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Professor Joseph Keane

Professor of Medicine 1955 (Clinical Medicine)

 

Professor of Medicine 1955 (School Office - Medicine)


  Apoptosis   Host, Pathogen interactions   Infectious diseases   Innate immunology   Lung Cancer   Medicine   Respiratory System
Details Date
Director: TB Immunology Lab, School of Medicine
Director: Clinical TB services, St. James's Supraregional Centre
Program Chair: American Thoracic Society, MTPI Assembly 2012
Details Date From Date To
TBNET, STOP TB Partnership, International Union Against Tuberculosis and Lung Disease
Royal College of Physicians
American Thoracic Society
Irish Thoracic Society
O'Connor G, Krishnan N, Fagan-Murphy A, Cassidy J, O'Leary S, Robertson BD, Keane J, O'Sullivan MP, Cryan SA., Inhalable poly(lactic-co-glycolic acid) (PLGA) microparticles encapsulating all-trans-Retinoic acid (ATRA) as a host-directed, adjunctive treatment for Mycobacterium tuberculosis infection., European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V, 134, 2019, p153-165 , Journal Article, PUBLISHED  DOI
Roycroft E, O'Toole RF, Fitzgibbon MM, Montgomery L, O'Meara M, Downes P, Jackson S, O'Donnell J, Laurenson IF, McLaughlin AM, Keane J, Rogers TR., Molecular epidemiology of multi- and extensively-drug-resistant mycobacterium tuberculosis in ireland, 2001-2014., The Journal of infection, 76, (1), 2018, p55-67 , Journal Article, PUBLISHED  DOI
Dockry É, O'Leary S, Gleeson LE, Lyons J, Keane J, Gray SG, Doherty DG, Epigenetic induction of CD1d expression primes lung cancer cells for killing by invariant natural killer T cells, OncoImmunology, 2018, pe1428156-, Journal Article, PUBLISHED  URL
Gleeson LE, O'Leary SM, Ryan D, McLaughlin AM, Sheedy FJ, Keane JM., Cigarette Smoking Impairs the Bioenergetic Immune Response to Mycobacterium Tuberculosis Infection., American journal of respiratory cell and molecular biology, 2018, Journal Article, PUBLISHED  DOI
Schwander, S. and Keane, J., Cause or effect? the elusive role of regulatory t cells in tuberculosis, American Journal of Respiratory and Critical Care Medicine, 198, (1), 2018, p11-12 , Notes: [cited By 0], Journal Article, PUBLISHED  DOI
Coleman MM, Basdeo SA, Coleman AM, Cheallaigh CN, Peral de Castro C, McLaughlin AM, Dunne PJ, Harris J, Keane J., All-trans Retinoic Acid Augments Autophagy during Intracellular Bacterial Infection., American journal of respiratory cell and molecular biology, 59, (5), 2018, p548-556 , Journal Article, PUBLISHED  DOI
Phelan JJ, Basdeo SA, Tazoll SC, McGivern S, Saborido JR and Keane J, Modulating Iron for Metabolic Support of TB Host Defense, Frontiers in Immunology, 2018, Journal Article, PUBLISHED  URL
Schwander, S., Keane, J., Cause or effect? the elusive role of regulatory t cells in tuberculosis, American Journal of Respiratory and Critical Care Medicine, 198, (1), 2018, p11-12 , Journal Article, PUBLISHED
Chong Sy Giin, Herron Malcolm, Dorman Anthony, Little Mark, Donnelly Seamas C, Keane Joseph, McLaughlin Anne Marie, Renal amyloidosis complicating multidrug-resistant tuberculosis , The International Journal of Tuberculosis and Lung Disease , 21 , (4 ), 2017, p476 - 477 , Journal Article, PUBLISHED
Chong SG, McLaughlin AM, Keane J., Response: Disseminated tuberculosis., QJM : monthly journal of the Association of Physicians, 110, (5), 2017, p333 , Journal Article, PUBLISHED  DOI
  

