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Dr. Sharon O'Toole

Snr Experimental Officer (Obstetrics)
COOMBE WOMENS HOSPITAL

 shotoole@tcd.ie

 3531896 2116

Senior Research Fellow (Histopathology)

 (3531896) 2106


Biography

Sharon O'Toole is a senior research fellow in Trinity College Dublin working in the area of ovarian cancer. She qualified with a BSc Hons in UCG in 1994 and then completed an MSc Biotechnology in 1996. Having worked in industry she then returned to research and completed a PhD in Trinity College in 2003. She has gained enormous experience in the area of ovarian cancer and has played a major role in the development of studies in gynaecological cancer. She was instrumental in establishing the DISCOVARY consortium which is a multidisciplinary and trans- institutional consortium dedicated to addressing the problems of ovarian and uterine cancer. The consortium manages the largest ovarian cancer bioresource in the country. The consortium has now merged to form INNOVATION- the Irish National Network for Ovarian Cancer Collaboration which has brought together the medical, research and charity organisations involved in ovarian cancer in Ireland. Her research interests centre around diagnostic and prognostic biomarkers and understanding the fundamental biology of the metastatic cascade and circulating tumour cells. She has been successful in identifying diagnostic and prognostic biomarkers for ovarian cancer and her ultimate aim is to translate these into the clinic. She has presented at both national and international conferences and published in peer-reviewed journals. She works closely with the 3 ovarian cancer charities in Ireland whose mission is to improve outcomes for ovarian cancer in Ireland. She was part of the organising committee of the first World Ovarian Cancer Day on May 8th in 2013 and this has now become an annual event.

Research Tags

  Gynaecology oncology   Obstetrics/Gynecology   Oestregens in age related urogenital diseases

Languages

Language Skill Reading Skill Writing Skill Speaking
English Fluent Fluent Fluent
French Fluent Medium Medium

