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Professor Aiden Corvin

Professor Consultant/Head of Discipline (Psychiatry)

Professor Consultant/Head of Discipline (Molecular Medicine Ireland)

I completed undergraduate medical training at University College Cork in 1993 and Membership of the Royal College of Psychiatrists (UK) in 1998. I was awarded a Wellcome Trust Research Training Fellowship in Mental Health in 2000 to develop my interest in the genetic etiology of psychosis and founded the Psychosis Research Group (­‐genetics/psychosis/). I was appointed Senior Lecturer in Psychiatry at TCD (now Professor) and Consultant Psychiatrist at St James's Hospital, Dublin in 2006. Since its inception my research group's goal has been to identify and investigate genetic mechanisms of psychosis, to define molecular etiology, and to use this information to serve patients by improving diagnostics and developing new therapeutic approaches. Through the commitment of more than 3,000 Irish participants we have contributed to substantial research breakthroughs in the field. From identifying molecular overlap between schizophrenia, bipolar disorder, and other psychiatric disorders; to going from finding the first identified risk genes, to the recent confirmation of 108 schizophrenia risk loci. We have identified novel, but rare large genetic effects that may be particularly important in understanding the underlying biology involved. We are increasingly interesting in modeling the risk mechanisms involved and looking at the extent of overlap with other neurological disorders (Brainstorm Project). I am a founder member of the International Schizophrenia Consortium, and lead the Wellcome Trust Case Control Consortium 2-schizophrenia study and Brainstorm (with Ben Neale, Broad Institute MIT/Harvard). I am Associated Editor for Genetics for the Schizophrenia Bulletin. I have authored 190 publications in international peer reviewed journals (Nature, Nature Genetics, Human Molecular Genetics, JAMA Psychiatry) and published 8 book chapters. My group's work has been funded by the Wellcome Trust, NIH, EU, Health Research Board, and Science Foundation Ireland. My h-index (Google Scholar, July 2014)is 43
  Aetiology of mental illness   Cognitive dysfunction in psychotic disorders   Neurodegenerative diseases including schizophrenia & Alzheimer's disease   Neurogenetics   Psychiatric genetics   Schizophrenia
Coleman C, Quinn E.M, Ryan A.W, Conroy J, Trimble V, Mahmud N, Kennedy N, Corvin A.P, Morris D.W, Donohoe G, O'Morain C, MacMathuna P, Byrnes V, Kiat C, Trynka G, Wijmenga C, Kelleher D, Ennis S, Anney R.J.L, McManus R, Common polygenic variation in coeliac disease and confirmation of ZNF335 and NIFA as disease susceptibility loci, Molecular Psychiatry, 24, 2016, p291 - 297, Journal Article, PUBLISHED  TARA - Full Text  DOI  URL
van Erp T.G.M, Hibar D.P, Rasmussen J.M, Glahn D.C, Pearlson G.D, Andreassen O.A, Agartz I, Westlye L.T, Haukvik U.K, Dale A.M, Melle I, Hartberg C.B, Gruber O, Kraemer B, Zilles D, Donohoe G, Kelly S, McDonald C, Morris D.W, Cannon D.M, Corvin A, Machielsen M.W.J, Koenders L, de Haan L, Veltman D.J, Satterthwaite T.D, Wolf D.H, Gur R.C, Gur R.E, Potkin S.G, Mathalon D.H, Mueller B.A, Preda A, Macciardi F, Ehrlich S, Walton E, Hass J, Calhoun V.D, Bockholt H.J, Sponheim S.R, Shoemaker J.M, van Haren N.E.M, Pol H.E.H, Ophoff R.A, Kahn R.S, Roiz-Santiañez R, Crespo-Facorro B, Wang L, Alpert K.I, Jönsson E.G, Dimitrova R, Bois C, Whalley H.C, McIntosh A.M, Lawrie S.M, Hashimoto R, Thompson P.M, Turner J.A, Subcortical brain volume abnormalities in 2028 individuals with schizophrenia and 2540 healthy controls via the ENIGMA consortium, Molecular Psychiatry, 21, 2016, p547-553 , Journal Article, IN_PRESS  TARA - Full Text  DOI  URL
Tropea D, Mortimer N, Bellini S, Molinos I, Sanfeliu A, Shovlin S, McAllister D, Gill M, Mitchell K, Corvin A, Expression of nuclear Methyl-CpG binding protein 2 (Mecp2) is dependent on neuronal stimulation and application of Insulin-like growth factor 1, Neuroscience Letters, 621, 2016, p111 - 116, Notes: [Export Date: 22 September 2016], Journal Article, PUBLISHED  DOI  URL
Corvin A, Sullivan P.F, What next in schizophrenia genetics for the psychiatric genomics consortium?, Schizophrenia Bulletin, 42, (3), 2016, p538 - 541, Notes: [Export Date: 22 September 2016], Journal Article, PUBLISHED  DOI  URL
Rautanen A, Pirinen M, Mills T.C, Rockett K.A, Strange A, Ndungu A.W, Naranbhai V, Gilchrist J.J, Bellenguez C, Freeman C, Band G, Bumpstead S.J, Edkins S, Giannoulatou E, Gray E, Dronov S, Hunt S.E, Langford C, Pearson R.D, Su Z, Vukcevic D, Macharia A.W, Uyoga S, Ndila C, Mturi N, Njuguna P, Mohammed S, Berkley J.A, Mwangi I, Mwarumba S, Kitsao B.S, Lowe B.S, Morpeth S.C, Khandwalla I, Blackwell J.M, Bramon E, Brown M.A, Casas J.P, Corvin A, Duncanson A, Jankowski J, Markus H.S, Mathew C.G, Palmer C.N.A, Plomin R, Sawcer S.J, Trembath R.C, Viswanathan A.C, Wood N.W, Deloukas P, Peltonen L, Williams T.N, Scott J.A.G, Chapman S.J, Donnelly P, Hill A.V.S, Spencer C.C.A, Polymorphism in a lincRNA Associates with a Doubled Risk of Pneumococcal Bacteremia in Kenyan Children, American Journal of Human Genetics, 98, (6), 2016, p1092 - 1100, Notes: [Export Date: 22 September 2016], Journal Article, PUBLISHED  DOI  URL
Corvin, A., O'Donovan, M.C., Psychiatric genetics: What's new in 2015?, The Lancet Psychiatry, 3, (1), 2016, p10-12 , Journal Article, PUBLISHED
Merikangas, A.K., Segurado, R., Kelleher, E., Hogan, D., Delaney, C., Gill, M., Gallagher, L., Corvin, A.P., and Heron, E.A. , Parental age, birth order and neurodevelopmental disorders, Molecular Psychiatry, 21, 2016, p728-730 , Journal Article, PUBLISHED  DOI
Mothersill O, Tangney N, Morris D.W, McCarthy H, Frodl T, Gill M, Corvin A, Donohoe G, Further evidence of alerted default network connectivity and association with theory of mind ability in schizophrenia, Schizophrenia Research, 2016, Notes: [Export Date: 27 January 2017 Article in Press], Journal Article, PUBLISHED  TARA - Full Text  DOI  URL
Baurecht, H. Hotze, M. Brand, S. Büning, C. Cormican, P. Corvin, A. Ellinghaus, D. Ellinghaus, E. Esparza-Gordillo, J. Fölster-Holst, R. Franke, A. Gieger, C. Hubner, N. Illig, T. Irvine, A.D. Kabesch, M. Lee, Y.A.E. Lieb, W. Marenholz, I. McLean, W.H.I. Morris, D.W. Mrowietz, U. Nair, R. Nöthen, M.M. Novak, N. O'Regan, G.M. Schreiber, S. Smith, C. Strauch, K. Stuart, P.E. Trembath, R. Tsoi, L.C. Weichenthal, M. Barker, J. Elder, J.T. Weidinger, S. Cordell, H.J. Brown, S.J., Genome-wide comparative analysis of atopic dermatitis and psoriasis gives insight into opposing genetic mechanisms, American Journal of Human Genetics, 96, (1), 2015, p104 - 120, Notes: [Export Date: 3 March 2015], Journal Article, PUBLISHED  TARA - Full Text  DOI  URL
Farrell M.S, Werge T, Sklar P, Owen M.J, Ophoff R.A, O'donovan M.C, Corvin A, Cichon S, Sullivan P.F, Evaluating historical candidate genes for schizophrenia, Molecular Psychiatry, 20, (5), 2015, p555 - 562, Notes: [Export Date: 20 July 2015], Journal Article, PUBLISHED  DOI  URL