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Keane, Joseph, Tuberculosis Guidelines: National TB Advisory Committee, 2008, Notes: [HPSC ], Working Paper, PUBLISHED
Keane, Joseph, American Thoracic Society - Programme committee, In:American Thoracic Society Conference, 2005, Notes: [2005 - present], Meetings /Conferences Organised, PRESENTED
Keane, Joseph, Institute of Molecular Medicine: Programme committee , 2004 - present, 2004, Meetings /Conferences Organised, PRESENTED
Keane, Joseph, International Conference on Cytokine Medicine , 2004 - present, 2004, Meetings /Conferences Organised, PUBLISHED
Keane, Joseph, TNF blockade and opportunistic infection -A position paper, Notes: [ ATS document writing committee ], Working Paper, SUBMITTED
Keane, Joseph, Diagnostic Standards & Classification of Tuberculosis in Adults and Children, Notes: [ ATS document writing committee ], Working Paper, SUBMITTED

  

Award Date
Health Research Board: Clinical Scientist Award 2012
THE HOST RESPONSE TO TUBERCULOSIS
  • Macrophage Responses We asses the macrophage response to infection using in vitro and ex vivo models of human alveolar macrophages infected with Mycobacterium tuberculosis. We have used these experiments to define the role of macrophage cytokine production, bacterial killing, phagolysosome maturation, and cell death in the immune response to tuberculosis. By using human alveolar macrophages from subjects undergoing bronchoscopy we have been able to define clinically relevant innate immune responses to this important organism.
  • Cell Mediated Immunity Using human and murine models of disease we have been able to characterise both the pro and anti inflammatory immune response to Mycobacterium tuberculosis. Specifically we have demonstrated new mechanism whereby human alveolar macrophages generate a tolerogenic response to Mtb infection; which is reflected in T-cell changes that can potentially accommodate the invading pathogen.
  • The study of tuberculosis susceptible human hosts In our translational work; we have characterised the immune response of patients taking TNF-Blockers, cigarette smokers, and patient deficient in vitamin D. In this regard we have helped define their unique host susceptibility to disease with Mycobacterium tuberculosis.
  • Dublin TB group Our lab is an integral part of the Trinity College Immunology Research centre, including investigators who do TB research such as L O'Neill, K. Mills, P. Fallon, E. Lavelle and C. O'Farrelly. We co-supervise work on new inhalable TB therapies for TB with Dr. Sally Ann Cryan (RCSI). These PI's and a critical mass of TB investigators across Dublin are available to collaborate on future grant calls, and include Prof. Stephen Gordon, mycobateriologist, UCD.
  • Clinical Tuberculosis Research With on-site access to the largest TB cohort in Ireland, we have been in a position to define the role of new diagnostic and therapeutic options for TB. We have reported on the use of EBUS-TBNA in the diagnosis of isolated mediastinal tuberculous lymphadenopathy. We have also defined the public health hazard of prolonged infectiousness seen in our patients who smoke cigarettes after commencement of anti-TB treatment.
  • New TB Diagnostics The role of IGRA in the diagnosis of Latent TB infection: We are undertaking bench experiments to improve the signal to noise ratio and potentially shorten the blood incubation period in IGRA tests. In our clinics, we are testing IGRA performance in selected populations that are uniquely susceptible to progression from LTBI to tuberculosis disease.
  • TB research is funded by SFI, HRB and the RCDH Trust
  • Lung Cancer
    • The genetic basis of lung cancer: At St. James's we see 25% of the Irish lung cancer patients. My lab is collaborating with Boston University who are looking at the genetic profile of cells from these patients to address the questions 'Why do some smoker get lung cancer, and some smokers do not'. It is hope that this transcriptomics approach will allow for early detection for this disease that is almost always lethal because it presents late.
    • The accurate staging of lung cancer using whole body MRI or PET