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Professor Marina Annetta Lynch

Fellow Emeritus (Physiology)

 Marina.Lynch@tcd.ie

 


Biography

Qualifications: BSc (NUI), PhD (TCD) 1981-1983 Pharmacology Department, King's College, London. 1983-1992 National Institute for Medical Research, Mill Hill, London 1990-1992 Pharmacology Department, RFH School of Medicine, London (Honorary Lecturer) 1992-now Department of Physiology, Trinity College, Dublin 2. (Lecturer) 1999 Associate Professor 2006 Director, Trinity College Institute of Neuroscience 2006 Personal Chair in Cellular Neuroscience

Research Tags

  Age related diseases   Aging/Gerontology   Antiinflammatory Cytokines   Brain   HIPPOCAMPUS   Inflammation   POLYUNSATURATED FATTY ACIDS   PROINFLAMMATORY CYTOKINES   SYNAPTIC PLASTICITY

Research Projects

 

Representations

Details Date
2001-2005: Member of Irish government-appointed Commission on Assisted Human Reproduction; Workgroup Chair & member of drafting group for the final report. 2001-2009: Member of Board of Trinity College Institute of Neuroscience 2005-2008: Member of Board of Trinity College Dublin 2006-2009: Director, Trinity College Institute of Neuroscience

Memberships

Membership of Professional Institutions, Associations, Societies

Details Date From Date To
British Neuroscience Association 1995 2017
Lynch, M.A., A case for seeking sex-specific treatments in Alzheimer†s disease, Frontiers in Aging Neuroscience, 16, (1346621), 2024, Notes: [cited By 0], Journal Article, PUBLISHED  DOI
Mela, V. and Gaban, A.S. and Shatz, P.M. and Guillot-Sestier, M.-V. and Lynch, M.A., Acute Stress, Induced by IFNγ + Aβ, and Chronic Stress, Induced by Age, Affect Microglia in a Sex-Specific Manner, Molecular Neurobiology, 60, (6), 2023, p3044-3053 , Notes: [cited By 0], Journal Article, PUBLISHED  DOI
Lynch, M.A., Exploring Sex-Related Differences in Microglia May Be a Game-Changer in Precision Medicine, Frontiers in Aging Neuroscience, 14, (868448), 2022, Notes: [cited By 0], Journal Article, PUBLISHED  TARA - Full Text  DOI
Mela, V. and Gaban, A.S. and O†neill, E. and Bechet, S. and Walsh, A. and Lynch, M.A., The Modulatory Effects of DMF on Microglia in Aged Mice Are Sex-Specific, Cells, 11, (4), 2022, Notes: [cited By 0], Journal Article, PUBLISHED  DOI
Paolicelli, R.C. and Sierra, A. and Stevens, B. and Tremblay, M.-E. and Aguzzi, A. and Ajami, B. and Amit, I. and Audinat, E. and Bechmann, I. and Bennett, M. and Bennett, F. and Bessis, A. and Biber, K. and Bilbo, S. and Blurton-Jones, M. and Boddeke, E. and Brites, D. and BrÃŽne, B. and Brown, G.C. and Butovsky, O. and Carson, M.J. and Castellano, B. and Colonna, M. and Cowley, S.A. and Cunningham, C. and Davalos, D. and De Jager, P.L. and de Strooper, B. and Denes, A. and Eggen, B.J.L. and Eyo, U. and Galea, E. and Garel, S. and Ginhoux, F. and Glass, C.K. and Gokce, O. and Gomez-Nicola, D. and González, B. and Gordon, S. and Graeber, M.B. and Greenhalgh, A.D. and Gressens, P. and Greter, M. and Gutmann, D.H. and Haass, C. and Heneka, M.T. and Heppner, F.L. and Hong, S. and Hume, D.A. and Jung, S. and Kettenmann, H. and Kipnis, J. and Koyama, R. and Lemke, G. and Lynch, M. and Majewska, A. and Malcangio, M. and Malm, T. and Mancuso, R. and Masuda, T. and Matteoli, M. and McColl, B.W. and Miron, V.E. and Molofsky, A.V. and Monje, M. and Mracsko, E. and Nadjar, A. and Neher, J.J. and Neniskyte, U. and Neumann, H. and Noda, M. and Peng, B. and Peri, F. and Perry, V.H. and Popovich, P.G. and Pridans, C. and Priller, J. and Prinz, M. and Ragozzino, D. and Ransohoff, R.M. and Salter, M.W. and Schaefer, A. and Schafer, D.P. and Schwartz, M. and Simons, M. and Smith, C.J. and Streit, W.J. and Tay, T.L. and Tsai, L.