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Professor Charles Dorman

Professor & Head of Discipline (Microbiology)


Charles J Dorman is a microbial geneticist and has held the Chair of Microbiology at Trinity College Dublin since 1994; currently he is in his second term as head of the School of Genetics and Microbiology. Professor Dorman is a Founding Member of the European Academy of Microbiology, a Fellow of the American Academy of Microbiology, a Member of the Royal Irish Academy (Ireland's highest academic honour), a Fellow of the Society of Biology and was made a Chartered Biologist by the Institute of Biology in 2009. He is a recipient of the Sir Alexander Fleming Medal of the Society for General Microbiology (SGM) and was formerly a Royal Society Research Fellow and Lecturer in Biochemistry at the Medical Sciences Institute at Dundee University in the United Kingdom. Professor Dorman has served as the Ambassador to Western Europe of the American Society for Microbiology (ASM) and as a member of the ASM Committee on Global Engagement. He has a keen interest in the development of microbiology internationally, is a visiting professor at the Indian Institute of Science at Bangalore and has delivered more than 180 invited lectures at conferences and other scientific meetings around the world over the past twenty years. From 2005 to 2010 Professor Dorman was Editor-in-Chief of 'Microbiology' (published by the SGM) and in 2014 was elected chair of the SGM Publications Committee with responsibility for its five scientific journals. He has served on the editorial boards of numerous scientific journals and has been an advisor to several national and international research funding agencies worldwide. In 2006-07 he chaired a review of all microbiological research in the United Kingdom for the Biotechnology and Biological Sciences Research Council (BBSRC). His own research focuses on the global regulation of gene expression in bacteria of medical importance, with an emphasis on the regulatory roles of DNA topology and nucleoid-associated proteins.
  BACTERIA   BACTERIAL   BACTERIAL GENE   BACTERIUM   BINDING-PROTEINS   BINDING-SITE   BINDING-SITES   BIOCHEMICAL   BIOCHEMICAL APPROACH   BIOCHEMISTRY   BIOLOGY   CURVED DNA   DEOXYRIBONUCLEIC-ACID GYRASE   DNA   DNA ARRAY   DNA BENDING   DNA BINDING   DNA GYRASE   DNA INVERSION   DNA MICROARRAYS   DNA RECOGNITION DOMAINS   DNA SUPERCOILING   DNA SUPERHELICITY   DNA TOPOLOGY   DNA-BINDING   DNA-BINDING ACTIVITY   DNA-BINDING DOMAIN   DNA-BINDING DOMAINS   DNA-BINDING PROTEIN   DNA-BINDING PROTEINS   DNA-BINDING SUBUNIT   ENVIRONMENTAL REGULATION   ENVIRONMENTAL-REGULATION   ESCHERICHIA-COLI K-12   FIMBRIAE   FIMBRIAL PHASE VARIATION   FIS PROTEIN   GENE REARRANGEMENTS   GENE REGULATION   GENE-EXPRESSION   GENES   GENETIC   GENETIC MANIPULATION   GENETIC STRUCTURE   GENETIC-ANALYSIS   GENETICS   GENOME   GENOME COMPACTION   GENOME EVOLUTION   GENOME EXPRESSION ANALYSIS   GENOMES   GENOMIC ORGANIZATION   GENOMICS   GLOBAL REGULATOR   GROWTH-PHASE CONTROL   GROWTH-PHASE REGULATION   HISTONE-LIKE PROTEINS   HNS   H-NS   INTEGRATION HOST FACTOR   MESSENGER-RNA   MICROARRAY   MICROARRAY DATA   MICROBIAL ACTIVITY   MICROBIOLOGY   MICROORGANISM   MICROORGANISMS   MOLECULAR-BIOLOGY   MOLECULAR-CLONING   MOLECULAR-GENETICS   MOLECULAR-STRUCTURE   SALMONELLA-TYPHIMURIUM   SHIGELLA-FLEXNERI   SITE-SPECIFIC RECOMBINASES   TRANSCRIPTIONAL ACTIVATION   TYPE-1 FIMBRIAE
 Bacterial gene regulation by DNA supercoiling.
 Bacterial DNA supercoiling and gene regulation.
 DNA supercoiling, gene expression and bacterial pathogenicity.
 Contribution of DNA topology to the control of virulence gene expression in Shigella flexneri.
