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Professor Luke O'Neill

Chair of Biochemistry(1960) (Biochemistry)

 Luke.ONeill@tcd.ie

 3531896 2439


Biography

CAMPUS COMPANY: Co-founder in March 2004 (with Prof Kingston Mills and Prof Dermot Kelleher) Opsona Therapeutics (www.opsona.com). Area: drug development company targeting inflammatory and autoimmune diseases. CEO: Dr Mark Heffernan. Chairman: Dr Cormac Kilty. Successfully completed A round financing in February 2005 of €6.25million (investors: Genentech (first investment outside USA), Enterprise Ireland, VC firms Inventages and Seroba). Largest A round fund for a Biotech startup in Europe.

Research Tags

  3-DIMENSIONAL STRUCTURE   ACCEPTOR   ACIDIC SPHINGOMYELINASE   ACTIN-BASED MOVEMENT   ACTIVATED PROTEIN-KINASE   ACTIVATION   ACTIVATION PATHWAY   ADHESION MOLECULE   ADHESION MOLECULE-1   ALPHA   ANTIGEN   ANTINEOPLASTIC AGENTS   ANTIOXIDANTS   ATHEROSCLEROTIC LESION   Autoimmune Diseases (Multiple Sclerosis, Rheumatoid Arthritis)   BACTERIAL LIPOPOLYSACCHARIDE   BLOOD MONONUCLEAR-CELLS   CALCIUM CURRENTS   CALCIUM INFLUX   CASCADE   CATALYTIC ACTIVITY   CD18   CELL-FREE SYSTEM   CELLS   CELLULAR STRESSES   CERAMIDE   CHEMOKINE GENE-EXPRESSION   CHROMOSOMAL LOCATION   C-JUN   CLOSTRIDIUM-DIFFICILE   COMPLEX FACTOR ELK-1   CORD BLOOD   CRYSTAL-STRUCTURE   CUTTING EDGE   CYCLIC-AMP   CYTOKINES   DAUNORUBICIN-INDUCED APOPTOSIS   DENTATE GYRUS   DEPENDENT GENE-EXPRESSION   DEPENDENT MECHANISM   DEPENDENT TRANSCRIPTION   DIACYLGLYCEROL PRODUCTION   DISEASE   DISULFIDE   DNA-BINDING   DNA-BINDING ACTIVITY   DNA-BINDING SUBUNIT   DORSOVENTRAL POLARITY   DROSOPHILA   E-CADHERIN   EFFECTOR PATHWAYS   ENDOTHELIAL-CELL LINE   ENDOTHELIAL-CELLS   ENDOTOXIN   EXPRESSION   FACTOR INCREASE PHOSPHORYLATION   FACTOR-ALPHA   FACTOR-KAPPA-B   FAMILY   FAS-LIGAND   FIBROBLASTS   FUNCTIONAL-RESPONSES   GENE   GENE-EXPRESSION   Genetics   GROWTH-FACTOR-BETA   GTP-BINDING   GTP-BINDING PROTEINS   HIPPOCAMPAL SLICE   HIPPOCAMPAL SLICES   HIPPOCAMPAL-NEURONS   HIPPOCAMPUS   HL-60 CELLS   HL-60 LEUKEMIA-CELLS   HOST-DEFENSE   HUMAN-ENDOTHELIAL-CELLS   HUMAN-IMMUNODEFICIENCY-VIRUS   IDENTIFICATION   IL-1   IL-1 RECEPTOR   IL-1, Toll Receptors, NF-KappaB   IL-1/MAP KINASES   IL1HY1   IL-2 MESSENGER-RNA   Immune System   Immunomodulatory molecules as therapy for inflammatory or immune-mediated diseasesPro-inflammatory cytokines, Interleukin-1, Toll-like receptors, Toll-IL-1 receptor domain, Lipopolysaccharide   INDUCED APOPTOSIS   Inflammation   INHIBITORS   INTACT-CELLS   INTERLEUKIN-1   INTERLEUKIN-1 BETA   INTERLEUKIN-1 RECEPTOR ANTAGONIST   INTERLEUKIN-1 RECEPTORS   INTERLEUKIN-1-BETA   INTERLEUKIN-2   INTERLEUKIN-2 PROMOTER   INTERNALIN MULTIGENE FAMILY   IN-VITRO   KAPPA-B   KAPPA-B ACTIVATION   KINASE   LETHAL TOXIN   LEUKOCYTE ADHESION MOLECULES   LINE ECV304   LIPOPOLYSACCARIDE   LIPOPOLYSACCHARIDE   LONG-TERM POTENTIATION   Long-term potentiation & signal transduction mechanisms including MAP kinases   MAMMALIAN-CELLS   MAP KINASE   MECHANISMS   Medicines   MESSENGER-RNA   MESSENGERS   Molecular basis to inflammation and innate immunity   MOLECULE CD28   MONOCYTE   MULTIPLE-SCLEROSIS   MURINE MACROPHAGES   MUTATIONS   NECROSIS-FACTOR-ALPHA   NEONATAL T CELLS   NF-KAPPA-B   NITRIC-OXIDE SYNTHASE   ORGANIZATION   P50 SUBUNIT   PATHWAY   Pharmacology   PHOSPHATIDYLINOSITOL 3-KINASE   PHOSPHOINOSITIDE 3-KINASE   PHOSPHORYLATION   PROTEINS   RECEPTOR   RECEPTOR ANTAGONIST BINDS   RECEPTOR CD44   RECEPTOR SUPERFAMILY   RECOGNITION   RICH REPEAT REGION   SIGNAL TRANSDUCTION   Signal transduction in the immune system, NF-kappaB, T1/ST2, MAP kinases   SIGNAL-TRANSDUCTION   SIGNAL-TRANSDUCTION PATHWAYS   SUBSTRATE-SPECIFICITY   SUPERFAMILY   SUPEROXIDE   SURFACE PROTEIN   T LYMPHOCYTES   T-CELL ACTIVATION   TERM POTENTIATION   T-LYMPHOCYTE ACTIVATION   TRANSCRIPTION FACTOR   TRANSDUCTION   TUMOR-NECROSIS-FACTOR

