Trinity College Dublin

Staff Details

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Personal Information
	Name	Molloy, Anne Marie
	Main Department	Clinical Medicine
	College Title	Research Senior Lecturer
	E-mail	amolloy@tcd.ie
	College Tel	+353 1 896 1616
	Web	http://people.tcd.ie/amolloy

Representations

Details	Date
Research Ethics Committee, Coombe womens' Hospital
Editorial Board, British Journal of Nutrition
WHO Technical Consultant on Folate and Vitamin B12 Deficiencies	October 2005

Membership of Professional Institutions, Associations, Societies

Details	Date From	Date To
The Biochemical Society
The Nutrition Society

Description of Research Interests

• The role of folate and vitamin B12 in pregnancy: This incorporates two principal areas; (1) the cause of folate responsive neural tube defects, in particular the nutritional, biochemical and genetic parameters associated with these disorders and (2) the effects of inadequate folate or vitamin B12 nutrition on complications of pregnancy and adverse pregnancy outcomes. The role of these vitamins in other congenital disorders including oro-facial clefts and congenital heart disease is an extension of this area of interest. • The uptake and utilisation of folates in normal and deficient states: A particular area of interest is the effect of genetic variants in folate related enzymes on folate status and metabolism. Research methods include cell culture studies and studies on nutritional status in human subjects, stratified according to a genotype of interest. • The development and application of new techniques in the analysis of folates and folate related metabolites. including HPLC methods, amino acid analysis, radioisotope methods, microbiological assays and cell culture technology. • Links between folate and vitamin B12; specifically, the influence of folate and vitamin B12 status on methylation reactions and s-adenosylmethionine metabolism.


Research Interests

Age related diseases	Folate, Vitamin B12	Metabolism and metabolic diseases	Molecular nutrition
Population based intervention trials

Publications

Peer Reviewed

Beaty TH, Murray JC, Marazita ML, Munger RG, Ruczinski I, Hetmanski JB, Liang KY, Wu T, Murray T, Fallin MD, Redett RA, Raymond G, Schwender H, Jin SC, Cooper ME, Dunnwald M, Mansilla MA, Leslie E, Bullard S, Lidral AC, Moreno LM, Menezes R, Vieira AR, Petrin A, Wilcox AJ, Lie RT, Jabs EW, Wu-Chou YH, Chen PK, Wang H, Ye X, Huang S, Yeow V, Chong SS, Jee SH, Shi B, Christensen K, Melbye M, Doheny KF, Pugh EW, Ling H, Castilla EE, Czeizel AE, Ma L, Field LL, Brody L, Pangilinan F, Mills JL, Molloy AM, Kirke PN, Scott JM, Scott JM, Arcos-Burgos M, Scott AF, A genome-wide association study of cleft lip with and without cleft palate identifies risk variants near MAFB and ABCA4., Nature Genetics, 42, (6), 2010, p525-529 DOI
Parle-McDermott A, Pangilinan F, O'Brien KK, Mills JL, Magee AM, Troendle J, Sutton M, Scott JM, Kirke PN, Molloy AM, Brody LC., A common variant in MTHFD1L is associated with neural tube defects and mRNA splicing efficiency, Human Mutation, 30, (12), 2009, p1650-1656 TARA - Full Text DOI
J.L. Mills, A.M. Molloy, A. Parle-McDermott, J.F. Troendle, L.C. Brody, M.R. Conley, C. Cox, F. Pangilinan, D.J. Orr, M. Earley, E. McKiernan, E.C. Lynn, A. Doyle, J.M. Scott, P.N. Kirke. , Folate-related gene polymorphisms as risk factors for cleft lip and cleft palate., Birth Defects Research Part A Clinical and Molecular Teratology. , 82, (9), 2008, p636 - 643 DOI
R. Clarke , P. Sherliker, H. Hin, A.M. Molloy, E. Nexo, P.M. Ueland, K. Emmens, J.M. Scott, J.G. Evans. , Folate and vitamin B12 status in relation to cognitive impairment and anaemia in the setting of voluntary fortification in the UK., British Journal of Nutrition, 100, (5), 2008, p1054 - 1059 Notes: [ PubMed ID: 18341758] DOI
J. Little, M. Gilmour, P.A. Mossey, D. Fitzpatrick, A. Cardy, J. Clayton-Smith, A. Hill, S.J. Duthie, A.E. Fryer, A.M. Molloy, J.M. Scott; ITS MAGIC Collaboration. , Folate and clefts of the lip and palate--a U.K.-based case-control study: Part II: Biochemical and genetic analysis, Cleft Palate Craniofacial Journal, 45, (4), 2008, p428 - 438 Notes: [ PubMed ID: 18616362] DOI
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Last Updated:16-MAY-2012



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