 Environmental stress, DNA supercoiling and the regulation of virulence in Salmonella typhimurium.

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Details Date
Chair of Microbiology, Trinity College Dublin 1994-present
Head of the School of Genetics and Microbiology. Trinity College Dublin 2008-2011; 2014-2017
Head of Microbiology Department, Trinity College Dublin 1994-2001; 2013-2014
Chair, Publications Committee, Society for General Microbiology 2014-2017
Member, Committee on Global Engagement, American Society for Microbiology 2012-2015
International Scientific Committee, IBEC Foundation, Barcelona University 2014-2017
European Ambassador of the American Society for Microbiology 2010-2013
Chair, AERES (French Higher Education Authority agency) research assessment visiting group, Inserm UMR 5240, University of Lyons, France 2015
Representative of the American Society for Microbiology at the 5th Congress of European Microbiology Societies, Leipzig, Germany 2013
Nomination Committee, American Academy of Microbiology Moselio Schaechter Distinguished Service Award 2010-2011
Assessment Committee, Heatley-Payne Exchange Program for Early Career Scientists (American Society for Microbiology and Society for General Microbiology) 2010-2014
Selection Committee, American Academy of Microbiology, GSK International Member of the Year Award 2011-2015
Award Committee, American Society for Microbiology and Federation of European Microbiology Mäkelä - Cassell Award 2012-2015
Chairman, Strategic Review of United Kingdom (UK) Microbial Science 2005-2006
Editor-in-Chief, Microbiology (Published by the Society for General Microbiology) 2005-2010
International Advisory Committee, International Union of Microbiological Societies (IUMS) Congress 2011, Sapporo, Japan 2011
Faculty of 1000 (Faculty Prime member) 2006-present
Molecular Microbiology (Editorial Board) 2005-2015
Journal of Bacteriology (Editorial Board) 2007-2015
Journal of Molecular Microbiology and Biotechnology (Editorial Board) 1998-present
International Journal of Medical Microbiology (Editorial Board). 1999-2007
Biochemical Journal (Biochemical Society Journal) (Editorial Advisory Board). 1996-2008
Pathogens and Disease (Editorial Board) from 2013
Associate Editor, PLoS Pathogens 2013
Current Opinion in Microbiology, Guest Editor 2008-2009
Organizer, American Society for Microbiology Symposium "Complex Genetic Switches" at the 4th Congress of the Federation of European Microbiological Societies, Geneva, Switzerland 2010-2011
Vice-President, Euroconference series on Bacterial Neural Networks, Strasbourg, France 2002
President, Euroconference on Intracellular Signalling and Global Regulation 2000
Council Member, Society for General Microbiology 2005-2009
SGM Journals Business Sub-Committee 2011-2012
SGM Policy Working Party 2011-2012
SGM Council Liaison Officer, SGM Irish Branch 2005-2009
Member, SGM Treasurer's Committee 2005-2010; 2011-2012
SGM Strategy Group 2006
Academy of Finland, Research Council for Bioscience and Environment, Biosciences Panel 2004-2006
Health Research Board of Ireland, Microbiology Committee 1995-98, 1998-00
BBSRC (UK) Plant and Microbial Sciences Research Committee 1995-1997
BBSRC (UK) Initiative on investigating gene function - E. coli bid: member of prefunding steering committee 1999
BBSRC/NERC Joint Initiative on Gene Flow in Plants and Microorganisms - member of expert panel 2000
BBSRC (UK) British Government Institutes Research Assessment Exercise: visiting group member 2001, 2006
BBSRC funding initiative on Prokaryotic Responses to Environmental Stress - steering committee member 1997-1998
American Society for Microbiology Colloquium on H-NS, Boston, USA Co-organizer 2008
Organizer, 2nd European Microbiology Congress: Systems Microbiology Symposium: Madrid, Spain 2006
Organizer, SGM Conference "Fifty Years of the Double Helix": Manchester, UK 2003
Veterinary Training and Research Initiative Bristol University (DEFRA, UK Government), member of scientific committee 2005-2009
Royal Irish Academy Seminar on Microbial Responses to Stress: Organizer 1998
Royal Irish Academy Seminar on Biotechnology: Organizer 1999
Irish representative at Scientia Europeae (French Academy of Science) 1997
