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Professor Orla Sheils

Professor (Histopathology)
SIR PATRICK DUN LAB

Director of Medical Ethics (School Office - Medicine)

I studied Biomedical Science and was appointed research scientist at TCD following undergraduate study. My appointment was in the academic department of Histopathology, where my remit was to develop translational research. I was seconded to the Department of Genetics and on return to Histopathology I established a molecular pathology laboratory affiliated to the academic Department of Histopathology at St James' Hospital (one of the University's main teaching hospitals). I currently head a research group based at the Institute of Molecular Medicine in TCD's Health Sciences Centre at St James' Hospital, with a satellite group in the Coombe Women's Hospital. I am involved with undergraduate and postgraduate teaching and have an active research portfolio. My PhD thesis examined molecular aspects of thyroid neoplasia. Following its completion I expanded this area of research and molecular endocrine pathology (emphasis on thyroid) remains one of the Department's core areas. Other core areas include cancers of the cervix, ovary, prostate and head & neck. My group also has an active interest in the molecular pathobiology of Inflammatory Bowel Diseases Translational research remains a common theme throughout linking identification of disease processes with targets for early disease detection or classification. My group works closely with a number of biotech companies including Applied Biosystems, Affymetrix, DAKO and NorChip. I am currently reading for a Masters degree in Medical Law and Bioethics and I sit on the College's Ethics Committee.
  Autoimmunity   Bioinformatics   Biomedical ethics   Cancer genetics and cell biology including metastasis   Cervical cancer   Commercialisation of scientific research   Diagnostics   Endocrine function and disease   Environmental Carcinogenesis   Foetal, maternal and neonatal physiology   Gene transcription in human cancer   Gynaecology oncology   HASHIMOTO THYROIDITIS   Immunochemistry and immunogenetics   Inflammatory bowel disease   Intra and intercellular signalling   Medical Law   Medical Sciences, Research   Membrane and protein trafficking   Oncogenes, apoptosis and tumour development   Oral diseases and Oral medicine   Oral pathology   Pathophysiology   Prostate cancer   Quantitative and molecular genetics   Regulatory methods of gene expression   RET ONCOGENE ACTIVATION   RNA processing, stability and degradation   Role of oestrogens in age related urogenital diseases   SIGNAL TRANSDUCTION   TAQMAN RT-PCR   Thyroid Cancer   Tumour immunology and immunotherapy   TYROSINE PHOSPHORYLATION   Virology and viral pathogenesis
 Current Projects
 Molecular Pathology of Thyroid Disease
 Head and Neck Oncology
 Molecular Markers in Cervical Cancer
 Molecular Profiling in Prostate Cancer

