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Professor Ross Mc Manus

Professor in Molecular Medicine (Clinical Medicine)

Professor in Molecular Medicine (Molecular Medicine Ireland)

  Autoimmunity   Chronic inflamation   Coeliac disease   GENE EXPRESSION ANALYSIS   GENE POLYMORPHISM   Genetic Analysis of Systemic Inflammatory Response Syndrome (SARS)   Genetic Mapping, Gene Sequence   Genetics   Genetics of inflammatory disease   Genomes, Genomics   Genomic structure and function, molecular approaches to gene function   Inflammatory bowel disease   Molecular Genetics   PSORIASIS   SEPSIS
Details Date
Member of Molecular Medicine Ireland (MMI) Education Committee 2003 - present
Council member, Irish Society of Human Genetics 2004 - 2008
Member, Scientific Committee, FINBAR, all-Ireland genetic epidemiology study of oesophageal cancer 2003-present
Member, PHG Funded PI's and Researchers, All Researchers funded under Cycle 3 PRTLI - Programme for Human Genomics
Member of LIPGENE WP1.1. Genetic association study of candidate genes in the Metabolic Syndrome in a large French cohort. 2004 - 2009
Member of Eurolife Network of European Universities in the Life Sciences Steering Committee 2005 - 2015
Chairperson of Eurolife Joint Educational Programme in Translational and Experimental Medicine 2008 - 2013
Coordinator, Eurolife Network 2009-2011
Details Date From Date To
American Society of Human Genetics 2003 present
Irish Society of Human Genetics 2001 present
European Society of Human Genetics 2005 present
Irish Society of Immunology 2008 present
Bowes J, Ashcroft J, Dand N, Jalali-najafabadi F, Bellou E, Ho P, Marzo-Ortega H, Helliwell P, Feletar M, Ryan A, Kane D, Korendowych E, Simpson M, Packham J, McManus R, Brown M, Smith C, Barker J, McHugh N, FitzGerald O, Warren R, Barton A. , Cross phenotype association mapping of the MHC identifies genetic variants that differentiate psoriatic arthritis from psoriasis , Annals of Rheumatic Diseases, 76, (10), 2017, p1774 - 1779, Journal Article, PUBLISHED  DOI
Radian S, Diekmann Y, Gabrovska P, Holland B, Bradley L, Wallace H, Stals K, Bussell AM, McGurren K, Cuesta M, Ryan AW, Herincs M, Hernández-Ramírez LC, Holland A, Samuels J, Aflorei ED, Barry S, Dénes J, Pernicova I, Stiles CE, Trivellin G, McCloskey R, Azjensztejn M, Abid N, Akker SA, Mercado M, Cohen M, Thakker RV, Baldeweg S, Barkan A, Musat M, Levy M, Orme S, Unterländer M, Burger J, Kumar AV, Ellard S, McPartlin J, McManus R, Linden GJ, Atkinson B, Balding D, Agha A, Thompson CJ, Hunter SJ, Thomas MG, Morrison PJ, Korbonits M., Increased Population Risk of AIP-related Acromegaly and Gigantism in Ireland, Human Mutation, 2017, p78-85 , Journal Article, PUBLISHED  TARA - Full Text  DOI
Dominguez Castro P, Harkin G, Hussey M, Christopher B, Kiat C, Chin JL, Trimble V, McNamara D, MacMathuna P, Egan B, Ryan B, Kevans D, Farrell R, Byrnes V, Mahmud N, McManus R. , Changes in Presentation of Celiac Disease in Ireland From the 1960s to 2015, Clinical Gastroenterology and Hepatology, 15, (1), 2017, p864 - 871, Journal Article, PUBLISHED  DOI
Budu-Aggrey A, Bowes J, Loehr S, Uebe S, Zervou M.I, Helliwell P, Ryan A.W, Kane D, Korendowych E, Giardina E, Packham J, McManus R, Fitzgerald O, McHugh N, Behrens F, Burkhardt H, Huffmeier U, Ho P, Martin J, Castañeda S, Goulielmos G, Reis A, Barton A, Replication of a distinct psoriatic arthritis risk variant at the IL23R locus, Annals of the Rheumatic Diseases, 75, (7), 2016, p1417 - 1418, Notes: [Export Date: 27 September 2016], Journal Article, PUBLISHED  TARA - Full Text  DOI  URL
Leahy T.R, McManus R, Doherty D.G, Grealy R, Carr M.J, Slattery D, Ryan T, Viral Bronchiolitis is Associated with Altered Cytokine Gene Expression and Lymphocyte Activation Status, Pediatric Infectious Disease Journal, 35, (11), 2016, pp e326-e338 , Journal Article, PUBLISHED  DOI  URL
Leahy TR, McManus R, Doherty DG, Grealy R, Coulter T, Smyth P, Blackshields G, Sheils O, Carr MJ, Purandare N, Geary M, Hodemaekers HM, Janssen R, Bont L, Slattery D, Ryan T, Interleukin-15 is associated with disease severity in viral bronchiolitis., The European respiratory journal, 47, (1), 2016, p212-22 , Journal Article, PUBLISHED  DOI
Coleman C, Quinn E.M, Ryan A.W, Conroy J, Trimble V, Mahmud N, Kennedy N, Corvin A.P, Morris D.W, Donohoe G, O'Morain C, MacMathuna P, Byrnes V, Kiat C, Trynka G, Wijmenga C, Kelleher D, Ennis S, Anney R.J.L, McManus R, Common polygenic variation in coeliac disease and confirmation of ZNF335 and NIFA as disease susceptibility loci, Molecular Psychiatry, 24, 2016, p291 - 297, Journal Article, PUBLISHED  TARA - Full Text  DOI  URL
Coleman C, Quinn EM, Ryan AW, Conroy J, Trimble V, Mahmud N, Kennedy N, Corvin AP, Morris DW, Donohoe G, O'Morain C, MacMathuna P, Byrnes V, Kiat C, Trynka G, Wijmenga C, Kelleher D, Ennis S, Anney RJ, McManus R., Common polygenic variation in coeliac disease and confirmation of ZNF335 and NIFA as disease susceptibility loci, European Journal of Human Genetics, 24, (2), 2016, p291 - 297, Notes: [doi: 10.1038/ejhg.2015.87 PMID: 25920553 ], Journal Article, PUBLISHED  DOI  Other
Candidate Gene Knockdown in Celiac Disease. in, Methods in Molecular Biology, 2015, pp159 - 173, [Molloy B, Freeley M, Long A, McManus R], Book Chapter, PUBLISHED  URL
Bowes, J. Budu-Aggrey, A. Huffmeier, U. Uebe, S. Steel, K. Hebert, H.L. Wallace, C. Massey, J. Bruce, I.N. Bluett, J. Feletar, M. Morgan, A.W. Marzo-Ortega, H. Donohoe, G. Morris, D.W. Helliwell, P. Ryan, A.W. Kane, D. Warren, R.B. Korendowych, E. Alenius, G.-M. Giardina, E. Packham, J. McManus, R. Fitzgerald, O. McHugh, N. Brown, M.A. Ho, P. Behrens, F. Burkhardt, H. Reis, A. Barton, A., Dense genotyping of immune-related susceptibility loci reveals new insights into the genetics of psoriatic arthritis, Nature Communications, 6, 2015, p6046-, Journal Article, PUBLISHED  TARA - Full Text  DOI  URL

