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Professor Aiden Corvin

Professor Consultant (Psychiatry)
TRINITY CENTRE, S J H

Deputy Director (Trinity Inst. of Neurosciences (TCIN))

Deputy Director (Trinity Translational Medicine Institute)


Professor Aiden Corvin (MB, PhD, MRCPsych, FTCD) is a Professor in the Discipline of Psychiatry TCD (formerly Head of Discipline 2016-2022) and Clinical Director of the St. James"s Hospital Mental Health Service. He leads the Neuropsychiatric Genetics Research Group at TCD. Over more than twenty years he has investigated the genetic basis of psychiatric disorders, in particular schizophrenia and bipolar disorder. His work is driven by the clinical imperatives of being able to answer the questions of patients and their families; to improve understanding of disease biology; and to develop better patient care. He has significantly contributed to a revolution in understanding of the genetic basis of psychiatric disorders. He was lead investigator for schizophrenia with the Wellcome Trust Case Control Consortium (WTCCCC) and is Chair of the Pedigree Sequencing Working Group of the Psychiatric Genomics Consortium (PGC), an international collaborative research project that includes more than 800 scientists. He has published in journals such as Science, Nature, Nature Genetics, JAMA Psychiatry, and the British Journal of Psychiatry. His work has been funded by the National Institute of Health (US), Wellcome, Science Foundation Ireland, and the Health Research Board, Ireland. He is consistently one of the most cited Irish biomedical scientists and has published more than 320 peer reviewed journal articles (h-index 100 and >65,000 citations as of October 2023).
  Aetiology of mental illness   Cognitive dysfunction in psychotic disorders   Neurodegenerative diseases including schizophrenia & Alzheimer's disease   Neurogenetics   Psychiatric genetics   Schizophrenia
King S., Mothersill D., Holleran L., Patlola S.R., Burke T., McManus R., Kenyon M., McDonald C., Hallahan B., Corvin A., Morris D.W., Kelly J.P., McKernan D.P., Donohoe G., Early life stress, low-grade systemic inflammation and weaker suppression of the default mode network (DMN) during face processing in Schizophrenia, Translational Psychiatry, 13, (1), 2023, Journal Article, PUBLISHED  DOI
Ormond C., Ryan N.M., Heron E.A., Gill M., Byerley W., Corvin A., Ultrarare Missense Variants Implicated in Utah Pedigrees Multiply Affected With Schizophrenia, Biological Psychiatry Global Open Science, 3, (4), 2023, p797 - 802, p797-802 , Journal Article, PUBLISHED  DOI
Ryan N, Ormond C, Chang YC, Contreras J, Raventos H, Gill M, Heron E, Mathews CA, & Corvin A, Identity-by-descent analysis of a large Tourette's syndrome pedigree from Costa Rica implicates genes involved in neuronal development and signal transduction, Molecular Psychiatry, 2022, Journal Article, PUBLISHED
Duncan S Palmer, Daniel P Howrigan, Sinéad B Chapman, Rolf Adolfsson, Nick Bass, Douglas Blackwood, Marco PM Boks, Chia-Yen Chen, Claire Churchhouse, Aiden P Corvin, Nicholas Craddock, Arianna Di Florio, Faith Dickerson, Fernando S Goes, Xiaoming Jia, Ian Jones, Lisa Jones, Lina Jonsson, Rene S Kahn, Mikael Landén, Adam Locke, Andrew McIntosh, Andrew McQuillin, Derek W Morris, Michael C O"Donovan, Roel A Ophoff, Michael J Owen, Nancy Pedersen, Danielle Posthuma, Andreas Reif, Neil Risch, Catherine Schaefer, Laura Scott, Tarjinder Singh, Jordan W Smoller, Matthew Solomonson, David St. Clair, Eli A Stahl, Annabel Vreeker, James Walters, Weiqing Wang, Nicholas A Watts, Robert Yolken, Peter Zandi, Benjamin M Neale, Exome sequencing in bipolar disorder reveals shared risk gene AKAP11 with schizophrenia, 2021, Journal Article, PUBLISHED
Ormond C, Ryan NM, Corvin A, Heron EA., Converting single nucleotide variants between genome builds: from cautionary tale to solution., Briefings in bioinformatics, 2021, Journal Article, PUBLISHED  DOI
O'Reilly, K., Donohoe, G., O'Sullivan, D., (...), O'Connell, P., Kennedy, H.G. , A randomized controlled trial of cognitive remediation for a national cohort of forensic patients with schizophrenia or schizoaffective disorder, BMC Psychiatry, 19, (1), 2019, p27-, Journal Article, PUBLISHED  TARA - Full Text  DOI
