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Professor Shane O'Mara

Professor of Experimental Brain Research (Psychology)
LLOYD INSTITUTE

Director of TCIN (Trinity Inst. of Neurosciences (TCIN))

I am Professor of Experimental Brain Research in Trinity College Dublin, and am a Principal Investigator in, and currently the Director of, the Trinity College Institute of Neuroscience and a member of the academic staff of the School of Psychology. I was an undergraduate and postgraduate at NUI Galway (BA, MA). I undertook my doctoral work (DPhil) at the University of Oxford. I am a Fellow of Trinity College, Dublin (FTCD) and a Fellow of the Association for Psychological Science (FAPS). I was also elected a Member of the Royal Irish Academy (MRIA). Research Focus: My research focuses on the relations between cognition, synaptic plasticity and behaviour, in the context of brain aging and depression. Research Interests: Biology of learning and memory; mechanisms of brain repair; drug action in CNS; synaptic plasticity; visualising in vivo neuronal activity; defining distribution of bioactive agents in CNS; imaging human brain during learning and memory; models of neurodegeneration; models of secondary depression and their treatment; organic disorders of memory. I am also interested in public policy applications and counterfactual interpretations of neuroscience. Research Support and Research Funding: My research work has been or currently is supported by the Wellcome Trust; Science Foundation Ireland; the Health Research Board; the European Commission; GlaxoSmithKline; Alkermes. I blog shaneomara.wordpress.com, mostly on neuroscience-, psychology-, science- and public policy-related themes (and maybe the intersection of all of these themes, but sometimes on other things entirely). I tweet at @smomara1.
  ACTIVATED PROTEIN-KINASE   ALZHEIMERS-DISEASE   AMINO-ACID RECEPTORS   AMMONS HORN   ANATOMICAL DATA   ANTERIOR CINGULATE CORTEX   ANTERIOR THALAMIC NUCLEI   ARACHIDONIC-ACID   AREA CA1   BDNF   BDNF PROTECTS   BEHAVIORAL STRESS   Biology of learning, memory and cognition   CA1   CALCIUM   CHRONIC NEUROINFLAMMATION   COGNITIVE MAPS   COMPLEX-SPIKE CELLS   CORTEX   CUE CONTROL   CYTOKINES   DENTATE GYRUS   DEPOTENTIATION   DISORIENTATION   EFFERENT CONNECTIONS   ELECTROPHYSIOLOGICALLY-DEFINED CLASSES   ENTORHINAL CORTEX   ENVIRONMENT   FIRING PATTERNS   FIRING PROPERTIES   FREELY-MOVING   FRONTAL-CORTEX   GYRUS IN-VITRO   HEAD DIRECTION CELLS   HIGH-FREQUENCY STIMULATION   HIPPOCAMPAL   HIPPOCAMPAL AREA CA1   HIPPOCAMPAL FORMATION   HIPPOCAMPAL SLICES   HIPPOCAMPUS   IN-VIVO   LASTING POTENTIATION   LEARNING AND MEMORY   LESIONS   LONG-TERM POTENTIATION   MESSENGER-RNA   METHYL-D-ASPARTATE   NEURONS   PAIRED-PULSE FACILITATION   PARIETAL CORTEX   PATH INTEGRATION   PLACE NAVIGATION   PLASTICITY   POTENTIATION   RAT   RAT HIPPOCAMPUS   RATS   SLICES   SPATIAL MEMORY   SUBICULUM   SYNAPTIC TRANSMISSION   WATER MAZE
Details Date
Major Conference Organization: The European Brain and Behaviour Society meeting Sept 2005. I was the Chair and Chief Organiser of this conference; I led the successful bid to bring this conference to Dublin and to have it hosted by the Trinity College Institute of Neuroscience. This was a major international meeting of some 450 delegates. 2005
Details Date From Date To
Association for Psychological Science; Society for Neuroscience; European Brain and Behaviour Society; Neuroscience Ireland
Cooke GE, Mullally S, Correia N, O'Mara SM, Gibney J. , Hippocampal Volume Is Decreased in Adults with Hypothyroidism, Thyroid, 24, (3), 2014, p433-40 , Journal Article, PUBLISHED  DOI
Smith KJ, Mullally S, McLoughlin D, O'Mara S., Validation of the face-name pairs task in major depression: impaired recall but not recognition., Front Psychol., 12, (5), 2014, 92, Notes: [. eCollection 2014.], Journal Article, PUBLISHED  TARA - Full Text  DOI
