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Dr. Friedrich Wetterling

Assistant Professor (Electronic & Elect. Engineering)

 FRIEDRICH.WETTERLING@tcd.ie

 


Biography

Assistant Professor for Biomedical Circuits and Systems at Trinity College and head of The MediCAS Lab, a position anchored at the Department of Electronic and Electrical Engineering within the School of Engineering. He led the radio-frequency and system development of an innovative implantable device for congestive heart failure monitoring at FIRE1 (2016-2024). He was a Marie-Curie Research Fellow at Trinity College where he developed a novel monitoring method for cardiac function using inductively coupled resonators, i.e. radio-frequency cardiography (2013-2015). Prior to that he led the Magnetic Resonance Methods and Imaging group at the Chair for Computer Assisted Clinical Medicine, Heidelberg University (2009-2012) where his team captured the first whole body tomographic image set solely based upon the local sodium concentration in a human. In 2010, he was awarded the Siemens Prize for establishing Sodium-23 Magnetic Resonance Imaging for stroke tissue viability assessment at the annual meeting of the German Medical Physics Association (DGMP) in Freiburg, Germany. He is a member of the International Society for Magnetic Resonance in Medicine (ISMRM). He has authored and co-authored over 40 publications in peer-reviewed scientific journals and conferences papers. And he has authored more than 30 patent applications. Dr. Friedrich Wetterling is head of the Medical Circuits and Systems Lab (MediCAS) at the department of Electronics and Electrical Engineering where he and his team are researching and developing: - #accessible devices that are remotely deployable using portable, wearable, and implantable circuits - #sustainable systems that reduce the need of finite resources such as helium - #meaningful solutions offering physiologically-relevant and accurate measurements to monitor and to manage chronic health conditions

Research Tags

  Magnetic Resonance Imaging (MRI)   Medical Devices   Radio-frequency resonator / coil systems for MRI   Tissue viability imaging after ischaemic stroke   Tissue viability imaging after tumor-therapy   Whole-body sodium-MRI in patients   X-nuclei MRI (i.e. 13C, 19F, 23Na, 31P, 35Cl, 39K)

Research Projects

 Unlocking the potential of ultrahigh field 23Na magnetic resonance to quantify tissue sodium content for probing viability of the heart: where physics, biology and medicine meet
 A non-invasive deep brain stimulation device
 Development of a nuclear magnetic resonance imaging technique for the accurate detection and quantification of tissue sodium concentration in animal models of disease.

Aristokleous N, Collopy D , Wetterling F., Sweeney F., O'Cearbhaill E., O"Rourke M., IN SILICO MODELLING OF FLOW-INDUCED COLLAPSE OF BLOOD VESSELS: A COMPARATIVE STUDY OF VOLUME STATUSES, 29th Annual Conference of the Section of Bioengineering of the Royal Academy of Medicine in Ireland (BinI 2024), Belfast, Northern Ireland, 26-27 January 2024, 2024, Conference Paper, PUBLISHED  TARA - Full Text
Málek F, Došká" P, Wetterling F, Marešová Z, Reddy V, Neužil P, MONITORING OF VOLUME STATUS USING A NOVEL SENSOR FOR THE ASSESSMENT OF INFERIOR VENA CAVA AREA AND COLLAPSIBILITY IN A PATIENT WITH HFREF RECEIVING ADVANCED HEART FAILURE THERAPIES, Czech Cardiovascular Research and Innovation Days 2023, Prague, Czech Republic, 20-21 November 2023, 2023, pp1 , Conference Paper, PUBLISHED  TARA - Full Text
Málek F, Došká" P, Wetterling F, Marešová Z, Reddy V, Neužil P, HOW INFERIOR VENA CAVA COLLAPSIBILITY INDEX FROM A NOVEL IMPLANTABLE SENSOR CORRELATES WITH ESTIMATED PLASMA VOLUME AND NT-PROBNP: A STUDY IN PATIENTS WITH CHRONIC HEART FAILURE, Czech Cardiovascular Research and Innovation Days 2023, Prague, Czech Republic, 20-21 November 2023, 2023, pp1 , Conference Paper, PUBLISHED
Wetterling F, Sheridan WS, Testani JM, Borlaug BA, Fudim M, Damman K, Gray A, Gaines P, Poloczek M, Madden S, Tucker J, Buxo T, Gaul R, Corcoran L, Sweeney F, Burkhoff D., Safety and performance of a novel implantable sensor in the inferior vena cava under acute and chronic intravascular volume modulation., European journal of heart failure, 25, (5), 2023, p754-763 , Journal Article, PUBLISHED  DOI
Wacker M, Wetterling F, Feczko T, Arkelius K, Arnou A, Lellouche J, Ansar S, Advanced theranostic nanocarrier-mediated delivery of NGF in a combination therapy trigger enhanced recovery after stroke, Journal of Cerebral Blood Flow & Metabolism, BRAIN and BRAIN-PET 2022, Glasgow, Scotland, 28 May - 1 June 2022, 42, (1S), 2022, pp263 - 264, Conference Paper, PUBLISHED
Ivey-Miranda JB, Wetterling F, Gaul R, Sheridan S, Asher JL, Rao VS, Maulion C, Mahoney D, Mebazaa A, Gray AP, Burkhoff D, Cowie MR, Cox ZL, Butler J, Fudim M, McDonald K, Damman K, Borlaug BA, Testani JM., Changes in inferior vena cava area represent a more sensitive metric than changes in filling pressures during experimental manipulation of intravascular volume and tone., European journal of heart failure, 24, (3), 2022, p455-462 , Journal Article, PUBLISHED  DOI
Raikhelkar J, Kebed K, Narang A, Kruse E, Weatherford S, Imamura T., Wetterling F, Nguyen A, Sayer G, Lang R., Uriel N., Inferior Vena Cava Collapsibility Index Assessed by 3D Echocardiography: A Novel Tool for the Assessment of Right Atrial Pressure in Heart Failure Patients, Journal of the American Society of Echocardiography, 32, (6), 2019, pp130 - 131, Conference Paper, PUBLISHED
Mostajeran M, Wetterling F, Blixt FW, Edvinsson L, Ansar S., Acute mitogen-activated protein kinase 1/2 inhibition improves functional recovery and vascular changes after ischaemic stroke in rat-monitored by 9.4 T magnetic resonance imaging., Acta physiologica (Oxford, England), 223, (1), 2018, pe12985 , Journal Article, PUBLISHED  DOI
McCarthy H., Stanley J., Piech R., Wetterling F., Skokauskas N., Mulligan A., Donohoe G., Mullins D., Kelly J., Johnson K., Fagan A., Gill M., Meaney J., Frodl T., Childhood-Diagnosed ADHD, Symptom Progression, and Reversal Learning in Adulthood, Journal of Attention Disorders, 22, (6), 2018, 561, p570 , Journal Article, PUBLISHED
Giblin, S., Meldrum D., McGroarty M., O'Brien S., Rand S., Smith S., Grogan K., Wetterling F., Bone length calibration can significantly improve the measurement accuracy of knee flexion angle when using a marker-less system to capture the motion of countermovement jump, 3rd IEEE EMBS International Conference on Biomedical and Health Informatics, BHI 2016, 2016, p392-397 , Journal Article, PUBLISHED  TARA - Full Text
  

