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Research Tags

Bacterial pathogenicity Fusobacterium nucleatum GASTRIC CANCER Helicobacter pylori Host-pathogen interaction Identification of vaccine candidates in vitro models of infection Infectious diseases Innate and acquired resistance to infection Innate Immunity Parasitology and parasitic diseases Protein chemistry, structure and folding Proteomics Vaccines

Research Projects

Project Title

Evaluation and Control of Neglected Mucosal Enteric Infections in Childhood

From

2006

2010

Summary

Microbial enteric pathogens are a major cause of childhood morbidity world-wide, contributing to impaired growth and cognitive function. In developing countries the diversity of childhood enteric infections makes diagnosis and disease surveillance difficult. To date there has been limited data on the impact of the major childhood infection Helicobacter pylori on global health issues in children in underdeveloped regions of the world. Initial infection with H. pylori is associated with a period of hypochlorhydria (reduced acid secretion), which we hypothesise is critical for the aquistion of other enteric infections, diarrhoeal disease and impaired childhood growth. In addition, we hypothesise that gastric H. pylori infection is a contributory factor to iron deficiency anaemia in childhood. The objective of the CONTENT project is to improve knowledge and apply new technologies to improve the control of neglected enteric pathogens in socio-economically disadvantaged childhood populations of Latin America

Funding Agency

European Union

Programme

FP6

Project Type

STREP

Project Title

Evaluation of the carcinogenic potential of Fusobacterium nucleatum

From

2013

2016

Summary

Identification of the constituent bacterial species of the intestinal microbiota under normal and disease conditions has led to the identification of associations between dysbiosis and several chronic disease states. In this regard, an association between the bacterium Fusobacterium nucleatum and intestinal cancer has been identified. Originally this organism was identified as an oral pathogen responsible in part for periodontitis but now is found to be significantly associated with several extraoral dieases, including colon cancer. Interestingly, this pathogen is also enriched at sites of adenoma formation, the precursors of carcinoma, suggesting that it may be a primary initiator of carcinogenesis. Although causality has not yet been established there is compelling evidence indicating a primary role for this pathogen in disease progression. This project aims to investigate the pathogenic/carcinogenic potential of F. nucleatum using in vitro models by evaluating its ability to induce a pro-inflammatory environment and modulate/subvert cellular signalling pathways.

Funding Agency

Dept of Education, Government of Saudi Arabia

Project Title

Development of Clostridium difficile vaccine

From

2002

2005

Summary

Funding Agency

Enterprise Ireland

Project Title

Development of a Helicobacter pylori vaccine

From

2009

2010

Summary

Funding Agency

Enterprise Ireland

Programme

POC

Representations

Details	Date
Member, DMMC Inflammation, Immunity & Infection Principal Investigators, DMMC Principal Investigators leading research in inflammation, immunit and infection.
Member, Centre for Research into Global Disease (Proposed), This consortium combines researchers with complementary interests in globally significant infectious disease. Interests include innate immunity, immune regulation, regional immunity, immune evasiob, vaccine & adjuvant development as well as drug & target development.
Member, Cycle 2 PI's & Researchers, All Cycle 2 Researchers & PI's

Languages

Language	Skill Reading	Skill Writing	Skill Speaking
English	Fluent	Fluent	Fluent

Memberships

Membership of Professional Institutions, Associations, Societies

Details	Date From	Date To
Biochemical Society

Publications and other Research Outputs

Isolation of outer membrane vesicles from Helicobacter pylori. in, editor(s)Sinead M Smith , Methods in Molecular Biology: Helicobacter pylori: Methods and Protocols, Springer, 2019, [Henry Windle], Notes: [Submitted], Book Chapter, SUBMITTED

Munshi RM, Windle HJ, Fusobacterium nucleatum extracellular vesicles: a role in host-pathogen interaction, Journal of Extracellular vesicles, 2019, Journal Article, SUBMITTED

Lynch M, Walsh TA, Marszalowska I, Webb AE, MacAogain M, Rogers TR, Windle H, Kelleher D, O'Connell MJ, Loscher CE., Surface layer proteins from virulent Clostridium difficile ribotypes exhibit signatures of positive selection with consequences for innate immune response., BMC Evolutionary Biology, 17, (1), 2017, p90-, Journal Article, PUBLISHED DOI

