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Personal Information
College Photo Name Dorman, Charles James
Main Department Microbiology
College Title Professor & Head of Discipline
E-mail cjdorman@tcd.ie
College Tel +353 1 896 2013/2521
Web http://people.tcd.ie/cjdorman
Fax 00353 1 679 9294
 
Biography
Charles J Dorman is a microbial geneticist and has held the Chair of Microbiology at Trinity College Dublin since 1994; currently he is in his second term as head of the School of Genetics and Microbiology. Professor Dorman is a Founding Member of the European Academy of Microbiology, a Fellow of the American Academy of Microbiology, a Member of the Royal Irish Academy (Ireland's highest academic honour), a Fellow of the Society of Biology and was made a Chartered Biologist by the Institute of Biology in 2009. He is a recipient of the Sir Alexander Fleming Medal of the Society for General Microbiology (SGM) and was formerly a Royal Society Research Fellow and Lecturer in Biochemistry at the Medical Sciences Institute at Dundee University in the United Kingdom. Professor Dorman has served as the Ambassador to Western Europe of the American Society for Microbiology (ASM) and as a member of the ASM Committee on Global Engagement. He has a keen interest in the development of microbiology internationally, is a visiting professor at the Indian Institute of Science at Bangalore and has delivered more than 180 invited lectures at conferences and other scientific meetings around the world over the past twenty years. From 2005 to 2010 Professor Dorman was Editor-in-Chief of 'Microbiology' (published by the SGM) and in 2014 was elected chair of the SGM Publications Committee with responsibility for its five scientific journals. He has served on the editorial boards of numerous scientific journals and has been an advisor to several national and international research funding agencies worldwide. In 2006-07 he chaired a review of all microbiological research in the United Kingdom for the Biotechnology and Biological Sciences Research Council (BBSRC). His own research focuses on the global regulation of gene expression in bacteria of medical importance, with an emphasis on the regulatory roles of DNA topology and nucleoid-associated proteins.
 
Representations
Details Date
Chair of Microbiology, Trinity College Dublin 1994-present
Head of the School of Genetics and Microbiology. Trinity College Dublin 2008-2011; 2014-2017
Head of Microbiology Department, Trinity College Dublin 1994-2001; 2013-2014
Chair, Publications Committee, Society for General Microbiology 2014-2017
Member, Committee on Global Engagement, American Society for Microbiology 2012-2015
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Membership of Professional Institutions, Associations, Societies
Details Date From Date To
European Academy of Microbiology (Founding Member) Current
American Academy of Microbiology (Fellow) Current
Royal Irish Academy (Member) Current
Society of Biology (Fellow) Current
Institute of Biology (Chartered Biologist) Current
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Awards and Honours
Award Date
Visiting Professor, Indian Institute of Science, Bangalore 2014-2017
Top performing editorial board member, Journal of Bacteriology (American Society for Microbiology) 2013
Representative, American Society for Microbiology at the European Congress of Microbiology, Leipzig, Germany 2013
Outstanding Service Award, American Society for Microbiology International Ambassador Programme 2012
Elected Chair of the Publications Committee, Society for General Microbiology 2014
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Description of Research Interests
1. Gene regulatory mechanisms in Gram-negative bacteria of medical importance, with an emphasis on the roles of nucleoid-associated proteins and DNA topology in controlling transcription and site-specific recombination. 2. Horizontal transfer of gene regulatory elements and the evolution of gene control networks. 3. The dissection and interpretation of complex gene regulatory circuits using genomics methods. 4. Modulation of gene expression patterns in pathogenic bacteria during infection and intracellular growth.
 
