| Staff Details | ||||
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| Personal Information | ||
| Name | Lynch, Marina Annetta | |
| Main Department | Physiology | |
| College Title | Professor | |
| marina.lynch@tcd.ie | ||
| College Tel | +353 1 896 8531 | |
| Web | http://people.tcd.ie/lynchma | |
| Notes | Current Address: Trinity College Institute of Neuroscience Lloyd Building, Trinity College, Dublin 2 | |
| Biography | |
| Qualifications: BSc (NUI), PhD (TCD) 1981-1983 Pharmacology Department, King's College, London. 1983-1992 National Institute for Medical Research, Mill Hill, London 1990-1992 Pharmacology Department, RFH School of Medicine, London (Honorary Lecturer) 1992-now Department of Physiology, Trinity College, Dublin 2. (Lecturer) 1999 Associate Professor 2006 Director, Trinity College Institute of Neuroscience 2006 Personal Chair in Cellular Neuroscience | |
| Awards and Honours | |
| Award | Date |
| 2006: Royal Academy of Medicine in Ireland Conway Review Lecturer and Silver medal recipient | |
| Elected to membership of the Royal Irish Academy | May 2009 |
| Description of Research Interests |
| RESEARCH INTERESTS 1. Analysis of the underlying cause(s) and consequences of age-related neuroinflammation in the brain, with a specific emphasis on assessing changes in microglial activation and the consequent inflammatory changes. 2. Assessment of the effect of neuroinflammation on synaptic function and modulation by anti-inflammatory strategies including neuroimmuneregulatory proteins, particularly CD200 ligand-receptor interaction. 3. Investigation of the different activation states of microglia in neuroinflammatory conditions including in the aged brain and in models of Alzheimer's disease. Assessment of the mechanisms by which activation states can be modulated. 4. Examination of the importance of polyunsaturated fatty acids in synaptic function, particularly in the aged brain. 5. Assessment of peripheral inflammatory changes as a means of identifying a biomarker which correlates with compromised cognitive function in prodromal Alzheimer's disease. |
| Research Interests | |||
| Age related diseases | Aging/Gerontology | Antiinflammatory Cytokines | Brain |
| HIPPOCAMPUS | Inflammation | POLYUNSATURATED FATTY ACIDS | PROINFLAMMATORY CYTOKINES |
| SYNAPTIC PLASTICITY |
| Publications |
| Peer Reviewed |
| Rebola N, Simőes AP, Canas PM, Tomé AR, Andrade GM, Barry CE, Agostinho PM, Lynch MA, Cunha RA, Adenosine A(2A) receptors control neuroinflammation and consequent hippocampal neuronal dysfunction., Journal of Neurochemistry, 117, (1), 2011, p100–111 Url TARA - Full Text DOI |
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| Derek A. Costello, Melanie B. Watson, Thelma R. Cowley, Niamh Murphy, Ciarán Murphy Royal, Cecilia Garlanda & Marina A. Lynch, IL-1alpha and HMGB1 mediate hippocampal dysfunction in SIGIRR-deficient mice , Journal of Neuroscience, 31, (10), 2011, p3871-3879 Notes: [PubMed ID: 21389242] Url TARA - Full Text DOI |
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| Kelly, L. , Grehan, B. , Chiesa, A.D. , O'Mara, S.M. , Downer, E. , Sahyoun, G. , Massey, K.A. , Nicolaou, A. , Lynch, M.A, The polyunsaturated fatty acids, EPA and DPA exert a protective effect in the hippocampus of the aged rat, Neurobiology of Aging, 2010 DOI |
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| Watson, M.B., Costello, D.A., Carney, D.G., McQuillan, K., Lynch, M.A., SIGIRR modulates the inflammatory response in the brain , Brain, Behavior, and Immunity, 24, (6), 2010, p985-995 Url TARA - Full Text DOI |
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| More Publications>>> | |
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