| Staff Details | ||||
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| Personal Information | ||
| Name | Dev, Kumlesh | |
| Main Department | Physiology | |
| College Title | Associate Professor | |
| devk@tcd.ie | ||
| College Tel | +353 1 896 4180 | |
| Web | http://people.tcd.ie/devk | |
| Notes | http://healthsciences.tcd.ie/pls/public/staff.detail?p_unit=physiology&p_name=devk#CV_CAR_DTLS_D_PREF | |
| Representations |
| Details | Date |
| Representative Director Ireland, Venture Valuation AG, Zurich, Switzerland |
| Membership of Professional Institutions, Associations, Societies |
| Details | Date From | Date To |
| Board Member of Journal of Biological Chemistry | ||
| Editorial Board Member of Canadian Journal of Pure and Applied Sciences |
| Description of Research Interests |
| Research is based on investigating mechanisms that control receptor surface expression and thereby receptor function. With an interest in Multiple Sclerosis and Parkinson's Disease, we are investigating surface expression of receptors that are drug targets for these diseases, including sphingosine 1-phosphate receptors (S1P-R), parkin-associated endothelial like receptor (PAEL-R) and the interleukin 2 receptor (IL2-R). Our approach is to engineer, formulate and chemically re-design competitive blocking peptides and discover small molecular weight compounds, which alter receptor surface expression and function in vivo. Development of such agents permits cell-selective receptor modulation and the regulation of orphan receptors or difficult-to-target receptors. We are funded in kind and in part by Trinity College Dublin, Science Foundation Ireland, Health Research Board Ireland, Enterprise Ireland, The Wellcome Trust, Lundbeck, Actelion, Servier and Novartis. |
| Research Interests | |||
| Drug Targets | Glutamate Receptors | Multiple Sclerosis | Neuroscience |
| Parkinson's Disease | Protein-Protein Interactions | Receptor Trafficking | Sphingosine 1-phosphate receptors |
| Publications |
| Peer Reviewed |
| S. Chatterjee, J.D. Szustakowski, N.R. Nanguneri, C. Mickanin, M.A. Labow, A. Nohturfft, K.K. Dev* and R. Sivasankaran. , Identification of Novel Genes and Pathways Regulating SREBP Transcriptional Activity. , PLoS ONE , 4, 2009, p5197- | |
| Y. Senechal, L. Prut, M. Staufenbiel, F. Natt, D. Hoyer, C. Wiessner, and K.K Dev., siRNA-mediated knockdown of APP reverses locomotor hyperactivity in the APP23 mouse model of Alzheimer's Disease., Brain Research , 1243, 2008, p124 - 133 | |
| M. Osinde, F. Clavaguera, R. May-Nass, M. Tolnay, and K.K. Dev. , Lentivirus Tau (P301S) expression in adult amyloid precursor protein (APP)-transgenic mice leads to tangle formation. , Neuropath Applied Neurobiol,, 34, 2008, p523 - 531 | |
| B.L. Olson, M.B. Hock, S. Ekholm-Reed, J.A. Wohlschlegel, K.K. Dev, A. Kralli, and S.I. Reed. , SCFCdc4 acts antagonistically to the PGC-1{alpha} transcriptional coactivator by targeting it for ubiquitin-mediated proteolysis. , Genes Development , 22, 2008, p252 - 264 | |
| Y. Senechal, P.H. Kelly, and K.K Dev. , APP knockout mice show age-dependent deficits in passive avoidance learning. , Behav Brian Res, 186, 2008, p126 - 132 | |
| More Publications>>> | |
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| Contact:helpdesk@tcd.ie Last Updated:12-FEB-2012 |
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