Research Projects

 Control of TLRs and NLRs by microRNAs
 Role of Nlrp3 in Type 2 diabetes
 . Novel proteins in the TLR and NLR systems
 Role of metabolism in innate immunity
 Circadian control of innate immunity

Representations

Details Date
External examiner for 30 PhD theses to date (Universities of Cambridge, London, Bath, Sheffield, Manchester, Liege, St. Andrews, Ulster, Melbourne, Sienna, University College Dublin, University College Cork, Queen's University Belfast).
External examiner for degree programme in Molecular Medicine, University of Wales
Section Editor for Journal of Leukocyte Biology
Chair of EU delegation to NSF/EU joint committee on Biotechnology of host defence
Member, DMMC Inflammation, Immunity & Infection Principal Investigators, DMMC Principal Investigators leading research in inflammation, immunit and infection.
Member, Centre for Research into Global Disease (Proposed), This consortium combines researchers with complementary interests in globally significant infectious disease. Interests include innate immunity, immune regulation, regional immunity, immune evasiob, vaccine & adjuvant development as well as drug & target development.
Member, Hepatitis C Focus Group Meeting, Focus group of investigators with Hepatitis C related research interests.Suggested themes : Immunogenomics of Hepatitis C or more broad theme
Member, Cycle 2 PI's & Researchers, All Cycle 2 Researchers & PI's
Member of the editorial boards of the Journal of Immunology (Section Editor), Trends in Immunology, Journal of Biological Chemistry, British Journal of Pharmacology and Cytokine
Member of board of external assessors for medical research at the Universities of Ghent and Melbourne (chairman of the latter)
Ad Hoc Member of Bacteriology and Mycology-2 Study Section, National Institutes of Health, USA
Ad Hoc Member of Cell and Molecular Immunology A Study Section, National Institutes of Health, USA
Member of Medical Research Council Advisory Board, UK
Member Avenir Committee INSERM, French National Insitute of Health
Member, Science Foundation Ireland Biotechnology Advisory Board
Chair, Scientific Advisory Board, Australian Co-operative Research Centre for Chronic Inflammatory Diseases
Member, Royal Irish Academy Life Sciences Committee
Member of the Pre-clinical committee, Irish Medicines Board
Member, Arthritis Foundation of Ireland academic advisory committee

