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Professor David Coleman

Professor of Oral & Applied Microbiology (Dental Science)
Personal Chair (School Office - Dental Science)
DENTAL SCHOOL, LINCOLN PLACE
      
Profile Photo

Professor David Coleman

Professor of Oral & Applied Microbiology (Dental Science)
DENTAL SCHOOL, LINCOLN PLACE

 dcoleman@tcd.ie

 3531 6127276

Personal Chair (School Office - Dental Science)


David Coleman received his B.A. (Mod.), Ph.D. and Sc.D. from Trinity College Dublin. Joining the School of Dental Science in 1989, he is now Professor of Oral and Applied Microbiology and head of the division of Oral Biosciences. He is a Fellow of Trinity (FTCD) and the Royal College of Pathologists (FRCPath.), London, member of the Royal Irish Academy (MRIA) and winner of the RIA silver medal for microbiology. Professor Coleman has published over 240 articles in peer-reviewed international journals and book chapters. His research interests focus on translational microbiology including automated minimisation of infection risks in healthcare facilities from water networks, wastewater systems and medical devices, and the population biology, evolution, genomics and antibiotic resistance mechanisms of methicillin resistant Staphylococcus aureus (MRSA), and vancomycin-resistant enterococci (VREs) by whole genome sequencing.
  A GENE   A GENE FAMILY   A GENE-EXPRESSION   A OUTBREAK   ABC TRANSPORTER   ACME   ACME III   ACME III Element   ACME Type IV   ACME TYPE V   ACQUIRED-IMMUNODEFICIENCY-SYNDROME   ACRYLIC RESIN   ACT1   ACTIVATION   AIDS   ANTIBIOTIC RESISTANCE   Antibiotics   Applied and Environmental microbiology   Arginine catabolic mobile element   BACTERIAL BIOFILMS   Bacterial pathogenicity   BACTERIAL-CONTAMINATION   Bacteriology and bacterial pathogenesis   BACTERIOPHAGE CONVERSION   BIOFILM   BIOFILM FORMATION   BIOFILMS   Biomedical sciences   CANDIDA ALBICANS   CANDIDA DUBLINIENSIS SP NOV   CANDIDA SPP   CANDIDA-ALBICANS   CANDIDA-ALBICANS STRAINS   CANDIDA-DUBLINIENSIS   CANDIDA-GLABRATA   Chemotherapeutic Agents   Communicable Diseases   DEFINITIVE DIAGNOSIS   DENTAL CHAIR WATERLINES   DENTAL CHAIRS   DENTAL CLINIC   DENTAL DISINFECTANTS   DENTAL HANDPIECES   DENTAL PLAQUE MICROBIOLOGY   DIAGNOSIS   Diagnostics   DIFFERENTIATION   DIVERSITY   DNA   DNA typing   DNA TYPING METHODS   Drug Resistance   DUBLIN   DUBLIN HOSPITALS   DUBLINIENSIS   DUODENAL-ULCER   ELECTROPHORETIC KARYOTYPE   ENVIRONMENTAL MICROBIOLOGY   ENZYME FRAGMENTATION PATTERNS   ENZYME-MEDIATED INTEGRATION   Epidemiology   EPITHELIAL-CELLS   EPSTEIN-BARR VIRUS   EPSTEIN-BARR-VIRUS   ESCHERICHIA-COLI   Eukaryotic gene regulation   Evolutionary genetics   EXPRESSION   FIELD GEL-ELECTROPHORESIS   FLUCONAZOLE   Fungal Diseases   FUNGAL-INFECTIONS   Fungi   FUSARIUM   FUSARIUM-SOLANI   GEL-ELECTROPHORESIS   GENE   Gene Cloning   Genetic Engineering   Genetic Manipulation   Genetic Mapping, Gene Sequence   Genetic Resistance   Genetic/Molecular epidemiology   Genetically Modified Organisms   Genetics   GENOME   Genomes, Genomics   Genomic structure and function, molecular approaches to gene function   GENTAMICIN-RESISTANT   GERM TUBES   GRAM-NEGATIVE BACTERIA   HAIRY LEUKOPLAKIA   HEALTHY-INDIVIDUALS   HIV Infection   HIV opportunistic