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Professor Aiden Corvin

Professor Consultant/Head of Discipline (Psychiatry)
TRINITY CENTRE, S J H

Deputy Director (Trinity Inst. of Neurosciences (TCIN))

Deputy Director (Trinity Translational Medicine Institute)


Aiden completed undergraduate medical training at University College Cork in 1993 and Membership of the Royal College of Psychiatrists (UK) in 1998. He was awarded a Wellcome Trust Fellowship in Mental Health in 2000 to explore the genetic aetiology of Psychotic Disorders. This was the seed for the development of the TCD Psychosis Research Group (www.medicine.tcd.ie/neuropsychiatric-¬-genetics/psychosis/). He was appointed Senior Lecturer in Psychiatry at TCD and Consultant Psychiatrist at St James's Hospital in 2006. Since 2017, Aiden has headed the Discipline of Psychiatry at the Medical School and been Clinical Director for the Dublin South Central Mental Health Service. His research team have made a substantial contribution to our understanding of the genetic aetiology of schizophrenia and bipolar disorder. Aiden was lead PI for Schizophrenia with the Wellcome Trust Case Control Consortium, a founder member of the Psychiatric Genomics Consortium and co-leads the Brainstorm Consortium (with Ben Neale, Broad Institute of MIT/Harvard). Work with Ben has recently identified significant genetic overlap across psychiatric disorders, suggesting that shared molecular mechanisms may contribute to symptoms affecting perception, mood and anxiety. He serves on the editorial board of two journals in the field and is a member of the UK MRC Neurosciences Panel. With generous help from more than 3,000 Irish participants, Aiden and his team continue to seek and investigate genes that contribute to the risk of serious mental illness, and to explore the biology involved with the aim of improving patient care. This work has been funded by Wellcome, SFI, HRB, EU and NIH. Aiden has published more than 240 peer-reviewed articles and 9 book chapters. His h-index is 68 (May 2018) and his work has received more than 21,000 citations.'
  Aetiology of mental illness   Cognitive dysfunction in psychotic disorders   Neurodegenerative diseases including schizophrenia & Alzheimer's disease   Neurogenetics   Psychiatric genetics   Schizophrenia
O'Reilly, K., O'Connell, P., Corvin, A., (...), Richter, M., Kennedy, H. , Moral cognition and homicide amongst forensic patients with schizophrenia and schizoaffective disorder: A cross-sectional cohort study, Schizophrenia Research, 193, 2018, p468-469 , Journal Article, IN_PRESS  TARA - Full Text  DOI
Donohoe, G. and Dillon, R. and Hargreaves, A. and Mothersill, O. and Castorina, M. and Furey, E. and Fagan, A.J. and Meaney, J.F. and Fitzmaurice, B. and Hallahan, B. and McDonald, C. and Wykes, T. and Corvin, A. and Robertson, I.H., Effectiveness of a low support, remotely accessible, cognitive remediation training programme for chronic psychosis: cognitive, functional and cortical outcomes from a single blind randomised controlled trial, Psychological Medicine, 48, (5), 2018, p751-764 , Journal Article, PUBLISHED  DOI