Research Interests
BACTERIA BACTERIAL BACTERIAL GENE BACTERIUM
BINDING-PROTEINS BINDING-SITE BINDING-SITES BIOCHEMICAL
BIOCHEMICAL APPROACH BIOCHEMISTRY BIOLOGY CURVED DNA
DEOXYRIBONUCLEIC-ACID GYRASE DNA DNA ARRAY DNA BENDING
DNA BINDING DNA GYRASE DNA INVERSION DNA MICROARRAYS
DNA RECOGNITION DOMAINS DNA SUPERCOILING DNA SUPERHELICITY DNA TOPOLOGY
DNA-BINDING DNA-BINDING ACTIVITY DNA-BINDING DOMAIN DNA-BINDING DOMAINS
DNA-BINDING PROTEIN DNA-BINDING PROTEINS DNA-BINDING SUBUNIT ENVIRONMENTAL REGULATION
ENVIRONMENTAL-REGULATION ESCHERICHIA-COLI K-12 FIMBRIAE FIMBRIAL PHASE VARIATION
FIS PROTEIN GENE REARRANGEMENTS GENE REGULATION GENE-EXPRESSION
GENES GENETIC GENETIC MANIPULATION GENETIC STRUCTURE
GENETIC-ANALYSIS GENETICS GENOME GENOME COMPACTION
GENOME EVOLUTION GENOME EXPRESSION ANALYSIS GENOMES GENOMIC ORGANIZATION
GENOMICS GLOBAL REGULATOR GROWTH-PHASE CONTROL GROWTH-PHASE REGULATION
H-NS HISTONE-LIKE PROTEINS HNS INTEGRATION HOST FACTOR
MESSENGER-RNA MICROARRAY MICROARRAY DATA MICROBIAL ACTIVITY
MICROBIOLOGY MICROORGANISM MICROORGANISMS MOLECULAR-BIOLOGY
MOLECULAR-CLONING MOLECULAR-GENETICS MOLECULAR-STRUCTURE SALMONELLA-TYPHIMURIUM
SHIGELLA-FLEXNERI SITE-SPECIFIC RECOMBINASES TRANSCRIPTIONAL ACTIVATION TYPE-1 FIMBRIAE
 
Research Projects
Project title Bacterial gene regulation by DNA supercoiling.
Summary
Funding Agency The Royal Society
Programme Royal Society University Research Fellowships
Type of Project
Date from 1988
Date to 1994
Person Months


Project title Bacterial DNA supercoiling and gene regulation.
Summary
Funding Agency The Royal Society
Programme Fellowship support award
Type of Project
Date from 1988
Date to 1994
Person Months


Project title DNA supercoiling, gene expression and bacterial pathogenicity.
Summary
Funding Agency Wellcome Trust
Programme Project Grants
Type of Project
Date from 1988
Date to 1991
Person Months


Project title Contribution of DNA topology to the control of virulence gene expression in Shigella flexneri.
Summary
Funding Agency Society for General Microbiology
Programme Studentship
Type of Project
Date from 1989
Date to 1991
Person Months


Project title Environmental stress, DNA supercoiling and the regulation of virulence in Salmonella typhimurium.
Summary A study of virulence gene expression in the pathogenic bacterium Salmonella
Funding Agency Medical Research Council
Programme Project Grants
Type of Project
Date from 1989
Date to 1992
Person Months


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Publications and Other Research Outputs
Peer Reviewed
Organization of the Bacterial Nucleoid (Chapter 311) in, Lennarz W, Lane MD , Encyclopedia of Biological Chemistry (2nd Edition), Waltham, MA, USA, Academic Press, 2013, pp367 - 370, [Dorman CJ]
URL
H-NS, global regulator of gene expression and organizer of the bacterial nucleoid in, A. Filloux , Bacterial Regulatory Networks, Norwich, Horizon Press, 2012, pp167 - 189, [CJ Dorman]
URL
Kröger C, SC Dillon, ADS Cameron, K Papenfort, SK Sivasankaran, K Hokamp, Y Chao, A Sittka, M Hébrard, K Händler, A Colgan, P Leekitcharoenphon, GC Langridge, AJ Lohan, B Loftus, S Lucchini, DW Ussery, CJ Dorman, N Thomson, J Vogel, JCD Hinton, The transcriptional landscape and small RNAs of Salmonella enterica serovar Typhimurium, Proceedings of the National Academy of Science USA , 109, (20), 2012, pE1277 - E1286
Notes: [Published online 25 April 2012]
DOI
Dillon SC, E Espinosa, K Hokamp, DW Ussery, J Casadesus, CJ Dorman, LeuO is a global regulator of gene expression in Salmonella enterica serovar Typhimurium, Molecular Microbiology, 85, (6), 2012, p1072 - 1089
Notes: [Published online 16 July 2012]
DOI
McFarland KA, Dorman CJ, Autoregulated expression of the gene coding for the leucine-responsive protein, Lrp, in Salmonella enterica serovar Typhimurium , Microbiology, 154, (7), 2008, p2008 - 2016
DOI
More Publications and Other Research Outputs >>>
 

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Last Updated:02-OCT-2014