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Trinity College Dublin

Personal Information
College Photo Name O'Neill, Luke Anthony John
Main Department Biochemistry
College Title Chair of Biochemistry(1960)
E-mail luke.oneill@tcd.ie
College Tel +353 1 896 2439
Web http://people.tcd.ie/laoneill
 
Biography
CAMPUS COMPANY: Co-founder in March 2004 (with Prof Kingston Mills and Prof Dermot Kelleher) Opsona Therapeutics (www.opsona.com). Area: drug development company targeting inflammatory and autoimmune diseases. CEO: Dr Mark Heffernan. Chairman: Dr Cormac Kilty. Successfully completed A round financing in February 2005 of €6.25million (investors: Genentech (first investment outside USA), Enterprise Ireland, VC firms Inventages and Seroba). Largest A round fund for a Biotech startup in Europe.
 
Representations
Details Date
External examiner for 30 PhD theses to date (Universities of Cambridge, London, Bath, Sheffield, Manchester, Liege, St. Andrews, Ulster, Melbourne, Sienna, University College Dublin, University College Cork, Queen’s University Belfast).
External examiner for degree programme in Molecular Medicine, University of Wales
Section Editor for Journal of Leukocyte Biology
Chair of EU delegation to NSF/EU joint committee on Biotechnology of host defence
Member, DMMC Inflammation, Immunity & Infection Principal Investigators, DMMC Principal Investigators leading research in inflammation, immunit and infection.
More Representations>>>
 
Membership of Professional Institutions, Associations, Societies
Details Date From Date To
International Cytokine Society (Councillor)
Biochemical Society
American Society for Biochemistry and Molecular Biology
Member Royal Irish Academy Life Sciences Committee
Member of the Pre-clinical committee, Irish Medicines Board
More Memberships>>>
 
Awards and Honours
Award Date
Irish Society for Immunology Medal for Immunology 2004
Elected Member of the Royal Irish Academy 2004
Dublin Institute of Molecular Medicine Medal Lecture 2004
Charnock Bradley Award Lecture, University of Edinburgh 2004
Elected President, Biomedical Sciences Section, British Association for the Advancement of Science 2004
More Awards and Honours>>>
 
Description of Research Interests
CURRENT RESEARCH: Research Area: Molecular and Cellular basis to inflammation and innate immunity. Toll-like receptors. Pro-inflammatory cytokines. Signal transduction in the immune system. Molecular analysis of inflammatory and infectious diseases.
RESEARCH FUNDING: €5.4m in active grants (Total funding raised since appointment to TCD: €12.2m).
Core grants: SFI research programme grant (€4.1m) HRB Unit grant (€220K)
 