Blokland, G.A.M. and del Re, E.C. and Mesholam-Gately, R.I. and Jovicich, J. and Trampush, J.W. and Keshavan, M.S. and DeLisi, L.E. and Walters, J.T.R. and Turner, J.A. and Malhotra, A.K. and Lencz, T. and Shenton, M.E. and Voineskos, A.N. and Rujescu, D. and Giegling, I. and Kahn, R.S. and Roffman, J.L. and Holt, D.J. and Ehrlich, S. and Kikinis, Z. and Dazzan, P. and Murray, R.M. and Di Forti, M. and Lee, J. and Sim, K. and Lam, M. and Wolthusen, R.P.F. and de Zwarte, S.M.C. and Walton, E. and Cosgrove, D. and Kelly, S. and Maleki, N. and Osiecki, L. and Picchioni, M.M. and Bramon, E. and Russo, M. and David, A.S. and Mondelli, V. and Reinders, A.A.T.S. and Falcone, M.A. and Hartmann, A.M. and Konte, B. and Morris, D.W. and Gill, M. and Corvin, A.P. and Cahn, W. and Ho, N.F. and Liu, J.J. and Keefe, R.S.E. and Gollub, R.L. and Manoach, D.S. and Calhoun, V.D. and Schulz, S.C. and Sponheim, S.R. and Goff, D.C. and Buka, S.L. and Cherkerzian, S. and Thermenos, H.W. and Kubicki, M. and Nestor, P.G. and Dickie, E.W. and Vassos, E. and Ciufolini, S. and Reis Marques, T. and Crossley, N.A. and Purcell, S.M. and Smoller, J.W. and van Haren, N.E.M. and Toulopoulou, T. and Donohoe, G. and Goldstein, J.M. and Seidman, L.J. and McCarley, R.W. and Petryshen, T.L., The Genetics of Endophenotypes of Neurofunction to Understand Schizophrenia (GENUS) consortium: A collaborative cognitive and neuroimaging genetics project, Schizophrenia Research, 195, 2018, p306-317 , Journal Article, PUBLISHED  TARA - Full Text  DOI
Iglesias, A.I. and Mishra, A. and Vitart, V. and Bykhovskaya, Y. and Höhn, R. and Springelkamp, H. and Cuellar-Partida, G. and Gharahkhani, P. and Bailey, J.N.C. and Willoughby, C.E. and Li, X. and Yazar, S. and Nag, A. and Khawaja, A.P. and PolaÅ¡ek, O. and Siscovick, D. and Mitchell, P. and Tham, Y.C. and Haines, J.L. and Kearns, L.S. and Hayward, C. and Shi, Y. and Van Leeuwen, E.M. and Taylor, K.D. and Wang, J.J. and Rochtchina, E. and Attia, J. and Scott, R. and Holliday, E.G. and Baird, P.N. and Xie, J. and Inouye, M. and Viswanathan, A. and Sim, X. and Bonnemaijer, P. and Rotter, J.I. and Martin, N.G. and Zeller, T. and Mills, R.A. and Staffieri, S.E. and Jonas, J.B. and Schmidtmann, I. and Boutin, T. and Kang, J.H. and Lucas, S.E.M. and Wong, T.Y. and Beutel, M.E. and Wilson, J.F. and Allingham, R.R. and Brilliant, M.H. and Budenz, D.L. and Christen, W.G. and Fingert, J. and Friedman, D.S. and Gaasterland, D. and Gaasterland, T. and Hauser, M.A. and Kraft, P. and Lee, R.K. and Lichter, P.R. and Liu, Y. and Loomis, S.J. and Moroi, S.E. and Pericak-Vance, M.A. and Realini, A. and Richards, J.E. and Schuman, J.S. and Scott, W.K. and Singh, K. and Sit, A.J. and Vollrath, D. and Weinreb, R.N. and Wollstein, G. and Zack, D.J. and Zhang, K. and Donnelly, P. and Barroso, I. and Blackwell, J.M. and Bramon, E. and Brown, M.A. and Casas, J.P. and Corvin, A. and Deloukas, P. and Duncanson, A. and Jankowski, J. and Markus, H.S. and Mathew, C.G. and Palmer, C.N.A. and Plomin, R. and Rautanen, A. and Sawcer, S.J. and Trembath, R.C. and Wood, N.W. and Spencer, C.C.A. and Band, G. and Bellenguez, C. and Freeman, C. and Hellenthal, G. and Giannoulatou, E. and Pirinen, M. and Pearson, R. and Strange, A. and Su, Z. and Vukcevic, D. and Langford, C. and Hunt, S.E. and Edkins, S. and Gwilliam, R. and Blackburn, H. and Bumpstead, S.J. and Dronov, S. and Gillman, M. and Gray, E. and Hammond, N. and Jayakumar, A. and McCann, O.T. and Liddle, J. and Potter, S.C. and Ravindrarajah, R. and Ricketts, M. and Waller, M. and Weston, P. and Widaa, S. and Whittaker, P. and Uitterlinden, A.G. and Vithana, E.N. and Foster, P.J. and Hysi, P.G. and Hewitt, A.W. and Khor, C.C. and Pasquale, L.R. and Montgomery, G.W. and Klaver, C.C.W. and Aung, T. and Pfeiffer, N. and MacKey, D.A. and Hammond, C.J. and Cheng, C.