Rees E, Carrera N, Morgan J, Hambridge K, Escott-Price V, Pocklington A.J, Richards A.L, Pardiñas A.F, Alizadeh B.Z, van Amelsvoort T, Bartels-Velthuis A.A, van Beveren N.J, Bruggeman R, Cahn W, de Haan L, Delespaul P, Meijer C.J, Myin-Germeys I, Kahn R.S, Schirmbeck F, Simons C.J.P, van Haren N.E, van Os J, van Winkel R, Luykx J.J, McDonald C, Donohoe G, Morris D.W, Kenny E, Kelleher E, Gill M, Corvin A, Kirov G, Walters J.T.R, Holmans P, Owen M.J, O'Donovan M.C, Targeted Sequencing of 10,198 Samples Confirms Abnormalities in Neuronal Activity and Implicates Voltage-Gated Sodium Channels in Schizophrenia Pathogenesis, Biological Psychiatry, 85, (7), 2019, p554 - 562, Journal Article, PUBLISHED  TARA - Full Text  DOI  URL
Morgan S.E, Seidlitz J, Whitaker K.J, Romero-Garcia R, Clifton N.E, Scarpazza C, van Amelsvoort T, Marcelis M, van Os J, Donohoe G, Mothersill D, Corvin A, Pocklington A, Raznahan A, McGuire P, Vértes P.E, Bullmore E.T, Cortical patterning of abnormal morphometric similarity in psychosis is associated with brain expression of schizophrenia-related genes, Proceedings of the National Academy of Sciences of the United States of America, 116, (19), 2019, p9604 - 9609, Journal Article, PUBLISHED  TARA - Full Text  DOI  URL
Richter MS, O'Reilly K, O'Sullivan D, O'Flynn P, Corvin A, Donohoe G, Coyle C, Davoren M, Higgins C, Byrne O, Nutley T, Nulty A, Sharma K, O'Connell P, Kennedy HG, Prospective observational cohort study of 'treatment as usual' over four years for patients with schizophrenia in a national forensic hospital., BMC psychiatry, 8, (1), 2018, p289-, Journal Article, PUBLISHED  TARA - Full Text  DOI
Kelly, S. and Jahanshad, N. and Zalesky, A. and Kochunov, P. and Agartz, I. and Alloza, C. and Andreassen, O.A. and Arango, C. and Banaj, N. and Bouix, S. and Bousman, C.A. and Brouwer, R.M. and Bruggemann, J. and Bustillo, J. and Cahn, W. and Calhoun, V. and Cannon, D. and Carr, V. and Catts, S. and Chen, J. and Chen, J.-X. and Chen, X. and Chiapponi, C. and Cho, K.K. and Ciullo, V. and Corvin, A.S. and Crespo-Facorro, B. and Cropley, V. and De Rossi, P. and Diaz-Caneja, C.M. and Dickie, E.W. and Ehrlich, S. and Fan, F.-M. and Faskowitz, J. and Fatouros-Bergman, H. and Flyckt, L. and Ford, J.M. and Fouche, J.-P. and Fukunaga, M. and Gill, M. and Glahn, D.C. and Gollub, R. and Goudzwaard, E.D. and Guo, H. and Gur, R.E. and Gur, R.C. and Gurholt, T.P. and Hashimoto, R. and Hatton, S.N. and Henskens, F.A. and Hibar, D.P. and Hickie, I.B. and Hong, L.E. and Horacek, J. and Howells, F.M. and Hulshoff Pol, H.E. and Hyde, C.L. and Isaev, D. and Jablensky, A. and Jansen, P.R. and Janssen, J. and Jönsson, E.G. and Jung, L.A. and Kahn, R.S. and Kikinis, Z. and Liu, K. and Klauser, P. and Knöchel, C. and Kubicki, M. and Lagopoulos, J. and Langen, C. and Lawrie, S. and Lenroot, R.K. and Lim, K.O. and Lopez-Jaramillo, C. and Lyall, A. and Magnotta, V. and Mandl, R.C.W. and Mathalon, D.H. and McCarley, R.W. and McCarthy-Jones, S. and McDonald, C. and McEwen, S. and McIntosh, A. and Melicher, T. and Mesholam-Gately, R.I. and Michie, P.T. and Mowry, B. and Mueller, B.A. and Newell, D.T. and O'Donnell, P. and Oertel-Knöchel, V. and Oestreich, L. and Paciga, S.A. and Pantelis, C. and Pasternak, O. and Pearlson, G. and Pellicano, G.R. and Pereira, A. and Pineda Zapata, J. and Piras, F. and Potkin, S.G. and Preda, A. and Rasser, P.E. and Roalf, D.R. and Roiz, R. and Roos, A. and Rotenberg, D. and Satterthwaite, T.D. and Savadjiev, P. and Schall, U. and Scott, R.J. and Seal, M.L. and Seidman, L.J. and Shannon Weickert, C. and Whelan, C.D. and Shenton, M.E. and Kwon, J.S. and Spalletta, G. and Spaniel, F. and Sprooten, E. and StÀblein, M. and Stein, D.J. and Sundram, S. and Tan, Y. and Tan, S. and Tang, S. and Temmingh, H.S. and Westlye, L.T. and TÞnnesen, S. and Tordesillas-Gutierrez, D. and Doan, N.T. and Vaidya, J. and Van Haren, N.E.M. and Vargas, C.D. and Vecchio, D. and Velakoulis, D. and Voineskos, A. and Voyvodic, J.Q. and Wang, Z. and Wan, P. and Wei, D. and Weickert, T.W. and Whalley, H. and White, T. and Whitford, T.J. and Wojcik, J.D. and Xiang, H. and Xie, Z. and Yamamori, H. and Yang, F. and Yao, N. and Zhang, G. and Zhao, J. and Van Erp, T.G.M. and Turner, J. and Thompson, P.M. and Donohoe, G., Widespread white matter microstructural differences in schizophrenia across 4322 individuals: Results from the ENIGMA Schizophrenia DTI Working Group, Molecular Psychiatry, 23, (5), 2018, p1261-1269 , Notes: [cited By 2], Journal Article, PUBLISHED  TARA - Full Text  DOI
  

