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Professor Veronica Ann Campbell

Adjunct Professor (Physiology)
      
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Professor Veronica Ann Campbell

Adjunct Professor (Physiology)

 vacmpbll@tcd.ie

 


Dr Campbell is a Pharmacology graduate (1991; University of Edinburgh) and was awarded her PhD in Neuropharmacology in 1995 (University of London). She took up an HRB post-doctoral fellowship in 1996, and was appointed to the Department of Physiology TCD in 1998.
  Apoptosis   Biology   Biomedical sciences   Intra and intercellular signalling   Neurochemistry and neuropharmacology   Neurodegeneration   Neuropharmacology   Physiology
Project Title
 Do cannabinoids confer neuroprotection by stabilizing lysosomes?
From
2009
To
2011
Summary
Funding Agency
Health Research Board
Person Months
36
Project Title
 Cannabinoids and mesenchymal stem cell differentiation
From
October 2007
To
September 2009
Summary
The aim of this project is to examine the role of cannabinoid pathways in the control of bone and cartilage development.
Funding Agency
Science Foundation Ireland
Programme
Research Frontiers
Person Months
24
Project Title
 Effect of hypoxia on tissue engineering of bone and cartilage
From
2005
To
2008
Summary
This interdisciplinary project aims to identify the optimal conditions for inducing differentiation of adult mesenchymal stem cells along the osteogenic and chondrogenic lineages. The study will identify the signal transduction pathways involved in these processes.
Funding Agency
Health Research Board
Programme
Basic Research Grant
Person Months
36
Project Title
 Cannabinoids and neuronal fate
From
2004
To
2007
Summary
Marijuana is the most commonly used illegal drug of abuse in Ireland, particularly amongst the 14-16 year old age group. ?9-tetrahydrocannabinol (THC) is the psychoactive ingredient of marijuana and this project is concerned with furthering our understanding of the impact of THC on the brain.
Funding Agency
Science Foundation Ireland
Programme
Basic Research Grant
Person Months
36
Project Title
 Investigation into the role of lysosomes in neuronal cell death
From
2003
To
2006
Summary
Alzheimer's disease is a devastating neurodegenerative condition which is associated with cognitive decline and neuronal loss. A neuropathological hallmark of this disease is the deposition of ß-amyloid (Aß) protein around neurons, and Aß is thought to contribute to the disease process by inducing neuronal cell death. We have identified that Aß increases intracellular Ca2+ concentration in cortical neurons (MacManus et al., 2000), leading to activation of Ca2+-dependent proteases and subsequent cell death (Boland et al., 2003). Understanding how Aß influences intracellular Ca2+ homeostasis is one of our key research questions given that dysregulation of this ion provides the basis for the "calcium hypothesis of neurodegeneration". Lysosomes are relatively understudied organelles that serve as reservoirs for Ca2+. Our recent work has demonstrated that Aß impacts on the lysosomal system, causing lysosomes to become leaky and release lysosomal proteases which then contribute to the cell death cascade (Boland et al., 2004). Events which cause the lysosomal membrane to become leaky are likely to promote the release of lysosomal Ca2+, as well as proteolytic enzymes, and contribute to the increase in intracellular Ca2+ concentration which is associated with many forms of cell death. We are currently attempting to examine the influence of Aß on lysosomal Ca2+ homeostasis since this may contribute to the induction of apoptosis that we observe following exposure of neurons to Aß in vitro .
Funding Agency
Enterprise Ireland
Programme
Basic Research Grant
Person Months
36

Details Date From Date To
Secretary, Biomedical Sciences Section (Royal Academy Medicine in Ireland) 2004 2007
Fellow, Royal Academy Medicine in Ireland
Member, Society for Neuroscience
Member, Physiological Society
Editor, British Journal of Pharmacology 2005
President, Royal Academy of Medicine in Ireland (Biomedical Sciences Section) 2015
Lyons A, Minogue A.M, Jones R.S, Fitzpatrick O, Noonan J, Campbell V.A, Lynch M.A, Analysis of the Impact of CD200 on Phagocytosis, Molecular Neurobiology, 54, (7), 2017, p5730 - 5739, Journal Article, PUBLISHED  DOI  URL
Haugh O, Penman J, Irving AJ, Campbell VA., The Emerging Role of the Cannabinoid Receptor Family in Peripheral and Neuro-immune Interactions., Curr Drug Targets, 17, (16), 2016, p1834 - 1840, Journal Article, PUBLISHED
McKayed K, Prendergast PJ, Campbell VA., Aging enhances the vulnerability of mesenchymal stromal cells to uniaxial tensile strain-induced apoptosis., Journal Biomechanics, 49, (3), 2016, p458 - 462, Journal Article, PUBLISHED  DOI
Endocannabinoids and Alzheimer's Disease in, editor(s)Liana Fattore , Cannabinoids in Neurologic and Mental Disease, Elsevier Academic Press, 2015, ppChapter 2 - [SG Fagan, VA Campbell], Book Chapter, PUBLISHED
Xue, F., Lennon, A.B., McKayed, K.K., Campbell, V.A., Prendergast, P.J., Effect of membrane stiffness and cytoskeletal element density on mechanical stimuli within cells: an analysis of the consequences of ageing in cells, Computer Methods in Biomechanics and Biomedical Engineering, 18, (5), 2015, p468 - 476, Journal Article, PUBLISHED  TARA - Full Text  DOI  URL
Fagan SG, Campbell VA., The influence of cannabinoids on generic traits of neurodegeneration, British Journal of Pharmacology, 171, (6), 2014, p1347 - 1360, Journal Article, PUBLISHED
Gowran A, McKayed K, Campbell VA, The cannabinoid receptor type 1 is essential for mesenchymal stem cell survival and differentiation: implications for bone health., Stem cells international, 2013, 2013, p796715 , Journal Article, PUBLISHED  TARA - Full Text  DOI
Tanveer R, Gowran A, Noonan J, Keating SE, Bowie AG, Campbell VA, The endocannabinoid, anandamide, augments Notch-1 signaling in cultured cortical neurons exposed to amyloid-β and in the cortex of aged rats., Journal of Biological Chemistry, 287(41), (41), 2012, p34709 - 34721, Notes: [PMID: 22891244], Journal Article, PUBLISHED  DOI
Murphy N, Cowley TR, Blau CW, Dempsey CN, Noonan J, Gowran A, Tanveer R, Olango WM, Finn DP, Campbell VA, Lynch MA, The fatty acid amide hydrolase inhibitor URB597 exerts anti-inflammatory effects in hippocampus of aged rats and restores an age-related deficit in long-term potentiation, Journal of Neuroinflammation, 9, (79), 2012, Journal Article, PUBLISHED  DOI
Murphy N, Cowley TR, Blau CW, Dempsey CN, Noonan J, Gowran A, Tanveer R, Olango WM, Finn DP, Campbell VA, Lynch MA, The fatty acid amide hydrolase inhibitor URB597 exerts anti-inflammatory effects in hippocampus of aged rats and restores an age-related deficit in long-term potentiation., Journal of neuroinflammation, 9, 2012, p79 , Journal Article, PUBLISHED  TARA - Full Text  DOI
  

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Award Date
Fellow of TCD 2004
Cannabinoid neuropharmacology; ß-amyloid; Neurodegeneration; Regulation of neuronal calcium homeostasis; Tissue engineering of bone and cartilage; Mesenchymal stem cells