Research Interests
3-DIMENSIONAL STRUCTURE ACCEPTOR ACIDIC SPHINGOMYELINASE ACTIN-BASED MOVEMENT
ACTIVATED PROTEIN-KINASE ACTIVATION ACTIVATION PATHWAY ADHESION MOLECULE
ADHESION MOLECULE-1 ALPHA ANTIGEN ANTINEOPLASTIC AGENTS
ANTIOXIDANTS ATHEROSCLEROTIC LESION Autoimmune Diseases (Multiple Sclerosis, Rheumatoid Arthritis) BACTERIAL LIPOPOLYSACCHARIDE
BLOOD MONONUCLEAR-CELLS C-JUN CALCIUM CURRENTS CALCIUM INFLUX
CASCADE CATALYTIC ACTIVITY CD18 CELL-FREE SYSTEM
CELLS CELLULAR STRESSES CERAMIDE CHEMOKINE GENE-EXPRESSION
CHROMOSOMAL LOCATION CLOSTRIDIUM-DIFFICILE COMPLEX FACTOR ELK-1 CORD BLOOD
CRYSTAL-STRUCTURE CUTTING EDGE CYCLIC-AMP CYTOKINES
DAUNORUBICIN-INDUCED APOPTOSIS DENTATE GYRUS DEPENDENT GENE-EXPRESSION DEPENDENT MECHANISM
DEPENDENT TRANSCRIPTION DIACYLGLYCEROL PRODUCTION DISEASE DISULFIDE
DNA-BINDING DNA-BINDING ACTIVITY DNA-BINDING SUBUNIT DORSOVENTRAL POLARITY
DROSOPHILA E-CADHERIN EFFECTOR PATHWAYS ENDOTHELIAL-CELL LINE
ENDOTHELIAL-CELLS ENDOTOXIN EXPRESSION FACTOR INCREASE PHOSPHORYLATION
FACTOR-ALPHA FACTOR-KAPPA-B FAMILY FAS-LIGAND
FIBROBLASTS FUNCTIONAL-RESPONSES GENE GENE-EXPRESSION
GROWTH-FACTOR-BETA GTP-BINDING GTP-BINDING PROTEINS Genetics
HIPPOCAMPAL SLICE HIPPOCAMPAL SLICES HIPPOCAMPAL-NEURONS HIPPOCAMPUS
HL-60 CELLS HL-60 LEUKEMIA-CELLS HOST-DEFENSE HUMAN-ENDOTHELIAL-CELLS
HUMAN-IMMUNODEFICIENCY-VIRUS IDENTIFICATION IL-1 IL-1 RECEPTOR
IL-1, Toll Receptors, NF-KappaB IL-1/MAP KINASES IL-2 MESSENGER-RNA IL1HY1
IN-VITRO INDUCED APOPTOSIS INFLAMMATION INHIBITORS
INTACT-CELLS INTERLEUKIN-1 INTERLEUKIN-1 BETA INTERLEUKIN-1 RECEPTOR ANTAGONIST
INTERLEUKIN-1 RECEPTORS INTERLEUKIN-1-BETA INTERLEUKIN-2 INTERLEUKIN-2 PROMOTER
INTERNALIN MULTIGENE FAMILY Immune System Immunomodulatory molecules as therapy for inflammatory or immune-mediated diseasesPro-inflammatory cytokines, Interleukin-1, Toll-like receptors, Toll-IL-1 receptor domain, Lipopolysaccharide Inflammation
KAPPA-B KAPPA-B ACTIVATION KINASE LETHAL TOXIN
LEUKOCYTE ADHESION MOLECULES LINE ECV304 LIPOPOLYSACCARIDE LIPOPOLYSACCHARIDE
LONG-TERM POTENTIATION Long-term potentiation & signal transduction mechanisms including MAP kinases MAMMALIAN-CELLS MAP KINASE
MECHANISMS MESSENGER-RNA MESSENGERS MOLECULE CD28
MONOCYTE MULTIPLE-SCLEROSIS MURINE MACROPHAGES MUTATIONS
Medicines Molecular basis to inflammation and innate immunity NECROSIS-FACTOR-ALPHA NEONATAL T CELLS
NF-KAPPA-B NITRIC-OXIDE SYNTHASE ORGANIZATION P50 SUBUNIT
PATHWAY PHOSPHATIDYLINOSITOL 3-KINASE PHOSPHOINOSITIDE 3-KINASE PHOSPHORYLATION
PROTEINS Pharmacology RECEPTOR RECEPTOR ANTAGONIST BINDS
RECEPTOR CD44 RECEPTOR SUPERFAMILY RECOGNITION RICH REPEAT REGION
SIGNAL TRANSDUCTION SIGNAL-TRANSDUCTION SIGNAL-TRANSDUCTION PATHWAYS SUBSTRATE-SPECIFICITY
SUPERFAMILY SUPEROXIDE SURFACE PROTEIN Signal transduction in the immune system, NF-kappaB, T1/ST2, MAP kinases
T LYMPHOCYTES T-CELL ACTIVATION T-LYMPHOCYTE ACTIVATION TERM POTENTIATION
TRANSCRIPTION FACTOR TRANSDUCTION TUMOR-NECROSIS-FACTOR
 
Research Projects
Project title Control of TLRs and NLRs by microRNAs
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Project title Role of Nlrp3 in Type 2 diabetes
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Project title • Novel proteins in the TLR and NLR systems
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Project title Role of metabolism in innate immunity
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Project title Circadian control of innate immunity
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Publications and Other Research Outputs
Peer Reviewed
Haneklaus M, O'Neill LA, Coll RC, Modulatory mechanisms controlling the NLRP3 inflammasome in inflammation: recent developments., Current opinion in immunology, 25, (1), 2013, p40-45
DOI
Fagundes, C.T., O'Neill, L.A.J., Building unique bonds to fight misplaced DNA, Cell Research , 23, (9), 2013, p1065-1066
DOI
Masters, S.L., Dunne, A., Subramanian, S.L., Hull, R.L., Tannahill, G.M., Sharp, F.A., Becker, C., Lavelle,E.C. and O'Neill, L.A.J., Activation of the NLRP3 inflammasome by islet amyloid polypeptide provides a mechanism for enhanced IL-1β 2 in type 2 diabetes , Nature Immunology, 11, (10), 2010, p897-904
DOI
Coll, R.C., O'Neill, L.A.J., New insights into the regulation of signalling by toll-like receptors and nod-like receptors, Journal of Innate Immunity, 2, (5), 2010, p406-421
DOI
O'Neill, L.A.J., Hennessy, E.J., Parker, A.E, Targeting Toll-like receptors: Emerging therapeutics?, Nature Reviews Drug Discovery, 9, (4), 2010, p293-307
Notes: [PubMed ID: 20380038]
DOI
More Publications and Other Research Outputs >>>
 

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Last Updated:24-APR-2014