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Professor Ross McManus

Professor in Molecular Medicine (Clinical Medicine)
TRINITY CENTRE, S J H

Professor in Molecular Medicine (Molecular Medicine Ireland)

  Autoimmunity   Chronic inflamation   Coeliac disease   GENE EXPRESSION ANALYSIS   GENE POLYMORPHISM   Genetic Analysis of Systemic Inflammatory Response Syndrome (SARS)   Genetic Mapping, Gene Sequence   Genetics   Genetics of inflammatory disease   Genomes, Genomics   Genomic structure and function, molecular approaches to gene function   Inflammatory bowel disease   Molecular Genetics   PSORIASIS   SEPSIS
Details Date
Member of Molecular Medicine Ireland (MMI) Education Committee 2003 - present
Council member, Irish Society of Human Genetics 2004 - 2008
Member, Scientific Committee, FINBAR, all-Ireland genetic epidemiology study of oesophageal cancer 2003-present
Member, PHG Funded PI's and Researchers, All Researchers funded under Cycle 3 PRTLI - Programme for Human Genomics
Member of LIPGENE WP1.1. Genetic association study of candidate genes in the Metabolic Syndrome in a large French cohort. 2004 - 2009
Member of Eurolife Network of European Universities in the Life Sciences Steering Committee 2005 - present
Chairperson of Eurolife Joint Educational Programme in Translational and Experimental Medicine 2008 - present
Coordinator, Eurolife Network 2009-2011
Details Date From Date To
American Society of Human Genetics 2003 present
Irish Society of Human Genetics 2001 present
European Society of Human Genetics 2005 present
Irish Society of Immunology 2008 present
Apel M, Uebe S, Bowes J, Giardina E, Korendowych E, Juneblad K, Pasutto F, Ekici AB, McManus R, Ho P, Bruce IN, Ryan AW, Behrens F, Böhm B, Traupe H, Lohmann J, Gieger C, Wichmann HE, Padyukov L, Fitzgerald O, Alenius GM, McHugh NJ, Novelli G, Burkhardt H, Barton A, Reis A, Hüffmeier U., Variants in RUNX3 contribute to susceptibility to psoriatic arthritis exhibiting further common ground with ankylosing spondylitis, Arthritis & Rheumatism, 2013, p00-00 , Journal Article, PUBLISHED  DOI
Grealy, R., White, M., Stordeur, P., Kelleher, D., Doherty, D.G., McManus, R., Ryan, T., Characterising cytokine gene expression signatures in patients with severe sepsis, Mediators of Inflammation, 2013, 2013, part. no. 164246 , Notes: [ ], Journal Article, PUBLISHED  TARA - Full Text  DOI
Babar M, Ryan AW, Anderson LA, Segurado R, Turner G, Murray LJ, Murphy SJ, Johnston BT, Comber H, Reynolds JV, McManus R, Genes of the Interleukin-18 pathway are associated with susceptibility to Barrett's Esophagus and Esophageal Adenocarcinoma, American Journal of Gastroenterology, 107, (9), 2012, p1331-1341 , Notes: [PMID: 22664470], Journal Article, PUBLISHED  DOI
Catherine M Phillips, Emmanuelle Kesse-Guyot, Namanjeet Ahluwalia, Ross McManus, Serge Hercberg, Denis Lairon, Richard Planells, Helen M Roche, Dietary fat, abdominal obesity and smoking modulate the relationship between plasma complement component 3 concentrations and metabolic syndrome risk, Atherosclerosis, 220, (2), 2012, p513-519 , Journal Article, PUBLISHED  TARA - Full Text  DOI
Bowes J, Ho P, Flynn E, Marzo-Ortega H, UKRAG Consortium, Coates L, McManus R, Ryan A, Kane D, Korendowych E, McHugh N, FitzGerald O, Packham J, Morgan AW, Bruce IN, Barton A, Comprehensive assessment of rheumatoid arthritis susceptibility loci in a large psoriatic arthritis cohort, Annals of Rheumatic Diseases, 71, (8), 2012, p1350-1354 , Journal Article, ACCEPTED  DOI
Knight J, Spain SL, Capon F, Hayday A, Nestle FO, Clop A, Wellcome Trust Case Control Consortium, Genetic Analysis of Psoriasis Consortium§, I-chip for Psoriasis Consortium, Barker JN. Weale ME, Trembath RC, Conditional analysis identifies three novel major histocompatibility complex loci associated with psoriasis, Human Molecular Genetics, 21, (23), 2012, p5185 - 5192, Journal Article, PUBLISHED  TARA - Full Text  DOI
Su Z, Gay LJ, Strange A, Palles C, Band G, Whiteman DC, Lescai F, Langford C, Nanji M, Edkins S, van der Winkel A, Levine D, Sasieni P, Bellenguez C, Howarth K, Freeman C, Trudgill N, Tucker AT, Pirinen M, Peppelenbosch MP, van der Laan LJ, Kuipers EJ, Drenth JP, Peters WH, Reynolds JV, Kelleher DP, McManus R, Grabsch H, Prenen H, Bisschops R, Krishnadath K, Siersema PD, van Baal JW, Middleton M, Petty R, Gillies R, Burch N, Bhandari P, Paterson S, Edwards C, Penman I, Vaidya K, Ang Y, Murray I, Patel P, Ye W, Mullins P, Wu AH, Bird NC, Dallal H, Shaheen NJ, Murray LJ, Koss K, Bernstein L, Romero Y, Hardie LJ, Zhang R, Winter H, Corley DA, Panter S, Risch HA, Reid BJ, Sargeant I, Gammon MD, Smart H, Dhar A, McMurtry H, Ali H, Liu G, Casson AG, Chow WH, Rutter M, Tawil A, Morris D, Nwokolo C, Isaacs P, Rodgers C, Ragunath K, MacDonald C, Haigh C, Monk D, Davies G, Wajed S, Johnston D, Gibbons M, Cullen S, Church N, Langley R, Griffin M, Alderson D, Deloukas P, Hunt SE, Gray E, Dronov S, Potter SC, Tashakkori-Ghanbaria A, Anderson M, Brooks C, Blackwell JM, Bramon E, Brown MA, Casas JP, Corvin A, Duncanson A, Markus HS, Mathew CG, Palmer CN, Plomin R, Rautanen A, Sawcer SJ, Trembath RC, Viswanathan AC, Wood N, Trynka G, Wijmenga C, Cazier JB, Atherfold P, Nicholson AM, Gellatly NL, Glancy D, Cooper SC, Cunningham D, Lind T, Hapeshi J, Ferry D, Rathbone B, Brown J, Love S, Attwood S, MacGregor S, Watson P, Sanders S, Ek W, Harrison RF, Moayyedi P, de Caestecker J, Barr H, Stupka E, Vaughan TL, Peltonen L, Spencer CC, Tomlinson I, Donnelly P, Jankowski JA, Common variants at the MHC locus and at chromosome 16q24.1 predispose to Barrett's esophagus., Nature genetics, 44, (10), 2012, p1131-6 , Journal Article, PUBLISHED  DOI
Tsoi LC, Spain SL, Knight J, Ellinghaus E, Stuart PE, Capon F, Ding J, Li Y, Tejasvi T, Gudjonsson JE, Kang HM, Allen MH, McManus R, Novelli G, Samuelsson L, Schalkwijk J, Ståhle M, Burden AD, Smith CH, Cork MJ, Estivill X, Bowcock AM, Krueger GG, Weger W, Worthington J, Tazi-Ahnini R, Nestle FO, Hayday A, Hoffmann P, Winkelmann J, Wijmenga C, Langford C, Edkins S, Andrews R, Blackburn H, Strange A, Band G, Pearson RD, Vukcevic D, Spencer CC, Deloukas P, Mrowietz U, Schreiber S, Weidinger S, Koks S, Kingo K, Esko T, Metspalu A, Lim HW, Voorhees JJ, Weichenthal M, Wichmann HE, Chandran V, Rosen CF, Rahman P, Gladman DD, Griffiths CE, Reis A, Kere J, Nair RP, Franke A, Barker JN, Abecasis GR, Elder JT, Trembath RC, Identification of 15 new psoriasis susceptibility loci highlights the role of innate immunity., Nature genetics, 44, (12), 2012, p1341-1348 , Journal Article, PUBLISHED  DOI
Phillips CM, Kesse-Guyot E, McManus R, Hercberg S, Lairon D, Planells R, Roche HM, High dietary saturated fat intake accentuates obesity risk associated with the fat mass and obesity-associated gene in adults., The Journal of nutrition, 142, (5), 2012, p824-831 , Journal Article, PUBLISHED  DOI
Thomas Ryan, Mary White, Owen Ross McManus, Dermot Kelleher, Patrick Stordeur, Vincent Young, 'Cytokines as prognostic markers of respiratory-tract infection following major surgery', European Patent Agency, US Patent and Trademark Office, WO2010064223, 2012, Patent, GRANTED  Other
  

