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Dr. Tim Mantle

Fellow Emeritus (Biochemistry)

 tmantle@tcd.ie

 


Research Tags

  3-DIMENSIONAL STRUCTURE   ACID   ALBUMIN-BOUND BILIRUBIN   ALPHA REDUCTASE   ANTIOXIDANT   ARYLSULPHATASE A   AUTONOMIC NEUROPATHY   BETA REDUCTASE   BILE-PIGMENTS   BILIRUBIN   BILIRUBIN ANALOGS   BINDING   C57BL/6 MICE   CANCER   CARDIOVASCULAR RISK-FACTORS   CELLS   CHEMICAL HEPATOCARCINOGENESIS   CIGARETTE SMOKING   CLEAVAGE   CROHNS-DISEASE   DISEASE   DNA   ENZYME KINETICS   ENZYME STRUCTURE   ETHACRYNIC-ACID   EXCRETION   EXPRESSION   FACTOR-I   FORMS   GENE   GLUTATHIONE   GLUTATHIONE S-TRANSFERASE   GLUTATHIONE-S-TRANSFERASE-MU   GLYCOSAMINOGLYCANS   HEME OXYGENASE   HEPATOCARCINOGENESIS   HIGH CATALYTIC ACTIVITY   HUMAN PLACENTA   HUMAN-SERUM   IGF-I   INACTIVATION   INDEX   INTESTINAL INFLAMMATION   KIDNEY   LEUKOCYTES   LIVER   LUNG CANCER   MARKER   PROTEINS   PURIFICATION   RAT-LIVER   SCHIZOPHRENIA   SMOKING   SOMATOMEDIN-C   ULCERATIVE-COLITIS

Research Projects

 
 
 
 

Representations

Details Date
Editorial Board of the Biochemical Journal 1993-2000
Director, National Pharmaceutical Biotechnology Centre, Trinity College, Dublin 1988-1992
Elected Secretary of the Molecular and Cellular Pharmacology Group of the Biochemical Society. 1995-1998
Editorial Adviser: Biochemical Journal; Biochim. Biophys. Acta; Eur. J. Biochem; Diabetologia 1990-
Editor: Glutathione S-transferases and Carcinogenesis, Taylor and Francis 1987
Editor: Glutathione S-transferases and Drug Resistance, Taylor and Francis 1989
Editor: Structure and function of glutathione S-transferases, CRC Press 1993

Memberships

Membership of Professional Institutions, Associations, Societies

Details Date From Date To
Nominated to the National Committee for Biochemistry (of the Royal Irish Academy) 1996 1999
European Environmental Mutagen Society: Councillor for Ireland 1987 1989
Biochemical Society: Editorial Board,Biochemical Journal 1993 -
Biochemical Society: Elected to the Molecular and Cellular Pharmacology Group 1993 -
Biochemical Society: Elected to the Molecular Enzymology Group 1988 1993
Biochemical Society: Elected to Irish Area Section Committee 1983 1988
Biochemical Society (Member) 1974 -
Director, National Pharmaceutical Biotechnology Centre, Trinity College, Dublin 1988 1992
Franklin, E., Mantle, T., Dunne, A., Activation of human biliverdin-IXα reductase by urea: Generation of kinetically distinct forms during the unfolding pathway, Biochimica et Biophysica Acta - Proteins and Proteomics, 1834, (12), 2013, p2573-2578 , Journal Article, PUBLISHED  DOI
McManus, G., Costa, M., Canals A., Coll, M., & Mantle, T.J. , Site-directed mutagenesis of mouse glutathione transferase P1-1 unlocks masked co-operativity, introduces a novel mechansim for ping-pong kinetic behaviour and provides further structural evidence for participation of a water molecule in proton abstraction from glutathione, FEBS Journal, 278, 2011, p273 - 281, Journal Article, PUBLISHED
Franklin, E., Browne, S., Horan, A.E., Inomata,K., Hammam, M.A.S., Kinoshita, H., Lamparter,T., Golfis, G. and Mantle, T.J. , The use of synthetic linear tetrapyrroles to probe the verdin sites of human biliverdin-IXα reductase and human biliverdin-IXβ reductase , FEBS Journal, 276, 2009, p4405-4413 , Journal Article, PUBLISHED  DOI
Hayes, J.M. and Mantle, T.J., The effect of pH on the initial rate kinetics of the dimeric biliverdin-IXα reductase from the cyanobacterium Synechocystis PCC6803 , FEBS Journal, 276, 2009, p4414-4425 , Journal Article, PUBLISHED  DOI
L. J.Smith, S. Browne, A. J. Mulholland and T. J. Mantle, Computational and experimental studies on the catalytic mechanism of biliverdin IXβ reductase, Biochemical Journal, 411, 2008, p475-484 , Journal Article, PUBLISHED  DOI
Edward Franklin, Seamus Browne, Jerrard Hayes, Coilin Boland, Aisling Dunne, Gordon Elliot, and Timothy J. Mantle, Activation of biliverdin-IXα reductase by inorganic phosphate and related anions, Biochemical Journal, 405, 2007, p61-67 , Journal Article, PUBLISHED  TARA - Full Text
Tetlow, N., Robinson , A., Mantle, T. & Board, P., Polymorphism of human Mu class glutathione transferases, Pharmacogenetics, 14 , 2004, p359 - 368, Journal Article, PUBLISHED
Mantle TJ & Noone P., Chromatofocusing, Methods Mol Biol, 244, 2004, p233 - 237, Journal Article, PUBLISHED
TJ Mantle (ed), The Behaviour of Enzymes in Cells, Biochem. Soc. Trans, 31, 2003, pp711 - 739, Conference Paper, PUBLISHED
MANTLE, TJ, HAEM DEGRADATION IN ANIMALS AND PLANTS, BIOCHEMICAL SOCIETY TRANSACTIONS, 30, 2002, p630 - 633, Journal Article, PUBLISHED
  

Page 1 of 12
Mantle, T.J., Enzymes: nature's exquisite nanomachines. A tale of two transients and some floppy bits, Royal Irish Academy, Dublin, 1999, Conference Paper, PUBLISHED
Tipton, K.F. & Mantle, T.J., Selective inhibition and the multiplicity of monoamine oxidase, Second World Congress of Biological Psychiatry, Barcelona, 1978, Meeting Abstract, PUBLISHED
Tipton, K.F., Houslay, M.D. & Mantle, T.J., The nature and locations of the multiple forms of monoamine oxidase, Ciba Foundation Symposium: "Monoamine oxidase and its inhibition", Excerpta Medica, North Holland, 1976, pp5 - 16, Conference Paper, PUBLISHED

  

Awards and Honours

Award Date
Elected Fellow of Trinity College 1985
Royal Irish Academy's Medal for Biochemistry 1999

Research Interests

Description Of Research Interests

. CURRENT RESEARCH INTERESTS: Research in the Molecular Enzymology Group centres on structural, kinetic and regulatory aspects of a number of enzymes. . BILIVERDIN-IX REDUCTASE AS A PHARMACOLOGICAL TARGET FOR NEONATAL JAUNDICE. . STRUCTURAL AND KINETIC STUDIES ON GST-P1-1. . . BILVERDIN REDUCTASE AND THE ANTIOXIDANT RESPONSE. . THE TRANSIENT KINETICS OF SULPHATASE A. . FINANCIAL SUPPORT: SFI, Enterprise Ireland (Proof of Concept), HRB, IACR, PRTLI . MAJOR COLLABORATORS: Miquel Coll (Barcelona), John Hayes (Dundee), Mike Gore (Southampton), Phil Board (Canberra), Pedro Pereira (Porto).