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Dr. Henry Windle

Asst Prof in Molecular Medicine (Clinical Medicine)
Asst Prof in Molecular Medicine (Molecular Medicine Ireland)
TRINITY CENTRE, S J H
      
Profile Photo

Dr. Henry Windle

Asst Prof in Molecular Medicine (Clinical Medicine)
TRINITY CENTRE, S J H

 hjwindle@tcd.ie

 3531896 2211

Asst Prof in Molecular Medicine (Molecular Medicine Ireland)


  Bacterial pathogenicity   Fusobacterium nucleatum   GASTRIC CANCER   Helicobacter pylori   Host-pathogen interaction   Identification of vaccine candidates   in vitro models of infection   Infectious diseases   Innate and acquired resistance to infection   Innate Immunity   Parasitology and parasitic diseases   Protein chemistry, structure and folding   Proteomics   Vaccines
Project Title
 Evaluation and Control of Neglected Mucosal Enteric Infections in Childhood
From
2006
To
2010
Summary
Microbial enteric pathogens are a major cause of childhood morbidity world-wide, contributing to impaired growth and cognitive function. In developing countries the diversity of childhood enteric infections makes diagnosis and disease surveillance difficult. To date there has been limited data on the impact of the major childhood infection Helicobacter pylori on global health issues in children in underdeveloped regions of the world. Initial infection with H. pylori is associated with a period of hypochlorhydria (reduced acid secretion), which we hypothesise is critical for the aquistion of other enteric infections, diarrhoeal disease and impaired childhood growth. In addition, we hypothesise that gastric H. pylori infection is a contributory factor to iron deficiency anaemia in childhood. The objective of the CONTENT project is to improve knowledge and apply new technologies to improve the control of neglected enteric pathogens in socio-economically disadvantaged childhood populations of Latin America
Funding Agency
European Union
Programme
FP6
Project Type
STREP
Project Title
 Evaluation of the carcinogenic potential of Fusobacterium nucleatum
From
2013
To
2016
Summary
Identification of the constituent bacterial species of the intestinal microbiota under normal and disease conditions has led to the identification of associations between dysbiosis and several chronic disease states. In this regard, an association between the bacterium Fusobacterium nucleatum and intestinal cancer has been identified. Originally this organism was identified as an oral pathogen responsible in part for periodontitis but now is found to be significantly associated with several extraoral dieases, including colon cancer. Interestingly, this pathogen is also enriched at sites of adenoma formation, the precursors of carcinoma, suggesting that it may be a primary initiator of carcinogenesis. Although causality has not yet been established there is compelling evidence indicating a primary role for this pathogen in disease progression. This project aims to investigate the pathogenic/carcinogenic potential of F. nucleatum using in vitro models by evaluating its ability to induce a pro-inflammatory environment and modulate/subvert cellular signalling pathways.
Funding Agency
Dept of Education, Government of Saudi Arabia
Project Title
 Development of Clostridium difficile vaccine
From
2002
To
2005
Summary
Funding Agency
Enterprise Ireland
Project Title
 Development of a Helicobacter pylori vaccine
From
2009
To
2010
Summary
Funding Agency
Enterprise Ireland
Programme
POC