-Y. and Craig, J.E. and Rabinowitz, Y.S. and Wiggs, J.L. and Burdon, K.P. and Van Duijn, C.M. and MacGregor, S., Cross-ancestry genome-wide association analysis of corneal thickness strengthens link between complex and Mendelian eye diseases, Nature Communications, 9, (1), 2018, p1864-, Notes: [cited By 0], Journal Article, PUBLISHED  DOI
Cosgrove, D. and Mothersill, D.O. and Whitton, L. and Harold, D. and Kelly, S. and Holleran, L. and Holland, J. and Anney, R. and Richards, A. and Mantripragada, K. and Owen, M. and O'Donovan, M.C. and Gill, M. and Corvin, A. and Morris, D.W. and Donohoe, G., Effects of MiR-137 genetic risk score on brain volume and cortical measures in patients with schizophrenia and controls, American Journal of Medical Genetics, Part B: Neuropsychiatric Genetics, 177, (3), 2018, p369-376 , Notes: [cited By 0], Journal Article, PUBLISHED  DOI
Donohoe, G. and Holland, J. and Mothersill, D. and McCarthy-Jones, S. and Cosgrove, D. and Harold, D. and Richards, A. and Mantripragada, K. and Owen, M.J. and O'Donovan, M.C. and Wtccc2 and Gill, M. and Corvin, A. and Morris, D.W., Genetically predicted complement component 4A expression: effects on memory function and middle temporal lobe activation, Psychological Medicine, 2018, p1-10 , Notes: [cited By 0; Article in Press], Journal Article, PUBLISHED  DOI
Walton, E. and Hibar, D.P. and Van Erp, T.G.M. and Potkin, S.G. and Roiz-Santiañez, R. and Crespo-Facorro, B. and Suarez-Pinilla, P. and Van Haren, N.E.M. and De Zwarte, S.M.C. and Kahn, R.S. and Cahn, W. and Doan, N.T. and Jorgensen, K.N. and Gurholt, T.P. and Agartz, I. and Andreassen, O.A. and Westlye, L.T. and Melle, I. and Berg, A.O. and Morch-Johnsen, L. and FÊrden, A. and Flyckt, L. and Fatouros-Bergman, H. and Jönsson, E.G. and Hashimoto, R. and Yamamori, H. and Fukunaga, M. and Jahanshad, N. and De Rossi, P. and Piras, F. and Banaj, N. and Spalletta, G. and Gur, R.E. and Gur, R.C. and Wolf, D.H. and Satterthwaite, T.D. and Beard, L.M. and Sommer, I.E. and Koops, S. and Gruber, O. and Richter, A. and KrÀmer, B. and Kelly, S. and Donohoe, G. and McDonald, C. and Cannon, D.M. and Corvin, A. and Gill, M. and Di Giorgio, A. and Bertolino, A. and Lawrie, S. and Nickson, T. and Whalley, H.C. and Neilson, E. and Calhoun, V.D. and Thompson, P.M. and Turner, J.A. and Ehrlich, S., Prefrontal cortical thinning links to negative symptoms in schizophrenia via the ENIGMA consortium, Psychological Medicine, 48, (1), 2018, p82-94 , Notes: [cited By 0], Journal Article, PUBLISHED  TARA - Full Text  DOI