Jankowski MM, Ronnqvist KC, Tsanov M, Vann SD, Wright NF, Erichsen JT, Aggleton JP, O'Mara SM, The anterior thalamus provides a subcortical circuit supporting memory and spatial navigation., Frontiers in systems neuroscience, 7, 2013, p45 , Journal Article, PUBLISHED  TARA - Full Text
Mullally, SL & O'Mara, SM , Suppressing the encoding of new information: A behavioral study derived from principles of hippocampal function. , PLoS One, 8, (1), 2013, pe50814 , Journal Article, PUBLISHED  TARA - Full Text  DOI
Tsanov M, Chah E, Reilly R, O'Mara SM. , Respiratory cycle entrainment of septal neurons mediates the fast coupling of sniffing rate and hippocampal theta rhythm. , Eur J Neurosci., 36, (6), 2013, p957-974 , Journal Article, PUBLISHED  TARA - Full Text  DOI
Wright, N, Vann, SD, Erichsen, J, O'Mara, SM & Aggleton, JP, Segregation of parallel inputs to the anteromedial and anteroventral thalamic nuclei of the rat, Journal of Comparative Neurology, 521, (13), 2013, p2966-2986 , Journal Article, PUBLISHED  TARA - Full Text  DOI
Steinemann N.A., Tsanov M., Reilly R.B., O'Mara S.M., Assessing Attractor Models as a means to Explain Sense of Head-Direction during Theta Sleep in Rodents, Proceedings of the 8th Federation of European Neuroscience Societies Forum (FENS),, 8th Federation of European Neuroscience Societies Forum (FENS),, Barcelona, July, 2012, Conference Paper, PUBLISHED
Noor M.S, Tsanov M, Reilly R.B., O'Mara S.M, Theta burst stimulation to medial septum enhances spatial coherence of hippocampal place cell representation, Proceedings of the AREADNE: Research in Encoding And Decoding of
Neural Ensembles, AREADNE: Research in Encoding And Decoding of
Neural Ensembles, Santorini, Greece, June, 2012, Conference Paper, PUBLISHED
Sinead O'Donovan, Mark Kennedy, Blaithin Guinan, Shane O'Mara, Declan M. McLoughlin, A comparison of brief pulse and ultrabrief pulse electroconvulsive stimulation on rodent brain and behaviour, Progress in Neuropsychopharmacology & Biological Psychiatry, 37, (1), 2012, p147-52 , Journal Article, PUBLISHED  TARA - Full Text  DOI
O'Donovan S, Kennedy M, Guinan B, O'Mara S, McLoughlin DM, A comparison of brief pulse and ultrabrief pulse electroconvulsive stimulation on rodent brain and behaviour., Progress in neuro-psychopharmacology & biological psychiatry, 37, (1), 2012, p147-52 , Journal Article, PUBLISHED  DOI
  

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Model Learning And Memory Systems In Neurobiological Research: Conditioning And Associative Learning Procedures And Spatial Learning Paradigms in, editor(s)Lynch, M.A., O'Mara, S.M. , Neuroscience Labfax, London, Academic Press, 1997, [Hölscher, C., O'Mara, S.M.], Book Chapter, PUBLISHED

  

Award Date
FAPS 2010
MRIA 2011
Biology of learning and memory; mechanisms of brain repair; drug action in CNS; synaptic plasticity; visualising in vivo neuronal activity; defining distribution of bioactive agents in CNS; imaging human brain during learning and memory; models of neurodegeneration; models of secondary depression and their treatment; organic disorders of memory. Key Research Question: How does the brain change as a result of experience? To investigate this general problem, I have adopted multidisciplinary techniques from diverse disciplines (e.g. neurophysiology, neuropharmacology, behavioural analysis, neuroimmunology). Techniques routinely used in my research group include: in vivo neurophysiology in freely-moving/anaesthetised rat (field potentials/action potential recordings of single neurons/neuronal ensembles); neurobehavioural assays (automated water, radial, open field; object exploration, odour discrimination, etc.); brain protein assays (BDNF; prostaglandins); radioimmunoassays; neurohistology.