Details Date
Member, DMMC Inflammation, Immunity & Infection Principal Investigators, DMMC Principal Investigators leading research in inflammation, immunit and infection.
Member, Centre for Research into Global Disease (Proposed), This consortium combines researchers with complementary interests in globally significant infectious disease. Interests include innate immunity, immune regulation, regional immunity, immune evasiob, vaccine & adjuvant development as well as drug & target development.
Member, Cycle 2 PI's & Researchers, All Cycle 2 Researchers & PI's
Language Skill Reading Skill Writing Skill Speaking
English Fluent Fluent Fluent
Details Date From Date To
Biochemical Society
Isolation of outer membrane vesicles from Helicobacter pylori. in, editor(s)Sinead M Smith , Methods in Molecular Biology: Helicobacter pylori: Methods and Protocols, Springer, 2019, [Henry Windle], Notes: [Submitted], Book Chapter, SUBMITTED
Munshi RM, Windle HJ, Fusobacterium nucleatum extracellular vesicles: a role in host-pathogen interaction, Journal of Extracellular vesicles, 2019, Journal Article, SUBMITTED
Lynch M, Walsh TA, Marszalowska I, Webb AE, MacAogain M, Rogers TR, Windle H, Kelleher D, O'Connell MJ, Loscher CE., Surface layer proteins from virulent Clostridium difficile ribotypes exhibit signatures of positive selection with consequences for innate immune response., BMC Evolutionary Biology, 17, (1), 2017, p90-, Journal Article, PUBLISHED  DOI
Xiaofang Liu, Helena Jahuira, Robert Gilman, Alicia Alva, Lilia Cabrera, Michiko Okamoto, Hang Xu, Dermot Kelleher, Henry Windle, Marco Varela, Manuela Verastegui, Maritza Calderon, Gerardo Sanchez, Vanessa Sarabia, Sarah Ballard, Caryn Bern, Holger Mayta, Jean Crabtree, Vita Cama, Mayuko Saito, and Hitoshi Oshitani , Etiological role and repeated infections of sapovirus among children aged less than two years in a cohort study in a peri-urban community of Peru, Journal of Clinical Microbiology, 54, (6), 2016, p1598-604 , Journal Article, PUBLISHED  DOI
Burrows, A.D., Jurcic, M., Mahon, M.F., Pierrat, S., Roffe, G.W., Windle, H.J., Spencer, J., Bismuth coordination networks containing deferiprone: synthesis, characterisation, stability and antibacterial activity., Dalton Transactions, 44, (31), 2015, p13814 - 13817, Journal Article, PUBLISHED  DOI
D Jaganath, M Saito, RH Gilman, V Cama, L Cabrera, D Kelleher, H Windle, J Crabtree, W Checkley, First detected Helicobacter pylori infection in infancy modifies the association between diarrheal disease and childhood growth in Peru, Helicobacter, 2014, Notes: [doi: 10.1111/hel.12130], Journal Article, PUBLISHED  TARA - Full Text
L.E. Collins, M Lynch, I Marszalowska, M. Kristek, K. Rochfort, M. O'Connell, H.J. Windle, D. Kelleher, C.E. Loscher, Surface layer proteins isolated from Clostridium difficile induce clearance responses in macrophages, Microbes and Infection, 2014, Notes: [PMID 24300042], Journal Article, PUBLISHED  TARA - Full Text  DOI
Saito M, Goel-Apaza S, Espetia S, Velasquez D, Cabrera L, Loli S, Crabtree JE, Black RE, Kosek M, Checkley W, Zimic M, Bern C, Cama V, Gilman RH; The Norovirus Working Group in Peru (Xiao L, Kelleher D, Windle HJ, van Doorn LJ, Varela M, Verastegui M, Calderon M, Alva A, Roman K), Multiple norovirus infections in a birth cohort in a Peruvian peri-urban community., Clin Infect Dis. , 58, (4), 2014, p483 - 491, Journal Article, PUBLISHED  TARA - Full Text  DOI
Queiroz DMM, Harris PR, Sanderson IR, Windle HJ, Walker MM, Rocha AMC, Rocha GA, Carvalho SD, Bittencourt PFS, de Castro LPF, Cillagran A, Serrano C, Kelleher D, Crabtree JE, Iron status and Helicobacter pylori infection in children: an international multi-centered study , PlosOne, 8, (7), 2013, pe6883-, Notes: [PMID: 23861946], Journal Article, PUBLISHED
Sing A, Windle HJ, Cornally D, Ryan B, Henehan GT., A Short-Chain NAD(H)-Dependent Alcohol dehydrogenase (HpSCADH) from Helicobactor pylori: A role in growth under neutral and acidic conditions., The International Journal of Biochemistry & Cell Biology, 45, (7), 2013, p1347-1355 , Notes: [PMID: 23583739], Journal Article, PUBLISHED
  

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Infectious pathogens: Helicobacter pylori, Fusobacterium nucleatum, Campylobacter showae, Clostridium difficile