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Trinity College Dublin

Personal Information
Name Kelly, Julie Anne
Main Department Biochemistry
College Title Senior Research Lecturer
E-mail kellyja@tcd.ie
College Tel +353 1 896 1604
Web http://people.tcd.ie/kellyja
 
Membership of Professional Institutions, Associations, Societies
Details Date From Date To
The Biochemical Society
American Chemical Society (ACS)
Royal Society of Chemistry (RCS)
International Society for Neurochemistry (ISN)
Sigma Xi
More Memberships>>>
 
Description of Research Interests
The main focus of Dr Kelly's research relates to understanding the functions of thyrotropin-releasing hormone (TRH) in the central nervous system (CNS) and to enhancing its central therapeutic actions. Based on its central actions, TRH has significant potential in treating a variety of CNS disorders with unmet clinical need, including CNS trauma, spinocerebellar degeneration, epilepsy and depression. Critically, however, the clinical use of TRH and investigation of its CNS functions are hindered due to its rapid degradation. Dr Kelly is currently investigating the properties of novel compounds that may provide a means to reduce TRH degradation and thus may facilitate investigation of TRH actions in an experimental setting and may have potential medical application.
 
Research Projects
Project title Preclinical Evaluation of a Novel Neurotherapeutic for ALS
Summary Principal Investigator
Funding Agency Fondation Thierry Latran
Programme
Type of Project Research Project
Date from 2011
Date to 2012
Person Months 12
Project title Determining beneficial effects of a new therapeutic compound, JAK4D, in the SOD1 mouse model of Amyotrophic Lateral Sclerosis (ALS)
Summary €128,500 Principal Investigator
Funding Agency Irish Motor Neurone Disease Research Foundation
Programme
Type of Project Research Project
Date from 2009
Date to 2011
Person Months 24
Project title Development of a Novel Compound for treating Neurological Disorders.
Summary €392,415 Principal Investigator (PI)
Funding Agency Enterprise Ireland CFTD/2006/122
Programme
Type of Project
Date from 2007
Date to 2009
Person Months
Project title Parenteral delivery system for first in class compound with potential therapeutic application in CNS disorders.
Summary €85,025 (2006-2007) Principal Investigator (PI)
Funding Agency Enterprise Ireland
Programme Enterprise Ireland PC/2005/201
Type of Project
Date from 2006
Date to 2007
Person Months
Project title Furthering the development of potent thyrotropin-releasing hormone-degrading ectoenzyme (TRH-DE inhibitors – toward a novel therapeutic strategy for CNS disorders.
Summary €238,703 (2005-2008) [Principal Investigator (PI)]
Funding Agency HRB Project Grant RP/2005/152
Programme
Type of Project
Date from 2005
Date to 2008
Person Months
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Publications
Peer Reviewed
Campbell M, Kiang AS, Kenna PF, Kerskens C, Blau C, O'Dwyer L, Tivnan A, Kelly JA, Brankin B, Farrar GJ, Humphries P. , RNAi-mediated reversible opening of the blood-brain barrier. , Journal of Gene Medicine, 10, (8), 2008, p930 - 947
Kelly JA, Scalabrino GA, Slator GR, Cullen AA, Gilmer JF, Lloyd DG, Bennett GW, Bauer K, Tipton KF, Williams CH., Structure-activity studies with high-affinity inhibitors of pyroglutamyl-peptidase II, Biochem J., 389, (Pt 2), 2005, p569 - 576
Notes: [PMID: 15799721]
Kelly JA, Slator GR, O’Boyle KM., Pharmacological distinct binding sites in rat brain for [3H]-thyrotropin-releasing hormone (TRH) and [3H][3-methyl-histidine2]TRH, Biochem. Pharmacol., 63, (12), 2002, p2197 - 2206
Notes: [PMID: 12110379]
Papadopoulos T, Kelly JA, Bauer K., Mutational analysis of the thyrotropin-releasing hormone-degrading ectoenzyme. Similarities and differences with other members of the M1 family of aminopeptidases and thermolysin, Biochemistry, 40, 2001, p9347 - 9355
Notes: [PMID: 11478903]
Kelly JA, Slator GR, Tipton KF, Williams CH, Bauer K., Kinetic investigation of the specificity of porcine brain thyrotropin-releasing hormone-degrading ectoenzyme for thyrotropin-releasing hormone-like peptides, J. Biol. Chem., 275, (22), 2000, p16746 - 16751
Notes: [PMID: 10748219]
More Publications>>>
 

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Last Updated:12-FEB-2012