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Trinity College Dublin

Personal Information
College Photo Name Rogers, Thomas Richard Frazer
Main Department Clinical Microbiology
College Title Chair in Clinical Microbiology/Head of
E-mail rogerstr@tcd.ie
College Tel +353 1 896 2131
Web http://people.tcd.ie/rogerstr
Fax 01 8968566
 
Biography
My main research interest is in invasive fungal infections, including molecular diagnostics, pathogenesis, host-pathogen interactions, and antifungal therapies. Also, research into nosocomial infections including Clostridium difficile colitis. Other current research includes study of Escherichia coli bacteraemia focusing on pathogenic mechanisms, epidemiology and antibiotic resistance.
 
Membership of Professional Institutions, Associations, Societies
Details Date From Date To
President of the Healthcare Infection Society 2010 2014
 
Description of Research Interests
Infections in immunocompromised hosts. Invasive fungal infections. Antifungal therapy. Host pathogen interactions. Escherichia coli bloodstream infection. Antibiotic resistance. Nosocomial infections. Epidemiology of tuberculosis. Diagnostic tests for tuberculosis.
 
Research Interests
Antibiotics Bacteriology and bacterial pathogenesis Fungal Diseases Infectious Diseases/Agents
Mycology and fungal pathogenesis Tuberculosis
 
Research Projects
Project title Development of novel management strategies for invasive aspergillosis "MANASP"
Summary Development of novel molecular diagnostics for invasive aspergillosis. Study of DNA release from Aspergillus fumigatus during in vitro growth and correlation with dynamics of DNA release during experimental infections in vivo. Study of Aspergillus fumigatus-human dendritic cells interaction ex vivo. Study of A fumigatus-human monocytes interaction ex vivo. Investigation of immunologically important Aspergillus antigens produced in human serum during invasive aspergillosis
Funding Agency European Union
Programme Framework 6
Type of Project STREP
Date from 2006
Date to 2010
Person Months 42


 
Publications and Other Research Outputs
Peer Reviewed
Morton CO, Clemons KV, Springer J, Mueller JG, Rogers TR, Stevens DA, Kurzai O, Einsele H, Loeffler J., Real-time PCR and quantitative culture for monitoring of experimental Aspergillus fumigatus intracranial infection in neutropenic mice, Journal of Medical Microbiology, E pub, 2011
Morton CO, Loeffler J, De Luca A, Frost S, Kenny C, Duval S, Romani L, Rogers TR, Dynamics of extracellular release of Aspergillus fumigatus DNA and galactomannan during growth in blood and serum, Journal of Medical Microbiology, 59, 2010, p408 - 413
Bignell E,Negrete-Urtasun S,Calcagno AM,Arst HN Jr,Rogers T,Haynes K,, Virulence comparisons of Aspergillus nidulans mutants are confounded by the inflammatory response of p47phox-/- mice. , Infection and Immunity, 73, (8), 2005, p5204 - 5207
URL
Bignell E,Negrete-Urtasun S,Calcagno AM,Haynes K,Arst HN Jr,Rogers T,, The Aspergillus pH-responsive transcription factor PacC regulates virulence. , Molecular Microbiology, 55, (4), 2005, p1072 - 1084
URL
Schrettl M,Bignell E,Kragl C,Joechl C,Rogers T,Arst HN Jr,Haynes K,Haas H,, Siderophore biosynthesis but not reductive iron assimilation is essential for Aspergillus fumigatus virulence, Journal of Experimental Medicine, 200, (9), 2004, p1213 - 1219
URL
More Publications and Other Research Outputs >>>
 

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Last Updated:17-SEP-2014