Ni, G. and Moser, G. and Ripke, S. and Neale, B.M. and Corvin, A. and Walters, J.T.R. and Farh, K.-H. and Holmans, P.A. and Lee, P. and Bulik-Sullivan, B. and Collier, D.A. and Huang, H. and Pers, T.H. and Agartz, I. and Agerbo, E. and Albus, M. and Alexander, M. and Amin, F. and Bacanu, S.A. and Begemann, M. and Belliveau, R.A. and Bene, J. and Bergen, S.E. and Bevilacqua, E. and Bigdeli, T.B. and Black, D.W. and Bruggeman, R. and Buccola, N.G. and Buckner, R.L. and Byerley, W. and Cahn, W. and Cai, G. and Campion, D. and Cantor, R.M. and Carr, V.J. and Carrera, N. and Catts, S.V. and Chambert, K.D. and Chan, R.C.K. and Chen, R.Y.L. and Chen, E.Y.H. and Cheng, W. and Cheung, E.F.C. and Chong, S.A. and Cloninger, C.R. and Cohen, D. and Cohen, N. and Cormican, P. and Craddock, N. and Crowley, J.J. and Curtis, D. and Davidson, M. and Davis, K.L. and Degenhardt, F. and Del Favero, J. and Demontis, D. and Dikeos, D. and Dinan, T. and Djurovic, S. and Donohoe, G. and Drapeau, E. and Duan, J. and Dudbridge, F. and Durmishi, N. and Eichhammer, P. and Eriksson, J. and Escott-Price, V. and Essioux, L. and Fanous, A.H. and Farrell, M.S. and Frank, J. and Franke, L. and Freedman, R. and Freimer, N.B. and Friedl, M. and Friedman, J.I. and Fromer, M. and Genovese, G. and Georgieva, L. and Giegling, I. and Giusti-Rodríguez, P. and Godard, S. and Goldstein, J.I. and Golimbet, V. and Gopal, S. and Gratten, J. and de Haan, L. and Hammer, C. and Hamshere, M.L. and Hansen, M. and Hansen, T. and Haroutunian, V. and Hartmann, A.M. and Henskens, F.A. and Herms, S. and Hirschhorn, J.N. and Hoffmann, P. and Hofman, A. and Hollegaard, M.V. and Hougaard, D.M. and Ikeda, M. and Joa, I. and Juliá, A. and Kahn, R.S. and Kalaydjieva, L. and Karachanak-Yankova, S. and Karjalainen, J. and Kavanagh, D. and Keller, M.C. and Kennedy, J.L. and Khrunin, A. and Kim, Y. and Klovins, J. and Knowles, J.A. and Konte, B. and Kucinskas, V. and Kucinskiene, Z.A. and Kuzelova-Ptackova, H. and KÃ"hler, A.K. and Laurent, C. and Keong, J.L.C. and Legge, S.E. and Lerer, B. and Li, M. and Li, T. and Liang, K.-Y. and Lieberman, J. and Limborska, S. and Loughland, C.M. and Lubinski, J. and Lönnqvist, J. and Macek, M. and Magnusson, P.K.E. and Maher, B.S. and Maier, W. and Mallet, J. and Marsal, S. and Mattheisen, M. and Mattingsda, M. and McCarley, R.W. and McDonald, C. and McIntosh, A.M. and Meier, S. and Meijer, C.J. and Melegh, B. and Melle, I. and Mesholam-Gately, R.I. and Metspalu, A. and Michie, P.T. and Milani, L. and Milanova, V. and Mokrab, Y. and Morris, D.W. and Mors, O. and Murphy, K.C. and Murray, R.M. and Myin-Germeys, I. and MÃ"ller-Myhsok, B. and Nelis, M. and Nenadic, I. and Nertney, D.A. and Nestadt, G. and Nicodemus, K.K. and Nikitina-Zake, L. and Nisenbaum, L. and Nordin, A. and O'Callaghan, E. and O'Dushlaine, C. and O'Neill, F.A. and Oh, S.-Y. and Olinc, A. and Olsen, L. and Van Os, J. and Pantelis, C. and Papadimitriou, G.N. and Papio, S. and Parkhomenko, E. and Pato, M.T. and Paunio, T. and Pejovic-Milovancevic, M. and Perkins, D.O. and PietilÃ"inenl, O. and Pimm, J. and Pocklington, A.J. and Powell, J. and Price, A. and Pulver, A.E. and Purcell, S.M. and Quested, D. and Rasmussen, H.B. and Reichenberg, A. and Reimers, M.A. and Richards, A.L. and Roffman, J.L. and Roussos, P. and Ruderfer, D.M. and Salomaa, V. and Sanders, A.R. and Schall, U. and Schubert, C.R. and Schulze, T.G. and Schwab, S.G. and Scolnick, E.M. and Scott, R.J. and Seidman, L.J. and Shi, J. and Sigurdsson, E. and Sila, Estimation of Genetic Correlation via Linkage Disequilibrium Score Regression and Genomic Restricted Maximum Likelihood, American Journal of Human Genetics, 102, (6), 2018, p1185-1194 , Journal Article, PUBLISHED  DOI
