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Professor Joseph Keane

Professor of Medicine 1955 (Clinical Medicine)
Professor of Medicine 1955 (School Office - Medicine)
      
Profile Photo

Professor Joseph Keane

Professor of Medicine 1955 (Clinical Medicine)

 josephmk@tcd.ie

 

Professor of Medicine 1955 (School Office - Medicine)


  Apoptosis   Host, Pathogen interactions   Infectious diseases   Innate immunology   Lung Cancer   Medicine   Respiratory System
Details Date
Director: TB Immunology Lab, School of Medicine
Director: Clinical TB services, St. James's Supraregional Centre
Program Chair: American Thoracic Society, MTPI Assembly 2012
Details Date From Date To
TBNET, STOP TB Partnership, International Union Against Tuberculosis and Lung Disease
Royal College of Physicians
American Thoracic Society
Irish Thoracic Society
Cilian Ó Maoldomhnaigh, Donal J Cox, Joseph Keane, Sharee A. Basdeo, P-450. Neonatal macrophages have an altered immunometabolic response to Mycobacterium tuberculosis which is modified by IFN-", IL-4 or lactate, 13, (Supplement_1), 2026, Conference Paper, PUBLISHED  DOI
Melva Tan, Zainab Albaggal, Ciara Anderson, Daragh McGee, Cian Carey, Aoife Hehir, Dominick Natin, Maria Lenehan, Brian McCullagh, Lorraine Dolan, Eleanor Cronin, N. Noonan, Michelle M. Coleman, Anne Marie McLaughlin, Eileen Sykes, J. Gallagher, Sarah L. O"Beirne, Deborah Moriarty, Grant Jeffrey, Eoin R. Feeney, Colm Bergin, Catherine Fleming, Arthur Jackson, Joseph Keane, Carlos Mejía-Chew, Liam Townsend, Latent tuberculosis infection screening and treatment outcomes in healthcare workers in Irish hospitals: a multi-centre cohort study, Infection Control and Hospital Epidemiology, 2026, p1 - 8, p1-8 , Journal Article, PUBLISHED  DOI
Murphy DM, Batten I, O'Farrell A, Carlile SR, O'Rourke SA, Court C, Morris B, Leisching G, Jameson G, Connolly SA, Dyer AH, McGrath JP, McNally E, Basdeo SA, IFN-Y-induced trained immunity enhances killing of priority pathogens in healthy and genetically vulnerable individuals., JCI insight, 2026, Journal Article, PUBLISHED  DOI
Gráinne Jameson, Isabella Batten, Adam H. Dyer, C. Geoghegan, Moninne Murray, Niamh McDonnell, Dearbhla M Murphy, Sarah A. Connolly, Anne Marie McLaughlin, Cilian Ó Maoldomhnaigh, Laura E. Gleeson, Joseph Keane, Sharee A. Basdeo, Monocyte metabolic plasticity and cytokine production differentiate latent TB infection from active disease, Journal of Infection, 92, (6), 2026, p106755 - 106755, p106755-106755 , Journal Article, PUBLISHED  DOI
Yennemadi A, Mitochondrial Bioenergetic Failure in SLE Immunocytes: Targeting Fitness for Therapy, Clinical Immunology, 2025, Journal Article, PUBLISHED
Yennemadi AS, Mitochondrial bioenergetic failure in SLE immunocytes: Targeting fitness for therapy, Clinical Immunology, 2025, Notes: [10.1016/j.clim.2025.110571], Journal Article, PUBLISHED  DOI
Gina Leisching, Donal J Cox, Vincent Bondet, Anjali S Yennemadi, Seán Donohue, Darragh Duffy, Joseph Keane, Human macrophages secrete both interferon " and interferon ß protein during infection with Mycobacterium tuberculosis, 2025, Journal Article, PUBLISHED  DOI
Aaron M. Walsh, Emma Roycroft, Kate Hinchion, Sharee A. Basdeo, Frederick J. Sheedy, Fiona Crispie, Paul D. Cotter, Anne-Marie McLaughlin, Joseph Keane, Margaret Fitzgibbon, Laura E. Gleeson, Genomic characterisation of recurrent Mycobacterium avium isolates from chronically infected patients reveals patterns of within-host evolution, Genome Medicine, 17, (1), 2025, p120 - 120, p120-120 , Journal Article, PUBLISHED  DOI
E McNally, Sarahjane O"Riordan, Margaret Fitzgibbon, Emma Roycroft, Lorraine Dolan, Catherine Flynn, Joseph Keane, Anne-Marie McLaughlin, Whole genome sequencing confirms reactivation of tuberculosis five years after initial infection despite adequate preventative therapy in a patient with profound immunosuppression, QJM, 119, (4), 2025, p342 - 344, p342-344 , Journal Article, PUBLISHED  DOI
John M. Murray, Lorraine Dolan, Ciara MacKenna, John Cooney, Joseph Keane, Anne Marie McLaughlin, First episode of psychosis in a patient undergoing tuberculosis treatment, Breathe, 21, (4), 2025, p250186 - 250186, p250186-250186 , Journal Article, PUBLISHED  DOI
  

