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Personal Information
College Photo Name Ramaswami, Mani
Main Department Genetics
College Title Professor of Neurogenetics
E-mail mani.ramaswami@tcd.ie
College Tel +353 1 896 8400
Web http://people.tcd.ie/ramaswam
Notes Professor (Adjunct), Department of Molecular and Cellular Biology and Division of Neurobiology, University of Arizona, Tucson, AZ 85721, U.S.A.
Professor (Adjunct), Tata Institute of Fundamental Research, Department of Biological Sciences, Mumbai, India 400005
 
Awards and Honours
Award Date
Professorial Fellowship, Trinity College Dublin. 2009
Galileo Circle Fellow, College of Science, University of Arizona. 2005
NIDA K (Career Development/ Research Leave) Award. (declined in 2008) 2004-2010
Cutting Edge Brain Research Award (CEBRA) from the NIDA. 2002
Early Tenure, University of Arizona 2000
More Awards and Honours>>>
 
Description of Research Interests
Research interests 
 My laboratory is interested in understanding molecular and circuit mechanisms of simple learned behaviors. We use the genetic model organism Drosophila melanogaster to study fundamental synaptic mechanisms as well as mechanisms of simple olfactory memory. An obvious extension of these studies to ask how these mechanisms are affected in disease and we currently study disease models for fragile-X mental retardation and spinocerebellar ataxia. Five post-doctoral researchers and three postgraduate students in my lab use many in vivo approaches including Drosophila genetics, two-photon microscopy based live-brain imaging, electrophysiology, and a range of cell biological, behavioral & molecular techniques. Several collaborations, particularly with top research groups in India and the US, expand our work into other fields such as natural products and peptide neurotoxins. Recent advances in the lab include the following. 1. Primarily in collaboration with Veronica Rodrigues’ group in the NCBS, Bangalore, we have discovered that gene expression- and synaptic growth dependent potentiation of GABAergic neurons drives specific forms of learned olfactory behavior. 2. In collaboration with Roy Parker at the University of Arizona, we have found that that proteins and mechanisms that control translation of mRNAs in yeast, also regulate the translation of mRNAs stored in synapses. Some of these regulatory mechanisms, required for proper neuronal homeostasis/plasticity are required for miRNA function and altered in human neurological disease.
 
Research Projects
Project title Science Foundation of Ireland Investigator
Summary
Funding Agency
Programme
Type of Project
Date from 2007
Date to 2011
Person Months


Project title Wellcome Trust Cellular and genetic analysis of synapse assembly and function (Project Grant)
Summary Role PI
Funding Agency Wellcome Trust
Programme
Type of Project
Date from 2006
Date to 2008
Person Months


Project title Dept of Biotechnology, Govt of India. Circuit mechanisms of long-term habituation
Summary Role: Collaborator (PI: Veronica Rodrigues)
Funding Agency
Programme
Type of Project
Date from
Date to
Person Months


Project title Deep sequencing of venom duct cDNAs from Indian cone snails
Summary Dept of Biotechnology, Govt of India. Role: Collaborator (PI: K.S. Krishnan)
Funding Agency
Programme
Type of Project
Date from
Date to
Person Months


Project title Science Foundation of Ireland Research Professor.
Summary
Funding Agency
Programme
Type of Project
Date from 2005
Date to 2007
Person Months


More Research Projects>>>
 
Publications and Other Research Outputs
Peer Reviewed
Sanyal S, Jennings T, Dowse H, Ramaswami M, Conditional mutations in SERCA, the sarco-endoplasmic reticulum Ca2+-ATPase, alter heart rate and rhythmicity in Drosophila, Journal of Comparative Physiology B: Biochemical, Systemic, and Environmental Physiology , 176, (3), 2006, p253 - 263
Notes: [PubMed ID: 16320060]
DOI
Sanyal S, Consoulas C, Kuromi H, Basole A, Mukai L, Kidokoro Y, Krishnan KS, Ramaswami M, Analysis of conditional paralytic mutants in Drosophila sarco-endoplasmic reticulum calcium ATPase reveals novel mechanisms for regulating membrane excitability, Genetics, 169, (2), 2005, p737 - 750
DOI
Menon KP, Sanyal S, Habara Y, Sanchez R, Wharton RP, Ramaswami M, Zinn K, The translational repressor Pumilio regulates presynaptic morphology and controls postsynaptic accumulation of translation factor elF-4E, Neuron, 44, (4), 2004, p663 - 676
Notes: [PubMed ID: 15541314]
DOI
Sanyal S, Kim SM, Ramaswami M, Retrograde regulation in the CNS: Neuron-specific interpretations of TGF-beta signaling, Neuron, 41, (6), 2004, p845 - 848
Notes: [PubMed ID: 15046717]
DOI
Rikhy R, Ramaswami M, Krishnan KS, A temperature-sensitive allele of Drosophila sesB reveals acute functions for the mitochondrial adenine nucleotide translocase in synaptic transmission and dynamin regulation, Genetics, 165, (3), 2003, p1243 - 1253
Notes: [PubMed ID: 14668379]
URL
More Publications and Other Research Outputs >>>
 

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Last Updated:25-APR-2014