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Professor Luke O'Neill

Chair of Biochemistry(1960) (Biochemistry)
BIOMEDICAL SCIENCES INSTITUTE


CAMPUS COMPANY: Co-founder in March 2004 (with Prof Kingston Mills and Prof Dermot Kelleher) Opsona Therapeutics (www.opsona.com). Area: drug development company targeting inflammatory and autoimmune diseases. CEO: Dr Mark Heffernan. Chairman: Dr Cormac Kilty. Successfully completed A round financing in February 2005 of €6.25million (investors: Genentech (first investment outside USA), Enterprise Ireland, VC firms Inventages and Seroba). Largest A round fund for a Biotech startup in Europe.
  3-DIMENSIONAL STRUCTURE   ACCEPTOR   ACIDIC SPHINGOMYELINASE   ACTIN-BASED MOVEMENT   ACTIVATED PROTEIN-KINASE   ACTIVATION   ACTIVATION PATHWAY   ADHESION MOLECULE   ADHESION MOLECULE-1   ALPHA   ANTIGEN   ANTINEOPLASTIC AGENTS   ANTIOXIDANTS   ATHEROSCLEROTIC LESION   Autoimmune Diseases (Multiple Sclerosis, Rheumatoid Arthritis)   BACTERIAL LIPOPOLYSACCHARIDE   BLOOD MONONUCLEAR-CELLS   C-JUN   CALCIUM CURRENTS   CALCIUM INFLUX   CASCADE   CATALYTIC ACTIVITY   CD18   CELL-FREE SYSTEM   CELLS   CELLULAR STRESSES   CERAMIDE   CHEMOKINE GENE-EXPRESSION   CHROMOSOMAL LOCATION   CLOSTRIDIUM-DIFFICILE   COMPLEX FACTOR ELK-1   CORD BLOOD   CRYSTAL-STRUCTURE   CUTTING EDGE   CYCLIC-AMP   CYTOKINES   DAUNORUBICIN-INDUCED APOPTOSIS   DENTATE GYRUS   DEPENDENT GENE-EXPRESSION   DEPENDENT MECHANISM   DEPENDENT TRANSCRIPTION   DIACYLGLYCEROL PRODUCTION   DISEASE   DISULFIDE   DNA-BINDING   DNA-BINDING ACTIVITY   DNA-BINDING SUBUNIT   DORSOVENTRAL POLARITY   DROSOPHILA   E-CADHERIN   EFFECTOR PATHWAYS   ENDOTHELIAL-CELL LINE   ENDOTHELIAL-CELLS   ENDOTOXIN   EXPRESSION   FACTOR INCREASE PHOSPHORYLATION   FACTOR-ALPHA   FACTOR-KAPPA-B   FAMILY   FAS-LIGAND   FIBROBLASTS   FUNCTIONAL-RESPONSES   GENE   GENE-EXPRESSION   GROWTH-FACTOR-BETA   GTP-BINDING   GTP-BINDING PROTEINS   Genetics   HIPPOCAMPAL SLICE   HIPPOCAMPAL SLICES   HIPPOCAMPAL-NEURONS   HIPPOCAMPUS   HL-60 CELLS   HL-60 LEUKEMIA-CELLS   HOST-DEFENSE   HUMAN-ENDOTHELIAL-CELLS   HUMAN-IMMUNODEFICIENCY-VIRUS   IDENTIFICATION   IL-1   IL-1 RECEPTOR   IL-1, Toll Receptors, NF-KappaB   IL-1/MAP KINASES   IL-2 MESSENGER-RNA   IL1HY1   IN-VITRO   INDUCED APOPTOSIS   INHIBITORS   INTACT-CELLS   INTERLEUKIN-1   INTERLEUKIN-1 BETA   INTERLEUKIN-1 RECEPTOR ANTAGONIST   INTERLEUKIN-1 RECEPTORS   INTERLEUKIN-1-BETA   INTERLEUKIN-2   INTERLEUKIN-2 PROMOTER   INTERNALIN MULTIGENE FAMILY   Immune System   Immunomodulatory molecules as therapy for inflammatory or immune-mediated diseasesPro-inflammatory cytokines, Interleukin-1, Toll-like receptors, Toll-IL-1 receptor domain, Lipopolysaccharide   Inflammation   KAPPA-B   KAPPA-B ACTIVATION   KINASE   LETHAL TOXIN   LEUKOCYTE ADHESION MOLECULES   LINE ECV304   LIPOPOLYSACCARIDE   LIPOPOLYSACCHARIDE   LONG-TERM POTENTIATION   Long-term potentiation & signal transduction mechanisms including MAP kinases   MAMMALIAN-CELLS   MAP KINASE   MECHANISMS   MESSENGER-RNA   MESSENGERS   MOLECULE CD28   MONOCYTE   MULTIPLE-SCLEROSIS   MURINE MACROPHAGES   MUTATIONS   Medicines   Molecular basis to inflammation and innate immunity   NECROSIS-FACTOR-ALPHA   NEONATAL T CELLS   NF-KAPPA-B   NITRIC-OXIDE SYNTHASE   ORGANIZATION   P50 SUBUNIT   PATHWAY   PHOSPHATIDYLINOSITOL 3-KINASE   PHOSPHOINOSITIDE 3-KINASE   PHOSPHORYLATION   PROTEINS   Pharmacology   RECEPTOR   RECEPTOR ANTAGONIST BINDS   RECEPTOR CD44   RECEPTOR SUPERFAMILY   RECOGNITION   RICH REPEAT REGION   SIGNAL TRANSDUCTION   SIGNAL-TRANSDUCTION   SIGNAL-TRANSDUCTION PATHWAYS   SUBSTRATE-SPECIFICITY   SUPERFAMILY   SUPEROXIDE   SURFACE PROTEIN   Signal transduction in the immune system, NF-kappaB, T1/ST2, MAP kinases   T LYMPHOCYTES   T-CELL ACTIVATION   T-LYMPHOCYTE ACTIVATION   TERM POTENTIATION   TRANSCRIPTION FACTOR   TRANSDUCTION   TUMOR-NECROSIS-FACTOR
Control of TLRs and NLRs by microRNAs
Role of Nlrp3 in Type 2 diabetes
. Novel proteins in the TLR and NLR systems
Role of metabolism in innate immunity
Circadian control of innate immunity

