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Professor Aiden Corvin

Professor Consultant/Head of Discipline (Psychiatry)

Professor Consultant/Head of Discipline (Molecular Medicine Ireland)

I completed undergraduate medical training at University College Cork in 1993 and Membership of the Royal College of Psychiatrists (UK) in 1998. I was awarded a Wellcome Trust Research Training Fellowship in Mental Health in 2000 to develop my interest in the genetic etiology of psychosis and founded the Psychosis Research Group (­‐genetics/psychosis/). I was appointed Senior Lecturer in Psychiatry at TCD (now Professor) and Consultant Psychiatrist at St James's Hospital, Dublin in 2006. Since its inception my research group's goal has been to identify and investigate genetic mechanisms of psychosis, to define molecular etiology, and to use this information to serve patients by improving diagnostics and developing new therapeutic approaches. Through the commitment of more than 3,000 Irish participants we have contributed to substantial research breakthroughs in the field. From identifying molecular overlap between schizophrenia, bipolar disorder, and other psychiatric disorders; to going from finding the first identified risk genes, to the recent confirmation of 108 schizophrenia risk loci. We have identified novel, but rare large genetic effects that may be particularly important in understanding the underlying biology involved. We are increasingly interesting in modeling the risk mechanisms involved and looking at the extent of overlap with other neurological disorders (Brainstorm Project). I am a founder member of the International Schizophrenia Consortium, and lead the Wellcome Trust Case Control Consortium 2-schizophrenia study and Brainstorm (with Ben Neale, Broad Institute MIT/Harvard). I am Associated Editor for Genetics for the Schizophrenia Bulletin. I have authored 190 publications in international peer reviewed journals (Nature, Nature Genetics, Human Molecular Genetics, JAMA Psychiatry) and published 8 book chapters. My group's work has been funded by the Wellcome Trust, NIH, EU, Health Research Board, and Science Foundation Ireland. My h-index (Google Scholar, July 2014)is 43
  Aetiology of mental illness   Cognitive dysfunction in psychotic disorders   Neurodegenerative diseases including schizophrenia & Alzheimer's disease   Neurogenetics   Psychiatric genetics   Schizophrenia
McCarthy-Jones S, Smailes D, Corvin A, Gill M, Morris D.W, Dinan T.G, Murphy K.C, Anthony O′Neill F, Waddington J.L, Australian Schizophrenia Research Ban, Donohoe G, Dudley R, Occurrence and co-occurrence of hallucinations by modality in schizophrenia-spectrum disorders, Psychiatry Research, 252, 2017, p154 - 160, Journal Article, PUBLISHED  DOI  URL
Haziza S, Mohan N, Loe-Mie Y, Lepagnol-Bestel A.-M, Massou S, Adam M.-P, Le X.L, Viard J, Plancon C, Daudin R, Koebel P, Dorard E, Rose C, Hsieh F.-J, Wu C.-C, Potier B, Herault Y, Sala C, Corvin A, Allinquant B, Chang H.-C, Treussart F, Simonneau M, Fluorescent nanodiamond tracking reveals intraneuronal transport abnormalities induced by brain-disease-related genetic risk factors, Nature Nanotechnology, 12, (4), 2017, p322 - 328, Journal Article, PUBLISHED  DOI  URL
Foley C, Corvin A, Nakagome S, Genetics of Schizophrenia: Ready to Translate?, Current Psychiatry Reports, 19, (9), 2017, p61-, Journal Article, PUBLISHED  DOI  URL
Ajetunmobi A, McAllister D, Jain N, Brazil O, Corvin A, Volkov Y, Tropea D, Prina-Mello A, Characterisation of SH-SY5Y Human Neuroblastoma cell growth over glass and SU-8 substrates., Journal of Biomedical Materials Research - Part A, 105, (8), 2017, p2129-2138 , Journal Article, PUBLISHED  DOI
Walton, E., Hibar, D.P., van Erp, T.G.M., (...), Malmqvist, A., Hedberg, M. , Positive symptoms associate with cortical thinning in the superior temporal gyrus via the ENIGMA Schizophrenia consortium, Acta Psychiatrica Scandinavica, 135, (5), 2017, p439-447 , Journal Article, PUBLISHED  DOI
McLaughlin RL, Schijven D, van Rheenen W, van Eijk KR, O'Brien M, Kahn RS, Ophoff RA, Goris A, Bradley DG, Al-Chalabi A, van den Berg LH, Luykx JJ, Hardiman O, Veldink JH, Project MinE GWAS Consortium, Schizophrenia Working Group of the Psychiatric Genomics Consortium, Genetic correlation between amyotrophic lateral sclerosis and schizophrenia., Nature Communications, 2017, p14774 , Journal Article, PUBLISHED  TARA - Full Text  DOI
Trampush J.W, Yang M.L.Z, Yu J, Knowles E, Davies G, Liewald D.C, Starr J.M, Djurovic S, Melle I, Sundet K, Christoforou A, Reinvang I, DeRosse P, Lundervold A.J, Steen V.M, Espeseth T, RÃ"ikkönen K, Widen E, Palotie A, Eriksson J.G, Giegling I, Konte B, Roussos P, Giakoumaki S, Burdick K.E, Payton A, Ollier W, Horan M, Chiba-Falek O, Attix D.K, Need A.C, Cirulli E.T, Voineskos A.N, Stefanis N.C, Avramopoulos D, Hatzimanolis A, Arking D.E, Smyrnis N, Bilder R.M, Freimer N.A, Cannon T.D, London E, Poldrack R.A, Sabb F.W, Congdon E, Conley E.D, Scult M.A, Dickinson D, Straub R.E, Donohoe G, Morris D, Corvin A, Gill M, Hariri A.R, Weinberger D.R, Pendleton N, Bitsios P, Rujescu D, Lahti J, Le Hellard S, Keller M.C, Andreassen O.A, Deary I.J, Glahn D.C, Malhotra A.K, Lencz T, GWAS meta-analysis reveals novel loci and genetic correlates for general cognitive function: a report from the COGENT consortium, Molecular Psychiatry, 22, (3), 2017, 336-345 , Journal Article, PUBLISHED  TARA - Full Text  DOI  URL
Hibar, D.P., Adams, H.H.H., Jahanshad, N., (...), Thompson, P.M., Ikram, M.A. , Novel genetic loci associated with hippocampal volume, Nature Communications , 8, 2017, p13624 , Journal Article, PUBLISHED  TARA - Full Text  DOI
O'Reilly, K., O'Connell, P., Corvin, A., (...), Richter, M., Kennedy, H. , Moral cognition and homicide amongst forensic patients with schizophrenia and schizoaffective disorder: A cross-sectional cohort study, Schizophrenia Research, 2017, Journal Article, IN_PRESS  TARA - Full Text  DOI
Marshall, C.R., Howrigan, D.P., Merico, D., (...), Neale, B.M., Sebat, J. , Contribution of copy number variants to schizophrenia from a genome-wide study of 41,321 subjects , Nature Genetics, 49, (1), 2017, p27-35 , Journal Article, PUBLISHED  DOI

