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Professor Aiden Corvin

Professor Consultant (Psychiatry)
TRINITY CENTRE, S J H

Professor Consultant (Molecular Medicine Ireland)

I completed undergraduate medical training at University College Cork in 1993 and Membership of the Royal College of Psychiatrists (UK) in 1998. I was awarded a Wellcome Trust Research Training Fellowship in Mental Health in 2000 to develop my interest in the genetic etiology of psychosis and founded the Psychosis Research Group (www.medicine.tcd.ie/neuropsychiatric-­‐genetics/psychosis/). I was appointed Senior Lecturer in Psychiatry at TCD (now Professor) and Consultant Psychiatrist at St James's Hospital, Dublin in 2006. Since its inception my research group's goal has been to identify and investigate genetic mechanisms of psychosis, to define molecular etiology, and to use this information to serve patients by improving diagnostics and developing new therapeutic approaches. Through the commitment of more than 3,000 Irish participants we have contributed to substantial research breakthroughs in the field. From identifying molecular overlap between schizophrenia, bipolar disorder, and other psychiatric disorders; to going from finding the first identified risk genes, to the recent confirmation of 108 schizophrenia risk loci. We have identified novel, but rare large genetic effects that may be particularly important in understanding the underlying biology involved. We are increasingly interesting in modeling the risk mechanisms involved and looking at the extent of overlap with other neurological disorders (Brainstorm Project). I am a founder member of the International Schizophrenia Consortium, and lead the Wellcome Trust Case Control Consortium 2-schizophrenia study and Brainstorm (with Ben Neale, Broad Institute MIT/Harvard). I am Associated Editor for Genetics for the Schizophrenia Bulletin. I have authored 190 publications in international peer reviewed journals (Nature, Nature Genetics, Human Molecular Genetics, JAMA Psychiatry) and published 8 book chapters. My group's work has been funded by the Wellcome Trust, NIH, EU, Health Research Board, and Science Foundation Ireland. My h-index (Google Scholar, July 2014)is 43
  Aetiology of mental illness   Cognitive dysfunction in psychotic disorders   Neurodegenerative diseases including schizophrenia & Alzheimer's disease   Neurogenetics   Psychiatric genetics   Schizophrenia
Fahey C, Byrne S, McLaughlin R, Kenna K, Shatunov A, Donohoe G, Gill M, Al-Chalabi A, Bradley DG, Hardiman O, Corvin AP, Morris DW, Analysis of the hexanucleotide repeat expansion and founder haplotype at C9ORF72 in an Irish psychosis case-control sample., Neurobiology of aging, 35, (6), 2014, p1510.e1-1510.e5 , Journal Article, PUBLISHED  TARA - Full Text  DOI
Mothersill O, Morris DW, Kelly S, Rose EJ, Fahey C, O'Brien C, Lyne R, Reilly R, Gill M, Corvin AP, Donohoe G, Effects of MIR137 on fronto-amygdala functional connectivity., NeuroImage, 90, 2014, p189-95 , Journal Article, PUBLISHED  TARA - Full Text  DOI
Corvin A, Morris DW, Genome-wide Association Studies: Findings at the Major Histocompatibility Complex Locus in Psychosis., Biological psychiatry, 75, (4), 2014, p276-83 , Journal Article, PUBLISHED  DOI
Rees E, Walters JT, Chambert KD, O'Dushlaine C, Szatkiewicz J, Richards AL, Georgieva L, Mahoney-Davies G, Legge SE, Moran JL, Genovese G, Levinson D, Morris DW, Cormican P, Kendler KS, O'Neill FA, Riley B, Gill M, Corvin A, Sklar P, Hultman C, Pato C, Pato M, Sullivan PF, Gejman PV, McCarroll SA, O'Donovan MC, Owen MJ, Kirov G, CNV analysis in a large schizophrenia sample implicates deletions at 16p12.1 and SLC1A1 and duplications at 1p36.33 and CGNL1., Human molecular genetics, 23, (6), 2014, 1669-1676 , Journal Article, PUBLISHED  TARA - Full Text  DOI
O'Donoghue T, Morris DW, Fahey C, Da Costa A, Moore S, Cummings E, Leicht G, Karch S, Hoerold D, Tropea D, Foxe JJ, Gill M, Corvin A, Donohoe G, Effects of ZNF804A on auditory P300 response in schizophrenia., Translational psychiatry, 4, 2014, pe345 , Journal Article, PUBLISHED  TARA - Full Text  DOI
Lencz, T., Knowles, E., Davies, G., (...), Glahn, D.C., Malhotra, A.K. , Molecular genetic evidence for overlap between general cognitive ability and risk for schizophrenia: A report from the Cognitive Genomics consorTium (COGENT), Molecular Psychiatry, 19, (2), 2014, 168-174 , Journal Article, PUBLISHED  DOI
Steinberg, S., De Jong, S., Mattheisen, M., (...), Stefansson, H., Stefansson, K., Common variant at 16p11.2 conferring risk of psychosis, Molecular Psychiatry, 19, (1), 2014, p108-114 , Notes: [ ], Journal Article, PUBLISHED  DOI
McCarthy, S.E., Gillis, J., Kramer, M., (...), McCombie, W.R., Corvin, A. , De novo mutations in schizophrenia implicate chromatin remodeling and support a genetic overlap with autism and intellectual disability, Molecular Psychiatry, 19, 2014, p652-658 , Journal Article, PUBLISHED  DOI
Lencz T, Knowles E, Davies G, Guha S, Liewald DC, Starr JM, Djurovic S, Melle I, Sundet K, Christoforou A, Reinvang I, Mukherjee S, DeRosse P, Lundervold A, Steen VM, John M, Espeseth T, Räikkönen K, Widen E, Palotie A, Eriksson JG, Giegling I, Konte B, Ikeda M, Roussos P, Giakoumaki S, Burdick KE, Payton A, Ollier W, Horan M, Donohoe G, Morris D, Corvin A, Gill M, Pendleton N, Iwata N, Darvasi A, Bitsios P, Rujescu D, Lahti J, Hellard SL, Keller MC, Andreassen OA, Deary IJ, Glahn DC, Malhotra AK, Molecular genetic evidence for overlap between general cognitive ability and risk for schizophrenia: a report from the Cognitive Genomics consorTium (COGENT)., Molecular psychiatry, 19, (2), 2014, p168-74 , Journal Article, PUBLISHED  TARA - Full Text  DOI
Rees E, Kirov G, Sanders A, Walters JT, Chambert KD, Shi J, Szatkiewicz J, O'Dushlaine C, Richards AL, Green EK, Jones I, Davies G, Legge SE, Moran JL, Pato C, Pato M, Genovese G, Levinson D, Duan J, Moy W, Göring HH, Morris D, Cormican P, Kendler KS, O'Neill FA, Riley B, Gill M, Corvin A, Craddock N, Sklar P, Hultman C, Sullivan PF, Gejman PV, McCarroll SA, O'Donovan MC, Owen MJ, Evidence that duplications of 22q11.2 protect against schizophrenia., Molecular psychiatry, 19, (1), 2014, p37-40 , Journal Article, PUBLISHED  TARA - Full Text  DOI
  

