| Staff Details | ||||
|
||||
| Personal Information | ||
| Name | Lynch, Aileen Maria | |
| Main Department | School of Nursing & Midwifery | |
| College Title | Lecturer | |
| amlynch@tcd.ie | ||
| College Tel | +353 1 896 8571 | |
| Web | http://people.tcd.ie/amlynch | |
| Membership of Professional Institutions, Associations, Societies |
| Details | Date From | Date To |
| Physiological Society (Affiliate Member) | ||
| American Society for Neuroscience | ||
| British Neuroscience Association | ||
| Neuroscience Ireland |
| Expertise Ireland Description of Research Interests |
| My earlier research identified that IL-1ƒÒ, IL-1ƒÒ-signaling proteins, stress-activated protein kinases, caspases and apoptosis are all up-regulated when inflammation is induced in the brain. More recently my research has indicated that neuroinflammation evolves as the brain ages. This is a significant problem, as it is well established that neuroinflammation contributes to pathology in neurodegenerative disorders such as Multiple Sclerosis, Alzheimer¡¦s disease and Parkinson¡¦s disease. Recently, I have investigated various ways of modulating the inflammatory process and one approach I took was to explore the reputed beneficial role the omega-3 fatty acids (i.e. EPA) have on the brain. The data indicates that EPA exerts an anti-inflammatory effect and mediates its action by restoring levels of the anti-inflammatory cytokines in the ageing brain. In addition, EPA has the ability to modulate microglial activity which is key, as the microglial are the main source of cytokines in the brain. Other research interests include how cell-cell interactions between neural cells maintains CNS homeostasis?; is the immune system compromised with age and do additional insults to the ageing brain further accentuated the inflammatory response? In humans, how does the inflammatory status influence disease processes or successful aging? Are cytokine polymorphisms linked with better clinical outcomes? Do anti-inflammatory agents which are already administered clinically, influence disease processes or contribute to successful ageing? Overall, measurement of markers of inflammation might be a useful indication of high-risk subgroups for anti-inflammatory interventions. |
| Research Interests | |||
| Ageing, memory and other cognitive processes | Alzheimer's disease | Apoptosis | Astrocyte |
| Autoimmunity | Cell and tissue maintenance, repair and ageing | Chronic inflamation | Consequences of ischemia or hypoxia, convulsive disorders |
| Cytokine | Immune system | Microglia | Multiple Sclerosis |
| Nervous system, development, plasticiy and ageing | Neurochemistry and neuropharmacology | Neurodegeneration | Neurodegeneration |
| Neuroendocrine Immunology | Neuropharmacology | Neurophysiology | Schizophrenia |
| Stress |
| Publications |
| Peer Reviewed |
| Barry CE, Nolan Y, Clarke RM, Lynch A, Lynch MA, Activation of c-Jun-N-terminal kinase is critical in mediating lipopolysaccharide-induced changes in the rat hippocampus , Journal of Neurochemistry, 93, (1), 2005, p221 - 231 Notes: [PMID: 15773921 ] Url DOI |
|
| Lynch AM, Moore M, Craig S, Lonergan PE, Martin DS, Lynch MA, Analysis of interleukin-1 beta-induced cell signaling activation in rat, Journal of Biological Chemistry, 278, (51), 2003, p51075 - 51084 | |
| Lynch AM, Lynch MA, The age-related increase in IL-1 type I receptor in rat hippocampus is coupled with an increase in caspase-3 activation., European Journal of Neuroscience, 15, (11), 2002, p1779 - 1788 Notes: [PMID: 12081657] Url DOI |
|
| Áine Kelly, Aileen Lynch, Emily Vereker, Yvonne Nolan, Patrice Queenan, Elizabeth Whittaker, Luke A. J. O' Neill, and Marina A. Lynch , The anti-inflammatory cytokine, interleukin (IL)-10, blocks the inhibatory effect of IL-1 beta on long term potentiation - a role for JNK, Journal of Biological Chemistry, 276, (49), 2001, p45564 - 45572 Notes: [PMID: 11581275] TARA - Full Text DOI |
|
| More Publications>>> | |
Log in to the TCD Portal |
| Contact:helpdesk@tcd.ie Last Updated:11-MAR-2010 |
| back to top | ||