| Project title |
TILDA - The Irish Longitudinal Study on Ageing |
| Summary |
TILDA is a longitudinal community based study which is cross-institutional. Trinity College will be the host institution. All participants (minimum 10,000) will be 55 years and over and will have detailed social, economic and health assessments at Wave 1 and, 5 & 10 years later, Waves 2 and 3. Participants will be drawn randomly from across southern Ireland and, in addition to survey and physical examination, will have blood tests for routine analysis and genetic analysis - all of which will be anonymised according to standard criteria set out by the Medical Research Council. Family Practitioners will be informed of abnormal results from routine examinations and blood samples. TILDA will mirror the methodology of the US Health and Retirement survey and the English Longitudinal Study on Ageing.
Lead PI:
Rose Anne Kenny, Professor of Clinical Gerontology.
PIs:
Charles Normand, Edward Kennedy Chair in Health Policy & Management
Virpi Timonen, Director of Social Policy & Ageing Research Programme.
Brendan Whelan, Professor of Statistics & Survey Design
Hannah McGee, Professor of Psychology, Royal College of Surgeons in Ireland.
Ivan Perry, Professor of Epidemiology, University College Cork
Research Team:
Dr. Hilary Cronin, Clinical Research Fellow
Dr. Amilcar Moreira, Social Scientist Research Fellow
Dr. Yumiko Kamiya, Social Scientist Research Fellow
Claire O'Regan, Clinical Research Nurse |
| Funding Agency |
Dept of Health & Children (€12million) Irish Life (€4million) and Atlantic Philanthropies (€800K) |
| Programme |
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| Type of Project |
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| Date from |
01/09/2006 |
| Date to |
30/08/2016 |
| Person Months |
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| Project title |
Neurocardiovascular influences on cognitive functioning: basic and clinical mechanisms |
| Summary |
This is a longitudinal study of older persons over 70 years who have mild cognitive impairment. All participants will have non-invasive heart, blood pressure, neurological examinations, MRI head scans, EEG testing and tests of cognitive and mental function. Clinical assessments will take place at St. James's Hospital and in the person's home with the exception of the MRI scans and EEG tests which will take place in the existing facilities at the Trinity College Institute of Neuroscience (TCIN). We plan to study 400 participants over a 5 year period. The objectives are to track the incidence of dementia and cardiovascular and neurological variables which predict conversion to dementia during long term follow up. The study is approved by the St. James's Hospital Ethics Committee & TCIN/Psychology Ethics Committee. In parallel, we will be studying animal (rat) responses to cardiovascular and heart rate challenges to further inform factors which might predict conversion from mild cognitive impairment (i.e. age related memory problems to dementia).
Lead PI: Professor Rose Anne Kenny, Professor of Clinical Gerontology
PIs: Professor Brian Lawlor, Conolly Norman Professor of Old Age Psychiatry
Professor Michael Rowan, Lecturer in Pharmacology.
Research Team: Dr. Orla Collins, Research Fellow
Dr. Gemma Irvine, Research Fellow
Dr. Christian Kerskens, Research Fellow
Sheila Dillon, Clinical Research Nurse |
| Funding Agency |
Health Research Board (€1.5 million) |
| Programme |
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| Type of Project |
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| Date from |
01/10/06 |
| Date to |
30/09/2011 |
| Person Months |
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| Project title |
Nilvadipine (Roskamp) Study - An open label evaluation of the safety and efficacy of Nilvadipine in mild to moderate Alzheimer's disease. |
| Summary |
The Nilvadipine (Roskamp) study is a 2 year grant to investigate the role of blood pressure and heart rate abnormalities in Alzhiemer's disease and the benefit of blood pressure treatment in Alzheimer's disease. During the course of the study we will investigate 150 patients with Alzhiemer's disease. These will be recruited through the existing structures within St. James's Hospital and our extended care unit and through the Mercer's Institute for Research on Ageing Memory Clinic. The study is sponsored by a not-for-profit neurosciences institute in America - the Roskamp Institute. www.rfdn.org
Lead PI: Professor Brian Lawlor, Conolly Norman Professor of Old Age Psychiatry
PI: Professor Rose Anne Kenny, Professor of Clinical Gerontology
Research Team:
Dr. Sean Kennelly, Clinical Research Fellow
Lisa Crosby, Clinical Research Nurse
Claire Mooney, Clinical Research Nurse
Linda Warren, Administrator |
| Funding Agency |
The Roskamp Institute, Florida (€850K) |
| Programme |
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| Type of Project |
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| Date from |
08/09/06 |
| Date to |
07/09/08 |
| Person Months |
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| Project title |
TRIL - Technology Research for Independent Living |
| Summary |
TRIL is a virtual centre of expertise and research into improving the health and happiness of older people. TRIL is a collaborative effort combining Intel personnel and researchers from Irish universities and hospitals in multi-disciplinary teams. TRIL focuses on understanding and delivering on the support needs and preferences of older people at home and in care environments. TRIL's mission is to discover and delivery technology solutions which support independent ageing, ideally in a home environment. This will improve the quality of life of older citizens while reducing the burden on carers and on the healthcare system.
