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Dr. Lucy Norris

SENIOR EXP OFFICER OBS&GYN (P/T 17/8/06) (Obstetrics)

Lucy Norris graduated from Trinity College Dublin with an honours degree in Biochemistry. She was awarded a PhD in 1992 from TCD Dept of Obstetrics and Gynaecology based on her work investigating platelet activation in pregnancy, pre-eclampsia and oral contraception. She was PI on several large scale studies investigating the mechanisms of haemostatic activation in hormone users (OC and HRT) collaborating with key figures in the field in Europe and North America and writing two consensus documents in this area. In 2002, she was awarded an MSc in Molecular Medicine from TCD and following this has established a group investigating the molecular effects of hormones on coagulation gene expression funded by the Health Research Board. Lucy's interests also extend to pregnancy where, in collaboration with Prof John Higgins in UCC, she is currently investigating new biomarkers to predict venous thrombosis in pregnancy and also the effects of LMWH on thrombin production in high risk pregnancy groups such as the obese. In collaboration with Dr. Noreen Gleeson and Prof. John O'Leary, her research programme has also extended to gynaecological cancers; the role of coagulation gene expression in the aetiology of ovarian cancer and in prediction of venous thrombosis post gynaecological surgery is currently being investigated (funded by the HRB). She has over 60 peer reviewed publications, many as senior author, including 5 invited reviews. She is a member of the International Society for Thrombosis and Haemostasis and is a member of the editorial board for the journal 'Thrombosis Research'.
  Biomedical sciences   Cardiovascular risk assessment and hormone replacement therapy   Clinical research, trials   Coagulation biochemistry and disorders   Cytokines, Nitric Oxide   Foetal, maternal and neonatal physiology   Haemotology   Hormone physiology and biochemistry   Inflammation and coagulation syndromes   Medical Sciences, Research   Menopause   Molecular haematology   Oral contaraceptives and haemostasis   Pre-eclampsia and intrauterine growth retardation   Prevention, treatment of thromboembolic complications in pregnancy   Reproduction, fertility and contraception   Thrombosis and haemostasis   Vascular Biology, Thrombosis
 A risk model for prediction of venous thromboembolism in gynaecological cancer patients post surgery
 Thromboelastography as a predictor of venous thrombosis in gynaecological oncology patients undergoing surgery.
 Interrogation of the Onco-metabolome in ovarian cancer
 Endogenous thrombin potential (ETP) and microparticle tissue factor(TF) activity as markers of venous thromboembolism in gynaecological cancer patients.

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Member of the Editorial board of Thrombosis Research
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Member of International Society for Thrombosis and Haemostasis
Langhe R, Norris L, Saadeh FA, Blackshields G, Varley R, Harrison A, Gleeson N, Spillane C, Martin C, O'Donnell DM, D'Arcy T, O'Leary J, O'Toole S, A novel serum microRNA panel to discriminate benign from malignant ovarian disease, Cancer Letters, 356, ((2ptB)), 2015, p628-636-, Journal Article, PUBLISHED  DOI
Kelly LA, Seidlova-Wuttke D, Wuttke W, O'Leary JJ, Norris LA, Estrogen receptor alpha augments changes in hemostatic gene expression in HepG2 cells treated with estradiol and phytoestrogens. , Phytomedicine , 21, (2), 2014, p155 - 158, Journal Article, PUBLISHED  URL
Ismail SK, Norris L, O'Shea S, Higgins JR, Weight-adjusted LMWH Prophylaxis Provides More Effective Thrombin Inhibition in Morbidly Obese Pregnant Women, Thrombosis Research, 134, (2), 2014, p234 - 239, Journal Article, PUBLISHED  DOI
Brosnan JF, Sheppard BL, Kelly LA, O'Leary JJ, Norris LA, Norethisterone acetate alters coagulation gene expression in vitro in human cell culture., Thrombosis research, 131, (1), 2013, p72 - 77, Journal Article, PUBLISHED
Laios A, Mohamed BM, Kelly L, Flavin R, Finn S, McEvoy L, Gallagher M, Martin C, Sheils O, Ring M, Davies A, Lawson M, Gleeson N, D'Arcy T, d'Adhemar C, Norris L, Langhe R, Saadeh FA, O'Leary JJ, O'Toole SA, Pre-Treatment of Platinum Resistant Ovarian Cancer Cells with an MMP-9/MMP-2 Inhibitor Prior to Cisplatin Enhances Cytotoxicity as Determined by High Content Screening., International journal of molecular sciences, 14, (1), 2013, p2085-103 , Journal Article, PUBLISHED  TARA - Full Text
Abu Saadeh F, Norris L, O'Toole S, Gleeson N, Venous thromboembolism in ovarian cancer: Incidence, risk factors and impact on survival., European Journal of Obstetrics & Gynecology and Reproductive Biology , 170, (1), 2013, p214 - 218, Journal Article, PUBLISHED  Other
Abu Saadeh, Norris L, O'Toole S, Mohamed BM, Langhe R, O'Leary J, Gleeson N, Tumour expresion of tissue factor and tissue factor pathway inhibitor in ovarian cancer- relationship with venous thrombosis risk., Thrombosis Research, 132, 2013, p627 - 634, Journal Article, PUBLISHED  DOI
Ismail SK, Norris L, Muttukrishna S, Higgins JR, Thrombin generation post elective caesarean section: Effect of low molecular weight heparin., Thrombosis research, 130, (5), 2012, p799 - 803, Journal Article, PUBLISHED
Karl Egan., Darragh Crowley., Paul Smyth, Sharon O'Toole, Cathy Spillane, Cara Martin, Michael Gallagher, Aoife Canney, Lucy Norris, Niamh Conlon, Lynda McEvoy2, Brendan Ffrench2, Britta Stordal, Helen Keegan, Stephen Finn, Victoria McEneaney, Alex Laios, Jens Ducre, Eimear Dunne, Leila Smith, Michael Berndt, Orla Sheils, Dermot Kenny, John O'Leary, Platelet Adhesion and Degranulation Induce Pro-Survival and Pro-Angiogenic Signalling in Ovarian Cancer Cells, PLoS ONE, 6, (10, e26125), 2011, Journal Article, PUBLISHED  TARA - Full Text
Kelly LA, O'Leary JJ, Seidlova-Wuttke D, Wuttke W, Norris LA, Genistein alters coagulation gene expression in ovariectomised rats treated with phytoestrogens, Thrombosis and Haemostasis, 104, (6), 2010, p1083-1289 , Journal Article, PUBLISHED  TARA - Full Text

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Award Date
Royal Academy of Medicine Donegan medal 2nd prize 1987
The role of coagulation proteases and platelets in the aetiology of gynaecological cancers. Development of risk models for the prediction of thrombosis in gynaecological cancer patients. Aetiology of thrombosis risk in high risk pregnancy patients. Effects of oestrogens, progestogens and phytoestogens on coagulation gene expression and their role in thrombosis risk. The role of coagulation gene expression in the transition from endometriosis to clear cell cancer.