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Professor Padraic Fallon

Professor of Translational Immunology (Clinical Medicine)

Interim IMM Director (Molecular Medicine Ireland)


Professor Padraic Fallon heads the Translational Immunology Group. Prof Fallon is the Science Foundation Ireland Stokes Professor in Translational Immunology in the School of Medicine, TCD. Previously, Fallon was a Wellcome Trust Fellow in the University of Cambridge, UK, investigating immune modulation by schistosomes. Since returning to Ireland in 2001, he has continued his research, elucidating underlying mechanisms of aberrant immune function and novel therapeutic strategies for inflammatory diseases. The main diseases addressed are allergic lung inflammation (asthma), skin inflammation (eczema) and inflammatory bowel disease (ulcerative colitis and Crohn's disease). Fallon is the Director of the Paediatric Research in Translational Immunology (PRiTI) Programme, a strategic partnership between Trinity College Dublin and the National Children's Research Centre http://www.nationalchildrensresearchcentre.ie/ The PRiTI programme bridges basic and clinician scientists and focuses on the underlying inflammatory processes associated with a number of childhood diseases. Prof Fallon is also the current Director of Research for the School of Medicine.
  Allergies   ALLERGY   Animal Models   ANIMAL-MODELS   Asthma   CYTOKINE RESPONSES   DISEASE MODELS   EXPERIMENTAL COLITIS   Helminths   Immunotherapies   INFECTION   Inflammatory Bowel Disease   MATERNAL-FETAL INTERFACE   Parasites   Transgenic Mice
Fallon, P.G. and Lavin, M. and O'Donnell, J.S., SIPPET: insights into factor VIII immunogenicity, Journal of Thrombosis and Haemostasis, 16, (1), 2018, p36-38 , Notes: [cited By 0], Journal Article, PUBLISHED  DOI
Gaya M, Barral P, Burbage M, Aggarwal S, Montaner B, Warren Navia A, Aid M, Tsui C, Maldonado P, Nair U, Ghneim K, Fallon PG, Sekaly RP, Barouch DH, Shalek AK, Bruckbauer A, Strid J, Batista FD., Initiation of Antiviral B Cell Immunity Relies on Innate Signals from Spatially Positioned NKT Cells., Cell, 172, (3), 2018, p517-533.e20 , Journal Article, PUBLISHED  TARA - Full Text  DOI
Schwartz, C., Hams, E., Fallon, P.G. , Helminth Modulation of Lung Inflammation, Trends in Parasitology, 2018, Journal Article, PUBLISHED  TARA - Full Text  DOI
Mills, E.L. and Ryan, D.G. and Prag, H.A. and Dikovskaya, D. and Menon, D. and Zaslona, Z. and Jedrychowski, M.P. and Costa, A.S.H. and Higgins, M. and Hams, E. and Szpyt, J. and Runtsch, M.C. and King, M.S. and McGouran, J.F. and Fischer, R. and Kessler, B.M. and McGettrick, A.F. and Hughes, M.M. and Carroll, R.G. and Booty, L.M. and Knatko, E.V. and Meakin, P.J. and Ashford, M.L.J. and Modis, L.K. and Brunori, G. and Sévin, D.C. and Fallon, P.G. and Caldwell, S.T. and Kunji, E.R.S. and Chouchani, E.T. and Frezza, C. and Dinkova-Kostova, A.T. and Hartley, R.C. and Murphy, M.P. and O'Neill, L.A., Itaconate is an anti-inflammatory metabolite that activates Nrf2 via alkylation of KEAP1, Nature, 556, (7699), 2018, p113-117 , Journal Article, PUBLISHED  DOI
Neill, D.R. and Fallon, P.G., Innate lymphoid cells and parasites: Ancient foes with shared history, Parasite Immunology, 40, (2), 2018, Notes: [cited By 0], Journal Article, PUBLISHED  DOI
Vandeghinste, N. and Klattig, J. and Jagerschmidt, C. and Lavazais, S. and Marsais, F. and Haas, J.D. and Auberval, M. and Lauffer, F. and Moran, T. and Ongenaert, M. and Van Balen, M. and Dupont, S. and Lepescheux, L. and Garcia, T. and HÀrtle, S. and Eyerich, K. and Fallon, P.G. and Brys, R. and Steidl, S., Neutralization of IL-17C Reduces Skin Inflammation in Mouse Models of Psoriasis and Atopic Dermatitis, Journal of Investigative Dermatology, 2018, Notes: [cited By 0; Article in Press], Journal Article, PUBLISHED  DOI
Oleszycka E, McCluskey S, Sharp FA, Muñoz-Wolf N, Hams E, Gorman AL, Fallon PG, Lavelle EC., The vaccine adjuvant alum promotes IL-10 production that suppresses Th1 responses., Eur J Immunol., 2018, 705-715 , Notes: [ ], Journal Article, PUBLISHED  DOI
Cooke G, Kamal I, Strengert M, Hams E, Mawhinney L, Tynan A, O' Reilly C, O' Dwyer DN, Kunkel SL, Knaus UG, Shields DC, Moller DR, Bowie AG, Fallon PG, Hogaboam CM, Armstrong ME, Donnelly SC., Toll-like receptor 3 L412F polymorphism promotes a persistent clinical phenotype in pulmonary sarcoidosis., QJM, 2018, p217-224 , Journal Article, PUBLISHED  URL
Halim, T.Y.F. and Rana, B.M.J. and Walker, J.A. and Kerscher, B. and Knolle, M.D. and Jolin, H.E. and Serrao, E.M. and Haim-Vilmovsky, L. and Teichmann, S.A. and Rodewald, H.-R. and Botto, M. and Vyse, T.J. and Fallon, P.G. and Li, Z. and Withers, D.R. and McKenzie, A.N.J., Tissue-Restricted Adaptive Type 2 Immunity Is Orchestrated by Expression of the Costimulatory Molecule OX40L on Group 2 Innate Lymphoid Cells, Immunity, 2018, Notes: [cited By 0; Article in Press], Journal Article, PUBLISHED  DOI
Kennedy, E.A., Connolly, J., Hourihane, J.O., Fallon, P.G., McLean, W.H.I., Murray, D., Jo, J.-H., Segre, J.A., Kong, H.H., Irvine, A.D., Skin microbiome before development of atopic dermatitis: Early colonization with commensal staphylococci at 2 months is associated with a lower risk of atopic dermatitis at 1 year, Journal of Allergy and Clinical Immunology, 139, (1), 2017, p166-172 , Journal Article, PUBLISHED  TARA - Full Text  DOI
  

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Award Date
Member Royal Irish Academy (MRIA) 2014
Fellow Trinity College Dublin (FTCD) 2009
Stokes Professorship from Science Foundation Ireland. 2008
My research involves two overlapping translational immunology themes. i. The use of mouse models to study pathogen modulation of human inflammatory diseases. ii. Immune phenotyping of patients, in particular children, with inflammatory diseases such as atopic dermatitis and pulmonary fibrosis. Research aims to elucidate new mechanism of modulation of immunity that can alter inflammation and have therapeutic potential. Collaborative activity involves the phenotyping of new transgenic mice. The main diseases addressed are allergic lung and skin inflammation and inflammatory bowel disease. A growing emphasis is applying extensive expertise in animal models of human inflammatory diseases and general pathophysiology of inflammation to functional analysis of new therapeutic molecules/strategies with clinical collaborators and Pharma.