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Professor Lidia Tajber

Professor (Pharmacy)
25/6/7 WESTLAND ROW
      
Profile Photo

Professor Lidia Tajber

Professor (Pharmacy)
25/6/7 WESTLAND ROW

 Lidia.Tajber@tcd.ie

 3531896 2787


Lidia is currently employed as an Associate Professor in Pharmaceutics and Pharmaceutical Technology in the School of Pharmacy and Pharmaceutical Sciences. She first gained M. Pharm. degree from Medical University of Silesia, Katowice, Poland (with first class honours, best in class) and then pursued her Ph.D. degree in the School of Pharmacy, Trinity College Dublin (completed in 2005). She holds a postgraduate diploma in quality improvement and completed "Research leaders" training. Lidia has published 76 high quality peer-review papers and contributed to numerous international conference presentations. Her current h-index is 25. She is also a co-inventor on a number of patent applications including "A method of producing porous microparticles" and "A polymeric nanoparticle". In addition to being an active researcher, she contributes to undergraduate (Pharmaceutics and Pharmaceutical Technology module) and postgraduate (Preformulation, Formulation and Advanced Drug Delivery modules) teaching. She is part of the coordinating team for the MSc in Pharmaceutical Sciences course. Lidia's research activities fit with national policy objectives supporting the development and production of a highly educated and relevant workforce in demand by the pharmaceutical industry. She and her team have successfully participated in collaborative, multidisciplinary and industry-led research consortia (IDDN, SSPC, H2020 RISE) leading to high impact research, leveraging international funding and attracting talented people to Ireland. The ultimate objective of her work is to advance the pharmaceutical product design and manufacture to benefit the general public and enhance the quality of health.
  Amorphous Materials   Computer modelling of pharmaceutical systems   Crystal engineering   DENDRIMERS   Drug Delivery Systems   Hydrogen bonding   LIQUID CRYSTALS   Nanotechnology   Pharmaceutical co-crystals   Pharmaceutical salts   Physical Chemistry   POLYMER   Polymers   POLYMORPHISM   Porous particles   Respiratory System   Spectroscopy   SPRAY DRYING   Thermal Analysis
Project Title
 Synthesis and Solid State Pharmaceutical Centre
From
2013
To
2019
Summary
Funding Agency
SFI
Programme
Reseach Centre
Project Title
 TRANS-INT
From
2012
To
Summary
Funding Agency
EU
Programme
7th European Framework Programme for Research and Technological Development
Project Title
 Solid State Pharmaceutical Cluster
From
2007
To
2013
Summary
Funding Agency
SFI
Programme
Strategic Research Cluster Programme
Project Title
 Active pharmaceutical ingredients as ionic liquids: significance of protonics and functional profiling for the design of effective medicines
From
2017
To
2021
Summary
A large proportion of pharmaceutical molecules exhibit low aqueous solubility and/or poor membrane transport properties resulting in low oral bioavailability and delivery problems. Thus, many compounds with high pharmacological activity are being dropped from development pipelines. To address the issue of poor solubility and/or permeability of active pharmaceutical ingredients, a new tactic is proposed whereby the active molecule is converted into an ionic liquid (IL), a functional material with superior physicochemical properties to the "parent" molecule. ILs comprise anions and cations and possess low lattice energy and low melting points, often well below 100 °C. Through the systematic investigations of structural properties of ILs, their methods of synthesis, the degree of ionisation and type of proton transport within the ILs as well as extensive pharmaceutical profiling including stability, solubility, permeability and in vitro toxicity, a new generation of ILs with tunable pharmaceutical properties (PILs) will be established. To demonstrate the pharmaceutical developability of PILs and their potential as a platform technology, prototype tablet formulations will be manufactured and tested using novel, bio-relevant dissolution stress test devices. A range of anti-inflammatory and anti-infective molecules will be examined due to their efficacy limitations that are often caused by low solubility and permeability.
Funding Agency
SFI
Programme
Career Development Award
Project Title
 Irish Drug Delivery Network
From
2007
To
2013
Summary
Funding Agency
SFI
Programme
Strategic Research Cluster Programme

