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Professor Padraic Fallon

Professor of Translational Immunology (Clinical Medicine)
BIOMEDICAL SCIENCES INSTITUTE

Interim IMM Director (Molecular Medicine Ireland)


Professor Padraic Fallon heads the Translational Immunology Group. Prof Fallon is the Science Foundation Ireland Stokes Professor in Translational Immunology in the School of Medicine, TCD. Previously, Fallon was a Wellcome Trust Fellow in the University of Cambridge, UK, investigating immune modulation by schistosomes. Since returning to Ireland in 2001, he has continued his research, elucidating underlying mechanisms of aberrant immune function and novel therapeutic strategies for inflammatory diseases. The main diseases addressed are allergic lung inflammation (asthma), skin inflammation (eczema) and inflammatory bowel disease (ulcerative colitis and Crohn's disease). Fallon is the Director of the Paediatric Research in Translational Immunology (PRiTI) Programme, a strategic partnership between Trinity College Dublin and the National Children's Research Centre http://www.nationalchildrensresearchcentre.ie/ The PRiTI programme bridges basic and clinician scientists and focuses on the underlying inflammatory processes associated with a number of childhood diseases. Prof Fallon is also the current Director of Research for the School of Medicine.
  Allergies   ALLERGY   Animal Models   ANIMAL-MODELS   Asthma   CYTOKINE RESPONSES   DISEASE MODELS   EXPERIMENTAL COLITIS   Helminths   Immunotherapies   INFECTION   Inflammatory Bowel Disease   MATERNAL-FETAL INTERFACE   Parasites   Transgenic Mice
Schiering C, Krausgruber T, Chomka A, Fröhlich A, Adelmann K, Wohlfert EA, Pott J, Griseri T, Bollrath J, Hegazy AN, Harrison OJ, Owens BM, Löhning M, Belkaid Y, Fallon PG, Powrie F., The alarmin IL-33 promotes regulatory T-cell function in the intestine., Nature, Jul 16, 2014, Journal Article, PUBLISHED  DOI
Oliphant CJ, Hwang YY, Walker JA, Salimi M, Wong SH, Brewer JM, Englezakis A, Barlow JL, Hams E, Scanlon ST, Ogg GS, Fallon PG, McKenzie AN., MHCII-Mediated Dialog between Group 2 Innate Lymphoid Cells and CD4(+) T Cells Potentiates Type 2 Immunity and Promotes Parasitic Helminth Expulsion., Immunity, 41, 2014, p283 - 295, Journal Article, PUBLISHED  Other
Doyle, SL, Ozaki, E, Brennan, K, Humphries, MM, Mulfaul, K, Keaney, J, Kenna, PF, Maminishkis, A, Kiang, AS, Saunders, SP, Hams, E, Lavelle, EC, Gardiner, C, Fallon, PG, Adamson, P, Humphries, P, Campbell, M, IL-18 Attenuates Experimental Choroidal Neovascularization as a Potential Therapy for Wet Age-Related Macular Degeneration, SCIENCE TRANSLATIONAL MEDICINE, 6, 2014, p230-, Journal Article, PUBLISHED  DOI
Linehan E, Dombrowski Y, Snoddy R, Fallon PG, Kissenpfennig A, Fitzgerald DC., Aging impairs peritoneal but not bone marrow-derived macrophage phagocytosis., Aging Cell, 14, 2014, p69 - 708, Journal Article, PUBLISHED  DOI
Aviello G, Corr SC, Johnston DG, O'Neill LA, Fallon PG., MyD88 adaptor-like (Mal) regulates intestinal homeostasis and colitis-associated colorectal cancer in mice. , Am J Physiol Gastrointest Liver Physiol., 306, 2014, pG769 - G778, Journal Article, PUBLISHED  DOI
Khan AR, Amu S, Saunders SP, Fallon PG, The generation of regulatory B cells by helminth parasites., Methods in molecular biology (Clifton, N.J.), 1190, 2014, p143-62 , Journal Article, PUBLISHED  DOI
Ní Gabhann J, Hams E, Smith S, Wynne C, Byrne JC, Brennan K, Spence S, Kissenpfennig A, Johnston JA, Fallon PG, Jefferies CA., Btk regulates macrophage polarization in response to lipopolysaccharide., PloS One, 21, 2014, pe85834. , Journal Article, PUBLISHED  DOI
Hams E, Armstrong ME, Barlow JL, Saunders SP, Schwartz C, Cooke G, Fahy RJ, Crotty TB, Hirani N, Flynn RJ, Voehringer D, McKenzie AN, Donnelly SC, Fallon PG, IL-25 and type 2 innate lymphoid cells induce pulmonary fibrosis., Proceedings of the National Academy of Sciences of the United States of America, 111, (1), 2014, p367-72 , Journal Article, PUBLISHED  DOI
Corr, S.C., Palsson-Mcdermott, E.M., Grishina, I., Barry, S.P., Aviello, G., Bernard, N.J., Casey, P.G., Ward, J.B.J., Keely, S.J., Dandekar, S., Fallon, P.G., O'Neill, L.A.J., MyD88 adaptor-like (Mal) functions in the epithelial barrier and contributes to intestinal integrity via protein kinase C, Mucosal Immunology, 7, (1), 2014, p57-67 , Journal Article, PUBLISHED  DOI
Gleeson EM, O'Donnell JS, Hams E, Ni Ainle F, Kenny BA, Fallon PG, Preston RJ. , Activated Factor X signaling via protease-activated receptor 2 suppresses pro-inflammatory cytokine prodution from LPS-stimulated myeloid cells., Haematologica, 99, (1), 2014, p185 - 193, Journal Article, PUBLISHED  DOI
  

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Award Date
Member Royal Irish Academy (MRIA) 2014
Fellow Trinity College Dublin (FTCD) 2009
Stokes Professorship from Science Foundation Ireland. 2008
My research involves two overlapping translational immunology themes. i. The use of mouse models to study pathogen modulation of human inflammatory diseases. ii. Immune phenotyping of patients, in particular children, with inflammatory diseases such as atopic dermatitis and pulmonary fibrosis. Research aims to elucidate new mechanism of modulation of immunity that can alter inflammation and have therapeutic potential. Collaborative activity involves the phenotyping of new transgenic mice. The main diseases addressed are allergic lung and skin inflammation and inflammatory bowel disease. A growing emphasis is applying extensive expertise in animal models of human inflammatory diseases and general pathophysiology of inflammation to functional analysis of new therapeutic molecules/strategies with clinical collaborators and Pharma.