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Personal Information
College Photo Name O'Mara, Shane Michael
Main Department Psychology
College Title Professor of Experimental Brain Research
E-mail shane.omara@tcd.ie
College Tel +353 1 896 8447
Web http://people.tcd.ie/smomara
 
Biography
I am Professor of Experimental Brain Research in Trinity College Dublin, and am a Principal Investigator in, and currently the Director of, the Trinity College Institute of Neuroscience and a member of the academic staff of the School of Psychology. I was an undergraduate and postgraduate at NUI Galway (BA, MA). I undertook my doctoral work (DPhil) at the University of Oxford. I am a Fellow of Trinity College, Dublin (FTCD) and a Fellow of the Association for Psychological Science (FAPS). I was also elected a Member of the Royal Irish Academy (MRIA). Research Focus: My research focuses on the relations between cognition, synaptic plasticity and behaviour, in the context of brain aging and depression. Research Interests: Biology of learning and memory; mechanisms of brain repair; drug action in CNS; synaptic plasticity; visualising in vivo neuronal activity; defining distribution of bioactive agents in CNS; imaging human brain during learning and memory; models of neurodegeneration; models of secondary depression and their treatment; organic disorders of memory. I am also interested in public policy applications and counterfactual interpretations of neuroscience. Research Support and Research Funding: My research work has been or currently is supported by the Wellcome Trust; Science Foundation Ireland; the Health Research Board; the European Commission; GlaxoSmithKline; Alkermes. I blog shaneomara.wordpress.com, mostly on neuroscience-, psychology-, science- and public policy-related themes (and maybe the intersection of all of these themes, but sometimes on other things entirely). I tweet at @smomara1.
 
Representations
Details Date
Major Conference Organization: The European Brain and Behaviour Society meeting Sept 2005. I was the Chair and Chief Organiser of this conference; I led the successful bid to bring this conference to Dublin and to have it hosted by the Trinity College Institute of Neuroscience. This was a major international meeting of some 450 delegates. 2005
 
Membership of Professional Institutions, Associations, Societies
Details Date From Date To
Association for Psychological Science; Society for Neuroscience; European Brain and Behaviour Society; Neuroscience Ireland
 
Awards and Honours
Award Date
FAPS 2010
MRIA 2011
 
Description of Research Interests
Biology of learning and memory; mechanisms of brain repair; drug action in CNS; synaptic plasticity; visualising in vivo neuronal activity; defining distribution of bioactive agents in CNS; imaging human brain during learning and memory; models of neurodegeneration; models of secondary depression and their treatment; organic disorders of memory. Key Research Question: How does the brain change as a result of experience? To investigate this general problem, I have adopted multidisciplinary techniques from diverse disciplines (e.g. neurophysiology, neuropharmacology, behavioural analysis, neuroimmunology). Techniques routinely used in my research group include: in vivo neurophysiology in freely-moving/anaesthetised rat (field potentials/action potential recordings of single neurons/neuronal ensembles); neurobehavioural assays (automated water, radial, open field; object exploration, odour discrimination, etc.); brain protein assays (BDNF; prostaglandins); radioimmunoassays; neurohistology.
 
Research Interests
ACTIVATED PROTEIN-KINASE ALZHEIMERS-DISEASE AMINO-ACID RECEPTORS AMMONS HORN
ANATOMICAL DATA ANTERIOR CINGULATE CORTEX ANTERIOR THALAMIC NUCLEI ARACHIDONIC-ACID
AREA CA1 BDNF BDNF PROTECTS BEHAVIORAL STRESS
Biology of learning, memory and cognition CA1 CALCIUM CHRONIC NEUROINFLAMMATION
COGNITIVE MAPS COMPLEX-SPIKE CELLS CORTEX CUE CONTROL
CYTOKINES DENTATE GYRUS DEPOTENTIATION DISORIENTATION
EFFERENT CONNECTIONS ELECTROPHYSIOLOGICALLY-DEFINED CLASSES ENTORHINAL CORTEX ENVIRONMENT
FIRING PATTERNS FIRING PROPERTIES FREELY-MOVING FRONTAL-CORTEX
GYRUS IN-VITRO HEAD DIRECTION CELLS HIGH-FREQUENCY STIMULATION HIPPOCAMPAL
HIPPOCAMPAL AREA CA1 HIPPOCAMPAL FORMATION HIPPOCAMPAL SLICES HIPPOCAMPUS
IN-VIVO LASTING POTENTIATION LEARNING AND MEMORY LESIONS
LONG-TERM POTENTIATION MESSENGER-RNA METHYL-D-ASPARTATE NEURONS
PAIRED-PULSE FACILITATION PARIETAL CORTEX PATH INTEGRATION PLACE NAVIGATION
PLASTICITY POTENTIATION RAT RAT HIPPOCAMPUS
RATS SLICES SPATIAL MEMORY SUBICULUM
SYNAPTIC TRANSMISSION WATER MAZE
 
Publications and Other Research Outputs
Peer Reviewed
Cowley TR, Fahey B, O'Mara SM, COX-2, but not COX-1, activity is necessary for the induction of perforant path long-term potentiation and spatial learning in vivo, European Journal of Neuroscience, 27, (11), 2008, p2999 - 3008
Kelly, AM, Larkin, A, Fahey, B, Gobbo, O, Callaghan, CK, Cahill, E, O'Mara, S.M. , Blockade of NMDA receptors pre-training, but not post-training, impairs object displacement learning in the rat, Brain Research, 1199, 2008, p126 - 132
O’Mara S.M., The Subiculum: What It Does, What It Might Do, And What Neuroanatomy Has Yet To Tell Us, Journal of Anatomy, 207, 2005, p271 - 282
URL
Anderson MI, O'Mara SM, Analysis of recordings of single-unit firing and population activity in the dorsal subiculum of unrestrained, freely moving rats, JOURNAL OF NEUROPHYSIOLOGY, 90, 2 , (AUG), 2003, p655 - 665
URL
More Publications and Other Research Outputs >>>
 

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Last Updated:18-APR-2014