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Professor Kumlesh Dev

Professor (Physiology)

Professor (Trinity Inst. of Neurosciences (TCIN))

  Drug Targets   Glutamate Receptors   Multiple Sclerosis   Neuroscience   Parkinson's Disease   Protein-Protein Interactions   Receptor Trafficking   Sphingosine 1-phosphate receptors
Details Date
Representative Director Ireland, Venture Valuation AG, Zurich, Switzerland
Details Date From Date To
Board Member of Journal of Biological Chemistry
Editorial Board Member of Canadian Journal of Pure and Applied Sciences
O'Sullivan S, Dev K.K, Sphingosine-1-phosphate receptor therapies: Advances in clinical trials for CNS-related diseases, Neuropharmacology, 113, 2017, p597 - 607, Journal Article, PUBLISHED  DOI  URL
O'Sullivan S.A, Velasco-Estevez M, Dev K.K, Demyelination induced by oxidative stress is regulated by sphingosine 1-phosphate receptors, GLIA, 2017, p23148-, Journal Article, PUBLISHED  DOI  URL
Dev K.K, Irving A.J, Lipid sensing G protein-coupled receptors in the CNS, Neuropharmacology, 113, 2017, p595 - 596, Journal Article, PUBLISHED  DOI  URL
O'Sullivan S.A, Gasparini F, Mir A.K, Dev K.K, Fractalkine shedding is mediated by p38 and the ADAM10 protease under pro-inflammatory conditions in human astrocytes, Journal of Neuroinflammation, 13, (1), 2016, p189-, Journal Article, PUBLISHED  TARA - Full Text  DOI  URL
O'Sullivan C, Schubart A, Mir A.K, Dev K.K, The dual S1PR1/S1PR5 drug BAF312 (Siponimod) attenuates demyelination in organotypic slice cultures, Journal of Neuroinflammation, 13, (1), 2016, p31-, Journal Article, PUBLISHED  TARA - Full Text  DOI  URL
Madill M, Fitzgerald D, O'Connell K.E, Dev K.K, Shen S, FitzGerald U, In vitro and ex vivo models of multiple sclerosis, Drug Discovery Today, 21, (9), 2016, p1504 - 1511, Journal Article, PUBLISHED  DOI  URL
Dev K.K, Common receptor signalling in glial & immune cells, Current Drug Targets, 17, (16), 2016, p1828-, Journal Article, PUBLISHED  URL
Rutkowska A, O'Sullivan S.A, Christen I, Zhang J, Sailer A.W, Dev K.K, The EBI2 signalling pathway plays a role in cellular crosstalk between astrocytes and macrophages, Scientific Reports, 6, 2016, p25520 -, Journal Article, PUBLISHED  TARA - Full Text  DOI  URL
Rutkowska, A. Preuss, I. Gessier, F. Sailer, A.W. Dev, K.K., EBI2 regulates intracellular signaling and migration in human astrocyte, Glia, 63, (2), 2015, p341 - 351, Journal Article, PUBLISHED  DOI  URL
O'Sullivan C, Dev K.K, Galactosylsphingosine (psychosine)-induced demyelination is attenuated by sphingosine 1-phosphate signalling, Journal of Cell Science, 128, (21), 2015, p3878 - 3887, Journal Article, PUBLISHED  DOI  URL

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Research is based on investigating mechanisms that control receptor surface expression and thereby receptor function. With an interest in Multiple Sclerosis and Parkinson's Disease, we are investigating surface expression of receptors that are drug targets for these diseases, including sphingosine 1-phosphate receptors (S1P-R), parkin-associated endothelial like receptor (PAEL-R) and the interleukin 2 receptor (IL2-R). Our approach is to engineer, formulate and chemically re-design competitive blocking peptides and discover small molecular weight compounds, which alter receptor surface expression and function in vivo. Development of such agents permits cell-selective receptor modulation and the regulation of orphan receptors or difficult-to-target receptors. We are funded in kind and in part by Trinity College Dublin, Science Foundation Ireland, Health Research Board Ireland, Enterprise Ireland, The Wellcome Trust, Lundbeck, Actelion, Servier and Novartis.