Memberships

Membership of Professional Institutions, Associations, Societies

Details Date From Date To
Member of European Association for Cancer Research. Member of Irish Association for Cancer Research
-Co-ordinator of INNOVATION- the Irish National Network for Ovarian Cancer Collaboration.
-Executive Committee of the Irish Society of Gynaecological Oncology (ISGO)
-Member of the European Society for Gynaecological Oncology (ESGO)
-Member of Cancer Trials Ireland
Ffrench B, Kashdan E, Huang Y, Spillane CD, Cocchiglia S, Charmsaz S, Varešlija D, O'Brien C, Scholz D, Martin C, Gallagher M, Brooks DA, Brooks RD, Selemidis S, Gleeson N, AbuSaadeh F, O'Riain C, Kamran W, Flavin R, Young L, O'Toole SA, O'Leary JJ., CTC-5: A novel digital pathology approach to characterise circulating tumour cell biodiversity., Heliyon, 9, (1), 2023, pe13044 , Journal Article, PUBLISHED  DOI
Bates M, Mohamed BM, Ward MP, Kelly TE, O'Connor R, Malone V, Brooks R, Brooks D, Selemidis S, Martin C, O'Toole S, O'Leary JJ., Circulating tumour cells: The Good, the Bad and the Ugly., Biochim Biophys Acta Rev Cancer, 1878, (2), 2023, p188863 , Journal Article, PUBLISHED  TARA - Full Text  DOI
Mohamed BM, Ward MP, Bates M, Spillane CD, Kelly T, Martin C, Gallagher M, Heffernan S, Norris L, Kennedy J, Saadeh FA, Gleeson N, Brooks DA, Brooks RD, Selemidis S, O'Toole S, O'Leary JJ., Ex vivo expansion of circulating tumour cells (CTCs)., Scientific reports, 13, (1), 2023, p3704 - 3704, Journal Article, PUBLISHED  DOI
Ward MP, O'Toole SA, Abu Saadeh F, Marchocki Z, Ibrahim EM, Martin F, Gleeon N, O'leary JJ, Norris LA, Mechanisms of cancer associated thrombosis in gynaecological cancer patients- tumour or treatment effect?, Research Practice in Thrombosis and Haemostasis, International Society for Thrombosis and Haemostasis, London, July 2022, 6, (Supplement 2), Wiley, 2022, ppPB0752 - PB0752, Conference Paper, PUBLISHED  URL
Oseghale O, Liong S, Coward-Smith M, To EE, Erlich JR, Luong R, Liong F, Miles M, Norouzi S, Martin C, O'Toole S, Brooks RD, Bozinovski S, Vlahos R, O'Leary JJ, Brooks DA, Selemidis S., Influenza A virus elicits peri-vascular adipose tissue inflammation and vascular dysfunction of the aorta in pregnant mice., PLoS pathogens, 18, (8), 2022, pe1010703 , Journal Article, PUBLISHED  DOI
Sharkey Ochoa I, O'Regan E, Toner M, Kay E, Faul P, O'Keane C, O'Connor R, Mullen D, Nur M, O'Murchu E, Barry-O'Crowley J, Kernan N, Tewari P, Keegan H, O'Toole S, Woods R, Kennedy S, Feeley K, Sharp L, Gheit T, Tommasino M, O'Leary JJ, Martin CM., The Role of HPV in Determining Treatment, Survival, and Prognosis of Head and Neck Squamous Cell Carcinoma., Cancers, 14, (17), 2022, p4321 , Journal Article, PUBLISHED  DOI
Martini C, Logan JM, Sorvina A, Gordon C, Beck AR, S-Y Ung B, Caruso MC, Moore C, Hocking A, Johnson IRD, Li KL, Karageorgos L, Hopkins AM, Esterman AJ, Huzzell C, Brooks RD, Lazniewska J, Hickey SM, Bader C, Parkinson-Lawrence E, Weigert R, Sorich MJ, Tewari P, Martin C, O'Toole S, Bates M, Ward M, Mohammed B, Keegan H, Watson W, Prendergast S, Heffernan S, NiMhaolcatha S, O'Connor R, Malone V, Carter M, Ryan K, Brady N, Clarke A, Sokol F, Prabhakaran S, Stahl J, Klebe S, Samaratunga H, Delahunt B, Selemidis S, Moretti KL, Butler LM, O'Leary JJ, Brooks DA., Aberrant protein expression of Appl1, Sortilin and Syndecan-1 during the biological progression of prostate cancer., Pathology, 2022, pS0031-3025(22)00226-4 , Journal Article, PUBLISHED  DOI
Di Fiore R, Suleiman S, Ellul B, O'Toole SA, Savona-Ventura C, Felix A, Napolioni V, Conlon NT, Kahramanoglu I, Azzopardi MJ, Dalmas M, Calleja N, Brincat MR, Muscat-Baron Y, Sabol M, Dimitrievska V, Dimitrievska V, Yordanov A, Vasileva-Slaveva M, von Brockdorff K, Micallef RA, Kubelac P, Achima"-Cadariu P, Vlad C, Tzortzatou O, Poka R, Giordano A, Felice A, Reed N, Herrington CS, Faraggi D, Faraggi D, Calleja-Agius J., GYNOCARE Update: Modern Strategies to Improve Diagnosis and Treatment of Rare Gynecologic Tumors"Current Challenges and Future Directions , Cancers, 13, (3), 2021, p493 , Journal Article, PUBLISHED  DOI
O'Toole SA, Huang Y, Norris L, Power Foley M, Shireen R, McDonald S, Kamran W, Ibrahim N, Ward M, Thompson C, Murphy C, D'Arcy T, Farah N, Heron E, O'Leary JJ, Abu Saadeh F, Gleeson N., HE4 and CA125 as preoperative risk stratifiers for lymph node metastasis in endometrioid carcinoma of the endometrium: A retrospective study in a cohort with histological proof of lymph node status., Gynecologic oncology, 2021, Journal Article, PUBLISHED  DOI
Kate McKendry Stephen Duff Yanmei Huang Mostafa Redha Áine Scanlon Feras Abu Saadeh Noreen Gleeson John O'Leary Lucy Norris Sharon O'Toole, The value of human epididymis 4, D‐dimer, and fibrinogen compared with CA 125 alone in triaging women presenting with pelvic masses: a retrospective cohort study, Acta Obstetricia et Gynecologica Scandinavica, 2021, Journal Article, PUBLISHED  URL
  