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Language Skill Reading Skill Writing Skill Speaking
English Fluent Fluent Fluent
Polish Fluent Fluent Fluent
Russian Basic Basic Medium
Details Date From Date To
International Association for Pharmaceutical Technology (APV) 2017 present
American Chemical Society 2013 present
Controlled Release Society 2008 present
American Association of Pharmaceutical Scientists 2007 present
Wdowiak K., Tajber L., Miklaszewski A., Cielecka-Piontek J., Application of the Box"Behnken Design in the Development of Amorphous PVP K30"Phosphatidylcholine Dispersions for the Co-Delivery of Curcumin and Hesperetin Prepared by Hot-Melt Extrusion, Pharmaceutics, 17, (1), 2025, Journal Article, PUBLISHED  DOI
Dudek M.K., Trzeciak K., Tajber L., Zajac J., Kazmierski S., Pindelska E., Makowski T., Svyntkivska M., Potrzebowski M.J., A New Look at the Mechanism of Cocrystal Formation and Coformers Exchange in Processes Forced by Mechanical and/or Thermal Stimuli " ex situ and in situ Studies of Low-Melting Eutectic Mixtures, Chemistry - A European Journal, 30, (11), 2024, pe202302138-, Journal Article, PUBLISHED  DOI
Kadri L, Carta M, Lampronti G, Delogu F, Tajber L., Mechanochemically Induced Solid-State Transformations of Levofloxacin., Molecular pharmaceutics, 21, (6), 2024, p2838-2853 , Journal Article, PUBLISHED  DOI
Kadri L, Casali L, Emmerling F, Tajber L., Mechanochemical comparison of ball milling processes for levofloxacin amorphous polymeric systems., International journal of pharmaceutics, 665, 2024, p124652 , Journal Article, PUBLISHED  DOI
Wdowiak K., Tajber L., Miklaszewski A., Cielecka-Piontek J., Sweeteners Show a Plasticizing Effect on PVP K30"A Solution for the Hot-Melt Extrusion of Fixed-Dose Amorphous Curcumin-Hesperetin Solid Dispersions, Pharmaceutics, 16, (5), 2024, Journal Article, PUBLISHED  DOI
Nandi S., Verstrepen L., Hugo Silva M., Padrela L., Tajber L., Collas A., Continuous Microfluidic Antisolvent Crystallization as a Bottom-Up Solution for the Development of Long-Acting Injectable Formulations, Pharmaceutics, 16, (3), 2024, Journal Article, PUBLISHED  DOI
Nandi S., Collas A., Tajber L., Padrela L., Supercritical enhanced atomization induced particle entrapment for continuous production of injectable micro and nano-suspensions, Journal of CO2 Utilization, 81, 2024, Journal Article, PUBLISHED  DOI
Mendez Canellas F., Geertman R., Tajber L., Padrela L., Sorbitol-coated indomethacin and naproxen particles produced by supercritical CO2-assisted spray drying, Journal of Supercritical Fluids, 199, 2023, p105969-, Journal Article, PUBLISHED  DOI
Nandi S., Padrela L., Tajber L., Collas A., Development of long-acting injectable suspensions by continuous antisolvent crystallization: An integrated bottom-up process, International Journal of Pharmaceutics, 648, 2023, p123550-, Journal Article, PUBLISHED  DOI
Garbiec E., Rosiak N., Zalewski P., Tajber L., Cielecka-Piontek J., Genistein Co-Amorphous Systems with Amino Acids: An Investigation into Enhanced Solubility and Biological Activity, Pharmaceutics, 15, (12), 2023, p2653-, Journal Article, PUBLISHED  DOI
  

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Tajber L, The curious case of ciprofloxacin: how to deal with "difficult" drugs molecules to improve their biopharmaceutical properties, Farmak's School of young scientists "Science and modern pharmaceutical manufacturing", Kiyv, Ukraine, 21 November, 2019, 2019, Invited Talk, PRESENTED
Umerska A, Tajber L, Polyelectrolyte complexes as nanoparticulate drug delivery systems, European Pharmaceutical Review, 20, (3), 2015, p36-40 , Notes: [Invited review], Journal Article, PUBLISHED

  


Award Date
Elected Fellow of Trinity College Dublin 2020
Researcher Highlight in 2018/19 Trinity College Dublin Provost & President's Annual Review 2019
Trinity College Postgraduate Award 2001
Distinction for the Masters thesis in the Master's Degree Dissertations Competition for Faculties of Pharmacy organised by Polish Pharmaceutical Society and Medical Universities 2001
First prize for the Masters thesis in the Interdepartmental Master's Degree Dissertations Competition 2000
Prize from the Czestochowa branch of the Polish Pharmaceutical Chamber for the grades achieved in university degree 2000
M.A. (jure officii) 2015
My research programme concentrates on the fundamental understanding of molecular interactions governing the properties and performance of pharmaceutical substances (actives and additives) at molecular, supramolecular and formulation (drug product) levels. More specifically, the research topics pursued by my group are: . Advancement of the physicochemical and biopharmaceutical properties of active pharmaceutical ingredients (APIs) by conversion into ionic liquids (anti-crystal engineering); development of oral solid formulations containing ionic liquids . Synthesis, phase characterisation and behaviour in formulation of alternative forms of APIs such as salts, cocrystals, amorphous materials, polymorphs and liquid crystals; construction of multi-phase diagrams for stability . Rational preformulation studies leading to quality solid-state formulations . Nanocrystal and polymeric nanoparticle formulation and characterisation methods My research efforts have been supported by Science Foundation Ireland (SFI), Enterprise Ireland, Irish Research Council as well as the European Union. I am involved in the Synthesis and Solid State Pharmaceuticals Centre (https://www.sspc.ie/ ) as a funded investigator. I was awarded a prestigious SFI Career Development Award in 2017 on the development of pharmaceutical ionic liquid forms and also currently serve as Director of Steering Committee in a H2020 RISE network "ORBIS" (Open Research Biopharmaceutical Internships Support (http://orbisproject.eu/ , awarded in 2017). I currently supervise a group of 8 researchers and host visiting ORBIS secondees from the pharmaceutical industry.