infections   HIV-INFECTED PATIENTS   HIV-INFECTION   Host, Pathogen interactions   HUMAN-IMMUNODEFICIENCY-VIRUS   IDENTIFICATION   IN SITU HYBRIDIZATION   INFECTED INDIVIDUALS   INFECTION   INFECTIONS   Infectious diseases   IN-SITU HYBRIDIZATION   IN-VITRO   LEGIONELLA   LYSIN   Medical Devices   METHICILLIN RESISTANCE   METHICILLIN-RESISTANCE   METHICILLIN-RESISTANT STAPHYLOCOCCUS AUREUS   Methicillin-susceptible S. aureus   Molecular Biology   Molecular Cloning   Molecular Genetics   Molecular genetics of gram positive pathogens   Molecular Probes   MRSA   Mycology   Mycology and fungal pathogenesis   Nucleic Acid Sequencing   Oral Diseases   Oral diseases and Oral medicine   Oral microbiology   Pathogenesis   PATHOGENS   PLASMID DNA   PREVALENCE   Procaryotic gene regulation   PROFILES   Prokaryotic and eukaryotic genetics and genomics   Quantitative and molecular genetics   RAPID IDENTIFICATION   Regulatory methods of gene expression   RIBOSOMAL-RNA   STAPHYLOCOCCUS AUREUS   STAPHYLOCOCCUS AUREUS INFECTION   Translational microbiology   WATER   WATER ACTIVITY   WATER MICROBIOLOGY   WATER QUALITY   WATER-BORNE   WATER-QUALITY   whole-genome sequencing   YEAST   YEAST CULTURES   YEAST KILLER PHENOMENON   YEAST TOXINS
Project Title
 An investigation of the role of Staphylococcus aureus colonisation of healthcare workers in nosocomial transmission of S. aureus to patients in an MRSA-endemic setting using whole-genome sequencing
From
12/12/2016
To
11/12/2019
Summary
Staphylococcus aureus is a bacterium that frequently causes serious infections among hospitalised patients. This project aims to investigate how commonly and for how long S. aureus is carried in the noses and mouth/throat of healthcare workers and whether some of these are transmitted to patients and how often. This information can be used to inform national policy on screening and eradication of S. aureus carriage among HCWs to reduce patient infections.
Funding Agency
Health Research Board
Programme
Health Research Awards
Person Months
36
Project Title
 An investigation of the prevalence and molecular epidemiology of vancomycin-resistant Enterococcus faecium in Irish hospitals using whole-genome sequencing
From
01/12/2019
To
31/12/24
Summary
Vancomycin-resistant Enterococcus faecium (VREfm) is a leading cause of nosocomial infections globally. Ireland has the highest prevalence of VREfm bloodstream infections (BSIs) in Europe but little is known about VREfm molecular epidemiology in Irish hospitals because traditional typing methods are poorly discriminatory. Currently, at-risk patients are routinely screened rectally for VREfm, with subsequent isolation/cohorting of VREfm-positive patients incurring extensive healthcare costs. Little is known about the prevalence of VREfm carriage beyond these at-risk groups or how this contributes to the nosocomial burden of VREfm. This study aims to investigate the true prevalence of VREfm carriage among patients in a large acute Irish hospital and the molecular epidemiology of nosocomial VREfm in Ireland using whole-genome sequencing (WGS) typing methods that provide robust typing of VREfm.
Funding Agency
Health Research Board
Programme
Investigator0Led Projects
Project Type
Patented-Oriented-Research
Person Months
48