Details Date
Ad Hoc Member of Bacteriology and Mycology-2 Study Section, National Institutes of Health, USA
Ad Hoc Member of Cell and Molecular Immunology A Study Section, National Institutes of Health, USA
Chair of EU delegation to NSF/EU joint committee on Biotechnology of host defence
Chair, Scientific Advisory Board, Australian Co-operative Research Centre for Chronic Inflammatory Diseases
External examiner for 30 PhD theses to date (Universities of Cambridge, London, Bath, Sheffield, Manchester, Liege, St. Andrews, Ulster, Melbourne, Sienna, University College Dublin, University College Cork, Queen's University Belfast).
External examiner for degree programme in Molecular Medicine, University of Wales
Member Avenir Committee INSERM, French National Insitute of Health
Member of Medical Research Council Advisory Board, UK
Member of board of external assessors for medical research at the Universities of Ghent and Melbourne (chairman of the latter)
Member of the Pre-clinical committee, Irish Medicines Board
Member of the editorial boards of the Journal of Immunology (Section Editor), Trends in Immunology, Journal of Biological Chemistry, British Journal of Pharmacology and Cytokine
Member, Arthritis Foundation of Ireland academic advisory committee
Member, Centre for Research into Global Disease (Proposed), This consortium combines researchers with complementary interests in globally significant infectious disease. Interests include innate immunity, immune regulation, regional immunity, immune evasiob, vaccine & adjuvant development as well as drug & target development.
Member, Cycle 2 PI's & Researchers, All Cycle 2 Researchers & PI's
Member, DMMC Inflammation, Immunity & Infection Principal Investigators, DMMC Principal Investigators leading research in inflammation, immunit and infection.
Member, Hepatitis C Focus Group Meeting, Focus group of investigators with Hepatitis C related research interests.Suggested themes : Immunogenomics of Hepatitis C or more broad theme
Member, Royal Irish Academy Life Sciences Committee
Member, Science Foundation Ireland Biotechnology Advisory Board
Section Editor for Journal of Leukocyte Biology
Details Date From Date To
American Society for Biochemistry and Molecular Biology
Biochemical Society
International Cytokine Society (Councillor)
Member Royal Irish Academy Life Sciences Committee
Member of Bacteriology and Mycology-2 Study Section, National Institutes of Health, USA
Member of MRC Advisory Board, UK
Member of the Pre-clinical committee, Irish Medicines Board
Corr, S.C., Palsson-Mcdermott, E.M., Grishina, I., Barry, S.P., Aviello, G., Bernard, N.J., Casey, P.G., Ward, J.B.J., Keely, S.J., Dandekar, S., Fallon, P.G., O'Neill, L.A.J., MyD88 adaptor-like (Mal) functions in the epithelial barrier and contributes to intestinal integrity via protein kinase C, Mucosal Immunology, 7, (1), 2014, p57-67 , Journal Article, PUBLISHED  DOI
Quinn SR, Mangan NE, Caffrey BE, Gantier MP, Williams BR, Hertzog PJ, McCoy CE, O'Neill LA., The role of Ets2 transcription factor in the induction of microRNA-155 by LPS, and its targeting by IL-10., The Journel of Biological Chemistry, 289, (9), 2014, p4316-4325 , Journal Article, PUBLISHED  TARA - Full Text  DOI
Anne M. Curtis, Marina M. Bellet, Paolo Sassone-Corsi & Luke A.J. O'Neill , Circadian Clock Proteins and Immunity, Immunity, Volume 40, (2), 2014, 178-186 , Journal Article, PUBLISHED  TARA - Full Text  DOI
Dowling, J.K., Becker, C.E., Bourke, N.M., (...), Mansell, A., O'Neill, L.A.J., Promyelocytic leukemia protein interacts with the apoptosis-associated speck-like protein to limit inflammasome activation, Journal of Biological Chemistry, 289, (10), 2014, p6429-6437 , Journal Article, PUBLISHED  DOI
O'Neill, L.A.J., Glycolytic reprogramming by TLRs in dendritic cells, Nature Immunology, 15, (4), 2014, p314-315 , Notes: [ ], Journal Article, PUBLISHED  DOI
d'Adhemar CJ, Spillane CD, Gallagher MF, Bates M, Costello KM, Barry-O'Crowley J, Haley K, Kernan N, Murphy C, Smyth PC, O'Byrne K, Pennington S, Cooke AA, Ffrench B, Martin CM, O'Donnell D, Hennessy B, Stordal B, Finn S, McCann A, Gleeson N, D'Arcy T, Flood B, O'Neill LA, Sheils O, O'Toole S, O'Leary JJ., The MyD88+ Phenotype Is an Adverse Prognostic Factor in Epithelial Ovarian Cancer., PLoS One. , 9, (6), 2014, pe100816-, Journal Article, PUBLISHED  TARA - Full Text  DOI
Mockler MB, Conroy MJ, Lysaght J, Targeting T cell immunometabolism for cancer immunotherapy; understanding the impact of the tumor microenvironment., Frontiers in oncology, 4, 2014, p107 , Journal Article, PUBLISHED  TARA - Full Text  DOI
Fagundes, C.T., O'Neill, L.A.J., Building unique bonds to fight misplaced DNA, Cell Research , 23, (9), 2013, p1065-1066 , Journal Article, PUBLISHED  DOI
Haneklaus M, O'Neill LA, Coll RC, Modulatory mechanisms controlling the NLRP3 inflammasome in inflammation: recent developments., Current opinion in immunology, 25, (1), 2013, p40-45 , Journal Article, PUBLISHED  DOI
Dowling JK, McCoy CE, Doyle SL, Benlarbi N, Canavan M, O'Neill LA, Loscher CE, Conjugated linoleic acid suppresses IRF3 activation via modulation of CD14., The Journal of nutritional biochemistry, 24, (5), 2013, p920-928 , Journal Article, PUBLISHED  TARA - Full Text  DOI
  