Royal Society Conference on Bacterial Pathogens In Vivo: Co-organizer 1999
Novartis Foundation Conference on Bacterial Pathogens In Vivo: Co-organizer 1999
Assoiciate Editor, Microbiology 1993-1998
Editor, Microbiology 1998-2003
PhD examiner University of Birmingham, University of Cambridge, University of Dublin, University of Dundee, University of East Anglia, University of Edinburgh, University of Leicester, Manipal University India, University of Nottingham, The National University of Ireland, The John Innes Centre, The Institute for Food Research UK, Imperial College London, University College London; Vrije Universiteit Amsterdam; Sanger Centre, Cambridge
External advisor appointments and promotions committees at Institute Pasteur, France; University of Bath, University of Birmingham, University College Cork, University College Dublin, University of Dundee, University of Edinburgh, University of Galway, University of Helsinki, Finland; New York State Department of Health, USA; University of Sheffield; University of East Anglia; Sultan Qaboos University, Muscat, Oman; University of North Carolina at Chapel Hill, USA; University of Houston, Texas, USA; Indian Institute for Science, Bangalore, India; Harvard University, Boston, USA
Ad hoc grant reviewer for: Agriculture and Food Research Council (UK), Austrian Science Fund, Biomedical Research Council (Singapore), Biotechnology and Biological Sciences Research Council (UK), Crumlin Hospital Children's Research Centre (Ireland), Danish Council for Independent Research, DFF (Denmark), Deutsche Forschungsgemeinschaft (Germany), Federal Ministry of Education and Research (Germany), Health and Medical Research Fund (Hong Kong), Health Research Board (Ireland), Human Frontier Science Program, Istituto Pasteur-Fondazione Cenci Bolognetti (Italy), Israel Science Foundation (ISF), Labex Jury, French National Research Agency ANR (France), Leverhulme Trust (UK), Medical Research Council (Canada), Medical Research Council (UK), National Science Foundation (USA), Natural Environment Research Council (UK), Netherlands Organization for Scientific Research, North Atlantic Treaty Organization (NATO), Nuffield Trust (UK),
Ad hoc grant reviewer for (contd): Pasteur Institute Fundamental Research Programme (France), Royal Society (UK), Science and Engineering Research Council (UK), Science Foundation Ireland, Swiss National Science Foundation (SNF), Third World Academy of Science (TWAS), United Nations (UNIDO/ICGEB), Wellcome Trust (UK),
Ad hoc journal referee for: Annual Review and Research in Biology, Antonie van Leeuwenhoek, Biochim Biophys Acta, BMC Genetics, BMC Genomics, BMC Microbiology, British Microbiology Research Journal, Cellular Microbiology, Cellular and Molecular Life Sciences, Computational Biology and Chemistry, Current Biology, DNA Repair, Electrophoresis, EMBO Journal, EMBO Reports, Endeavour, Environmental Microbiology, Essays in Biochemistry, FEBS Lett, FEMS Lett, Functional & Integrative Genomics, G3: Genes Genomes Genetics, Gene Regulation and Systems Biology, Genes and Development, Genes and Function, Genetics, Genetic Research, Heredity, Infection and Immunity, International Journal of Evolutionary Biology, Journal of Bacteriology, Journal of Basic Microbiology, Journal of Biological Chemistry, Journal of the Royal Society Interface
Ad hoc journal referee for (contd): Journal of Biosciences, Journal of Biotechnology, Journal of Clinical Microbiology, Journal of General Microbiology, Journal of Medical Microbiology, Journal of Molecular Biology, Journal of Molecular Biology and Biotechnology, Journal of Molecular Evolution, Journal of Structural Biology, mBio, Microbes and Infection, Molecular and General Genetics, Molecular Biosystems, Molecular Microbiology, Microbiology, Microbiology Today, Nature, Nature Methods, Nature Reviews Microbiology, Nature Structural and Molecular Biology, Nucleic Acids Research, Philos Trans R Soc Lond B Biol Sci., Physical Biology, PLoS Biology, PLoS Genetics, PLoS One, PLoS Pathogens, Proceedings of the National Academy of Sciences USA, Protein Science, Science, Soft Matter, Trends in Genetics, Trends in Microbiology, Vaccine, Veterinary Microbiology, Wiley-Blackwell book proposals.