Details Date
Member of the National Decontamination of Reusable Invasive Medical Devices Advisory Group-Health Services Executive Quality Improvement Division 2014-Present
Health Protection Surveillance Centre (HPSC) Prevention of Infection from Water Systems in Healthcare Facilities Sub-Committee of the HPSC Scientific Advisory Committee 2012-2014
Health Protection Surveillance Centre Scientific Advisory Committee Legionnaires' Disease Sub-Committee 2005-2009
Health Research Board Physiological Systems Committee 2005-2009
Chairman of the Investigation Team on Legionellosis at Waterford Regional Hospital 2003
Health Research Board Infection and Immunity Committee 2000-2004
Health Research Board Digestive Sciences Committee 2000-2004
National Disease Sureveillance Centre Scientific Advisory Committee Legionnaires' Disease Sub-Committee 2002
National Disease Surveilance Centre Scientific Advisory Committee: A Strategy for the Control of Antimicrobial Resistance in Ireland (SARI) 2001
Ad hoc referee for the following peer-review international journals: Journal of Clinical Microbiology; Antimicrobial Agents and Chemotherapy; Journal of Antimicrobial Chemotherapy; AIDS; Journal of Hospital Infection; Applied and Environmental Microbiology; Medical Mycology; Oral Diseases; Journal of Dentistry; Journal of Infection; Mycoses 1990-Present
External Examiner for Ph.D. theses for: University of Aberdeen; University of Lausanne; University of Manchester
Ad hoc grant reviewer for: Wellcome Trust, Austrian Government, European Union, The Medical Research Council (UK), Swiss National Science Foundation
Member of the UK Medical Research Council College of Experts 2005-2009
Health Service Executive Steering Committee for Decontamination of Reusable Invasive Medical Devices 2007
Language Skill Reading Skill Writing Skill Speaking
English Fluent Fluent Fluent
Details Date From Date To
MEMBER OF THE EDITORIAL BOARD OF THE JOURNAL OF HOSPITAL INFECTION 2015 Present
FELLOW OF THE ROYAL COLLEGE OF PATHOLOGISTS 2001 PRESENT
MEMBER OF THE ROYAL COLLEGE OF PATHOLOGISTS 1993 2000
MEMBER OF THE BRITISH SOCIETY FOR MEDICAL MYCOLOGY 1990 PRESENT
MEMBER OF THE AMERICAN SOCIETY FOR MICROBIOLOGY 1990 PRESENT
EDITORIAL BOARD MEMBER FOR THE JOURNAL MICROBIOLOGY 1994 1998
MEMBER OF THE SOCIETY FOR GENERAL MICROBIOLOGY 1982 Present
MEMBER OF THE INTERNATIONAL SOCIETY FOR HUMAN AND ANIMAL MYCOLOGY 2009 Present
MEMBER OF THE HOSPITAL INFECTION SOCIETY 2017 Present
Kavanagh NL, Kinnevey PM, Brennan GI, O'Connell B, Goering RV, Coleman DC, Co-carriage of diverse vancomycin-resistant Enterococcus faecium ST80-lineages by 70% of patients in an Irish hospital, JAC-Antimicrobial Resistance, 7, (3), 2025, pdlaf065 , Notes: [Published 29th April 2025], Journal Article, PUBLISHED  TARA - Full Text  DOI  URL
KAVANAGH NL, KINNEVEY PM, EGAN SA, McMANUS BA, O'CONNELL B, BRENNAN GI, COLEMAN DC, PROTRACTED TRANSMISSION AND PERSISTENCE OF ST80 VANCOMYCIN-RESISTANT Enterococcus faecium CLONAL COMPLEX TYPES CT2933, CT2932 AND CT1916 IN A LARGE IRISH HOSPITAL: A 39-MONTH WGS STUDY, JOURNAL OF HOSPITAL INFECTION, 151, (9 (September)), 2024, p11 - 20, Notes: [27th June 2024; Pub ahead of print], Journal Article, PUBLISHED  TARA - Full Text  DOI  URL
ALOBA BK, KINNEVEY PM, MONECKE S, BRENNAN GI, O'CONNELL B, BLOMFELDT A, McMANUS B, SCHNEIDER-BRACHERT W, TKADLEC J, EHRICHT R, SENOK A, DAMKJAER BARTELS M, COLEMAN DC, AN EMERGING PANTON-VALENTINE (PVL)-POSITIVE CC5-METICILLIN-RESISTANT Staphylococcus aureus-IVc CLONE RECEOVERED FROM HOSPITAL AND COMMUNITY SETTINGS OVER A 17-YEAR PERIOD FROM 12 COUNTRIES INVESTIGATED BY WHOLE-GENOME SEQUENCING, JOURNAL OF HOSPITAL INFECTION, 132, (February), 2023, p8 - 19, Notes: [5th December 2022; Pub ahead of print], Journal Article, PUBLISHED  TARA - Full Text  DOI  URL  Other