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O'Neill, LAJ (Chair) and organising committee, International Cytokine Society meeting, September, 2003, TCD, Notes: [ 550 delegates from 32 countries attended.], Meetings /Conferences Organised, PUBLISHED
O'Neill, LAJ (Chair) and organising committee , Biochemical Society meeting, 2001, TCD, Notes: [held at TCD and attended by 400 biochemists.], Meetings /Conferences Organised, PUBLISHED
Murphy, M and O'Neill, LAJ , 'What is Life? The Next 50 years', 1993, Notes: [to commemorate the 50th anniversary of Schodinger's 'What is Life?' lectures. 450 delegates attended talks by 11 eminent speakers, including 3 Nobel Laureates.], Meetings /Conferences Organised, PUBLISHED

  

Award Date
Appointed Councillor of the International Cytokine Society(and rising to President in 2012) 2008
Advisor to the 2009 Nobel Committee for Physiology or Medicine 2009
Appointed Chair of the European Research Council Infection and Immunity Panel 2008
Charnock Bradley Award Lecture, University of Edinburgh 2004
Conway Medal for Biomedical Research by the Royal Academy of Medicine in Ireland 1995
Dolph Adams Award, Society for Leukocyte Biology USA 2003
Dublin Institute of Molecular Medicine Medal Lecture 2004
Elected Councillor, International Cytokine Society 2003
Elected Member of the Royal Irish Academy 2004
Elected President, Biomedical Sciences Section, British Association for the Advancement of Science 2004
Elected member of European Molecular Biology Organisation (EMBO) 2005
Fellow, Trinity College Dublin 1996
Immunology 'Guru', National Institutes of Health 2009
Irish Society for Immunology Medal for Immunology 2004
Royal Dublin Society / Irish Times Boyle Medal for Scientific Excellence 2009
Royal Irish Academy Medal for Biochemistry 1996
Science Foundation Ireland Researcher of the Year Award 2009
Short-listed for the Boyle Medal, Royal Dublin Society 1999
Shortlisted for the Boyle Medal, Royal Dublin Society 2002
Young Investigator Award, International Cytokine Society 1997
CURRENT RESEARCH: Research Area: Molecular and Cellular basis to inflammation and innate immunity. Toll-like receptors. Pro-inflammatory cytokines. Signal transduction in the immune system. Molecular analysis of inflammatory and infectious diseases.
RESEARCH FUNDING: €5.4m in active grants (Total funding raised since appointment to TCD: €12.2m).
Core grants: SFI research programme grant (€4.1m) HRB Unit grant (€220K)