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Robinson, P.C., Leo, P.J., Pointon, J.J., (...), Duncan, E.L., Wordsworth, B.P., The genetic associations of acute anterior uveitis and their overlap with the genetics of ankylosing spondylitis, Genes and Immunity, 17, (1), 2016, p46-51 , Journal Article, PUBLISHED
Corvin, A., Schizophrenia: Evolution and Synthesis: A think tank to accelerate treatment development and prevention efforts. , Ernst Strungman Forum, Frankfurt, Germany, 20-28th July, 2012, Notes: [Invited contributor], Invited Talk, PUBLISHED
Corvin, A., Symposium Organizer, Schizophrenia International Research Society,, April 16th, In:Schizophrenia International Research Society,, 2012, Florence, Italy, Meetings /Conferences Organised, PUBLISHED
Corvin A. , The changing faces of schizophrenia. The Big Idea. , 2012, -, Miscellaneous, PUBLISHED
Corvin AP, McGhee K, Murphy K, Walsh C, Kenny N, Nangle J, Schwaiger S, Baldwin P, Scully P, Quinn J, Crumlish N, O'Callaghan E, Waddington J, Morris D, Gill M, Evidence for association and interaction between G72 and DAAO markers in an Irish case-control schizophrenia sample, American Journal of Medical Genetics Part B: Neuropsychiatric Genetics, SEP 5, 138B, (1), 2005, pp25 - 25, Meeting Abstract, PUBLISHED


I am interested in applying genomics methods to improving understanding of heritable major mental disorders and cognitive processes. Specifically, my research involves the identification and characterization of genes/molecular pathways contributing to disorders such as schizophrenia and bipolar disorder. I have headed the Psychosis Research Group at the Neuropsychiatric Genetics Laboratory since 1999. The group's research activities span from the genome to clinical symptoms (including genomics, biostatistics, bioinformatics, clinical phenotyping, neuropsychology, electrophysiology and neuroimaging). We collaborate with local researchers at the Institute of Molecular Medicine, Department of Genetics and TCIN. We are members of the International Schizophrenia Consortium and collaborate with researchers in the UK, Italy, Australia and US. I am also involved in projects relating to the genetics of cognition and synaesthesia.