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Details Date
Member, MMI Cancer Principal Investigators, Trans-institutional grouping of Principal Investigators leading research on Cancer themes
Member, Core Technology PI's, DMMC Principal Investigators leading the development of core technology platforms.
Language Skill Reading Skill Writing Skill Speaking
English Fluent Fluent Fluent
Details Date From Date To
Member of Coombe Women's Hospital 'Hospital Research Committee 2006 present
Member of the Ethics Working Group Royal College of Physicians of Ireland 2005 present
Member of the Pathological Society of Great Britain and Ireland 2001 present
Member of Medico-legal Society of Ireland 2006 present
Member of Editorial board of Journal of Endocrine Pathology 2009
Smyth, C.M., Akasheh, N., Woods, S., Kay, E., Morgan, R.K., Thornton, M.A., O'Grady, A., Cummins, R., Sheils, O., Smyth, P., Gleich, G.J., Murray, F.M., Costello, R.W., Activated Eosinophils in Association with Enteric Nerves in Inflammatory Bowel Disease, PLoS ONE, 8, (5), 2013, Journal Article, PUBLISHED  DOI
Murphy MA, O'Connell DJ, O'Kane SL, O'Brien JK, O'Toole S, Martin C, Sheils O, O'Leary JJ, Cahill DJ, Epitope presentation is an important determinant of the utility of antigens identified from protein arrays in the development of autoantibody diagnostic assays, Journal of Proteomics, 75, (15), 2012, p4668 - 4675, Notes: [. ], Journal Article, PUBLISHED  TARA - Full Text
Astbury K, McEvoy L, Brian H, Spillane C, Sheils O, Martin C, O'Leary JJ, MYBL2 (B-MYB) in cervical cancer: putative biomarker., International journal of gynecological cancer : official journal of the International Gynecological Cancer Society, 21, (2), 2011, p206-12 , Journal Article, PUBLISHED  DOI
Karl Egan., Darragh Crowley., Paul Smyth, Sharon O'Toole, Cathy Spillane, Cara Martin, Michael Gallagher, Aoife Canney, Lucy Norris, Niamh Conlon, Lynda McEvoy2, Brendan Ffrench2, Britta Stordal, Helen Keegan, Stephen Finn, Victoria McEneaney, Alex Laios, Jens Ducre, Eimear Dunne, Leila Smith, Michael Berndt, Orla Sheils, Dermot Kenny, John O'Leary, Platelet Adhesion and Degranulation Induce Pro-Survival and Pro-Angiogenic Signalling in Ovarian Cancer Cells, PLoS ONE, 6, (10, e26125), 2011, Journal Article, PUBLISHED  TARA - Full Text
O'Hurley G, Perry AS, O'Grady A, Loftus B, Smyth P, O'Leary JJ, Sheils O, Fitzpatrick JM, Hewitt SM, Lawler M, Kay EW, The role of secreted frizzled-related protein 2 expression in prostate cancer., Histopathology, 59, (6), 2011, p1240-1248 , Journal Article, PUBLISHED
O'Hurley, G, Perry, AS, O'Grady, A, Loftus, B, Smyth, P, O'Leary, JJ, Sheils, O, Fitzpatrick, JM, Hewitt, SM, Lawler, M, Kay, EW, The role of secreted frizzled-related protein 2 expression in prostate cancer, HISTOPATHOLOGY, 59, 2011, Journal Article, PUBLISHED
Egan, K, Crowley, D, Smyth, P, O'Toole, S, Spillane, C, Martin, C, Gallagher, M, Canney, A, Norris, L, Conlon, N, McEvoy, L, Ffrench, B, Stordal, B, Keegan, H, Finn, S, McEneaney, V, Laios, A, Ducree, J, Dunne, E, Smith, L, Berndt, M, Sheils, O, Kenny, D, O'Leary, J, Platelet Adhesion and Degranulation Induce Pro-Survival and Pro-Angiogenic Signalling in Ovarian Cancer Cells, PLOS ONE, 6, 2011, Journal Article, PUBLISHED
O'Hurley, G., Perry, A.S., O'Grady, A., Loftus, B., Smyth, P., O'Leary, J.J., Sheils, O., Fitzpatrick, J.M., Hewitt, S.M., Lawler, M., Kay, E.W., The role of secreted frizzled-related protein 2 expression in prostate cancer, Histopathology, 59, (6), 2011, p1240-1248 , Journal Article, PUBLISHED  DOI
Egan, K., Crowley, D., Smyth, P., O'Toole, S., Spillane, C., Martin, C., Gallagher, M., Canney, A., Norris, L., Conlon, N., McEvoy, L., Ffrench, B., Stordal, B., Keegan, H., Finn, S., McEneaney, V., Laios, A., Ducrée, J., Dunne, E., Smith, L., Berndt, M., Sheils, O., Kenny, D., O'Leary, J., Platelet adhesion and degranulation induce pro-survival and pro-angiogenic signalling in ovarian cancer cells, PLoS ONE, 6, (10), 2011, Journal Article, PUBLISHED  DOI
Burger, R., Kijanka, G., Sheils, O., O'Leary, J., Ducrée, J., Arrayed capture, assaying and binary counting of cells in a stopped-flow sedimentation mode, 15th International Conference on Miniaturized Systems for Chemistry and Life Sciences 2011, MicroTAS 2011, 1, 2011, p538-540 , Journal Article, PUBLISHED
  

