Skip to main content

Trinity College Dublin, The University of Dublin

Menu Search

Trinity College Dublin By using this website you consent to the use of cookies in accordance with the Trinity cookie policy. For more information on cookies see our cookie policy.

Profile Photo

Dr. James Spiers

Associate Professor (Pharmacology & Therapeutics)

Associate Professor (Molecular Medicine Ireland)

  CALCIUM   Cardiac physiology   Cardiovascular and molecular pharmacology   Cardiovascular disease, pharmacology   CLINICAL-TRIALS   CONVERTING ENZYME   CYCLOSPORINE-A   CYP3A4   Cytokines, Nitric Oxide   DEPRESSION   DIGOXIN   ENDOTHELIN   ENDOTHELIN RECEPTOR   ENDOTHELIN-1   ENDOTOXIN   ETA-RECEPTOR   FAILURE   FLOW CYTOMETRY   Heart Failure and transplantation   HIV PROTEASE INHIBITORS   Human genetics   HUMAN HEART   HYPERICUM-PERFORATUM   Intra and intercellular signalling   INVITRO   MDR1   Membrane and protein trafficking   MESSENGER-RNA   NITRIC OXIDE   NUCLEAR RECEPTOR   Pathophysiology   PEPTIDES   P-GLYCOPROTEIN   PP2A   PREGNANE-X RECEPTOR   Protein Phosphatase 2A   RELEASE   REMODELING   RITONAVIR   SEPSIS   SMOOTH-MUSCLE CELLS   ST JOHN'S WORT   Vascular Biology, Thrombosis
 Cardiovascular Remodeling in Heart Failure
 Novel Mechanism Associated with the Development of Heart Failure
 Immunomodulatory-matrix metalloproteinase (MMP) inhibition with tetracyclines in obesity, diabetes and asymptomatic left ventricular diastolic dysfunction: impact on MMP-9 levels and cardiovascular structure and function

Language Skill Reading Skill Writing Skill Speaking
English Fluent Fluent Fluent
Details Date From Date To
British Pharmacological Society 1988 present
Scottish Cardiovascular Society 1992 present
Irish Association of Pharmacologists 1990 present
European Society for Cardiology 2003 2014
International Society for Heart Research 1997 2014
British Society for Cardiovascular Research 1997 2014
American Heart Association 2005 2012
Chris Watson, J Paul Spiers, Max Waterstone, Joseph Gallagher, Cristin Ryan, John Gilmer, Kenneth McDonald, Mark T Ledwidge, Investigation of association of genetic variant rs3918242 of matrix metalloproteinase-9 with hypertension, myocardial infarction and progression of ventricular dysfunction in European patients with diabetes: a report from the STOP-HF follow-up programme, BMC Cardiovascular Disorders, 21, 2021, p87 , Journal Article, PUBLISHED
Sotirakos, S. Wheen, P. Spiers, J. Armstrong, R., New pharmacotherapy for heart failure with reduced ejection fraction, Expert Reviews in Cardiovascular Therapy, 18, 2020, p405 - 414, Journal Article, PUBLISHED
Holmes, D. Corr, M. Thomas, G. Harbinson, M. Campbell, M. Spiers, J.P. Bell, D., Protective effects of intermedin/adrenomedullin-2 in a cellular model of human pulmonary arterial hypertension, Peptides, 126, 2020, p170267 , Journal Article, PUBLISHED
Mahmud, A Zhou, S Yasmin, Y Spiers, JP Feely, J Silke, B, Haplotype of receptor for advanced glycation end products is associated with arterial stiffness in essential hypertension, European Heart Journal, 41, 2020, ppehaa946. 2705 , Meeting Abstract, PUBLISHED
MAHMUD, A., MCNULTY, M., MCGOVERN, E., SPIERS, J., KAVANAGH, P., TOLAN, M., YOUNG, V., FEELY, J. & SILKE, B., Arterial stiffness is associated with elastin fragmentation and medial collagen content in the human aorta, European Heart Journal, 41, 2020, ppehaa946. 2706 , Meeting Abstract, PUBLISHED
KONIECZNA, S., OHLMEYER, M. & SPIERS, J. P., Role of protein phosphatase 2a inhibition in modulation of claudin-5 and ve-cadherin in human brain microvascular endothelial cells., Heart, 2020, Meeting Abstract, PUBLISHED
I.S. Elgenaidi, J.P. Spiers, Hypoxia Modulates the PP2A system in Human Cardiovascular Cell Lines: HIF-1alpha Dependent and Independent Regulation of PP2A in Aortic Smooth Muscle Cells and Ventricular Cardiomyocytes, British Journal of Pharmacology, 176, (11), 2019, p1745 - 1763, Journal Article, PUBLISHED  DOI
I.S. Elgenaidi, J.P. Spiers, Regulation of the Phosphoprotein Phosphatase 2A System and its Modulation during Oxidative Stress: A Potential Therapeutic Target?, Pharmacology and Therapeutics, 2019, p68 - 89, Journal Article, PUBLISHED  DOI
Elgenaidi, I.S. and Spiers, J.P., 5†HIF-1alpha dependent and independent regulation of PP2A in human aortic smooth muscle cells under hypoxia , Heart, Scottish Cardiovascular Forum, Dublin, 104, Heart, 2018, Meeting Abstract, PUBLISHED  DOI
MAHMUD, A., ROUF, A., SPIERS, J. P., ALJIZEERI, A., FEELY, J. & JERRARD-DUNNE,, Relationship between smoking and smoking cessation with vasculature inflammation and arterial stiffness, ournal of the American College of Cardiology, 71, 2018, ppA2114-A211 , Meeting Abstract, PUBLISHED

Page 1 of 11


Award Date
Fellow of the British Pharmacological Society 1st November 2021
Provost's Teaching Award 2008
MA from Trinity College Dublin 2003
Wellcome Trust Travelling Fellowship 2002
Harold McCauley Scholarship for Cardiovascular Research 1995
Samuel Haslett Brown Scholarship 1990
Pathophysiological mechanisms of cardiovascular disease processes: activation of compensatory/ decompensatory mechanisms. Cellular and molecular investigations of cardioactive substances in normal and diseased myocardium: changes in myocyte function in response to overexpression of neurohormones and peptides; long-term cellular changes, including hypertrophy and altered gene expression; extracellular and cytoskeleton changes - ventricular remodelling. Roles of endothelin, nitric oxide, cytokines and heat shock proteins in heart failure and septic shock: factors implicated in altered myocardial responses, including receptor and post-receptor mechanisms of action; mechanical, biochemical, molecular and electrophysiological effects.