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CO Maoldomhnaigh, D Cox, K McQuaid, K Gogan, S Basdeo, J Keane, Lactate improves killing of Mycobacterium tuberculosis in human macrophages, IRISH JOURNAL OF MEDICAL SCIENCE, Dublin, 2019, 2019, Conference Paper, PUBLISHED
Keane, Joseph, Tuberculosis Guidelines: National TB Advisory Committee, 2008, Notes: [HPSC ], Working Paper, PUBLISHED
Laios A, O'Toole SA, Sheppard BL, Gleeson NC, D'Arcy T, McGuinness EPJ, Ring M, Sheils O, O'Leary JJ. (ed.), Irish Association for Cancer Research, Galway, Ireland, March 2006, 2006, Proceedings of a Conference, PRESENTED
Keane, Joseph, American Thoracic Society - Programme committee, In:American Thoracic Society Conference, 2005, Notes: [2005 - present], Meetings /Conferences Organised, PRESENTED
Keane, Joseph, Institute of Molecular Medicine: Programme committee , 2004 - present, 2004, Meetings /Conferences Organised, PRESENTED
Keane, Joseph, International Conference on Cytokine Medicine , 2004 - present, 2004, Meetings /Conferences Organised, PUBLISHED
DJ Cox, O Sandyby-Thomas, D Murphy, LE Gleeson, SA Basdeo, J Keane, Driving Resolution of Tuberculosis: Ifn-" Induced Plasticity in Human Alveolar Macrophages Can Be Resolved With IL-10: Implications for Macrophage Plasticity as a Therapeutic Target for Tuberculosis, American Thoracic Society, San Diego, USA, May 2024, Conference Paper, PUBLISHED
Keane, Joseph, TNF blockade and opportunistic infection -A position paper, Notes: [ ATS document writing committee ], Working Paper, SUBMITTED
Keane, Joseph, Diagnostic Standards & Classification of Tuberculosis in Adults and Children, Notes: [ ATS document writing committee ], Working Paper, SUBMITTED

  


Award Date
Health Research Board: Clinical Scientist Award 2012
THE HOST RESPONSE TO TUBERCULOSIS
  • Macrophage Responses We asses the macrophage response to infection using in vitro and ex vivo models of human alveolar macrophages infected with Mycobacterium tuberculosis. We have used these experiments to define the role of macrophage cytokine production, bacterial killing, phagolysosome maturation, and cell death in the immune response to tuberculosis. By using human alveolar macrophages from subjects undergoing bronchoscopy we have been able to define clinically relevant innate immune responses to this important organism.
  • Cell Mediated Immunity Using human and murine models of disease we have been able to characterise both the pro and anti inflammatory immune response to Mycobacterium tuberculosis. Specifically we have demonstrated new mechanism whereby human alveolar macrophages generate a tolerogenic response to Mtb infection; which is reflected in T-cell changes that can potentially accommodate the invading pathogen.
  • The study of tuberculosis susceptible human hosts In our translational work; we have characterised the immune response of patients taking TNF-Blockers, cigarette smokers, and patient deficient in vitamin D. In this regard we have helped define their unique host susceptibility to disease with Mycobacterium tuberculosis.
  • Dublin TB group Our lab is an integral part of the Trinity College Immunology Research centre, including investigators who do TB research such as L O'Neill, K. Mills, P. Fallon, E. Lavelle and C. O'Farrelly. We co-supervise work on new inhalable TB therapies for TB with Dr. Sally Ann Cryan (RCSI). These PI's and a critical mass of TB investigators across Dublin are available to collaborate on future grant calls, and include Prof. Stephen Gordon, mycobateriologist, UCD.
  • Clinical Tuberculosis Research With on-site access to the largest TB cohort in Ireland, we have been in a position to define the role of new diagnostic and therapeutic options for TB. We have reported on the use of EBUS-TBNA in the diagnosis of isolated mediastinal tuberculous lymphadenopathy. We have also defined the public health hazard of prolonged infectiousness seen in our patients who smoke cigarettes after commencement of anti-TB treatment.
  • New TB Diagnostics The role of IGRA in the diagnosis of Latent TB infection: We are undertaking bench experiments to improve the signal to noise ratio and potentially shorten the blood incubation period in IGRA tests. In our clinics, we are testing IGRA performance in selected populations that are uniquely susceptible to progression from LTBI to tuberculosis disease.
  • TB research is funded by SFI, HRB and the RCDH Trust
  • Lung Cancer
    • The genetic basis of lung cancer: At St. James's we see 25% of the Irish lung cancer patients. My lab is collaborating with Boston University who are looking at the genetic profile of cells from these patients to address the questions 'Why do some smoker get lung cancer, and some smokers do not'. It is hope that this transcriptomics approach will allow for early detection for this disease that is almost always lethal because it presents late.
    • The accurate staging of lung cancer using whole body MRI or PET