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Corvin, A., Schizophrenia: Evolution and Synthesis: A think tank to accelerate treatment development and prevention efforts. , Ernst Strungman Forum, Frankfurt, Germany, 20-28th July, 2012, Notes: [Invited contributor], Invited Talk, PUBLISHED
Corvin, A., Symposium Organizer, Schizophrenia International Research Society,, April 16th, In:Schizophrenia International Research Society,, 2012, Florence, Italy, Meetings /Conferences Organised, PUBLISHED
Corvin A. , The changing faces of schizophrenia. The Big Idea. , 2012, -, Miscellaneous, PUBLISHED
Morris DW, Nangle JM, Kiely B, Corvin A, Gill M. , The molecular basis of schizophrenia: a complex genetic disorder. , Irish Psychiatrist, 5, 2004, p134 - 137, Journal Article, PUBLISHED

  

I am interested in applying genomics methods to improving understanding of heritable major mental disorders and cognitive processes. Specifically, my research involves the identification and characterization of genes/molecular pathways contributing to disorders such as schizophrenia and bipolar disorder. I have headed the Psychosis Research Group at the Neuropsychiatric Genetics Laboratory since 1999. The group's research activities span from the genome to clinical symptoms (including genomics, biostatistics, bioinformatics, clinical phenotyping, neuropsychology, electrophysiology and neuroimaging). We collaborate with local researchers at the Institute of Molecular Medicine, Department of Genetics and TCIN. We are members of the International Schizophrenia Consortium and collaborate with researchers in the UK, Italy, Australia and US. I am also involved in projects relating to the genetics of cognition and synaesthesia.