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Professor Aiden Corvin

Professor Consultant (Psychiatry)
TRINITY CENTRE, S J H

 acorvin@tcd.ie

 3531896 2467

Deputy Director (Trinity Inst. of Neurosciences (TCIN))

Deputy Director (Trinity Translational Medicine Institute)


Biography

Professor Aiden Corvin (MB, PhD, MRCPsych, FTCD) is a Professor in the Discipline of Psychiatry TCD (formerly Head of Discipline 2016-2022) and Clinical Director of the St. James"s Hospital Mental Health Service. He leads the Neuropsychiatric Genetics Research Group at TCD. Over more than twenty years he has investigated the genetic basis of psychiatric disorders, in particular schizophrenia and bipolar disorder. His work is driven by the clinical imperatives of being able to answer the questions of patients and their families; to improve understanding of disease biology; and to develop better patient care. He has significantly contributed to a revolution in understanding of the genetic basis of psychiatric disorders. He was lead investigator for schizophrenia with the Wellcome Trust Case Control Consortium (WTCCCC) and is Chair of the Pedigree Sequencing Working Group of the Psychiatric Genomics Consortium (PGC), an international collaborative research project that includes more than 800 scientists. He has published in journals such as Science, Nature, Nature Genetics, JAMA Psychiatry, and the British Journal of Psychiatry. His work has been funded by the National Institute of Health (US), Wellcome, Science Foundation Ireland, and the Health Research Board, Ireland. He is consistently one of the most cited Irish biomedical scientists and has published more than 320 peer reviewed journal articles (h-index 100 and >65,000 citations as of October 2023).

Research Tags

  Aetiology of mental illness   Cognitive dysfunction in psychotic disorders   Neurodegenerative diseases including schizophrenia & Alzheimer's disease   Neurogenetics   Psychiatric genetics   Schizophrenia
Ormond C, Ryan NM, Byerley W, Heron EA, Corvin A, Investigating copy number variants in schizophrenia pedigrees using a new consensus pipeline called PECAN, Scientific Reports, 2024, Journal Article, PUBLISHED  DOI
King S., Mothersill D., Holleran L., Patlola S.R., Burke T., McManus R., Kenyon M., McDonald C., Hallahan B., Corvin A., Morris D.W., Kelly J.P., McKernan D.P., Donohoe G., Early life stress, low-grade systemic inflammation and weaker suppression of the default mode network (DMN) during face processing in Schizophrenia, Translational Psychiatry, 13, (1), 2023, Journal Article, PUBLISHED  DOI
Ormond C., Ryan N.M., Heron E.A., Gill M., Byerley W., Corvin A., Ultrarare Missense Variants Implicated in Utah Pedigrees Multiply Affected With Schizophrenia, Biological Psychiatry Global Open Science, 3, (4), 2023, p797 - 802, p797-802 , Journal Article, PUBLISHED  DOI
Ryan N, Ormond C, Chang YC, Contreras J, Raventos H, Gill M, Heron E, Mathews CA, & Corvin A, Identity-by-descent analysis of a large Tourette's syndrome pedigree from Costa Rica implicates genes involved in neuronal development and signal transduction, Molecular Psychiatry, 2022, Journal Article, PUBLISHED
Duncan S Palmer, Daniel P Howrigan, Sinéad B Chapman, Rolf Adolfsson, Nick Bass, Douglas Blackwood, Marco PM Boks, Chia-Yen Chen, Claire Churchhouse, Aiden P Corvin, Nicholas Craddock, Arianna Di Florio, Faith Dickerson, Fernando S Goes, Xiaoming Jia, Ian Jones, Lisa Jones, Lina Jonsson, Rene S Kahn, Mikael Landén, Adam Locke, Andrew McIntosh, Andrew McQuillin, Derek W Morris, Michael C O"Donovan, Roel A Ophoff, Michael J Owen, Nancy Pedersen, Danielle Posthuma, Andreas Reif, Neil Risch, Catherine Schaefer, Laura Scott, Tarjinder Singh, Jordan W Smoller, Matthew Solomonson, David St. Clair, Eli A Stahl, Annabel Vreeker, James Walters, Weiqing Wang, Nicholas A Watts, Robert Yolken, Peter Zandi, Benjamin M Neale, Exome sequencing in bipolar disorder reveals shared risk gene AKAP11 with schizophrenia, 2021, Journal Article, PUBLISHED
Ormond C, Ryan NM, Corvin A, Heron EA., Converting single nucleotide variants between genome builds: from cautionary tale to solution., Briefings in bioinformatics, 2021, Journal Article, PUBLISHED  DOI
Daniela Tropea, Snow Bach, Aiden Corvin, Methyl-Cpg-Binding Protein 2 Mediates Overlapping Mechanisms Across Brain Disorders, American College of Neuropshychopharmacology Annual meeting, on-line, edited by Neuropsychopharmacology , 2020, Conference Paper, PUBLISHED  URL
O'Reilly, K., Donohoe, G., O'Sullivan, D., (...), O'Connell, P., Kennedy, H.G. , A randomized controlled trial of cognitive remediation for a national cohort of forensic patients with schizophrenia or schizoaffective disorder, BMC Psychiatry, 19, (1), 2019, p27-, Journal Article, PUBLISHED  TARA - Full Text  DOI
Rees E, Carrera N, Morgan J, Hambridge K, Escott-Price V, Pocklington A.J, Richards A.L, Pardiñas A.F, Alizadeh B.Z, van Amelsvoort T, Bartels-Velthuis A.A, van Beveren N.J, Bruggeman R, Cahn W, de Haan L, Delespaul P, Meijer C.J, Myin-Germeys I, Kahn R.S, Schirmbeck F, Simons C.J.P, van Haren N.E, van Os J, van Winkel R, Luykx J.J, McDonald C, Donohoe G, Morris D.W, Kenny E, Kelleher E, Gill M, Corvin A, Kirov G, Walters J.T.R, Holmans P, Owen M.J, O'Donovan M.C, Targeted Sequencing of 10,198 Samples Confirms Abnormalities in Neuronal Activity and Implicates Voltage-Gated Sodium Channels in Schizophrenia Pathogenesis, Biological Psychiatry, 85, (7), 2019, p554 - 562, Journal Article, PUBLISHED  TARA - Full Text  DOI  URL
Morgan S.E, Seidlitz J, Whitaker K.J, Romero-Garcia R, Clifton N.E, Scarpazza C, van Amelsvoort T, Marcelis M, van Os J, Donohoe G, Mothersill D, Corvin A, Pocklington A, Raznahan A, McGuire P, Vértes P.E, Bullmore E.T, Cortical patterning of abnormal morphometric similarity in psychosis is associated with brain expression of schizophrenia-related genes, Proceedings of the National Academy of Sciences of the United States of America, 116, (19), 2019, p9604 - 9609, Journal Article, PUBLISHED  TARA - Full Text  DOI  URL
  