Details Date From Date To
European Academy of Microbiology (Founding Member) Current
American Academy of Microbiology (Fellow) Current
Royal Irish Academy (Member) Current
Society of Biology (Fellow) Current
Institute of Biology (Chartered Biologist) Current
Faculty of 1000 (Faculty Member) Current
Member of the National Commission for Microbiology, Royal Irish Academy 1995 1999
Society for General Microbiology Since 1982
American Society for Microbiology Since 1985
Royal Society Alumnus Group Since 2000
Stochastic modelling of gene regulation in prokaryotes (StoMP Group) Since 2007
Biochemical Society 1988 2008
Society for Experimental Biology 2013 2014
Coordination of bacterial virulence gene expression (Chapter 17) in, editor(s)Y-W Tang , Molecular Medical Microbiology 2nd Edition , San Diego, Elsevier, 2014, pp315 - 355, [Dorman CJ], Book Chapter, PUBLISHED
Paytubi S, Aznar S, Madrid C, Balsalobre C, Dillon S, Dorman CJ, Juarez A, A novel role for antibiotic resistance plasmids in facilitating Salmonella adaptation to nonhost environments, Environmental Microbiology, 16, (4), 2014, p950 - 962, Notes: [Published online 19 August 2013], Journal Article, PUBLISHED  DOI
Quinn HJ, Cameron ADS, Dorman CJ, Bacterial regulon evolution: distinct responses and roles for the identical OmpR proteins of Salmonella Typhimurium and Escherichia coli in the acid stress response, PLoS Genetics, 10, (3), 2014, pe1004215 , Journal Article, PUBLISHED  TARA - Full Text  DOI
Dorman CJ, H-NS-like proteins, mobile genetic elements and horizontal gene transfer in bacteria, Plasmid, 75, (9), 2014, p1 - 11, Journal Article, PUBLISHED  DOI
Dorman CJ, Function of nucleoid-associated proteins in chromosome structuring and transcriptional regulation, Journal of Molecular Microbiology and Biotechnology, 24, (6), 2014, p317 - 332, Notes: [DOI: 10.1159/isbn.978-3-318-03009-9], Journal Article, IN_PRESS
Organization of the Bacterial Nucleoid (Chapter 311) in, Lennarz W, Lane MD , Encyclopedia of Biological Chemistry (2nd Edition), Waltham, MA, USA, Academic Press, 2013, pp367 - 370, [Dorman CJ], Book Chapter, PUBLISHED  URL
Dorman CJ, Hokamp K, Dillon SC, Fitzgerald S, E-GEOD-52235 - Gene expression analysis of Salmonella enterica serovar Typhimurium strain SL1344 swap, EMBL-EBI, 2013, Dataset, PUBLISHED  URL
Dorman CJ, Guadarrama S, Dillon SC, E-GEOD-38661 - Fis occupancy along the Salmonella enterica serovar Typhimurium SL1344 fis::3XFlag strain grown in different aeration regimes., EMBL-EBI, 2013, Dataset, PUBLISHED  URL
Dorman CJ, Co-operative roles for DNA supercoiling and nucleoid-associated proteins in the regulation of bacterial transcription, Biochemical Society Transactions, 41, (2), 2013, p542 - 547, Journal Article, PUBLISHED  DOI
Dorman CJ, Genome architecture and global transcriptional control in bacteria: making progress towards a unified model? , Nature Reviews Microbiology, 11, (5), 2013, p349 - 355, Notes: [Published online 3 April 2013], Journal Article, PUBLISHED  DOI
  

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Dorman CJ, TBA, Twelfth Analytical Genetics Meeting, Rotorua Lake Side Novotel, Rotorua, New Zealand, Jan 10-14, 2016, Invited Talk, IN_PRESS
Dorman CJ, Horizontal gene transfer, microbial evolution and host adaptation , 6th FEMS Congress of European Microbiology, Maastricht, The Netherlands, 7-11 June, 2015, Invited Talk, IN_PRESS
Dorman CJ, Genetic switches and bacterial decision making, 115th General Meeting of the American Society for Microbiology, New Orleans, USA, 2 June, 2015, Invited Talk, IN_PRESS
Dorman CJ, Transcription regulation and bacterial species identity, FASEB Meeting on Transcription, Saxtons River, Vermont, USA, 21-26 June, 2015, Invited Talk, IN_PRESS
Dorman CJ, Genomic rewiring and bacterial identity, MCB75: Molecules to organism, Indian Institute of Science, Bangalore, India, 11-14 December, 2015, Invited Talk, IN_PRESS