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Feighery CF, McManus R, Recent advances in the genetic understanding of coeliac disease, Proceedings of the Nutrition Society, 68, 2009, p1 - 5, Journal Article, PUBLISHED
Kelleher D, McManus R., Mechanisms of steroid action and resistance in inflammatory bowel disease , Falk Symposia, 2005, Journal Article, PUBLISHED
Kelleher D, Farrell R, McManus R, Pharmacogenetics of inflammatory bowel disease, in 'Inflammatory bowel disease - crossroads between microbes, epithelium and immune systems' , Novartis Foundation Symposium , 263, 2004, Journal Article, PUBLISHED
McManus R, Kelleher D. , Celiac disease - the villain unmasked? , New England Journal of Medicine, 348, 2003, p2573 - 2574, Journal Article, PUBLISHED
McManus R, Mechanisms of Steroid Action and Resistance in Inflammation and Disease., Journal of Endocrinology, 178, (1), 2003, p1-4 , Notes: [(Invited meeting review). PMID: 12844329 ], Journal Article, PUBLISHED


Award Date
Wellcome Trust / Health Research Board 'New Blood' Fellowship 1998
Science Foundation Ireland Principal Investigator 2010
Fellow, Trinity College Dublin 2009
I am interested in the genetics/genomics of common diseases with an inflammatory component, particularly coeliac disease, inflammatory bowel disease and sepsis. We currently also have programmes into the genetic basis of psoriasis and oesophageal cancers in conjunction with collaborators nationwide and in Europe.