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Profile Photo

Dr. Sharon O'Toole

Snr Experimental Officer (Obstetrics)
Senior Research Fellow (Histopathology)
 (3531896) 2106
COOMBE WOMENS HOSPITAL
      
Profile Photo

Dr. Sharon O'Toole

Snr Experimental Officer (Obstetrics)
COOMBE WOMENS HOSPITAL

 shotoole@tcd.ie

 3531896 2116

Senior Research Fellow (Histopathology)

 (3531896) 2106


Sharon O'Toole is a senior research fellow in Trinity College Dublin working in the area of ovarian cancer. She qualified with a BSc Hons in UCG in 1994 and then completed an MSc Biotechnology in 1996. Having worked in industry she then returned to research and completed a PhD in Trinity College in 2003. She has gained enormous experience in the area of ovarian cancer and has played a major role in the development of studies in gynaecological cancer. She was instrumental in establishing the DISCOVARY consortium which is a multidisciplinary and trans- institutional consortium dedicated to addressing the problems of ovarian and uterine cancer. The consortium manages the largest ovarian cancer bioresource in the country. The consortium has now merged to form INNOVATION- the Irish National Network for Ovarian Cancer Collaboration which has brought together the medical, research and charity organisations involved in ovarian cancer in Ireland. Her research interests centre around diagnostic and prognostic biomarkers and understanding the fundamental biology of the metastatic cascade and circulating tumour cells. She has been successful in identifying diagnostic and prognostic biomarkers for ovarian cancer and her ultimate aim is to translate these into the clinic. She has presented at both national and international conferences and published in peer-reviewed journals. She works closely with the 3 ovarian cancer charities in Ireland whose mission is to improve outcomes for ovarian cancer in Ireland. She was part of the organising committee of the first World Ovarian Cancer Day on May 8th in 2013 and this has now become an annual event.
  Gynaecology oncology   Obstetrics/Gynecology   Oestregens in age related urogenital diseases
Language Skill Reading Skill Writing Skill Speaking
English Fluent Fluent Fluent
French Fluent Medium Medium
Details Date From Date To
Member of European Association for Cancer Research. Member of Irish Association for Cancer Research
-Co-ordinator of INNOVATION- the Irish National Network for Ovarian Cancer Collaboration.
-Executive Committee of the Irish Society of Gynaecological Oncology (ISGO)
-Member of the European Society for Gynaecological Oncology (ESGO)
-Member of Cancer Trials Ireland
Batog WI, Norris L, O'Toole S, Maguire P, O'Gorman C, Kelly M, Saadeh FA., Identification of groin node metastasis in squamous cell vulval cancer using preoperative [<sup>18</sup>F] FDG-PET/CT. Can unnecessary lymphadenectomy be prevented?, European journal of obstetrics, gynecology, and reproductive biology, 310, 2025, p113959 , Journal Article, PUBLISHED  DOI
O'Toole, Sharon and Tzortzatou, Olga and Casati, Sara and Beirne, James P. and Savona-Ventura, Charles and Azzopardi, Miriam J. and Micallef, Rita and Calleja-Agius, Jean and Ellul, Bridget, Biobanking rare gynaecological tumours â€" How harmonised is data collection?, European Journal of Surgical Oncology, 51, (4), 2025, Notes: [Cited by: 1], Journal Article, PUBLISHED  DOI
Azzopardi, Miriam J. and Calleja-Agius, Jean and Calleja, Neville and Galea, Darren and Ellul, Bridget and Micallef, Rita and O'Toole, Sharon A. and Savona-Ventura, Charles, Rare gynaecological cancers in Malta â€" An analysis of incidence between 2010 and 2021, European Journal of Surgical Oncology, 51, (4), 2025, Notes: [Cited by: 1], Journal Article, PUBLISHED  DOI
