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Professor Padraic Fallon

Professor of Translational Immunology (Clinical Medicine)
BIOMEDICAL SCIENCES INSTITUTE

Interim IMM Director (Molecular Medicine Ireland)


Professor Padraic Fallon heads the Translational Immunology Group. Prof Fallon is the Science Foundation Ireland Stokes Professor in Translational Immunology in the School of Medicine, TCD. Previously, Fallon was a Wellcome Trust Fellow in the University of Cambridge, UK, investigating immune modulation by schistosomes. Since returning to Ireland in 2001, he has continued his research, elucidating underlying mechanisms of aberrant immune function and novel therapeutic strategies for inflammatory diseases. The main diseases addressed are allergic lung inflammation (asthma), skin inflammation (eczema) and inflammatory bowel disease (ulcerative colitis and Crohn's disease). Fallon is the Director of the Paediatric Research in Translational Immunology (PRiTI) Programme, a strategic partnership between Trinity College Dublin and the National Children's Research Centre http://www.nationalchildrensresearchcentre.ie/ The PRiTI programme bridges basic and clinician scientists and focuses on the underlying inflammatory processes associated with a number of childhood diseases. Prof Fallon is also the current Director of Research for the School of Medicine.
  Allergies   ALLERGY   Animal Models   ANIMAL-MODELS   Asthma   CYTOKINE RESPONSES   DISEASE MODELS   EXPERIMENTAL COLITIS   Helminths   Immunotherapies   INFECTION   Inflammatory Bowel Disease   MATERNAL-FETAL INTERFACE   Parasites   Transgenic Mice
Khan AR, Hams E, Floudas A, Sparwasser T, Weaver CT, Fallon PG, PD-L1(hi) B cells are critical regulators of humoral immunity., Nature communications, 6, 2015, p5997 , Journal Article, PUBLISHED  DOI
Saunders SP, Moran T, Floudas A, Wurlod F, Kaszlikowska A, Salimi M, Quinn EM, Oliphant CJ, Núñez G, McManus R, Hams E, Irvine AD, McKenzie AN, Ogg GS, Fallon PG, Spontaneous atopic dermatitis is mediated by innate immunity, with the secondary lung inflammation of the atopic march requiring adaptive immunity., Journal of Allergy and Clinical Immunology, 2015, p10.1016/j.jaci.2015.06.045. , Journal Article, IN_PRESS  DOI
Cluxton, C.D., Caffrey, B.E., Kinsella, G.K., (...), Fares, M.A., Fallon, P.G., Functional conservation of an ancestral Pellino protein in helminth species, Scientific Reports, 5, 2015, p11687-, Journal Article, PUBLISHED  TARA - Full Text  DOI
Walker JA, Oliphant CJ, Englezakis A, Yu Y, Clare S, Rodewald HR, Belz G, Liu P, Fallon PG, McKenzie AN, Bcl11b is essential for group 2 innate lymphoid cell development, The Journal of Experimental Medicine, 212 , (6), 2015, - , Journal Article, PUBLISHED  DOI
Barr MP, Gray SG, Gately K, Hams E, Fallon PG, Davies AM, Richard DJ, Pidgeon GP, O'Byrne KJ., Vascular endothelial growth factor is an autocrine growth factor, signaling through neuropilin-1 in non-small cell lung cancer, Molecular Cancer, ( ), 2015, p0.1186/s12943-015-0310-8 , Journal Article, PUBLISHED  DOI
Khan AR, Amu S, Saunders SP, Hams E, Blackshields G, Leonard MO, Weaver CT, Sparwasser T, Sheils O, Fallon PG., Ligation of TLR7 on CD19(+) CD1d(hi) B cells suppresses allergic lung inflammation via regulatory T cells., European Journal of Immunology, 2015, Journal Article, PUBLISHED  DOI
MacLeod AK, Fallon PG, Sharp S, Henderson CJ, Wolf CR, Huang JT., An enhanced in vivo stable isotope labeling by amino acids in cell culture (SILAC) model for quantification of drug metabolism enzymes., Molecular & Cellular Proteomics, 2015, Journal Article, PUBLISHED  DOI
Saunders SP, Moran T, Floudas A, Wurlod F, Kaszlikowska A, Salimi M, Quinn EM, Oliphant CJ, Núñez G, McManus R, Hams E, Irvine AD, McKenzie AN, Ogg GS, Fallon PG, Spontaneous atopic dermatitis is mediated by innate immunity, with the secondary lung inflammation of the atopic march requiring adaptive immunity., The Journal of allergy and clinical immunology, 2015, Journal Article, PUBLISHED  TARA - Full Text  DOI
Schiering C, Krausgruber T, Chomka A, Fröhlich A, Adelmann K, Wohlfert EA, Pott J, Griseri T, Bollrath J, Hegazy AN, Harrison OJ, Owens BM, Löhning M, Belkaid Y, Fallon PG, Powrie F., The alarmin IL-33 promotes regulatory T-cell function in the intestine., Nature, Jul 16, 2014, Journal Article, PUBLISHED  TARA - Full Text  DOI
Oliphant CJ, Hwang YY, Walker JA, Salimi M, Wong SH, Brewer JM, Englezakis A, Barlow JL, Hams E, Scanlon ST, Ogg GS, Fallon PG, McKenzie AN., MHCII-Mediated Dialog between Group 2 Innate Lymphoid Cells and CD4(+) T Cells Potentiates Type 2 Immunity and Promotes Parasitic Helminth Expulsion., Immunity, 41, 2014, p283 - 295, Journal Article, PUBLISHED  TARA - Full Text  Other
  

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Award Date
Member Royal Irish Academy (MRIA) 2014
Fellow Trinity College Dublin (FTCD) 2009
Stokes Professorship from Science Foundation Ireland. 2008
My research involves two overlapping translational immunology themes. i. The use of mouse models to study pathogen modulation of human inflammatory diseases. ii. Immune phenotyping of patients, in particular children, with inflammatory diseases such as atopic dermatitis and pulmonary fibrosis. Research aims to elucidate new mechanism of modulation of immunity that can alter inflammation and have therapeutic potential. Collaborative activity involves the phenotyping of new transgenic mice. The main diseases addressed are allergic lung and skin inflammation and inflammatory bowel disease. A growing emphasis is applying extensive expertise in animal models of human inflammatory diseases and general pathophysiology of inflammation to functional analysis of new therapeutic molecules/strategies with clinical collaborators and Pharma.