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Professor Aiden Corvin

Professor Consultant/Head of Discipline (Psychiatry)
TRINITY CENTRE, S J H

 acorvin@tcd.ie

 3531896 2467

Deputy Director (Trinity Translational Medicine Institute)

Deputy Director (Trinity Inst. of Neurosciences (TCIN))


Biography

Aiden completed undergraduate medical training at University College Cork in 1993 and Membership of the Royal College of Psychiatrists (UK) in 1998. He was awarded a Wellcome Trust Fellowship in Mental Health in 2000 to explore the genetic aetiology of Psychotic Disorders. This was the seed for the development of the TCD Psychosis Research Group (www.medicine.tcd.ie/neuropsychiatric-¬-genetics/psychosis/). He was appointed Senior Lecturer in Psychiatry at TCD and Consultant Psychiatrist at St James's Hospital in 2006. Since 2017, Aiden has headed the Discipline of Psychiatry at the Medical School and been Clinical Director for the Dublin South Central Mental Health Service. His research team have made a substantial contribution to our understanding of the genetic aetiology of schizophrenia and bipolar disorder. Aiden was lead PI for Schizophrenia with the Wellcome Trust Case Control Consortium, a founder member of the Psychiatric Genomics Consortium and co-leads the Brainstorm Consortium (with Ben Neale, Broad Institute of MIT/Harvard). Work with Ben has recently identified significant genetic overlap across psychiatric disorders, suggesting that shared molecular mechanisms may contribute to symptoms affecting perception, mood and anxiety. He serves on the editorial board of two journals in the field and is a member of the UK MRC Neurosciences Panel. With generous help from more than 3,000 Irish participants, Aiden and his team continue to seek and investigate genes that contribute to the risk of serious mental illness, and to explore the biology involved with the aim of improving patient care. This work has been funded by Wellcome, SFI, HRB, EU and NIH. Aiden has published more than 240 peer-reviewed articles and 9 book chapters. His h-index is 68 (May 2018) and his work has received more than 21,000 citations.'

