neill, LAJ (Chair) and organising committee , Biochemical Society meeting, 2001, TCD, Notes: [held at TCD and attended by 400 biochemists.], Meetings /Conferences Organised, PUBLISHED
Bowie, A. and O'Neill, L.A.J., Studies into the mechanism of NF kappa B activation by IL1, TNF and H2O2 in primary and transformed endothelial cells., Biochemistry Society Transactions, 25, (1), 1997, pp125S , Notes: [PMID: 9057023], Conference Paper, PUBLISHED
Bowie, A. and O'Neill, L.A.J., Vitamin C inhibits NF kappa B activation in endothelial cells., Biochemistry Society Transactions, 25, (1), 1997, pp131S. , Notes: [PMID: 9057029], Conference Paper, PUBLISHED
A. Bowie, P. N. Moynagh and L. A. O'Neill, Mechanism of NF kappa B activation by interleukin-1 and tumour necrosis factor in endothelial cells, 24, (1), 1996, pp2S , Notes: [PMID: 8674662], Conference Paper, PUBLISHED
A. Bowie, P. N. Moynagh and L. A. O'Neill, The human endothelial cell line ECY304 as a model of endothelial cell activation by interleukin-1, 23, (1), 1995, pp109S , Notes: [PMID: 7758669], Conference Paper, PUBLISHED
Brennan, P., Bowie, A. and O'Neill, L.A.J., The Effect of Thiol Modifiers on the Activation of NF kappa B by Interleukin-1., 21, (4), 1993, pp390S , Notes: [PMID: 8131967], Conference Paper, PUBLISHED
Murphy, M and O'Neill, LAJ , 'What is Life? The Next 50 years', 1993, Notes: [to commemorate the 50th anniversary of Schodinger's 'What is Life?' lectures. 450 delegates attended talks by 11 eminent speakers, including 3 Nobel Laureates.], Meetings /Conferences Organised, PUBLISHED
Hughes, O'Neill, Solution structure of the TLR adaptor MAL/TIRAP reveals an intact BB loop and supports MAL Cys91 glutathionylation for signaling, Proceedings of the National Academy of Sciences of the United States of America, Journal Article, PUBLISHED

  

Awards and Honours

Award Date
Irish Society for Immunology Medal for Immunology 2004
Elected Member of the Royal Irish Academy 2004
Dublin Institute of Molecular Medicine Medal Lecture 2004
Charnock Bradley Award Lecture, University of Edinburgh 2004
Elected President, Biomedical Sciences Section, British Association for the Advancement of Science 2004
Elected Councillor, International Cytokine Society 2003
Dolph Adams Award, Society for Leukocyte Biology USA 2003
Shortlisted for the Boyle Medal, Royal Dublin Society 2002
Short-listed for the Boyle Medal, Royal Dublin Society 1999
Young Investigator Award, International Cytokine Society 1997
Royal Irish Academy Medal for Biochemistry 1996
Fellow, Trinity College Dublin 1996
Conway Medal for Biomedical Research by the Royal Academy of Medicine in Ireland 1995
Elected member of European Molecular Biology Organisation (EMBO) 2005
Appointed Chair of the European Research Council Infection and Immunity Panel 2008
Appointed Councillor of the International Cytokine Society(and rising to President in 2012) 2008
Immunology 'Guru', National Institutes of Health 2009
Advisor to the 2009 Nobel Committee for Physiology or Medicine 2009
Royal Dublin Society / Irish Times Boyle Medal for Scientific Excellence 2009
Science Foundation Ireland Researcher of the Year Award 2009
McGill University Dan Perry Award Lecture 2010
University of Oxford Jenner Institute Distinguished Lecturer 2010
President, International Cytokine Society 2012
Royal Irish Academy Gold Medal for Life Sciences 2012
European Federation of Immunology Societies Medal 2014
Visiting Fellow, Christ's College Cambridge 2016
Fellow of the Royal Society (FRS) 2016
International Cytokine and Interferon Society Milstein Award 2018
Queen's University Belfast Barcroft Medal 2018
Austrian Academy of Sciences Landsteiner Award 2019
Nobel Assembly, Karolinska Institute Research Lecture 2018

Research Interests

Description Of Research Interests

CURRENT RESEARCH: Research Area: Molecular and Cellular basis to inflammation and innate immunity. Toll-like receptors. Pro-inflammatory cytokines. Signal transduction in the immune system. Molecular analysis of inflammatory and infectious diseases. Inflammasomes. Immunometabolism.