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Dr. John Southern

Assistant Professor (Chemistry)
BIOMEDICAL SCIENCES INSTITUTE


Details Date
Reviewer of Dublin City University's Periodic Programme Review - a review of the BSc in Chemical and Pharmacuetical Sciences. 2020
Details Date From Date To
Chartered Chemist and Member of the Royal Society of Chemistry
McDonnell, C.M. and Ghanim, M. and Mike Southern, J. and Kelly, V.P. and Connon, S.J., De-novo designed β-lysine derivatives can both augment and diminish the proliferation rates of E. coli through the action of Elongation Factor P, Bioorganic and Medicinal Chemistry Letters, 59, (128545), 2022, Journal Article, PUBLISHED  TARA - Full Text  DOI
Introduction to Aromatic Chemistry in, editor(s)Chris Rostron, Jill Barber , Pharmaceutical Chemistry, Second Edition, Oxford University Press, 2021, pp208 - 243, [Mike Southern], Book Chapter, PUBLISHED
Fergus C, Al-Qasem M, Cotter M, McDonnell CM, Sorrentino E, Chevot F, Hokamp K, Senge MO, Southern JM, Connon SJ, Kelly VP, The human tRNA-guanine transglycosylase displays promiscuous nucleobase preference but strict tRNA specificity., Nucleic acids research, 2021, p4877-4890 , Journal Article, PUBLISHED  TARA - Full Text  DOI
Mashael A. Alqasem, Claire Fergus, J. Mike Southern, Stephen J. Connon and Vincent P. Kelly, The eukaryotic tRNA-guanine transglycosylase enzyme inserts queuine into tRNA via a sequential bi-bi mechanism, Chemical communications, 56, 2020, p3915 - 3918, Journal Article, PUBLISHED  TARA - Full Text  DOI
S.J. Connon and J.M. Southern, 'Substituted Pyrimidine Derivatives useful in the Treatment of Autoimmune Diseases', Rouse, WO2016050804 (A1), 2020, Patent, GRANTED  URL
Mangan D., Mcnabola N., Clark E.H., Bermudez I., Wonnacott S., Southern J.M., Ethyl-for-methyl substitution enhances the subtype specificity of mecamylamine analogues, Organic and Biomolecular Chemistry, 17, (46), 2019, p9892 - 9905, Journal Article, PUBLISHED  DOI
Varghese S, Cotter M, Chevot F, Fergus C, Cunningham C, Mills KH, Connon SJ, Southern JM, Kelly VP. , In vivo modification of tRNA with an artificial nucleobase leads to full disease remission in an animal model of multiple sclerosis, Nucleic Acid Research, 45, (4), 2017, p2029 - 2039, Journal Article, PUBLISHED  URL
David Mangan, Neasa McNabola, Emily H. Clark, Isabel Bermudez, Susan Wonnacott and J. Mike Southern, A new synthesis and preliminary evaluation of some analogues of mecamylamine - a compound with anti-addiction properties, Organic and Biomolecular Chemistry, 14, 2016, p10787 - 10798, Journal Article, PUBLISHED  URL
Neasa McNabola, Cornelius J. O'Connor, Mark D. Roydhouse, Michael D. Wall, J. Mike Southern, A one-pot synthesis of 3-nitrothiophene and 3-nitro-2-substituted thiophenes, Tetrahedron, 71, (28), 2015, p4598 - 4603, Journal Article, PUBLISHED  URL
Introduction to Aromatic Chemistry in, editor(s)Chris Rostron Jill Barber , Pharmaceutical Chemistry (Integrated Foundations of Pharmacy), Oxford University Press, 2013, [Mike Southern], Book Chapter, PUBLISHED
  

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J.M. Southern, Commercialisation of research, 1st year medicinal chemistry external lecture series, DIT, 2019, Invited Talk, PUBLISHED

  

Award Date
Visiting Professor, Louvain-la-Neuve University, Belgium Jan-Apr 2006