COLEMAN DC, DEASY EC, SWAN JS, O'DONNELL MJ, SCOTT TA, DIRECT EVIDENCE FOR EFFECTIVE CLEANING AND DECONTAMINATION OF THE INTERNAL AIR AND WATER CHANNELS, HEADS AND HEAD-GEARS OF MULTIPLE CONTRA-ANGLE DENTAL HANDPIECES USING AN ENZYMATIC DETERGENT AND AUTOMATED WASHER-DISINFECTION IN A DENTAL HOSPITAL SETTING, JOURNAL OF HOSPITAL INFECTION, 135, (May), 2023, p204 - 205, Notes: [Pub ahead of print, 9th March 2023], Journal Article, PUBLISHED  DOI  URL
GREALY L, WILSON P, GILLEN C, DUFFY E, HEALY M-L, DALY B, POLYZOIS I, VAN HARTEN M, DIUGALL A, BRENNAN GI, COLEMAN DC, McMANUS BA, IMMERSION OF DEBRIDED DIABETIC FOOT ULCER (DFU) TISSUE IN ELECTROCHEMICALLY GENERATED PH NEUTRAL HYPOCHLOROUS ACID SIGNIFICANTLY REDUCES THE MICROBIAL BIOBURDEN: WHOLE-GENOME SEQUENCING OF Staphylococcus aureus, THE MOST PREVALENT SPECIES RECOVERED, JOURNAL OF HOSPITAL INFECTION, 138, (August), 2023, p42 - 51, Notes: [10th June 2023; Pub ahead of print], Journal Article, PUBLISHED  TARA - Full Text  DOI  URL
EGAN SA, KAVANAGH NL, SHORE AC, MOLLERUP S, SAMANIEGO CASTRUITA JA, O'CONNELL B, McMANUS BA, BRENNAN GI, PINHOLT M, WESTH H, COLEMAN DC, GENOMIC ANALYSIS OF 600 VANCOMYCIN-RESISTANTEnterococcus faecium REVEALS A HIGH PREVALENCE OF ST80 AND SPREAD OF SIMILAR vanA REGIONS VIA IS1216E AND PLASMID TRANSFER IN DIVERSE GENETIC LINEAGES IN IRELAND , JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY, 77, (2), 2022, p320 - 330, Notes: [8th November 2021;Epub ahead of print], Journal Article, PUBLISHED  DOI  URL
KINNEVEY, PM, KEARNEY A, SHORE AC, EARLS MR, BRENNAN GI, POOVELIKUNNEL TT, HUMPHREYS H, COLEMAN DC, METHICILLIN-SUSCEPTIBLE Staphylococcus aureus TRANSMISSION AMONG HEALTHCARE WORKERS, PATIENTS AND THE ENVIRONMENT IN A LARGE ACUTE HOSPITAL UNDER NON-OUTBREAK CONDITIONS INVESTIGATED USING WHOLE-GENOME SEQUENCING, JOURNAL OF HOSPITAL INFECTION, 127, (September), 2022, p15 - 25, Notes: [18th May 2022, Epub ahead of print], Journal Article, PUBLISHED  TARA - Full Text  DOI  URL
DEASY, EC, SCOTT, TA, SWAN JS, O'DONNELL MJ, COLEMAN DC, EFFECTIVE CLEANING AND DECONTAMINATION OF THE INTERNAL AIR AND WATER CHANNELS, HEADS AND HEAD-GEARS OF MULTIPLE CONTRA ANGLE DENTAL HANDPIECES USING AN ENZYMATIC DETERGENT AND AUTOMATED WASHER DISINFECTION IN A DENTAL HOSPITAL SETTING, JOURNAL OF HOSPITAL INFECTION, 128, (October), 2022, p80-88 , Notes: [6th August 2022, Epub ahead of print], Journal Article, PUBLISHED  TARA - Full Text  DOI  URL
STEINIG E, AGLUA I, DUCHENE S, MEEHAN MT, YOANNES M, FIRTH C, JAWORSKI J, DREKORE J, URAKOKO B, POKA H, WURR C, EBOS E, NANGM D, MULLER E, MULVEY P, JACKSON C, BLOMFELDT A, VANGSTEIN AAMOT H, LAMAN M, MANNING L, EARLS M, COLEMAN DC, GREENHILL A, FORD R, STEGG M, ALI SYED M, JAMIL B, MONECKE S, EHRICHT R, SMITH S, POMAT W, HORWOOD P, TONG SYC, McBRYDE E, PHYLODYNAMIC SIGNATURES IN THE EMERGENCE OF COMMUNITY-ASSOCIATED MRSA, PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 119, (45), 2022, pe2204993119 , Notes: [Published 2nd November 2022], Journal Article, PUBLISHED  DOI  URL
McMANUS BA, ALOBA BK, EARLS MR, BRENNAN GI, O'CONNELL B, MONECKE S, EHRICHT R, SHORE AC, COLEMAN DC, MULTIPLE DISTINCT OUTBREAKS OF PANTON-VALENTINE LEUKOCIDIN (PVL)-POSITIVE COMMUNITY-ASSOCIATED METHICILLIN-RESISTANT Staphylococcus aureus (CA-MRSA) IN IRELAND INVESTIGATED BY WHOLE-GENOME SEQUENCING, JOURNAL OF HOSPITAL INFECTION, 108, (February 2021), 2021, p72 - 80, Notes: [28th November 2020; Epup ahead of print], Journal Article, PUBLISHED  TARA - Full Text  DOI  URL
  