Davies, G. and Lam, M. and Harris, S.E. and Trampush, J.W. and Luciano, M. and Hill, W.D. and Hagenaars, S.P. and Ritchie, S.J. and Marioni, R.E. and Fawns-Ritchie, C. and Liewald, D.C.M. and Okely, J.A. and Ahola-Olli, A.V. and Barnes, C.L.K. and Bertram, L. and Bis, J.C. and Burdick, K.E. and Christoforou, A. and Derosse, P. and Djurovic, S. and Espeseth, T. and Giakoumaki, S. and Giddaluru, S. and Gustavson, D.E. and Hayward, C. and Hofer, E. and Ikram, M.A. and Karlsson, R. and Knowles, E. and Lahti, J. and Leber, M. and Li, S. and Mather, K.A. and Melle, I. and Morris, D. and Oldmeadow, C. and Palviainen, T. and Payton, A. and Pazoki, R. and Petrovic, K. and Reynolds, C.A. and Sargurupremraj, M. and Scholz, M. and Smith, J.A. and Smith, A.V. and Terzikhan, N. and Thalamuthu, A. and Trompet, S. and Van Der Lee, S.J. and Ware, E.B. and Windham, B.G. and Wright, M.J. and Yang, J. and Yu, J. and Ames, D. and Amin, N. and Amouyel, P. and Andreassen, O.A. and Armstrong, N.J. and Assareh, A.A. and Attia, J.R. and Attix, D. and Avramopoulos, D. and Bennett, D.A. and Böhmer, A.C. and Boyle, P.A. and Brodaty, H. and Campbell, H. and Cannon, T.D. and Cirulli, E.T. and Congdon, E. and Conley, E.D. and Corley, J. and Cox, S.R. and Dale, A.M. and Dehghan, A. and Dick, D. and Dickinson, D. and Eriksson, J.G. and Evangelou, E. and Faul, J.D. and Ford, I. and Freimer, N.A. and Gao, H. and Giegling, I. and Gillespie, N.A. and Gordon, S.D. and Gottesman, R.F. and Griswold, M.E. and Gudnason, V. and Harris, T.B. and Hartmann, A.M. and Hatzimanolis, A. and Heiss, G. and Holliday, E.G. and Joshi, P.K. and KÃ"hönen, M. and Kardia, S.L.R. and Karlsson, I. and Kleineidam, L. and Knopman, D.S. and Kochan, N.A. and Konte, B. and Kwok, J.B. and Le Hellard, S. and Lee, T. and LehtimÃ"ki, T. and Li, S.-C. and Liu, T. and Koini, M. and London, E. and Longstreth, W.T. and Lopez, O.L. and Loukola, A. and Luck, T. and Lundervold, A.J. and Lundquist, A. and LyytikÃ"inen, L.-P. and Martin, N.G. and Montgomery, G.W. and Murray, A.D. and Need, A.C. and Noordam, R. and Nyberg, L. and Ollier, W. and Papenberg, G. and Pattie, A. and Polasek, O. and Poldrack, R.A. and Psaty, B.M. and Reppermund, S. and Riedel-Heller, S.G. and Rose, R.J. and Rotter, J.I. and Roussos, P. and Rovio, S.P. and Saba, Y. and Sabb, F.W. and Sachdev, P.S. and Satizabal, C.L. and Schmid, M. and Scott, R.J. and Scult, M.A. and Simino, J. and Slagboom, P.E. and Smyrnis, N. and Soumaré, A. and Stefanis, N.C. and Stott, D.J. and Straub, R.E. and Sundet, K. and Taylor, A.M. and Taylor, K.D. and Tzoulaki, I. and Tzourio, C. and Uitterlinden, A. and Vitart, V. and Voineskos, A.N. and Kaprio, J. and Wagner, M. and Wagner, H. and Weinhold, L. and Wen, K.H. and Widen, E. and Yang, Q. and Zhao, W. and Adams, H.H.H. and Arking, D.E. and Bilder, R.M. and Bitsios, P. and Boerwinkle, E. and Chiba-Falek, O. and Corvin, A. and De Jager, P.L. and Debette, S. and Donohoe, G. and Elliott, P. and Fitzpatrick, A.L. and Gill, M. and Glahn, D.C. and HÃ"gg, S. and Hansell, N.K. and Hariri, A.R. and