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O'Leary JJ, White C, Spillane C, Naik, P, O'Brien, R, Reynolds, S, Pham, T, Pilkington, L, Sharkey Ochoa, I, Bolger, N, Barry O'Crowley, J, Tewari, P, O'Toole, S, Sweeney, M, Keegan, H, Normand, C, Sharp, L, Flannelly, G, Martin, CM. , Cervical screening: A new way forward (tests of risk and tests of disease) [version 1; referees: 1 approved, 1 approved with reservations]., HRB Open Research, 1, (3), 2018, Journal Article, PUBLISHED
Ibrahim N, Norris L, O'Toole S, McHugh T, Gleeson N, Does extended thromboprophylaxis help reduce the incidence of venous thromboembolism in gynaecological cancer patients?, Thrombosis Research, 7th Internation Conference onal Thrombosis & Hemostatis Issues in Cancer,, Bergamo Italy, May 2014, edited by A Falanga, B. Brenner, F, Rickles , 133, (Suppl 2), Elsevier, 2014, Published Abstract, PUBLISHED
Laios A, O'Toole SA, Sheppard BL, Gleeson NC, D'Arcy T, McGuinness EPJ, Ring M, Sheils O, Smyth P, O'Leary JJ., Recurrent ovarian cancer cDNA signatures., Centenary Meeting of the Pathological Society of Great Britain and Ireland , Manchester, July 2006, 2006, Meeting Abstract, PRESENTED
CM Martin, K Astbury, R Henfrey, O Sheils, M Gallagher, C Heffron, C Logan, SA O'Toole, JJ O'Leary, miRNA expression signatures in cervical cancer, Journal of RNAi and Gene Silencing, RNAi2006: Advances in RNA Interference Research, St Anne's College, Oxford, United Kingdom, March 2006, 2, (2), 2006, Meeting Abstract, PUBLISHED
Laios A, O'Toole SA, Sheppard BL, Gleeson NC, D'Arcy T, McGuinness EPJ, Ring M, Sheils O, O'Leary JJ. (ed.), Irish Association for Cancer Research, Galway, Ireland, March 2006, 2006, Proceedings of a Conference, PRESENTED
A Laios, SA O'Toole, B Sheppard, N Gleeson, T D'Arcy, E PJ McGuinness, M Ring, O Sheils and JJ O'Leary. , Transcriptome profiling of primary and recurrent ovarian cancers, Junior Obstetrics and Gynaecology Society, Dublin, Nov 2005, 2005, Meeting Abstract, PRESENTED
O'Toole S, Laios A, Sheppard B, Smyth P, O'Regan E, Sheils O, O'Leary J. , Expression profiling of endometrial stromal cells treated with estradiol and phytoestrogens. , 20th European Congress of Pathology, Paris, Sept 2005, 2005, Meeting Abstract, PRESENTED
O'Toole SA, Laios A, Sheppard BL, Gleeson NC, D'Arcy T, Mc Guinness EPJ, Bonnar J, Sheils O, O'Leary JJ. , Angiogenesis markers in ovarian cancer act as prognostic markers but not indicators of chemotherapy response, Pathological Society of Great Britain and Ireland, Newcastle, UK, July 2005, 2005, Meeting Abstract, PRESENTED
O'Toole SA, Laios A, Sheppard BL, Gleeson NC, D'Arcy T, Mc Guinness EPJ, Bonnar J, Sheils O, O'Leary JJ. , Potential Predictors of Chemotherapy Response in Ovarian Cancer., Irish gynaecological oncology society, Belfast, 2005, 2005, Meeting Abstract, PRESENTED
O'Toole SA, Sheppard BL, D'Arcy T, Mc Guinness EPJ, Gleeson NC, Bonnar J, Sheils O, O'Leary JJ. , Angiogenesis in Ovarian Cancer does not predict response to chemotherapy., Irish Association for Cancer Research, Kilkenny, Ireland, March 2005, 2005, Meeting Abstract, PRESENTED

  

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Research Interests

Description Of Research Interests

-Early diagnostics in ovarian cancer -Chemoresistance in ovarian cancer Chemosensitivity/Resistance testing of malignant gynaecological tumours -Examination of Fibrinolytic systems of malignant gynaecological tumours -Examination of angiogenesis in ovarian cancers. -Examination of multidrug resistance genes in gynaecological tumours. -Estrogen regulated genes in endometrial cancer. -PhytoSERMs and Endometrial Cancer