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CCBB Heffron, MF Gallagher, S Guenther, R Henfrey, J Sherlock, O Sheils, C Martin, J O'Leary, Regulation of Cancer Stemness: Understanding Self-Renewal and Early Differentiation in Cancer Stem Cells, USCAP 96th Annual Meeting, San Diego, CA, March, 2007, Conference Paper, PUBLISHED
RJ Flavin, S O'Toole, P Smyth, A Laois, S Cahill, J Li, K Denning, C Martin, S Finn, B Shepherd, K Lao, O Sheils, JJ O'Leary, MicroRNA Gene Expression Profiling in Human Ovarian and Primary Peritoneal Serous Carcinomas, USCAP 96th Annual Meeting, San Diego, CA, March, 2007, Conference Paper, PRESENTED
J Li, P Smyth, S Cahill, K Denning, R Flavin, S Guenther, J O'Leary, O Sheils, Extraction and Amplification Methods To Enhance Expression Analysis from Formalin Fixed Paraffin Embedded (FFPE) Tissues, USCAP 96th Annual Meeting, San Diego, CA, March, 2007, Conference Paper, PRESENTED
K Denning, P Smyth, S Cahill, S Finn, E Conlon, JH Li, R Flavin, S Guenther, A Ferlinz, JJ O'Leary, O Sheils, Molecular Markers of Follicular Variant Papillary Thyroid Carcinoma (FVPTC) and Follicular Adenoma, USCAP 96th Annual Meeting, San Diego, CA, March, 2007, Conference Paper, PRESENTED
P Smyth, S Cahill, K Denning, J Li, SP Finn, S Guenther, R Henfrey, JJ O'Leary, O Sheils, MicroRNA Profiling of Papillary Thyroid Carcinoma Cell Lines, USCAP 96th Annual Meeting, San Diego, CA,, March, 2007, Conference Paper, PUBLISHED
SA O'Toole, A Laios, B Sheppard, N Gleeson, T D'Arcy, E McGuinness, M Ring, E Gaffney, C Martin, R Flavin, D Cahill, D O'Connell, J O'Brien, O Sheils, JJ O'Leary, miRNA Signatures in Primary Versus Recurrent Ovarian Cancers, USCAP 96th Annual Meeting, San Diego, CA, March, 2007, Conference Paper, PUBLISHED
A Laios, SA O'Toole, B Sheppard, N Gleeson, T D'Arcy, E McGuinness, M Ring, R Flavin, C Martin, J O'Brien, D O'Connell, O Sheils, D Cahill, E Gaffney, JJ O'Leary, Recurrence in Ovarian Cancer; a Transcriptomic Approach, USCAP 96th Annual Meeting, San Diego, CA, March, 2007, Conference Paper, PUBLISHED
CM Martin, K Astbury, C Becker, R Henfrey, J Sherlock, S Guenther, O Sheils, JJ O'Leary, MicroRNA Signatures in Cervical Cancer: Suggests Hierarchical miRNA Control of Gene Expression, USCAP 96th Annual Meeting, San Diego, CA, March, 2007, Conference Paper, PUBLISHED
M Ring, S Crowther, C Martin, K Astbury, O Sheils, M Griffin, E Gaffney, D Gibbons, JJ O'Leary, Significant Dysregulation of DNA Replication License and Replisome Proteins in Villoglandular Carcinomas of the Cervix Indicates Possible Aggressive Biological Behaviour, Significant Dysregulation of DNA Replication License and Replisome Proteins in Villoglandular Carcinomas of the Cervix Indicates Possible Aggressive Biological Behaviour, San Diego, CA, March, 2007, Conference Paper, PUBLISHED
M Ring, S Crowther, C Martin, K Astbury, O Sheils, M Griffin, E Gaffney, D Gibbons, JJ O'Leary, Significant Dysregulation of DNA Replication License and Replisome Proteins in Villoglandular Carcinomas of the Cervix Indicates Possible Aggressive Biological Behaviour, USCAP 96th Annual Meeting, San Diego, CA, March, 2007, Conference Paper, PUBLISHED

  

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Award Date
FTCD 2009
Provost's Teaching Award 2012
I have been an independent investigator since 2001 and the underlying theme of my research is to understand the causes and molecular basis of the development of disease, with particular reference to cancer, and to apply this knowledge to improving disease prevention, detection, diagnosis and treatment. Improving the outlook for cancer patients can only come from an understanding of molecular and cell biology. There has been a dramatic increase in knowledge of the molecular genetics of cancers over the last few years and already we have reached the point where this can be translated into clinical application. With increased understanding of the mechanics of disease progression comes a requirement for innovative methods to detect nuances of patient specific tumours to triage those most likely to benefit from particular chemotherapeutic approaches and to discriminate between individual prognostic outcomes. Translational research remains a common theme throughout my research, linking identification of disease processes with targets for early disease detection or classification. I chair the TCD Faculty of Health Sciences Research Ethics Committee and provide legal and ethics advice within the department and to other researchers embarking on research projects. I have been responsible for the procurement of grants valued in excess of €30M during this time from national funding agencies such as S.F.I., EU, HRB, ICS and HEA in addition to the Meath Foundation and the Emer Casey Foundation. I have also been fortunate in securing industrial support from Life technologies (Applied Biosystems/Ambion/Invitrogen), Affymetrix, Vysis., Johnson & Johnson, Merck-Serono and Amgen.