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Feighery CF, McManus R, Recent advances in the genetic understanding of coeliac disease, Proceedings of the Nutrition Society, 68, 2009, p1 - 5, Journal Article, PUBLISHED
Kelleher D, McManus R., Mechanisms of steroid action and resistance in inflammatory bowel disease , Falk Symposia, 2005, Journal Article, PUBLISHED
Kelleher D, Farrell R, McManus R, Pharmacogenetics of inflammatory bowel disease, in 'Inflammatory bowel disease - crossroads between microbes, epithelium and immune systems' , Novartis Foundation Symposium , 263, 2004, Journal Article, PUBLISHED
McManus R, Kelleher D. , Celiac disease - the villain unmasked? , New England Journal of Medicine, 348, 2003, p2573 - 2574, Journal Article, PUBLISHED
McManus R, Mechanisms of Steroid Action and Resistance in Inflammation and Disease., Journal of Endocrinology, 178, (1), 2003, p1-4 , Notes: [(Invited meeting review). PMID: 12844329 ], Journal Article, PUBLISHED

  

Award Date
Wellcome Trust / Health Research Board 'New Blood' Fellowship 1998
Fellow, Trinity College Dublin 2009
Science Foundation Ireland Principal Investigator 2010
I am interested in the genetics/genomics of common diseases with an inflammatory component, particularly coeliac disease, inflammatory bowel disease and sepsis. We currently also have programmes into the genetic basis of psoriasis and oesophageal cancers in conjunction with collaborators nationwide and in Europe.