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Hanson S Gifford III, Conor M Hanley, Jessi Johnson, Pablo Martin, Stephen Sheridan, Douglas S Sutton, Fiachra M Sweeney, Friedrich Wetterling, 'Wireless resonant circuit and variable inductance vascular monitoring implants and anchoring structures therefore', USPTO, 2023, 26 March 2024, Foundry Innovation and Research 1 Ltd, Patent, GRANTED
Hanson S Gifford III, Conor M Hanley, Jessi Johnson, Pablo Martin, Shriram Raghunathan, Stephen Sheridan, Douglas S Sutton, Fiachra M Sweeney, Friedrich Wetterling, 'Wireless vascular monitoring implants', USPTO, 10806352, 2020, 24 March 2024, Foundry Innovation & Research1, Ltd.,Dublin(IE), Patent, GRANTED

  

Awards and Honours

Award Date
AI Ireland award for best use of robotic process automation and cognitive Artificial Intelligence (AI) 2021
Intel Prize at DCU Hackathon for presenting a low cost MRI solution to assess beef quality (as part of the Bó Selecta team) 2015
Enterprise Ireland Commercialization Feasibility Grant (15.000EUR): A non-invasive deep brain stimulation device 2014
Poster Prize (Ultra High Field Symposium, Berlin), Multi-nuclear magnetic resonance imaging at ultra-high magnetic field strength: probing sodium-23, chlorine-35, potassium-39, and phosphorus-31 signals in tissue deprived of arterial blood supply 2013
Summa Cum Laude Merit Award (International Society for Magnetic Resonance in Medicine), 'In vivo Hydrogen-1, Sodium-23, Phosphorus-31, and Potassium-39 Magnetic Resonance Imaging after Middle Cerebral Artery Occlusion' 2012
Summa Cum Laude Merit Award (International Society for Magnetic Resonance in Medicine), 'Temporally-resolved imaging of renal sodium-23 changes after furosemid injection' 2012
Siemens Young Investigator Award (German Society for Medical Physics), 'Sodium Concentration as a Marker for Tissue Viability after Ischaemic Stroke' 2010
Selected member (by research proposal) of the 4th excellence initiative for molecular and disease-related imaging; German Science Foundation (DFG), Aachen, Germany 2010
Selected member (by research proposal) of the 4th excellence initiative "molecular and disease-related imaging" 2010 German research association (DFG), Aachen, Germany 2010
AstraZeneca Award (British Chapter of the International Society for Magnetic Resonance Imaging) for 'outstanding, innovative research with potential utility in medicine or medical research' 2009
Award for the best oral presentation from a young scientist (Association of Physical Scientists in Medicine), 'A Dual RF Resonator System for Sodium MRI' 2008