Memberships

Membership of Professional Institutions, Associations, Societies

Details Date From Date To
International Cytokine Society (Councillor)
Biochemical Society
American Society for Biochemistry and Molecular Biology
Member Royal Irish Academy Life Sciences Committee
Member of the Pre-clinical committee, Irish Medicines Board
Member of MRC Advisory Board, UK
Member of Bacteriology and Mycology-2 Study Section, National Institutes of Health, USA
Joosten L.A.B, Abdollahi-Roodsaz S, Dinarello C.A, O'Neill L, Netea M.G, Toll-like receptors and chronic inflammation in rheumatic diseases: New developments, Nature Reviews Rheumatology, 12, (6), 2016, p344 - 357, Notes: [Cited By :1 Export Date: 27 September 2016], Journal Article, PUBLISHED  DOI  URL
Mills E.L, O'Neill L.A, Reprogramming mitochondrial metabolism in macrophages as an anti-inflammatory signal, European Journal of Immunology, 46, (1), 2016, p13 - 21, Notes: [Cited By :2 Export Date: 27 September 2016], Journal Article, PUBLISHED  DOI  URL
O'Neill L.A.J, Pearce E.J, Immunometabolism governs dendritic cell and macrophage function, Journal of Experimental Medicine, 213, (1), 2016, p15 - 23, Notes: [Cited By :19 Export Date: 27 September 2016], Journal Article, PUBLISHED  DOI  URL
Arbore G, West E.E, Spolski R, Robertson A.A.B, Klos A, Rheinheimer C, Dutow P, Woodruff T.M, Yu Z.X, O'Neill L.A, Coll R.C, Sher A, Leonard W.J, Köhl J, Monk P, Cooper M.A, Arno M, Afzali B, Lachmann H.J, Cope A.P, Mayer-Barber K.D, Kemper C, T helper 1 immunity requires complement-driven NLRP3 inflammasome activity in CD4+ T cells, Science, 352, (6292), 2016, Notes: [Cited By :3 Export Date: 27 September 2016], Journal Article, PUBLISHED  DOI  URL
McIntyre J, Verma N.K, Smith R.J, Moore C, Nerl H, McEvoy N, Berner N, McGovern I, Khan U, Lyons P, O'Neill L, Nicolosi V, Duesberg G.S, Byrne H.J, Coleman J, Volkov Y, A comparison of catabolic pathways induced in primary macrophages by pristine single walled carbon nanotubes and pristine graphene, RSC Advances, 6, (70), 2016, p65299 - 65310, Notes: [Export Date: 15 September 2016], Journal Article, PUBLISHED  TARA - Full Text  DOI  URL
Netea M.G, Joosten L.A.B, Latz E, Mills K.H.G, Natoli G, Stunnenberg H.G, O'Neill L.A.J, Xavier R.J, Trained immunity: A program of innate immune memory in health and disease, Science, 352, (6284), 2016, p427-, Notes: [Cited By :2 Export Date: 26 September 2016], Journal Article, PUBLISHED  DOI  URL
Ní Cheallaigh C, Sheedy FJ, Harris J, Muñoz-Wolf N, Lee J, West K, McDermott EP, Smyth A, Gleeson LE, Coleman M, Martinez N, Hearnden CH, Tynan GA, Carroll EC, Jones SA, Corr SC, Bernard NJ, Hughes MM, Corcoran SE, O'Sullivan M, Fallon CM, Kornfeld H, Golenbock D, Gordon SV, O'Neill LA, Lavelle EC, Keane J, A Common Variant in the Adaptor Mal Regulates Interferon Gamma Signaling., Immunity, 44, (2), 2016, p368-79 , Journal Article, PUBLISHED  URL
Gleeson LE, Sheedy FJ, Palsson-McDermott EM, Triglia D, O'Leary SM, O'Sullivan MP, O'Neill LA, Keane J, Cutting Edge: Mycobacterium tuberculosis Induces Aerobic Glycolysis in Human Alveolar Macrophages That Is Required for Control of Intracellular Bacillary Replication., Journal of immunology (Baltimore, Md. : 1950), 196, (6), 2016, p2444-2449 , Journal Article, PUBLISHED  DOI  URL
Menon D, Coll R, O'Neill L.A.J, Board P.G, GSTO1-1 modulates metabolism in macrophages activated through the LPS and TLR4 pathway, Journal of Cell Science, 128, (10), 2015, p1982 - 1990, Notes: [Export Date: 18 August 2015], Journal Article, PUBLISHED  DOI  URL
Haneklaus M, O'Neill L.A.J, NLRP3 at the interface of metabolism and inflammation, Immunological Reviews, 265, (1), 2015, p53 - 62, Notes: [Cited By :1 Export Date: 18 August 2015], Journal Article, PUBLISHED  DOI  URL
  