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Corvin, A., Schizophrenia: Evolution and Synthesis: A think tank to accelerate treatment development and prevention efforts. , Ernst Strungman Forum, Frankfurt, Germany, 20-28th July, 2012, Notes: [Invited contributor], Invited Talk, PUBLISHED
Corvin, A., Symposium Organizer, Schizophrenia International Research Society,, April 16th, In:Schizophrenia International Research Society,, 2012, Florence, Italy, Meetings /Conferences Organised, PUBLISHED
Corvin A. , The changing faces of schizophrenia. The Big Idea. , 2012, -, Miscellaneous, PUBLISHED
Corvin AP, McGhee K, Murphy K, Walsh C, Kenny N, Nangle J, Schwaiger S, Baldwin P, Scully P, Quinn J, Crumlish N, O'Callaghan E, Waddington J, Morris D, Gill M, Evidence for association and interaction between G72 and DAAO markers in an Irish case-control schizophrenia sample, American Journal of Medical Genetics Part B: Neuropsychiatric Genetics, SEP 5, 138B, (1), 2005, pp25 - 25, Meeting Abstract, PUBLISHED
Morris DW, Nangle JM, Kiely B, Corvin A, Gill M. , The molecular basis of schizophrenia: a complex genetic disorder. , Irish Psychiatrist, 5, 2004, p134 - 137, Journal Article, PUBLISHED


I am interested in applying genomics methods to improving understanding of heritable major mental disorders and cognitive processes. Specifically, my research involves the identification and characterization of genes/molecular pathways contributing to disorders such as schizophrenia and bipolar disorder. I have headed the Psychosis Research Group at the Neuropsychiatric Genetics Laboratory since 1999. The group's research activities span from the genome to clinical symptoms (including genomics, biostatistics, bioinformatics, clinical phenotyping, neuropsychology, electrophysiology and neuroimaging). We collaborate with local researchers at the Institute of Molecular Medicine, Department of Genetics and TCIN. We are members of the International Schizophrenia Consortium and collaborate with researchers in the UK, Italy, Australia and US. I am also involved in projects relating to the genetics of cognition and synaesthesia.