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Professor Padraic Fallon

Professor of Translational Immunology (Clinical Medicine)

 pfallon@tcd.ie

 3531896 3297

Interim IMM Director (Molecular Medicine Ireland)


Biography

Professor Padraic Fallon heads the Translational Immunology Group. Prof Fallon is Professor of Translational Immunology in the School of Medicine, TCD. Previously, Fallon was a Wellcome Trust Fellow in the University of Cambridge, UK, investigating immune modulation by schistosomes. Since returning to Ireland in 2001, he has continued his research, elucidating underlying mechanisms of aberrant immune function and novel therapeutic strategies for inflammatory diseases. The main diseases addressed are allergic lung inflammation (asthma), skin inflammation (eczema), inflammatory bowel disease (ulcerative colitis and Crohn's disease).,as well as haemophilia . Since 2007, Prof Fallon has generated over €13 million of funding as Principal Investigator supporting research programmes on inflammatory diseases, clinical immunology and infections (helminths and COVID-19). The main diseases addressed are fibrotic disorders, allergic lung and skin inflammation, inflammatory bowel disease and haemophilia. The research on inflammatory diseases is across the human lifespan; from studies on skin diseases in infants, asthma in adults to the metabolic syndrome in the elderly. Prof Fallon has delivered a number of seminal discoveries across the field of immunology. He is an author of ~220 papers peer-reviwed publications in the leading scientifc journals. Fallon and Luke O"Neill, also Trinity College, are the only scientists in Ireland that have been ranked in top 1% of scientists in the world by citations for publications from 2018-2022 in immunology (Clarivate Analytics).