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O'Neill, LAJ (Chair) and organising committee, International Cytokine Society meeting, September, 2003, TCD, Notes: [ 550 delegates from 32 countries attended.], Meetings /Conferences Organised, PUBLISHED
O'Neill, LAJ (Chair) and organising committee , Biochemical Society meeting, 2001, TCD, Notes: [held at TCD and attended by 400 biochemists.], Meetings /Conferences Organised, PUBLISHED
Murphy, M and O'Neill, LAJ , 'What is Life? The Next 50 years', 1993, Notes: [to commemorate the 50th anniversary of Schodinger's 'What is Life?' lectures. 450 delegates attended talks by 11 eminent speakers, including 3 Nobel Laureates.], Meetings /Conferences Organised, PUBLISHED

  

Awards and Honours

Award Date
Irish Society for Immunology Medal for Immunology 2004
Elected Member of the Royal Irish Academy 2004
Dublin Institute of Molecular Medicine Medal Lecture 2004
Charnock Bradley Award Lecture, University of Edinburgh 2004
Elected President, Biomedical Sciences Section, British Association for the Advancement of Science 2004
Elected Councillor, International Cytokine Society 2003
Dolph Adams Award, Society for Leukocyte Biology USA 2003
Shortlisted for the Boyle Medal, Royal Dublin Society 2002
Short-listed for the Boyle Medal, Royal Dublin Society 1999
Young Investigator Award, International Cytokine Society 1997
Royal Irish Academy Medal for Biochemistry 1996
Fellow, Trinity College Dublin 1996
Conway Medal for Biomedical Research by the Royal Academy of Medicine in Ireland 1995
Elected member of European Molecular Biology Organisation (EMBO) 2005
Appointed Chair of the European Research Council Infection and Immunity Panel 2008
Appointed Councillor of the International Cytokine Society(and rising to President in 2012) 2008
Immunology 'Guru', National Institutes of Health 2009
Advisor to the 2009 Nobel Committee for Physiology or Medicine 2009
Royal Dublin Society / Irish Times Boyle Medal for Scientific Excellence 2009
Science Foundation Ireland Researcher of the Year Award 2009

Research Interests

Description Of Research Interests

CURRENT RESEARCH: Research Area: Molecular and Cellular basis to inflammation and innate immunity. Toll-like receptors. Pro-inflammatory cytokines. Signal transduction in the immune system. Molecular analysis of inflammatory and infectious diseases.
RESEARCH FUNDING: €5.4m in active grants (Total funding raised since appointment to TCD: €12.2m).
Core grants: SFI research programme grant (€4.1m) HRB Unit grant (€220K)