Kary SC, Dorman CJ, Cameron ADS, Mutations in global regulatory proteins confer resistance to fluoroquinolone and aminocoumarin antibiotics and alter DNA topology in Salmonella enterica, IUMS Congress, Montreal, Canada, 27 July, 2014, Conference Paper, PUBLISHED
Dorman CJ, 'Genes and Society', Trinity College Dublin Research Themes, Trinity College Dublin, 2014, -, Notes: [http://www.youtube.com/watch?v=ur8VikGCTiY], Film production, PUBLISHED
Dorman CJ, Regulon evolution in Gram-negative bacteria, Institute Seminar, Indian Institute for Science, Bangalore, India, 19th March 2014, 2014, Invited Talk, PUBLISHED
Dorman CJ, Regulon evolution in bacteria - a new twist, Genome Science Seminar Series, University of Leicester UK, 7 May, 2014, Notes: [http://www2.le.ac.uk/colleges/medbiopsych/research/r-themes/genome/seminars], Invited Talk, PUBLISHED
Dorman CJ, Gene regulatory orthologues, paralogues and bacterial genome evolution, 2nd International Workshop on the Biology and Physics of Bacterial Chromosomes, Institute for Advanced Studies, University of Birmingham, UK, 16-18 June, 2014, 17pp, Notes: [http://www.birmingham.ac.uk/research/activity/ias/workshops/2014/the-biology-and-physics-of-bacterial-genomes.aspx], Invited Talk, PUBLISHED

  

Page 1 of 34
Award Date
Visiting Professor, Indian Institute of Science, Bangalore 2014-2017
Top performing editorial board member, Journal of Bacteriology (American Society for Microbiology) 2013
Representative, American Society for Microbiology at the European Congress of Microbiology, Leipzig, Germany 2013
Outstanding Service Award, American Society for Microbiology International Ambassador Programme 2012
Elected Chair of the Publications Committee, Society for General Microbiology 2014
Outstanding Service Award, American Society for Microbiology International Board 2011
Ambassador to Europe, American Society for Microbiology 2010-2012
Elected Fellow of the American Academy of Microbiology 2010
Elected Fellow of the Society of Biology (FSB) 2009
Elected Member of the European Academy of Microbiology 2009
Chartered Biologist (C.Biol.) status conferred by the Institute of Biology (UK) 2009
Elected Member of the Royal Irish Academy (MRIA) 2005
E.S. and R. Duthie Lecturer, TCD 2003
Lecture to Royal Swedish Academy of Sciences (hosted by the Nobel Prize Committee for Chemistry) 2002
Fellow of Trinity College Dublin (FTCD) 1997
Royal Irish Academy representative at Scientia Europaea, French Academy of Science 1997
MA (juri officii) Trinity College, Dublin 1995
Fleming Lecture, 50th Anniversary Meeting of the Society for General Microbiology, University of Bath, UK 1995
Sir Alexander Fleming Medal of the Society for General Microbiology. 1994
Royal Society Fellowship Renewal 1992
Royal Society University Research Fellowship, Biochemistry Department, Medical Sciences Institute, Dundee University, UK 1988-1994
Elected to a Personal Research Fellowship of the Royal Society of Edinburgh. 1988
Searle/Monsanto Postdoctoral Fellow, Department of Biochemistry, Medical Sciences Institute, University of Dundee 1984-1988
EMBO Fellowship (Biochemistry Department, Leicester University, UK) 1983-1984
College Prize (First place, degree exams; National University of Ireland) 1981
University Scholarship (First place, annual exams; UCD) 1980
University Scholarship (First place, annual exams; UCD) 1979
1. Gene regulatory mechanisms in Gram-negative bacteria of medical importance, with an emphasis on the roles of nucleoid-associated proteins and DNA topology in controlling transcription and site-specific recombination. 2. Horizontal transfer of gene regulatory elements and the evolution of gene control networks. 3. The dissection and interpretation of complex gene regulatory circuits using genomics methods. 4. Modulation of gene expression patterns in pathogenic bacteria during infection and intracellular growth.