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Robinson, P.C., Leo, P.J., Pointon, J.J., (...), Duncan, E.L., Wordsworth, B.P., The genetic associations of acute anterior uveitis and their overlap with the genetics of ankylosing spondylitis, Genes and Immunity, 17, (1), 2016, p46-51 , Journal Article, PUBLISHED
Corvin, A., Schizophrenia: Evolution and Synthesis: A think tank to accelerate treatment development and prevention efforts. , Ernst Strungman Forum, Frankfurt, Germany, 20-28th July, 2012, Notes: [Invited contributor], Invited Talk, PUBLISHED
Corvin, A., Symposium Organizer, Schizophrenia International Research Society,, April 16th, In:Schizophrenia International Research Society,, 2012, Florence, Italy, Meetings /Conferences Organised, PUBLISHED
Corvin A. , The changing faces of schizophrenia. The Big Idea. , 2012, -, Miscellaneous, PUBLISHED
Corvin AP, McGhee K, Murphy K, Walsh C, Kenny N, Nangle J, Schwaiger S, Baldwin P, Scully P, Quinn J, Crumlish N, O'Callaghan E, Waddington J, Morris D, Gill M, Evidence for association and interaction between G72 and DAAO markers in an Irish case-control schizophrenia sample, American Journal of Medical Genetics Part B: Neuropsychiatric Genetics, SEP 5, 138B, (1), 2005, pp25 - 25, Meeting Abstract, PUBLISHED

  

Research Interests

Description Of Research Interests

I am interested in applying genomics methods to improving understanding of heritable major mental disorders and cognitive processes. Specifically, my research involves the identification and characterization of genes/molecular pathways contributing to disorders such as schizophrenia and bipolar disorder. I have headed the Psychosis Research Group at the Neuropsychiatric Genetics Laboratory since 1999. The group's research activities span from the genome to clinical symptoms (including genomics, biostatistics, bioinformatics, clinical phenotyping, neuropsychology, electrophysiology and neuroimaging). We collaborate with local researchers at the Institute of Molecular Medicine, Department of Genetics and TCIN. We are members of the International Schizophrenia Consortium and collaborate with researchers in the UK, Italy, Australia and US. I am also involved in projects relating to the genetics of cognition and synaesthesia.