Xiaofang Liu, Helena Jahuira, Robert Gilman, Alicia Alva, Lilia Cabrera, Michiko Okamoto, Hang Xu, Dermot Kelleher, Henry Windle, Marco Varela, Manuela Verastegui, Maritza Calderon, Gerardo Sanchez, Vanessa Sarabia, Sarah Ballard, Caryn Bern, Holger Mayta, Jean Crabtree, Vita Cama, Mayuko Saito, and Hitoshi Oshitani , Etiological role and repeated infections of sapovirus among children aged less than two years in a cohort study in a peri-urban community of Peru, Journal of Clinical Microbiology, 54, (6), 2016, p1598-604 , Journal Article, PUBLISHED DOI

Burrows, A.D., Jurcic, M., Mahon, M.F., Pierrat, S., Roffe, G.W., Windle, H.J., Spencer, J., Bismuth coordination networks containing deferiprone: synthesis, characterisation, stability and antibacterial activity., Dalton Transactions, 44, (31), 2015, p13814 - 13817, Journal Article, PUBLISHED DOI

D Jaganath, M Saito, RH Gilman, V Cama, L Cabrera, D Kelleher, H Windle, J Crabtree, W Checkley, First detected Helicobacter pylori infection in infancy modifies the association between diarrheal disease and childhood growth in Peru, Helicobacter, 2014, Notes: [doi: 10.1111/hel.12130], Journal Article, PUBLISHED TARA - Full Text

L.E. Collins, M Lynch, I Marszalowska, M. Kristek, K. Rochfort, M. O'Connell, H.J. Windle, D. Kelleher, C.E. Loscher, Surface layer proteins isolated from Clostridium difficile induce clearance responses in macrophages, Microbes and Infection, 2014, Notes: [PMID 24300042], Journal Article, PUBLISHED TARA - Full Text DOI

Saito M, Goel-Apaza S, Espetia S, Velasquez D, Cabrera L, Loli S, Crabtree JE, Black RE, Kosek M, Checkley W, Zimic M, Bern C, Cama V, Gilman RH; The Norovirus Working Group in Peru (Xiao L, Kelleher D, Windle HJ, van Doorn LJ, Varela M, Verastegui M, Calderon M, Alva A, Roman K), Multiple norovirus infections in a birth cohort in a Peruvian peri-urban community., Clin Infect Dis. , 58, (4), 2014, p483 - 491, Journal Article, PUBLISHED TARA - Full Text DOI

Queiroz DMM, Harris PR, Sanderson IR, Windle HJ, Walker MM, Rocha AMC, Rocha GA, Carvalho SD, Bittencourt PFS, de Castro LPF, Cillagran A, Serrano C, Kelleher D, Crabtree JE, Iron status and Helicobacter pylori infection in children: an international multi-centered study , PlosOne, 8, (7), 2013, pe6883-, Notes: [PMID: 23861946], Journal Article, PUBLISHED

Sing A, Windle HJ, Cornally D, Ryan B, Henehan GT., A Short-Chain NAD(H)-Dependent Alcohol dehydrogenase (HpSCADH) from Helicobactor pylori: A role in growth under neutral and acidic conditions., The International Journal of Biochemistry & Cell Biology, 45, (7), 2013, p1347-1355 , Notes: [PMID: 23583739], Journal Article, PUBLISHED

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Research Interests

Description Of Research Interests

Infectious pathogens: Helicobacter pylori, Fusobacterium nucleatum, Campylobacter showae, Clostridium difficile

Trinity College Dublin, The University of Dublin

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Dr. Henry Windle

Dr. Henry Windle

Asst Prof in Molecular Medicine (Clinical Medicine)

TRINITY CENTRE, S J H

hjwindle@tcd.ie

3531896 2211

Asst Prof in Molecular Medicine (Molecular Medicine Ireland)

http://people.tcd.ie/hjwindle

Research Tags

Research Projects

Representations

Languages

Memberships

Membership of Professional Institutions, Associations, Societies

Publications and other Research Outputs

Publications

Research Interests

Description Of Research Interests