Page 1 of 25
McCreary CE, Coleman DC, Mulcahy FM, A prospective study to examine the effect of HIV-protease inhibitor therapy on clinical signs of oral candidosis and oral Candida cell density in an IVDU population with AIDS, AIDS, 14, (Oct. 2002, Suppl. 4), 2002, ppP388 - P388, Meeting Abstract, PUBLISHED
Mahmoudabadi AZ, Coleman D, Drucker DB, Differentiation of Candida dubliniensis from Candida albicans based on polar lipids., JOURNAL OF DENTAL RESEARCH , 81, (Mar. 02, Sp. Iss. SI), 2002, pp3878 - 3878, Meeting Abstract, PUBLISHED
HARRINGTON F, TUTTLEBEE C, O'DONNELL M, COLEMAN D, EFFECTIVE DECONTAMINATION OF DENTAL UNIT WATERLINES USING A NOVEL DISINFECTION MODULE., JOURNAL OF DENTAL RESEARCH , 81, (Mar. 02, Sp. Iss. SI), 2002, pp0707 - 0707, Meeting Abstract, PUBLISHED
Hughes D, Coleman D, O'Connell B, et al., Susceptibility of Candida dublinensis species to salivary Histatin 3., JOURNAL OF DENTAL RESEARCH , 81, (Mar 02, Sp. Iss. SI), 2002, pp0707 - 0707, Meeting Abstract, PUBLISHED
TUTTLEBEE C, O'DONNELL M, COLEMAN D, EFFECTIVE DECONTAMINATION OF DENTAL UNIT WATERLINES USING PEROXIDE-BASED DISINFECTANTS., JOURNAL OF DENTAL RESEARCH , 81, (Dec 02, Sp. Iss. B), 2002, ppB296 - B296, Meeting Abstract, PUBLISHED
CLARKE M, COLEMAN D, DIFFERENTIATION BETWEEN CANDIDA ALBICANS AND C.DUBLINIENSIS USING TWO DIFFERENT METHODS., JOURNAL OF DENTAL RESEARCH , 2001, 80, (April (4)), 2002, pp1177 - 1177, Meeting Abstract, PUBLISHED
Donnelly S, Sullivan D, Coleman D, Rapid PCR identification of Candida dubliniensis using ACT1 intron sequences., JOURNAL OF DENTAL RESEARCH , 79, (Sp. Iss. SI), 2000, pp3016 - 3016, Meeting Abstract, PUBLISHED
Donnelly S, Sullivan D, Coleman D, Rapid PCR identification of Candida dubliniensis using ACT1-intron sequences., JOURNAL OF DENTAL RESEARCH , 79, (May 2000, 5), 2000, pp1228 - 1228, Meeting Abstract, PUBLISHED
Marshall DG, Hynes SO, Coleman DC, et al., Lack of relationship between cagA status and expression of Lewis antigens in Irish Helicobacter pylori isolates, GUT, 43, (Sept. 1998, Suppl. 2), 1998, ppA18 - A19, Meeting Abstract, PUBLISHED
Lloyd SP, Coleman DC, Candida dubliniensis: A novel oral pathogenic yeast mimicking Candida albicans., JOURNAL OF DENTAL RESEARCH , 76, (Sp. Iss. SI), 1997, pp2288 - 2288, Meeting Abstract, PUBLISHED

  


Page 1 of 2
Award Date
Elected as a Member of the Royal Irish Academy (M.R.I.A.) March 2015
ROYAL IRISH ACADEMY, NATIONAL COMMISSION FOR MICROBIOLOGY SILVER MEDAL AWARD FOR RESEARCH EXCELLENCE IN MICROBIOLOGY 1997
Elected as a Fellow of Trinity College Dublin (F.T.C.D.) 1994
Automated control and management of microbial biofilms in water systems linked to medical devices. Automated microbial biofilm management in large water distribution systems in healthcare facilities. Molecular epidemiology and population structure of hospital-acquired and community acquired MRSA. Molecular analysis of SCCmec elements in pandemic, epidemic and sporadic MRSA and MSSA. Molecular epidemiology, population structure, antifungal drug resistance mechanisms in Candida dubliniensis and other oral Candida species. Management of Legionella bacteria in water distribution systems Application of electrochemically activated solutions to control microbial proliferation in the environment, in water distribution systems and in medical devices. Molecular epidemiology, population biology, evolution, genomics and antibiotic resistance mechanisms of hospital-acquired and community-acquired MRSA and VRE populations.