LEWIS, F., WARD, M. P., SAADEH, F. A., O'GORMAN, C., MAGUIRE, P. J., BEIRNE, J. P., KAMRAN, W., IBRAHIM, E., NORRIS, L., KELLY, T., HURLEY, S., HENDERSON, B., KANJUGA, M., O'DRISCOLL, L., GATELY, K., ONER, E., SAINI, V. M., CADOO, K., MARTIN, C., O'LEARY, J. J. & O'TOOLE, S. A., A pilot study evaluating the feasibility of enriching and detecting circulating tumour cells from peripheral and ovarian veins in rare epithelial ovarian carcinomas, European Journal of Surgical Oncology, 2025, Journal Article, PUBLISHED
Miriam J Azzopardi, Jean Calleja"Agius, Neville Calleja, Darren Galea, Bridget Ellul, R. Micallef, Sharon O"Toole, Charles Savona"Ventura, RARE GYNAECOLOGICAL CANCERS IN MALTA " An Analysis of Incidence between 2010 and 2021, European Journal of Surgical Oncology, 2025, p109971 - 109971, p109971-109971 , Journal Article, PUBLISHED  DOI
Ward MP, Ibrahim EM, O'Toole SA, Marchocki Z, O'Leary JJ, Saadeh FA, Norris LA., Chemotherapy alters thrombomodulin and factor VIIIc expression resulting in acquired activated protein C resistance and enhanced thrombin generation in cancer associated thrombosis., Thrombosis research, 246, 2024, p109251 , Journal Article, PUBLISHED  DOI
M Saini, Volga, Oner, Ezgi, Ward, Mark P., Hurley, Sinead, Henderson, Brian David, Lewis, Faye, Finn, Stephen P., Fitzmaurice, Gerard J., O'Leary, John J., O'Toole, Sharon, O'Driscoll, Lorraine, Gately, Kathy, A comparative study of circulating tumor cell isolation and enumeration technologies in lung cancer, Molecular Oncology, 2024, Journal Article, PUBLISHED  DOI
White, Christine and Reynolds, Stephen and Murphy, Katherine and Keegan, Helen and Naik, Padma and O'Brien, Roisin and Pilkington, Loretto and Sharkey Ochoa, Imogen and Glesson, Grainne and Russell, Noirin and Nuttall, David and Tewari, Prerna and Wright, Fiona and O'Toole, Sharon and Sharp, Linda and Flannelly, Grainne and O'Leary, John J. and Martin, Cara M., Performance of the HPV E6/E7 mRNA Aptima HPV assay combined with partial genotyping compared with the HPV DNA Cobas 4800 HPV test for use in primary screening: Results from the CERVIVA HPV primary screening study in Ireland, International Journal of Cancer, 154, (1), 2024, p53 â€" 64 , Notes: [Cited by: 5], Journal Article, PUBLISHED  DOI
Bates M, Mullen D, Lee E, Costigan D, Heron EA, Kernan N, Barry-OCrowley J, Martin C, Keegan H, Malone, V, Brooks R, Brooks D, Logan, JM, Martini, C, Selemidis S, McFadden J, ORiain C, Spillane CD, Gallagher MF, McCann A, OToole S, OLeary JJ, P53 and TLR4 expression are prognostic markers informing progression free survival of advanced stage high grade serous ovarian cancer, Pathology - Research and Practice, 2024, Journal Article, PUBLISHED
Sehouli, Jalid and Boer, Jolijn and Brand, Alison H. and Oza, Amit M. and O†Donnell, Jennifer and Bennett, Katherine and Glaspool, Ros and Lee, Chee Khoon and Ethier, Josee-Lyne and Harter, Philipp and Seebacher-Shariat, Veronika and Chang, Ting-Chang and Cohen, Paul A. and van Gorp, Toon and Chavez-Blanco, Adriana and Welch, Stephen and Hranovska, Hanna and O'Toole, Sharon and Lok, Christianne A.R. and Madariaga, Ainhoa and Rauh-Hain, Jose Alejandro and Fidalgo, Alejandro Perez and Tan, David and Michels, Judith and Pothuri, Bhavana and Fujiwara, Noriko and Rosengarten, Ora and Nishio, Hiroshi and Kim, Se Ik and Mukopadhyay, Asima and Piovano, Elisa and Cecere, Sabrina Chiara and Kohn, Elise C. and Mukherjee, Uma and Nasser, Sara and Lindemann, Kristina and Croke, Jennifer and Chen, Xiaojun and Geissler, Franziska and Bookman, Michael A., How to optimize and evaluate diversity in gynecologic cancer clinical trials: statements from the GCIG Barcelona Meeting, International Journal of Gynecological Cancer, 34, (11), 2024, p1677 â€" 1684 , Notes: [Cited by: 4], Journal Article, PUBLISHED  DOI
  