FALLS STRAND: The fall strand addresses a common source of injury and even death to older persons. It aims to leverage ehtnographic research to characterise proneness to falling in terms of behavioural markers such as cardiovascular variables, visual and vestibular measures, cognitive measures, gait instability and loss of balance, to monitor these markers in real time and to provide feedback to the older person before a fall occurs. The engineering aspects of the falls strand are supported by the Research Commons Platform. |
| Funding Agency |
Intel / IDA (€2.8million) |
| Programme |
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| Type of Project |
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| Date from |
01/01/2007 |
| Date to |
01/01/2010 |
| Person Months |
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| Project title |
Vascular factors in late dementia |
| Summary |
Longitudinal neuropathological series of stroke cohort.
Lead PI: Prof R Kalaria
PI: Prof RA Kenny.
Vascular factors are increasingly important as risk f actors for cognitive impairment and dementia. We are studying the mechanisms underpinning vascular risk, in particular microvascular disease, in neurodegenerative dementias, in an ongoing clinical pathological longitudinal stud of well-characterised vascular risk cohorts (post-stroke) |
| Funding Agency |
NIH Grant (£300K) |
| Programme |
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| Type of Project |
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| Date from |
2006 |
| Date to |
2008 |
| Person Months |
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| More Research Projects>>> |
Parry SW, Nath S, Bourke JP, Bexton RS, Kenny RA, Adenosine test in the diagnosis of unexplained syncope: marker of conducting tissue disease or neurally mediated syncope?, EUROPEAN HEART JOURNAL, 27, (12), 2006, p1396 - 1400
Notes: [PMID: 16574690]
Url |
Parry SW, Steen N, Baptist M, Fiaschi KA, Parry O, Kenny RA, Cerebral autoregulation is impaired in cardioinhibitory carotid sinus syndrome, HEART, 92, (6), 2006, p792 - 797
Notes: [PMID: 16449521]
Url |
Kerr SRJ, Pearce MS, Brayne C, Davis RJ, Kenny RA, Carotid sinus hypersensitivity in asymptomatic older persons - Implications for diagnosis of syncope and falls, ARCHIVES OF INTERNAL MEDICINE, 166, (5), 2006, p515 - 520
Notes: [PMID: 16534037]
Url |
Lewis H, Beher D, Cookson N, Oakley A, Piggott M, Morris CM, Jaros E, Perry R, Ince P, Kenny RA, Ballard CG, Shearman MS, Kalaria RN, Quantification of Alzheimer pathology in ageing and dementia: age-related accumulation of amyloid-beta(42) peptide in vascular dementia, NEUROPATHOLOGY AND APPLIED NEUROBIOLOGY, 32, (2), 2006, p103 - 118
Notes: [PMID: 16599940] |
McKeith IG, Dickson DW, Lowe J, Emre M, O'Brien JT, Feldman H, Cummings J, Duda JE, Lippa C, Perry EK, Aarsland D, Arai H, Ballard CG, Boeve B, Burn DJ, Costa D, Del Ser T, Dubois B, Galasko D, Gauthier S, Goetz CG, Gomez-Tortosa E, Halliday G, Hansen LA, Hardy J, Iwatsubo T, Kalaria RN, Kaufer D, Kenny RA, Korczyn A, Kosaka K, Lee VMY, Lees A, Litvan I, Londos E, Lopez OL, Minoshima S, Mizuno Y, Molina JA, Mukaetova-Ladinska EB, Pasquier F, Perry RH, Schulz JB, Trojanowski JQ, Yamada M, Diagnosis and management of dementia with Lewy bodies - Third report of the DLB consortium, NEUROLOGY, 65, (12), 2005, p1863-1872
Notes: [PMID: 16237129] |
| More Publications>>> |
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Last Updated:12-FEB-2012 |