-H. and Verkhratsky, A. and von Bernhardi, R. and Wake, H. and Wittamer, V. and Wolf, S.A. and Wu, L.-J. and Wyss-Coray, T., Microglia states and nomenclature: A field at its crossroads, Neuron, 110, (21), 2022, p3458-3483 , Notes: [cited By 25], Journal Article, PUBLISHED  DOI
Guillot-Sestier MV, Araiz AR, Mela V, Gaban AS, O'Neill E, Joshi L, Chouchani ET, Mills EL, Lynch MA., Microglial metabolism is a pivotal factor in sexual dimorphism in Alzheimer's disease., Commun Biol, 4, (1), 2021, p711 , Journal Article, PUBLISHED  DOI
Mela, V. and Mota, B.C. and Milner, M. and McGinley, A. and Mills, K.H.G. and Kelly, Ã .M. and Lynch, M.A., Exercise-induced re-programming of age-related metabolic changes in microglia is accompanied by a reduction in senescent cells, Brain, Behavior, and Immunity, 87, 2020, p413-428 , Notes: [cited By 1], Journal Article, PUBLISHED  DOI
Lynch, M.A., Can the emerging field of immunometabolism provide insights into neuroinflammation?, Progress in Neurobiology, 184, (101719), 2020, Notes: [cited By 13], Journal Article, PUBLISHED  DOI
Finucane O.M, Sugrue J, Rubio-Araiz A, Guillot-Sestier M.-V, Lynch M.A, The NLRP3 inflammasome modulates glycolysis by increasing PFKFB3 in an IL-1β-dependent manner in macrophages, Scientific Reports, 9, (1), 2019, Journal Article, PUBLISHED  TARA - Full Text  DOI  URL
McIntosh A, Mela V, Harty C, Minogue AM, Costello DA, Kerskens C, Lynch MA., Iron accumulation in microglia triggers a cascade of events that leads to altered metabolism and compromised function in APP/PS1 mice., Brain Pathology, 2019, p10.1111/bpa.12704. , Journal Article, PUBLISHED  TARA - Full Text  DOI
  

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Awards and Honours

Award Date
Royal Academy of Medicine in Ireland Conway Review Lecturer and Silver medal recipient 2006
Elected to membership of the Royal Irish Academy May 2009
Recipient of Tom Connor Distinguished Researcher Award In Neuroscience 2013
Recipient of the Irish Area Section of the Biochemical Society Silver Medal 2013
Elected Fellow of Trinity College, Dublin 1997

Research Interests

Description Of Research Interests

RESEARCH INTERESTS 1. Analysis of the underlying cause(s) and consequences of age-related neuroinflammation in the brain, with a specific emphasis on assessing changes in microglial activation and the consequent inflammatory changes. 2. Assessment of the effect of neuroinflammation on synaptic function and modulation by anti-inflammatory strategies including neuroimmuneregulatory proteins, particularly CD200 ligand-receptor interaction. 3. Investigation of the different activation states of microglia in neuroinflammatory conditions including in the aged brain and in models of Alzheimer's disease. Assessment of the mechanisms by which activation states can be modulated. 4. Examination of the importance of polyunsaturated fatty acids in synaptic function, particularly in the aged brain. 5. Assessment of peripheral inflammatory changes as a means of identifying a biomarker which correlates with compromised cognitive function in prodromal Alzheimer's disease.