Research Tags

  Aetiology of mental illness   Cognitive dysfunction in psychotic disorders   Neurodegenerative diseases including schizophrenia & Alzheimer's disease   Neurogenetics   Psychiatric genetics   Schizophrenia
Ormond C, Ryan NM, Corvin A, Heron EA., Converting single nucleotide variants between genome builds: from cautionary tale to solution., Briefings in bioinformatics, 2021, Journal Article, PUBLISHED  DOI
Rees E, Carrera N, Morgan J, Hambridge K, Escott-Price V, Pocklington A.J, Richards A.L, Pardiñas A.F, Alizadeh B.Z, van Amelsvoort T, Bartels-Velthuis A.A, van Beveren N.J, Bruggeman R, Cahn W, de Haan L, Delespaul P, Meijer C.J, Myin-Germeys I, Kahn R.S, Schirmbeck F, Simons C.J.P, van Haren N.E, van Os J, van Winkel R, Luykx J.J, McDonald C, Donohoe G, Morris D.W, Kenny E, Kelleher E, Gill M, Corvin A, Kirov G, Walters J.T.R, Holmans P, Owen M.J, O'Donovan M.C, Targeted Sequencing of 10,198 Samples Confirms Abnormalities in Neuronal Activity and Implicates Voltage-Gated Sodium Channels in Schizophrenia Pathogenesis, Biological Psychiatry, 85, (7), 2019, p554 - 562, Journal Article, PUBLISHED  TARA - Full Text  DOI  URL
Morgan S.E, Seidlitz J, Whitaker K.J, Romero-Garcia R, Clifton N.E, Scarpazza C, van Amelsvoort T, Marcelis M, van Os J, Donohoe G, Mothersill D, Corvin A, Pocklington A, Raznahan A, McGuire P, Vértes P.E, Bullmore E.T, Cortical patterning of abnormal morphometric similarity in psychosis is associated with brain expression of schizophrenia-related genes, Proceedings of the National Academy of Sciences of the United States of America, 116, (19), 2019, p9604 - 9609, Journal Article, PUBLISHED  TARA - Full Text  DOI  URL
O'Reilly, K., Donohoe, G., O'Sullivan, D., (...), O'Connell, P., Kennedy, H.G. , A randomized controlled trial of cognitive remediation for a national cohort of forensic patients with schizophrenia or schizoaffective disorder, BMC Psychiatry, 19, (1), 2019, p27-, Journal Article, PUBLISHED  TARA - Full Text  DOI
O'Reilly, K., O'Connell, P., Corvin, A., (...), Richter, M., Kennedy, H. , Moral cognition and homicide amongst forensic patients with schizophrenia and schizoaffective disorder: A cross-sectional cohort study, Schizophrenia Research, 193, 2018, p468-469 , Journal Article, PUBLISHED  TARA - Full Text  DOI
Donohoe, G. and Dillon, R. and Hargreaves, A. and Mothersill, O. and Castorina, M. and Furey, E. and Fagan, A.J. and Meaney, J.F. and Fitzmaurice, B. and Hallahan, B. and McDonald, C. and Wykes, T. and Corvin, A. and Robertson, I.H., Effectiveness of a low support, remotely accessible, cognitive remediation training programme for chronic psychosis: cognitive, functional and cortical outcomes from a single blind randomised controlled trial, Psychological Medicine, 48, (5), 2018, p751-764 , Journal Article, PUBLISHED  DOI
Blokland, G.A.M. and del Re, E.C. and Mesholam-Gately, R.I. and Jovicich, J. and Trampush, J.W. and Keshavan, M.S. and DeLisi, L.E. and Walters, J.T.R. and Turner, J.A. and Malhotra, A.K. and Lencz, T. and Shenton, M.E. and Voineskos, A.N. and Rujescu, D. and Giegling, I. and Kahn, R.S. and Roffman, J.L. and Holt, D.J. and Ehrlich, S. and Kikinis, Z. and Dazzan, P. and Murray, R.M. and Di Forti, M. and Lee, J. and Sim, K. and Lam, M. and Wolthusen, R.P.F. and de Zwarte, S.M.C. and Walton, E. and Cosgrove, D. and Kelly, S. and Maleki, N. and Osiecki, L. and Picchioni, M.M. and Bramon, E. and Russo, M. and David, A.S. and Mondelli, V. and Reinders, A.A.T.S. and Falcone, M.A. and Hartmann, A.M. and Konte, B. and Morris, D.W. and Gill, M. and Corvin, A.P. and Cahn, W. and Ho, N.F. and Liu, J.J. and Keefe, R.S.E. and Gollub, R.L. and Manoach, D.S. and Calhoun, V.D. and Schulz, S.C. and Sponheim, S.R. and Goff, D.C. and Buka, S.L. and Cherkerzian, S. and Thermenos, H.W. and Kubicki, M. and Nestor, P.G. and Dickie, E.W. and Vassos, E. and Ciufolini, S. and Reis Marques, T. and Crossley, N.A. and Purcell, S.M. and Smoller, J.W. and van Haren, N.E.M. and Toulopoulou, T. and Donohoe, G. and Goldstein, J.M. and Seidman, L.J. and McCarley, R.W. and Petryshen, T.L., The Genetics of Endophenotypes of Neurofunction to Understand Schizophrenia (GENUS) consortium: A collaborative cognitive and neuroimaging genetics project, Schizophrenia Research, 195, 2018, p306-317 , Journal Article, PUBLISHED  TARA - Full Text  DOI
Iglesias, A.I. and Mishra, A. and Vitart, V. and Bykhovskaya, Y. and Höhn, R. and Springelkamp, H. and Cuellar-Partida, G. and Gharahkhani, P. and Bailey, J.N.C. and Willoughby, C.E. and Li, X. and Yazar, S. and Nag, A. and Khawaja, A.P. and PolaÅ¡ek, O. and Siscovick, D. and Mitchell, P. and Tham, Y.C. and Haines, J.L. and Kearns, L.S. and Hayward, C. and Shi, Y. and Van Leeuwen, E.M. and Taylor, K.D. and Wang, J.J. and Rochtchina, E. and Attia, J. and Scott, R. and Holliday, E.G. and Baird, P.N. and Xie, J. and Inouye, M. and Viswanathan, A. and Sim, X. and Bonnemaijer, P. and Rotter, J.I. and Martin, N.G. and Zeller, T. and Mills, R.A. and Staffieri, S.E. and Jonas, J.B. and Schmidtmann, I. and Boutin, T. and Kang, J.H. and Lucas, S.E.M. and Wong, T.Y. and Beutel, M.E. and Wilson, J.F. and Allingham, R.R. and Brilliant, M.H. and Budenz, D.L. and Christen, W.G. and Fingert, J. and Friedman, D.S. and Gaasterland, D. and Gaasterland, T. and Hauser, M.A. and Kraft, P. and Lee, R.K. and Lichter, P.R. and Liu, Y. and Loomis, S.J. and Moroi, S.E. and Pericak-Vance, M.A. and Realini, A. and Richards, J.E. and Schuman, J.S. and Scott, W.K. and Singh, K. and Sit, A.J. and Vollrath, D. and Weinreb, R.N. and Wollstein, G. and Zack, D.J. and Zhang, K. and Donnelly, P. and Barroso, I. and Blackwell, J.M. and Bramon, E. and Brown, M.A. and Casas, J.P. and Corvin, A. and Deloukas, P. and Duncanson, A. and Jankowski, J. and Markus, H.S. and Mathew, C.G. and Palmer, C.N.A. and Plomin, R. and Rautanen, A. and Sawcer, S.J. and Trembath, R.C. and Wood, N.W. and Spencer, C.C.A. and Band, G. and Bellenguez, C. and Freeman, C. and Hellenthal, G. and Giannoulatou, E. and Pirinen, M. and Pearson, R. and Strange, A. and Su, Z. and Vukcevic, D. and Langford, C. and Hunt, S.E. and Edkins, S. and Gwilliam, R. and Blackburn, H. and Bumpstead, S.J. and Dronov, S. and Gillman, M. and Gray, E. and Hammond, N. and Jayakumar, A. and McCann, O.T. and Liddle, J. and Potter, S.C. and Ravindrarajah, R. and Ricketts, M. and Waller, M. and Weston, P. and Widaa, S. and Whittaker, P. and Uitterlinden, A.G. and Vithana, E.N. and Foster, P.J. and Hysi, P.G. and Hewitt, A.W. and Khor, C.C. and Pasquale, L.R. and Montgomery, G.W. and Klaver, C.C.W. and Aung, T. and Pfeiffer, N. and MacKey, D.A. and Hammond, C.J. and Cheng, C.-Y. and Craig, J.E. and Rabinowitz, Y.S. and Wiggs, J.L. and Burdon, K.P. and Van Duijn, C.M. and MacGregor, S., Cross-ancestry genome-wide association analysis of corneal thickness strengthens link between complex and Mendelian eye diseases, Nature Communications, 9, (1), 2018, p1864-, Notes: [cited By 0], Journal Article, PUBLISHED  TARA - Full Text  DOI
Cosgrove, D. and Mothersill, D.O. and Whitton, L. and Harold, D. and Kelly, S. and Holleran, L. and Holland, J. and Anney, R. and Richards, A. and Mantripragada, K. and Owen, M. and O'Donovan, M.C. and Gill, M. and Corvin, A. and Morris, D.W. and Donohoe, G., Effects of MiR-137 genetic risk score on brain volume and cortical measures in patients with schizophrenia and controls, American Journal of Medical Genetics, Part B: Neuropsychiatric Genetics, 177, (3), 2018, p369-376 , Notes: [cited By 0], Journal Article, PUBLISHED  DOI
Donohoe, G. and Holland, J. and Mothersill, D. and McCarthy-Jones, S. and Cosgrove, D. and Harold, D. and Richards, A. and Mantripragada, K. and Owen, M.J. and O'Donovan, M.C. and Wtccc2 and Gill, M. and Corvin, A. and Morris, D.W., Genetically predicted complement component 4A expression: effects on memory function and middle temporal lobe activation, Psychological Medicine, 2018, p1-10 , Notes: [cited By 0; Article in Press], Journal Article, PUBLISHED  DOI
  