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O'Leary JJ, White C, Spillane C, Naik, P, O'Brien, R, Reynolds, S, Pham, T, Pilkington, L, Sharkey Ochoa, I, Bolger, N, Barry O'Crowley, J, Tewari, P, O'Toole, S, Sweeney, M, Keegan, H, Normand, C, Sharp, L, Flannelly, G, Martin, CM. , Cervical screening: A new way forward (tests of risk and tests of disease) [version 1; referees: 1 approved, 1 approved with reservations]., HRB Open Research, 1, (3), 2018, Journal Article, PUBLISHED
Ibrahim N, Norris L, O'Toole S, McHugh T, Gleeson N, Does extended thromboprophylaxis help reduce the incidence of venous thromboembolism in gynaecological cancer patients?, Thrombosis Research, 7th Internation Conference onal Thrombosis & Hemostatis Issues in Cancer,, Bergamo Italy, May 2014, edited by A Falanga, B. Brenner, F, Rickles , 133, (Suppl 2), Elsevier, 2014, Published Abstract, PUBLISHED
Laios A, O'Toole SA, Sheppard BL, Gleeson NC, D'Arcy T, McGuinness EPJ, Ring M, Sheils O, Smyth P, O'Leary JJ., Recurrent ovarian cancer cDNA signatures., Centenary Meeting of the Pathological Society of Great Britain and Ireland , Manchester, July 2006, 2006, Meeting Abstract, PRESENTED
CM Martin, K Astbury, R Henfrey, O Sheils, M Gallagher, C Heffron, C Logan, SA O'Toole, JJ O'Leary, miRNA expression signatures in cervical cancer, Journal of RNAi and Gene Silencing, RNAi2006: Advances in RNA Interference Research, St Anne's College, Oxford, United Kingdom, March 2006, 2, (2), 2006, Meeting Abstract, PUBLISHED
Laios A, O'Toole SA, Sheppard BL, Gleeson NC, D'Arcy T, McGuinness EPJ, Ring M, Sheils O, O'Leary JJ. (ed.), Irish Association for Cancer Research, Galway, Ireland, March 2006, 2006, Proceedings of a Conference, PRESENTED
A Laios, SA O'Toole, B Sheppard, N Gleeson, T D'Arcy, E PJ McGuinness, M Ring, O Sheils and JJ O'Leary. , Transcriptome profiling of primary and recurrent ovarian cancers, Junior Obstetrics and Gynaecology Society, Dublin, Nov 2005, 2005, Meeting Abstract, PRESENTED
O'Toole S, Laios A, Sheppard B, Smyth P, O'Regan E, Sheils O, O'Leary J. , Expression profiling of endometrial stromal cells treated with estradiol and phytoestrogens. , 20th European Congress of Pathology, Paris, Sept 2005, 2005, Meeting Abstract, PRESENTED
O'Toole SA, Laios A, Sheppard BL, Gleeson NC, D'Arcy T, Mc Guinness EPJ, Bonnar J, Sheils O, O'Leary JJ. , Angiogenesis markers in ovarian cancer act as prognostic markers but not indicators of chemotherapy response, Pathological Society of Great Britain and Ireland, Newcastle, UK, July 2005, 2005, Meeting Abstract, PRESENTED
O'Toole SA, Laios A, Sheppard BL, Gleeson NC, D'Arcy T, Mc Guinness EPJ, Bonnar J, Sheils O, O'Leary JJ. , Potential Predictors of Chemotherapy Response in Ovarian Cancer., Irish gynaecological oncology society, Belfast, 2005, 2005, Meeting Abstract, PRESENTED
O'Toole SA, Sheppard BL, D'Arcy T, Mc Guinness EPJ, Gleeson NC, Bonnar J, Sheils O, O'Leary JJ. , Angiogenesis in Ovarian Cancer does not predict response to chemotherapy., Irish Association for Cancer Research, Kilkenny, Ireland, March 2005, 2005, Meeting Abstract, PRESENTED

  


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-Early diagnostics in ovarian cancer -Chemoresistance in ovarian cancer Chemosensitivity/Resistance testing of malignant gynaecological tumours -Examination of Fibrinolytic systems of malignant gynaecological tumours -Examination of angiogenesis in ovarian cancers. -Examination of multidrug resistance genes in gynaecological tumours. -Estrogen regulated genes in endometrial cancer. -PhytoSERMs and Endometrial Cancer