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Trinity College Dublin

Personal Information
College Photo Name Corvin, Aiden Peter
Main Department Psychiatry
College Title Professor Consultant
E-mail acorvin@tcd.ie
College Tel +353 1 896 2468
Web http://people.tcd.ie/acorvin
 
Biography
I completed undergraduate medical training at University College Cork in 1993 and Membership of the Royal College of Psychiatrists (UK) in 1998. I was awarded a Wellcome Trust Research Training Fellowship in Mental Health in 2000 to develop my interest in the genetic etiology of psychosis and founded the Psychosis Research Group (www.medicine.tcd.ie/neuropsychiatric-­‐genetics/psychosis/). I was appointed Senior Lecturer in Psychiatry at TCD (now Professor) and Consultant Psychiatrist at St James's Hospital, Dublin in 2006. Since its inception my research group’s goal has been to identify and investigate genetic mechanisms of psychosis, to define molecular etiology, and to use this information to serve patients by improving diagnostics and developing new therapeutic approaches. Through the commitment of more than 3,000 Irish participants we have contributed to substantial research breakthroughs in the field. From identifying molecular overlap between schizophrenia, bipolar disorder, and other psychiatric disorders; to going from finding the first identified risk genes, to the recent confirmation of 108 schizophrenia risk loci. We have identified novel, but rare large genetic effects that may be particularly important in understanding the underlying biology involved. We are increasingly interesting in modeling the risk mechanisms involved and looking at the extent of overlap with other neurological disorders (Brainstorm Project). I am a founder member of the International Schizophrenia Consortium, and lead the Wellcome Trust Case Control Consortium 2-schizophrenia study and Brainstorm (with Ben Neale, Broad Institute MIT/Harvard). I am Associated Editor for Genetics for the Schizophrenia Bulletin. I have authored 190 publications in international peer reviewed journals (Nature, Nature Genetics, Human Molecular Genetics, JAMA Psychiatry) and published 8 book chapters. My group's work has been funded by the Wellcome Trust, NIH, EU, Health Research Board, and Science Foundation Ireland. My h-index (Google Scholar, July 2014)is 43
 
Description of Research Interests
I am interested in applying genomics methods to improving understanding of heritable major mental disorders and cognitive processes. Specifically, my research involves the identification and characterization of genes/molecular pathways contributing to disorders such as schizophrenia and bipolar disorder. I have headed the Psychosis Research Group at the Neuropsychiatric Genetics Laboratory since 1999. The group's research activities span from the genome to clinical symptoms (including genomics, biostatistics, bioinformatics, clinical phenotyping, neuropsychology, electrophysiology and neuroimaging). We collaborate with local researchers at the Institute of Molecular Medicine, Department of Genetics and TCIN. We are members of the International Schizophrenia Consortium and collaborate with researchers in the UK, Italy, Australia and US. I am also involved in projects relating to the genetics of cognition and synaesthesia.
 
Research Interests
Aetiology of mental illness Cognitive dysfunction in psychotic disorders Neurodegenerative diseases including schizophrenia & Alzheimer's disease Neurogenetics
Psychiatric genetics Schizophrenia
 
Publications and Other Research Outputs
Peer Reviewed
Donohoe G, Walters J, Hargreaves A, Rose EJ, Morris DW, Fahey C, Bellini S, Cummins E, Giegling I, Hartmann AM, Möller HJ, Muglia P, Owen MJ, Gill M, O'Donovan MC, Tropea D, Rujescu D, Corvin A, Neuropsychological Effects Of The CSMD1 Genome-Wide Associated Schizophrenia Risk Variant rs10503253., Genes, Brain, and Behavior, 12, (12), 2013, p203- 209
Notes: [PMID: 23320435]
DOI
Ruderfer DM, Chambert K, Moran J, Talkowski M, Chen ES, Gigek C, Gusella JF, Blackwood DH, Corvin A, Gurling HM, Hultman CM, Kirov G, Magnusson P, O'Donovan MC, Owen MJ, Pato C, St Clair D, Sullivan PF, Purcell SM, Sklar P, Ernst C, Mosaic copy number variation in schizophrenia., European journal of human genetics : EJHG, 2013
Notes: [pre-print]
DOI
Hamshere M, Walters JT, Smith R, et al., Genome-wide significant associations in schizophrenia to ITHIH3/4, CACNA1C and SDCCAG8, and extensive replication of associations reported by the schizophrenia PGC., Molecular Psychiatry, 18, (6), 2013, p708-712
DOI
More Publications and Other Research Outputs >>>
 

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Last Updated:01-OCT-2014