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Trinity College Dublin

Personal Information
Name Dev, Kumlesh
Main Department Physiology
College Title Professor
E-mail devk@tcd.ie
College Tel +353 1 896 4180
Web http://people.tcd.ie/devk
Notes http://healthsciences.tcd.ie/pls/public/staff.detail?p_unit=physiology&p_name=devk#CV_CAR_DTLS_D_PREF
 
Representations
Details Date
Representative Director Ireland, Venture Valuation AG, Zurich, Switzerland
 
Membership of Professional Institutions, Associations, Societies
Details Date From Date To
Board Member of Journal of Biological Chemistry
Editorial Board Member of Canadian Journal of Pure and Applied Sciences
 
Description of Research Interests
Research is based on investigating mechanisms that control receptor surface expression and thereby receptor function. With an interest in Multiple Sclerosis and Parkinson's Disease, we are investigating surface expression of receptors that are drug targets for these diseases, including sphingosine 1-phosphate receptors (S1P-R), parkin-associated endothelial like receptor (PAEL-R) and the interleukin 2 receptor (IL2-R). Our approach is to engineer, formulate and chemically re-design competitive blocking peptides and discover small molecular weight compounds, which alter receptor surface expression and function in vivo. Development of such agents permits cell-selective receptor modulation and the regulation of orphan receptors or difficult-to-target receptors. We are funded in kind and in part by Trinity College Dublin, Science Foundation Ireland, Health Research Board Ireland, Enterprise Ireland, The Wellcome Trust, Lundbeck, Actelion, Servier and Novartis.
 
Research Interests
Drug Targets Glutamate Receptors Multiple Sclerosis Neuroscience
Parkinson's Disease Protein-Protein Interactions Receptor Trafficking Sphingosine 1-phosphate receptors
 
Publications and Other Research Outputs
Peer Reviewed
S. Chatterjee, J.D. Szustakowski, N.R. Nanguneri, C. Mickanin, M.A. Labow, A. Nohturfft, K.K. Dev* and R. Sivasankaran. , Identification of Novel Genes and Pathways Regulating SREBP Transcriptional Activity. , PLoS ONE , 4, 2009, p5197-
Y. Senechal, L. Prut, M. Staufenbiel, F. Natt, D. Hoyer, C. Wiessner, and K.K Dev., siRNA-mediated knockdown of APP reverses locomotor hyperactivity in the APP23 mouse model of Alzheimer's Disease., Brain Research , 1243, 2008, p124 - 133
M. Osinde, F. Clavaguera, R. May-Nass, M. Tolnay, and K.K. Dev. , Lentivirus Tau (P301S) expression in adult amyloid precursor protein (APP)-transgenic mice leads to tangle formation. , Neuropath Applied Neurobiol,, 34, 2008, p523 - 531
B.L. Olson, M.B. Hock, S. Ekholm-Reed, J.A. Wohlschlegel, K.K. Dev, A. Kralli, and S.I. Reed. , SCFCdc4 acts antagonistically to the PGC-1{alpha} transcriptional coactivator by targeting it for ubiquitin-mediated proteolysis. , Genes Development , 22, 2008, p252 - 264
Y. Senechal, P.H. Kelly, and K.K Dev. , APP knockout mice show age-dependent deficits in passive avoidance learning. , Behav Brian Res, 186, 2008, p126 - 132
More Publications and Other Research Outputs >>>
 

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Last Updated:17-SEP-2014