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Dr. Yvonne Langan

Clinical Senior Lecturer (Clinical Medicine)
      
Profile Photo

Dr. Yvonne Langan

Clinical Senior Lecturer (Clinical Medicine)

 ylangan@tcd.ie

 


Dr Langan is a Consultant in Clinical Neurophysiology in St James's Hospital. She undertook clinical training in Neurology and Neurophysiology in Dublin, London and Newcastle upon Tyne. She spent three years in the Department of Experimental Epileptology in the Institute of Neurology in Queen Square, London, undertaking research into Sudden Unexpected Death in Epilepsy (SUDEP). Dr Langan continues to be involved in research into SUDEP along with projects involving EEG and peripheral neurophysiology. She is President of the Irish Society of Clinical Neurophysiology and is active in teaching at undergraduate and postgraduate level.
  Clinical neurology   EEG   ELECTROMYOGRAPHY (EMG)   EPILEPSY   MEDICAL EDUCATION   NEUROPHYSIOLOGY
Project Title
 The incidence of sudden unexpected death in epilepsy (SUDEP) in Ireland
From
2019
To
2025
Summary
This work was undertaken in collaboration with the Health Research Board and coronial records form 2019 were examined to allow the identification of SUDEP cases and the subsequent calculation of an incidence rate for Ireland.
Funding Agency
Epilepsy Ireland, Irish Institute of Clinical Neuroscience
Project Title
 Disorders of brain development across the slifespan: insights from rare genetic conditions
From
01/09/2025
To
01/09/2030
Summary
Funding Agency
TRDA
Project Title
 Epilepsy related deaths in Ireland
From
2020
To
Summary
In collaboration with the HRB coronial records for 2019 have been examined in an effort to identify non SUDEP epilepsy related deaths.
Funding Agency
Epilepsy Ireland, Irish Institute of Clinical Neuroscience
Project Title
 EEG in CAR-T patients
From
To
Summary
To examine whether EEG changes in patients being treated with CAR-T are predictive of ICANS
Funding Agency
Consultant Innovation fund
Project Title
 Case control study of SUDEP
From
To
Summary
International SUDEP case control study

Page 1 of 2
Details Date From Date To
Fellowhip Royal College of Physicians of Ireland 15/10/2025
Royal College of Physicians of Ireland 1993 present
The Irish Institute of Clinical Neuroscience 2009 present
International League against Epilepsy 2015 present
Irish Society of Clinical Neurophysiology 2009 present
Langan Y., Lynn E., The incidence of sudden unexpected death in epilepsy (SUDEP) in the Republic of Ireland, Seizure, 122, 2024, p34 - 38, p34-38 , Journal Article, PUBLISHED  DOI
McKenna MC, O'Connor A, Lockhart A, Bogdanova-Mihaylova P, Brett F, Langan Y, Meaney J, Costigan D, Doherty CP, Bede P, Murphy SM, Hutchinson S., POLR3A-related disorders: expanding the clinical phenotype., J Neurol., 2024, Notes: [2024 Feb 27. doi: 10.1007/s00415-024-12265-9. Online ahead of print. PMID: 38413463], Journal Article, PUBLISHED  DOI
McGonigle O., Russell C., Langan Y., Advice following a possible first seizure: what do patients attending for EEG remember?, Seizure, 113, 2023, p19 - 22, p19-22 , Journal Article, PUBLISHED  DOI
Al Bayati F, McGrane C, Sweeney A, Langan Y., The role of ambulatory EEG in the investigation of paroxysmal events, Irish Medical Journal, 114, (3), 2021, p304 - 304, Journal Article, PUBLISHED
McKenna MC, Al-Hinai M, Bradley D, Doran E, Hunt I, Hutchinson S, Langan Y, O'Rourke D, Qasem R, Redmond J, Troy E, Doherty CP., Patients' Experiences of Remote Neurology Consultations during the COVID-19 Pandemic, European Neurology, 83, (6), 2021, p622 - 625, Journal Article, PUBLISHED  DOI
Bergin P, Langan Y, Beghi E, Donner E, Cock H, D'Souza W, Thomas R, Scragg R, Invitiation to participate in a prospective case control study of sudden unexpected death in epilepsy, Epilepsia, 62, (5), 2021, p1280 - 1281, Journal Article, PUBLISHED  DOI
Togher Z, Redmond A, Troy E, Penugonda M, Crumlish N, Langan Y, Hutchinson S., A case of Urbach Wiethe disease asssociated with ictal fear, Neurology, American Academy of Neurology, Toronto, 2020, 2021, Poster, PUBLISHED  URL
Fearon C, Lonergan R, Ferguson D, Byrne S, Bradley D, Langan Y, Redmond J., Very-late-onset Friedreich's ataxia: Diagnosis in a kindred with late-onset cerebellar ataxia, Practical Neurology, 1, (20), 2020, p55 - 58, Journal Article, PUBLISHED  DOI
Moloney PB, Hutchinson S, Heskin J, Mulcahy F, Langan Y, Conlon NP, Linas BP, Takashi C, Cervantes-Arslanian AM., Possible N methyl D asparatate receptor antibody mediated encephalitis in the setting of HIV cerebrospinal escape., Journal of Neurology, 267, (5), 2020, p1348 - 1352, Journal Article, PUBLISHED  DOI
O Donnell M, Hunt I, McKenna MC, Armstrong C, Flynn C, Leonard N, Cryan J, Langan Y Redmond J., When you cannot 'keep your chin up'. An unusual case of head drop., Irish Neurological Association, virtual, October 2020, 2020, Poster, PUBLISHED
  

Page 1 of 6
Langan Y, SUDEP and Alcohol, Royal Society of Medicine Epilepsy session, RSM, London, 26/01/21, 2021, B McDonald, Invited Talk, PUBLISHED

  


I have a particular interest in epilepsy mortality and sudden unexpected death in epilepsy (SUDEP) has been a major focus of my research. I was responsible for the design, conduct and analysis of a case control study examining risk factors for SUDEP, the largest such study to date which has established me as an expert in the field. I was awarded the Hastings Fellowship in support of this work which was also supported by the UK charity Epilepsy Bereaved. This work made a significant contribution to the body of knowledge on the subject and has informed guidelines such as those produced by NICE. This work led to international collaboration with with other experts as part of the work of the International League against Epilepsy(ILAE) commission on epidemiology. I have supported and supervised a Research Fellow in the Department of Clinical Neurophysiology to investigate the role of baroreceptor sensitivity in the genesis of SUDEP, work which was successfully awarded MD and which was supporting by funding from Epilepsy Ireland. This work was awarded the Kirker prize in epilepsy at the Irish Neurological Association meeting in 2013. I have undertaken a study on epilepsy mortality in Ireland in collaboration with the Health Research Board(HRB)and the Irish coroners. We have examined coronial records from 2019 in order to identify and categorise deaths in those with epilepsy with a particular focus on epilepsy related deaths. This work is supported by a grant from the Irish Institute of Clinical Neuroscience and Epilepsy Ireland. This work has resulted in a publication of the incidence of SUDEP in Ireland with work ongoing on other epilepsy related deaths. Presently I am on the steering committee of an International multicentre case control study in SUDEP coordinated by Prof. Peter Bergin in New Zealand and am awaiting ethics approval to identify Irish cases. I am examining EEG changes in those undergoing CAR-T therapy. Further work on this topic will be undertaken with Dr Roisin McMackin of the McMackin Institute. I am one of a number of principal investigators from a number of schools who have been awarded a TRDA undertaking research into disorders of brain development across the lifespan.