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Professor Padraic Fallon

Professor of Translational Immunology (Clinical Medicine)

Interim IMM Director (Molecular Medicine Ireland)


Professor Padraic Fallon heads the Translational Immunology Group. Prof Fallon is the Science Foundation Ireland Stokes Professor in Translational Immunology in the School of Medicine, TCD. Previously, Fallon was a Wellcome Trust Fellow in the University of Cambridge, UK, investigating immune modulation by schistosomes. Since returning to Ireland in 2001, he has continued his research, elucidating underlying mechanisms of aberrant immune function and novel therapeutic strategies for inflammatory diseases. The main diseases addressed are allergic lung inflammation (asthma), skin inflammation (eczema) and inflammatory bowel disease (ulcerative colitis and Crohn's disease). Fallon is the Director of the Paediatric Research in Translational Immunology (PRiTI) Programme, a strategic partnership between Trinity College Dublin and the National Children's Research Centre http://www.nationalchildrensresearchcentre.ie/ The PRiTI programme bridges basic and clinician scientists and focuses on the underlying inflammatory processes associated with a number of childhood diseases. Prof Fallon is also the current Director of Research for the School of Medicine.
  Allergies   ALLERGY   Animal Models   ANIMAL-MODELS   Asthma   CYTOKINE RESPONSES   DISEASE MODELS   EXPERIMENTAL COLITIS   Helminths   Immunotherapies   INFECTION   Inflammatory Bowel Disease   MATERNAL-FETAL INTERFACE   Parasites   Transgenic Mice
Senra L, Mylonas A, Kavanagh R.D, Fallon P.G, Conrad C, Borowczyk-Michalowska J, Wrobel L.J, Kaya G, Yawalkar N, Boehncke W.-H, Brembilla N.C, IL-17E (IL-25) Enhances Innate Immune Responses during Skin Inflammation, Journal of Investigative Dermatology, 2019, Journal Article, PUBLISHED  DOI  URL
Schwartz C, Moran T, Saunders S.P, Kaszlikowska A, Floudas A, Bom J, Nunez G, Iwakura Y, O†Neill L, Irvine A.D, McKenzie A.N.J, Ogg G, Walsh P.T, Demengeot J, Fallon P.G, Spontaneous atopic dermatitis in mice with a defective skin barrier is independent of ILC2 and mediated by IL-1β, Allergy: European Journal of Allergy and Clinical Immunology, 2019, Journal Article, PUBLISHED  DOI  URL
de Gaetano M, Butler E, Gahan K, Zanetti A, Marai M, Chen J, Cacace A, Hams E, Maingot C, McLoughlin A, Brennan E, Leroy X, Loscher CE, Fallon P, Perretti M, Godson C, Guiry PJ., Asymmetric synthesis and biological evaluation of imidazole- and oxazole-containing synthetic lipoxin A4 mimetics (sLXms)., Eur J Med Chem, 162, 2019, p80 - 108, Journal Article, PUBLISHED  DOI
Nanda S.K, Nagamori T, Windheim M, Amu S, Aviello G, Patterson-Kane J, Simon C. Arthur J, Ley S.C, Fallon P, Prof P.C, Abin2 function is required to suppress DSS-induced colitis by a TPL2-independent mechanism, Journal of Immunology, 201, (11), 2018, p3373 - 3382, Journal Article, PUBLISHED  DOI  URL
Fallon, P.G. and Lavin, M. and O'Donnell, J.S., SIPPET: insights into factor VIII immunogenicity, Journal of Thrombosis and Haemostasis, 16, (1), 2018, p36-38 , Notes: [cited By 0], Journal Article, PUBLISHED  DOI
Gaya M, Barral P, Burbage M, Aggarwal S, Montaner B, Warren Navia A, Aid M, Tsui C, Maldonado P, Nair U, Ghneim K, Fallon PG, Sekaly RP, Barouch DH, Shalek AK, Bruckbauer A, Strid J, Batista FD., Initiation of Antiviral B Cell Immunity Relies on Innate Signals from Spatially Positioned NKT Cells., Cell, 172, (3), 2018, p517-533.e20 , Journal Article, PUBLISHED  TARA - Full Text  DOI
Schwartz, C., Hams, E., Fallon, P.G. , Helminth Modulation of Lung Inflammation, Trends in Parasitology, 2018, Journal Article, PUBLISHED  TARA - Full Text  DOI
Mills, E.L. and Ryan, D.G. and Prag, H.A. and Dikovskaya, D. and Menon, D. and Zaslona, Z. and Jedrychowski, M.P. and Costa, A.S.H. and Higgins, M. and Hams, E. and Szpyt, J. and Runtsch, M.C. and King, M.S. and McGouran, J.F. and Fischer, R. and Kessler, B.M. and McGettrick, A.F. and Hughes, M.M. and Carroll, R.G. and Booty, L.M. and Knatko, E.V. and Meakin, P.J. and Ashford, M.L.J. and Modis, L.K. and Brunori, G. and Sévin, D.C. and Fallon, P.G. and Caldwell, S.T. and Kunji, E.R.S. and Chouchani, E.T. and Frezza, C. and Dinkova-Kostova, A.T. and Hartley, R.C. and Murphy, M.P. and O'Neill, L.A., Itaconate is an anti-inflammatory metabolite that activates Nrf2 via alkylation of KEAP1, Nature, 556, (7699), 2018, p113-117 , Journal Article, PUBLISHED  DOI
Neill, D.R. and Fallon, P.G., Innate lymphoid cells and parasites: Ancient foes with shared history, Parasite Immunology, 40, (2), 2018, Notes: [cited By 0], Journal Article, PUBLISHED  DOI
Vandeghinste, N. and Klattig, J. and Jagerschmidt, C. and Lavazais, S. and Marsais, F. and Haas, J.D. and Auberval, M. and Lauffer, F. and Moran, T. and Ongenaert, M. and Van Balen, M. and Dupont, S. and Lepescheux, L. and Garcia, T. and HÃ"rtle, S. and Eyerich, K. and Fallon, P.G. and Brys, R. and Steidl, S., Neutralization of IL-17C Reduces Skin Inflammation in Mouse Models of Psoriasis and Atopic Dermatitis, Journal of Investigative Dermatology, 2018, p1555-1563 , Notes: [cited By 0; Article in Press], Journal Article, PUBLISHED  DOI
  

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Award Date
Member Royal Irish Academy (MRIA) 2014
Stokes Professorship from Science Foundation Ireland. 2008
Fellow Trinity College Dublin (FTCD) 2009
My research involves two overlapping translational immunology themes. i. The use of mouse models to study pathogen modulation of human inflammatory diseases. ii. Immune phenotyping of patients, in particular children, with inflammatory diseases such as atopic dermatitis and pulmonary fibrosis. Research aims to elucidate new mechanism of modulation of immunity that can alter inflammation and have therapeutic potential. Collaborative activity involves the phenotyping of new transgenic mice. The main diseases addressed are allergic lung and skin inflammation and inflammatory bowel disease. A growing emphasis is applying extensive expertise in animal models of human inflammatory diseases and general pathophysiology of inflammation to functional analysis of new therapeutic molecules/strategies with clinical collaborators and Pharma.