| Staff Details | ||||
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| Personal Information | ||
| Name | Rogers, Thomas Richard Frazer | |
| Main Department | Clinical Microbiology | |
| College Title | Chair in Clinical Microbiology/Head of | |
| rogerstr@tcd.ie | ||
| College Tel | +353 1 896 2131 | |
| Web | http://people.tcd.ie/rogerstr | |
| Fax | 01 8968566 | |
| Biography | |
| My main research interest is in invasive fungal infections, including molecular diagnostics, pathogenesis, host-pathogen interactions, and antifungal therapies. Also, research into nosocomial infections including Clostridium difficile colitis. Other current research includes study of Escherichia coli bacteraemia focusing on pathogenic mechanisms, epidemiology and antibiotic resistance. | |
| Membership of Professional Institutions, Associations, Societies |
| Details | Date From | Date To |
| President of the Healthcare Infection Society | 2010 | 2014 |
| Description of Research Interests |
| Infections in immunocompromised hosts. Invasive fungal infections. Antifungal therapy. Host pathogen interactions. Escherichia coli bloodstream infection. Antibiotic resistance. Nosocomial infections. Epidemiology of tuberculosis. Diagnostic tests for tuberculosis. |
| Research Interests | |||
| Antibiotics | Bacteriology and bacterial pathogenesis | Fungal Diseases | Infectious Diseases/Agents |
| Mycology and fungal pathogenesis | Tuberculosis |
| Research Projects | |
| Project title | Development of novel management strategies for invasive aspergillosis "MANASP" |
| Summary | Development of novel molecular diagnostics for invasive aspergillosis. Study of DNA release from Aspergillus fumigatus during in vitro growth and correlation with dynamics of DNA release during experimental infections in vivo. Study of Aspergillus fumigatus-human dendritic cells interaction ex vivo. Study of A fumigatus-human monocytes interaction ex vivo. Investigation of immunologically important Aspergillus antigens produced in human serum during invasive aspergillosis |
| Funding Agency | European Union |
| Programme | Framework 6 |
| Type of Project | STREP |
| Date from | 2006 |
| Date to | 2010 |
| Person Months | 42 |
| Publications |
| Peer Reviewed |
| Morton CO, Clemons KV, Springer J, Mueller JG, Rogers TR, Stevens DA, Kurzai O, Einsele H, Loeffler J., Real-time PCR and quantitative culture for monitoring of experimental Aspergillus fumigatus intracranial infection in neutropenic mice, Journal of Medical Microbiology, E pub, 2011 | |
| Morton CO, Loeffler J, De Luca A, Frost S, Kenny C, Duval S, Romani L, Rogers TR, Dynamics of extracellular release of Aspergillus fumigatus DNA and galactomannan during growth in blood and serum, Journal of Medical Microbiology, 59, 2010, p408 - 413 | |
| Bignell E,Negrete-Urtasun S,Calcagno AM,Arst HN Jr,Rogers T,Haynes K,, Virulence comparisons of Aspergillus nidulans mutants are confounded by the inflammatory response of p47phox-/- mice. , Infection and Immunity, 73, (8), 2005, p5204 - 5207 Url |
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| Bignell E,Negrete-Urtasun S,Calcagno AM,Haynes K,Arst HN Jr,Rogers T,, The Aspergillus pH-responsive transcription factor PacC regulates virulence. , Molecular Microbiology, 55, (4), 2005, p1072 - 1084 Url |
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| Schrettl M,Bignell E,Kragl C,Joechl C,Rogers T,Arst HN Jr,Haynes K,Haas H,, Siderophore biosynthesis but not reductive iron assimilation is essential for Aspergillus fumigatus virulence, Journal of Experimental Medicine, 200, (9), 2004, p1213 - 1219 Url |
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| More Publications>>> | |
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