Research Tags

  Allergies   ALLERGY   Animal Models   ANIMAL-MODELS   Asthma   CYTOKINE RESPONSES   DISEASE MODELS   EXPERIMENTAL COLITIS   Helminths   Immunotherapies   INFECTION   Inflammatory Bowel Disease   MATERNAL-FETAL INTERFACE   Parasites   Transgenic Mice
Yin M, Wadhwa R, Marshall JE, Gillis CM, Kim RY, Dua K, Palsson-McDermott EM, Fallon PG, Hansbro PM, O'Neill LAJ., 4-Octyl Itaconate Alleviates Airway Eosinophilic Inflammation by Suppressing Chemokines and Eosinophil Development., Journal of immunology (Baltimore, Md. : 1950), 212, (1), 2024, p13-23 , Journal Article, PUBLISHED  DOI
Klement JD, Redd PS, Lu C, Merting AD, Poschel DB, Yang D, Savage NM, Zhou G, Munn DH, Fallon PG, Liu K., Tumor PD-L1 engages myeloid PD-1 to suppress type I interferon to impair cytotoxic T lymphocyte recruitment., Cancer cell, 41, (3), 2023, p620-636.e9 , Journal Article, PUBLISHED  DOI
Einas Elsheikh, Michelle Lavin, Lilian Antunes Heck, Niamh Larkin, Brendan Mullaney, Dearbhla Doherty, Megan Kennedy, Catriona Keenan, Thomas Guest, Brian O'Mahony, Judicael Fazavana, Padraic G. Fallon, Roger J.S. Preston, John Gormley, Kevin Ryan, Niamh M. O'Connell, Evelyn Singleton, Mary Byrne, Mark McGowan, Sheila Roche, Mairead Doyle, Maeve P. Crowley, Susan I. O'Shea, Birgit M. Reipert, Jill M. Johnsen, Steven W. Pipe, Jorge Di Paola, Peter L. Turecek, James S. O'Donnell, Heterogeneity in the half-life of factor VIII concentrate in patients with hemophilia A is due to variability in the clearance of endogenous von Willebrand factor, Journal of Thrombosis and Haemostasis, 2023, Journal Article, PUBLISHED  DOI
Ward SE, Guest T, Byrne C, Lopes P, O'Sullivan JM, Doherty D, O'Connell D, Gutierrez Llaneza S, Chion A, Fazavana J, Fallon PG, Preston RJS, Johnsen JM, Pipe SW, Turecek PL, O'Donnell JS, iPATH Study Group., Macrophage Galactose Lectin Contributes to the Regulation of FVIII (Factor VIII) Clearance in Mice-Brief Report., Arteriosclerosis, thrombosis, and vascular biology, 43, (4), 2023, p540-546 , Journal Article, PUBLISHED  DOI
Dietschmann A, Ruhl A, Murray PJ, Günther C, Becker C, Fallon P, Voehringer D., Th2-dependent disappearance and phenotypic conversion of mouse alveolar macrophages., European journal of immunology, 53, (10), 2023, pe2350475 , Journal Article, PUBLISHED  DOI
Lavazais S, Jargosch M, Dupont S, Labéguère F, Menet C, Jagerschmidt C, Ohm F, Kupcsik L, Parent I, Cottereaux C, Marsais F, Oste L, Van de Water A, Christophe T, De Vos S, Fallon P, Lauffer F, Clément-Lacroix P, Eyerich K, Brys R., IRAK4 inhibition dampens pathogenic processes driving inflammatory skin diseases., Science translational medicine, 15, (683), 2023, peabj3289 , Journal Article, PUBLISHED  DOI
Runtsch, M.C. and Angiari, S. and Hooftman, A. and Wadhwa, R. and Zhang, Y. and Zheng, Y. and Spina, J.S. and Ruzek, M.C. and Argiriadi, M.A. and McGettrick, A.F. and Mendez, R.S. and Zotta, A. and Peace, C.G. and Walsh, A. and Chirillo, R. and Hams, E. and Fallon, P.G. and Jayamaran, R. and Dua, K. and Brown, A.C. and Kim, R.Y. and Horvat, J.C. and Hansbro, P.M. and Wang, C. and O'Neill, L.A.J., Itaconate and itaconate derivatives target JAK1 to suppress alternative activation of macrophages, Cell Metabolism, 34, (3), 2022, p487-501.e8 , Notes: [cited By 0], Journal Article, PUBLISHED  DOI
Matarazzo, L. and Hernandez Santana, Y.E. and Walsh, P.T. and Fallon, P.G., The IL-1 cytokine family as custodians of barrier immunity, Cytokine, 154, (155890), 2022, Notes: [cited By 0], Journal Article, PUBLISHED  DOI
Kevin McCarthy, Eamon Laird, Aisling M. O"Halloran, Cathal Walsh, Martin Healy, Annette L. Fitzpatrick, James B. Walsh, Belinda Hernandez, Padraic Fallon, Anne Molloy, Rose Anne Kenny, Association between vitamin D deficiency and the risk of prevalent type 2 diabetes and incident prediabetes: A prospective cohort study using data from The Irish Longitudinal Study on Ageing (TILDA), eClinical Medicine, 53, 2022, p101654 , Journal Article, PUBLISHED
McElroy AN, Invernizzi R, Laskowska JW, O'Neill A, Doroudian M, Moghoofei M, Mostafaei S, Li F, Przybylski AA, O'Dwyer DN, Bowie AG, Fallon PG, Maher TM, Hogaboam CM, Molyneaux PL, Hirani N, Armstrong ME, Donnelly SC., Candidate Role for Toll-like Receptor 3 L412F Polymorphism and Infection in Acute Exacerbation of Idiopathic Pulmonary Fibrosis., American journal of respiratory and critical care medicine, 2022, Journal Article, PUBLISHED  DOI
  

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Awards and Honours

Award Date
Member Royal Irish Academy (MRIA) 2014
Stokes Professorship from Science Foundation Ireland. 2008
Fellow Trinity College Dublin (FTCD) 2009

Research Interests

Description Of Research Interests

My research involves two overlapping translational immunology themes. i. The use of mouse models to study pathogen modulation of human inflammatory diseases. ii. Immune phenotyping of patients, in particular children, with inflammatory diseases such as atopic dermatitis and pulmonary fibrosis. Research aims to elucidate new mechanism of modulation of immunity that can alter inflammation and have therapeutic potential. Collaborative activity involves the phenotyping of new transgenic mice. The main diseases addressed are allergic lung and skin inflammation and inflammatory bowel disease. A growing emphasis is applying extensive expertise in animal models of human inflammatory diseases and general pathophysiology of inflammation to functional analysis of new therapeutic molecules/strategies with clinical collaborators and Pharma.