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Robinson, P.C., Leo, P.J., Pointon, J.J., (...), Duncan, E.L., Wordsworth, B.P., The genetic associations of acute anterior uveitis and their overlap with the genetics of ankylosing spondylitis, Genes and Immunity, 17, (1), 2016, p46-51 , Journal Article, PUBLISHED
Merikangas, A.K., Segurado, R., Kelleher, E., Hogan, D., Delaney, C., Gill, M., Gallagher, L., Corvin, A.P., and Heron, E.A. , Parental age, birth order and neurodevelopmental disorders, 1826, 2016, -, Miscellaneous, PUBLISHED
Corvin, A., Schizophrenia: Evolution and Synthesis: A think tank to accelerate treatment development and prevention efforts. , Ernst Strungman Forum, Frankfurt, Germany, 20-28th July, 2012, Notes: [Invited contributor], Invited Talk, PUBLISHED
Corvin, A., Symposium Organizer, Schizophrenia International Research Society,, April 16th, In:Schizophrenia International Research Society,, 2012, Florence, Italy, Meetings /Conferences Organised, PUBLISHED
Corvin A. , The changing faces of schizophrenia. The Big Idea. , 2012, -, Miscellaneous, PUBLISHED
Corvin AP, McGhee K, Murphy K, Walsh C, Kenny N, Nangle J, Schwaiger S, Baldwin P, Scully P, Quinn J, Crumlish N, O'Callaghan E, Waddington J, Morris D, Gill M, Evidence for association and interaction between G72 and DAAO markers in an Irish case-control schizophrenia sample, American Journal of Medical Genetics Part B: Neuropsychiatric Genetics, SEP 5, 138B, (1), 2005, pp25 - 25, Meeting Abstract, PUBLISHED

  

Research Interests

Description Of Research Interests

I am interested in applying genomics methods to improving understanding of heritable major mental disorders and cognitive processes. Specifically, my research involves the identification and characterization of genes/molecular pathways contributing to disorders such as schizophrenia and bipolar disorder. I have headed the Psychosis Research Group at the Neuropsychiatric Genetics Laboratory since 1999. The group's research activities span from the genome to clinical symptoms (including genomics, biostatistics, bioinformatics, clinical phenotyping, neuropsychology, electrophysiology and neuroimaging). We collaborate with local researchers at the Institute of Molecular Medicine, Department of Genetics and TCIN. We are members of the International Schizophrenia Consortium and collaborate with researchers in the UK, Italy, Australia and US. I am also involved in projects relating to the genetics of cognition and synaesthesia.