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Professor Thomas Richard Frazer Rogers

Fellow Emeritus (Clinical Microbiology)
      
Profile Photo

Professor Thomas Richard Frazer Rogers

Fellow Emeritus (Clinical Microbiology)

 


My main research interest is in invasive fungal infections, including molecular diagnostics, pathogenesis, host-pathogen interactions, and antifungal therapies. Also, research into nosocomial infections including Clostridium difficile colitis. Other current research includes study of Escherichia coli bacteraemia focusing on pathogenic mechanisms, epidemiology and antibiotic resistance.
  Antibiotics   Bacteriology and bacterial pathogenesis   Fungal Diseases   Infectious Diseases/Agents   Mycology and fungal pathogenesis   Tuberculosis
Project Title
 Evaluation of next generation sequencing to investigate the epidemiology of Clostridium difficile infection
From
September 2014
To
August 2017
Summary
A prospective study of C difficile infection in hospitalised patients using next generation sequencing as a tool to provide high level discrimination between strains. An additional theme will be investigation of the intestinal microbiota in selected patients with C difficile infection
Funding Agency
Health Research Board
Programme
Research Training Fellowship scheme
Project Type
Translational research
Person Months
36
Project Title
 Development of novel management strategies for invasive aspergillosis "MANASP"
From
2006
To
2010
Summary
Development of novel molecular diagnostics for invasive aspergillosis. Study of DNA release from Aspergillus fumigatus during in vitro growth and correlation with dynamics of DNA release during experimental infections in vivo. Study of Aspergillus fumigatus-human dendritic cells interaction ex vivo. Study of A fumigatus-human monocytes interaction ex vivo. Investigation of immunologically important Aspergillus antigens produced in human serum during invasive aspergillosis
Funding Agency
European Union
Programme
Framework 6
Project Type
STREP
Person Months
42

Details Date From Date To
President of the Healthcare Infection Society 2010 2014
President Irish Fungal Society 2011 2015
Talento AF, Fitzgerald M, Redington B, O'Sullivan N, Fenelon N, Rogers TR, Prevention of healthcare-associated invasive aspergillosis during hospital construction/renovation works, Journal of Hospital Infection, 101, (1), 2019, Notes: [pii: S0195-6701(19)30001-5. doi: 10.1016/j.jhin.2018.12.020. [Epub ahead of print]], Journal Article, PUBLISHED
Talento AF, Fitzgerald M, Redington B, O'Sullivan N, Fenelon N, Rogers TR, Prevention of healthcare-associated invasive aspergillosis during hospital construction/renovation works, Journal of Hospital Infection, 101, (1), 2019, Notes: [pii: S0195-6701(19)30001-5. doi: 10.1016/j.jhin.2018.12.020. [Epub ahead of print]], Journal Article, PUBLISHED
Talento AF, Fitzgerald M, Redington B, O'Sullivan N, Fenelon N, Rogers TR, Prevention of healthcare-associated invasive aspergillosis during hospital construction/renovation works, Journal of Hospital Infection, 101, (1), 2019, Notes: [pii: S0195-6701(19)30001-5. doi: 10.1016/j.jhin.2018.12.020. [Epub ahead of print]], Journal Article, PUBLISHED
Talento AF, Fitzgerald M, Redington B, O'Sullivan N, Fenelon N, Rogers TR, Prevention of healthcare-associated invasive aspergillosis during hospital construction/renovation works, Journal of Hospital Infection, 101, (1), 2019, Notes: [pii: S0195-6701(19)30001-5. doi: 10.1016/j.jhin.2018.12.020. [Epub ahead of print] PMID: 30629998], Journal Article, PUBLISHED
Roycroft E, O'Toole RF, Fitzgibbon MM, Montgomery L, O'Meara M, Downes P, Jackson S, O'Donnell J, Laurenson IF, McLaughlin AM, Keane J, Rogers TR, Molecular epidemiology of multi and extensively drug-resistant Mycobacterium tuberculosis in Ireland, 2001-2004, Journal of Infection, 76, (1), 2018, p55 - 67, Notes: [ PMID: 29031637], Journal Article, PUBLISHED  DOI
Talento AF, Dunne K, Murphy N, O'Connell B, Chan G, Joyce EA, Hagen F, Meis JF, Fahy R, Bacon L, Vandenberge E, Rogers TR, Post-influenzal triazole-resistant aspergillosis following allogeneic stem cell transplantation., Mycoses, 2018, Journal Article, PUBLISHED
Dunne PJ, Maher CO, Freeley M, Dunne K, Petrasca A, Orikiiriza J, Dunne MR, Reidy D, O'Dea S, Loy A, Woo J, Long A, Rogers TR, Mulcahy F, Doherty DG, CD3" Expression Defines Functionally Distinct Subsets of V"1 T Cells in Patients With Human Immunodeficiency Virus Infection., Frontiers in Immunology, 2018, Journal Article, PUBLISHED  TARA - Full Text
Guinea J, Verweij PE, Meletiadis J, Mouton JW, Barchiesi F, Arendrup MC, How to: EUCAST recommendations on the screening procedure E.Def 10.1 for the detection of azole resistance in Aspergillus fumigatus isolates using four-well azole-containing agar plates., Clinical Microbiology and Infection, (9), 2018, Notes: [PMID: 30268672 DOI: 10.1016/j.cmi.2018.09.008 pii: S1198-743X(18)30630-X. [Epub ahead of print]], Journal Article, PUBLISHED
Lynch M, Walsh TA, Marszalowska I, Webb AE, MacAogain M, Rogers TR, Windle H, Kelleher D, O'Connell MJ, Loscher CE., Surface layer proteins from virulent Clostridium difficile ribotypes exhibit signatures of positive selection with consequences for innate immune response., BMC Evolutionary Biology, 17, (1), 2017, p90 - 90, Notes: [doi: 10.1186/s12862-017-0937-8. PMID:28335725 ], Journal Article, PUBLISHED  URL
Lynch M, Walsh TA, Marszalowska I, Webb AE, Mac Aogáin M, Rogers TR, Windle H, Kelleher D, O'Connell MJ, Loscher CE, Erratum to: Surface layer proteins from virulent Clostridium difficile ribotypes exhibit signatures of positive selection with consequences for innate immune response., BMC Evolutionary Biology, 17, (1), 2017, p135-, Notes: [DOI: 10.1186/s12862-017-0990-3 PMID:28606132 PMCID:PMC5469175], Journal Article, PUBLISHED  URL
  

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Infections in immunocompromised hosts. Invasive fungal infections. Antifungal therapy. Host pathogen interactions. Escherichia coli bloodstream infection. Antibiotic resistance. Nosocomial infections. Epidemiology of tuberculosis. Diagnostic tests for tuberculosis.