Ikram, M.K. and Jukema, J.W. and Vuoksimaa, E. and Keller, M.C. and Kremen, W.S. and Launer, L. and Lindenberger, U. and Palotie, A. and Pedersen, N.L. and Pendleton, N. and Porteous, D.J. and RÃ"ikkönen, K. and Raitakari, O.T. and Ramirez, A. and Reinvang, I. and Rudan, I. and Rujescu, D. and Schmidt, R. and Schmidt, H. and Schofield, P.W. and Schofield, P.R. and Starr, J.M. and Steen, V.M. and Trollor, J.N. and Turner, S.T. and Van Duijn, C.M. and Vill, Study of 300,486 individuals identifies 148 independent genetic loci influencing general cognitive function, Nature Communications, 9, (1), 2018, p2098-, Notes: [cited By 0], Journal Article, PUBLISHED  TARA - Full Text  DOI
McCarthy-Jones S, Smailes D, Corvin A, Gill M, Morris D.W, Dinan T.G, Murphy K.C, Anthony O′Neill F, Waddington J.L, Australian Schizophrenia Research Ban, Donohoe G, Dudley R, Occurrence and co-occurrence of hallucinations by modality in schizophrenia-spectrum disorders, Psychiatry Research, 252, 2017, p154 - 160, Journal Article, PUBLISHED  DOI  URL
  

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Robinson, P.C., Leo, P.J., Pointon, J.J., (...), Duncan, E.L., Wordsworth, B.P., The genetic associations of acute anterior uveitis and their overlap with the genetics of ankylosing spondylitis, Genes and Immunity, 17, (1), 2016, p46-51 , Journal Article, PUBLISHED
Corvin, A., Schizophrenia: Evolution and Synthesis: A think tank to accelerate treatment development and prevention efforts. , Ernst Strungman Forum, Frankfurt, Germany, 20-28th July, 2012, Notes: [Invited contributor], Invited Talk, PUBLISHED
Corvin, A., Symposium Organizer, Schizophrenia International Research Society,, April 16th, In:Schizophrenia International Research Society,, 2012, Florence, Italy, Meetings /Conferences Organised, PUBLISHED
Corvin A. , The changing faces of schizophrenia. The Big Idea. , 2012, -, Miscellaneous, PUBLISHED
Corvin AP, McGhee K, Murphy K, Walsh C, Kenny N, Nangle J, Schwaiger S, Baldwin P, Scully P, Quinn J, Crumlish N, O'Callaghan E, Waddington J, Morris D, Gill M, Evidence for association and interaction between G72 and DAAO markers in an Irish case-control schizophrenia sample, American Journal of Medical Genetics Part B: Neuropsychiatric Genetics, SEP 5, 138B, (1), 2005, pp25 - 25, Meeting Abstract, PUBLISHED

  

I am interested in applying genomics methods to improving understanding of heritable major mental disorders and cognitive processes. Specifically, my research involves the identification and characterization of genes/molecular pathways contributing to disorders such as schizophrenia and bipolar disorder. I have headed the Psychosis Research Group at the Neuropsychiatric Genetics Laboratory since 1999. The group's research activities span from the genome to clinical symptoms (including genomics, biostatistics, bioinformatics, clinical phenotyping, neuropsychology, electrophysiology and neuroimaging). We collaborate with local researchers at the Institute of Molecular Medicine, Department of Genetics and TCIN. We are members of the International Schizophrenia Consortium and collaborate with researchers in the UK, Italy, Australia and US. I am also involved in projects relating to the genetics of cognition and synaesthesia.