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Robinson, P.C., Leo, P.J., Pointon, J.J., (...), Duncan, E.L., Wordsworth, B.P., The genetic associations of acute anterior uveitis and their overlap with the genetics of ankylosing spondylitis, Genes and Immunity, 17, (1), 2016, p46-51 , Journal Article, PUBLISHED
Merikangas, A.K., Segurado, R., Kelleher, E., Hogan, D., Delaney, C., Gill, M., Gallagher, L., Corvin, A.P., and Heron, E.A. , Parental age, birth order and neurodevelopmental disorders, 1826, 2016, -, Miscellaneous, PUBLISHED
Corvin, A., Schizophrenia: Evolution and Synthesis: A think tank to accelerate treatment development and prevention efforts. , Ernst Strungman Forum, Frankfurt, Germany, 20-28th July, 2012, Notes: [Invited contributor], Invited Talk, PUBLISHED
Corvin, A., Symposium Organizer, Schizophrenia International Research Society,, April 16th, In:Schizophrenia International Research Society,, 2012, Florence, Italy, Meetings /Conferences Organised, PUBLISHED
Corvin A. , The changing faces of schizophrenia. The Big Idea. , 2012, -, Miscellaneous, PUBLISHED
Corvin AP, McGhee K, Murphy K, Walsh C, Kenny N, Nangle J, Schwaiger S, Baldwin P, Scully P, Quinn J, Crumlish N, O'Callaghan E, Waddington J, Morris D, Gill M, Evidence for association and interaction between G72 and DAAO markers in an Irish case-control schizophrenia sample, American Journal of Medical Genetics Part B: Neuropsychiatric Genetics, SEP 5, 138B, (1), 2005, pp25 - 25, Meeting Abstract, PUBLISHED

  

I am interested in applying genomics methods to improving understanding of heritable major mental disorders and cognitive processes. Specifically, my research involves the identification and characterization of genes/molecular pathways contributing to disorders such as schizophrenia and bipolar disorder. I have headed the Psychosis Research Group at the Neuropsychiatric Genetics Laboratory since 1999. The group's research activities span from the genome to clinical symptoms (including genomics, biostatistics, bioinformatics, clinical phenotyping, neuropsychology, electrophysiology and neuroimaging). We collaborate with local researchers at the Institute of Molecular Medicine, Department of Genetics and TCIN. We are members of the International Schizophrenia Consortium and collaborate with researchers in the UK, Italy, Australia and US. I am also involved in projects relating to the genetics of cognition and synaesthesia.