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Dr. Maria Santos-Martinez

Associate Professor (Pharmacy)
25/6/7 WESTLAND ROW

 MariaJose.Santos@tcd.ie

 3531896 4281

Associate Professor (Clinical Medicine)


Biography

Dr Maria J Santos-Martinez is a medical doctor Specialist in Respiratory Medicine from the Universidad Autónoma de Barcelona (Spain). She started her training as basic researcher in The Brown Foundation Institute of Molecular Medicine for the Prevention of Human Diseases at UTHealth (University of Texas Health Science-Houston-USA) in 2004. In 2006 she moved to Ireland and defended her PhD in 2009 (Trinity College Dublin). She was appointed as Assistant Professor (Ussher) in Nanopharmaceutical Drug Discovery (School of Pharmacy and Pharmaceutical Sciences & School of Medicine) in 2010.

Research Tags

  ANGIOGENESIS   Blood Platelets   CANCER   MATRIX METALLOPROTEINASES   Nanomedicine   nanotoxicology   Pulmonary Diseases   QUARTZ CRYSTAL MICROBALANCE

Representations

Details Date
Reviewer:PNAS; Nanomedicine: Nanotechnology, Biology, and Medicine (Nanomedicine); Critical Care Medicine, Thrombosis and Haemostasis

Languages

Language Skill Reading Skill Writing Skill Speaking
English Fluent Fluent Fluent
Spanish Fluent Fluent Fluent

Memberships

Membership of Professional Institutions, Associations, Societies

Details Date From Date To
COST Action 17140 'Cancer nanomedicine - from the bench to the bedside'(NANO2CLINIC) 2018 date
Irish Association of Pharmacologists (IAP) 2017 date
Member and co-founder of the Spanish Research Society in Ireland 2016 date
Spanish Respiratory Medicine Association (SEPAR) 2002 date
Svenja Sladek, Fiona McCartney, Mena Eskander, David J. Dunne, Maria Jose Santos-Martinez, Federico Benetti, Lidia Tajber, David J. Brayden, An Enteric-Coated Polyelectrolyte Nanocomplex Delivers Insulin in Rat Intestinal Instillations when Combined with a Permeation Enhancer, Pharmaceutics, 12, (3), 2020, p259 , Journal Article, PUBLISHED
Smeaton T; McElwaine P; Cullen J; Santos-Martinez MJ; Deasy E; Widdowson M; Grimes T., A prospective observational pilot study of adverse drug reactions contributing to hospitalization in a cohort of middle-aged adults aged 45-64 years., Drugs & Therapy Perspectives , 36, 2020, p123 - 130, Journal Article, PUBLISHED  Other
Vasconcelos JM, Zen F, Angione MD, Cullen RJ, Santos-Martinez MJ, Colavita PE. , Understanding the Carbon-Bio Interface: Influence of Surface Chemistry and Buffer Composition on the Adsorption of Phospholipid Liposomes at Carbon Surfaces., ACS Applied Bio Materials., 3, (2), 2020, p997 - 1007, Journal Article, PUBLISHED  TARA - Full Text  DOI  URL
Paweł Melchior Pasieka; Krzysztof Marycz; Marek Radomski; Maria Jose Santos-Martinez; Przemysław Andrzej Pękala; Iwona Tomaszewska; Krzysztof Andrzej Tomaszewski., Cobalt Nanoparticles Cause Major Platelet Aggregation In Vitro While Chromium Nanoparticles Induce Platelet Lysis In Vitro., The FASEB Journal, Experimental Biology (EB) 2020 meeting, , San Diego, 4th-7th April 2020, 34, (S1), 2020, Notes: [ ], Poster, PUBLISHED  URL
Jakub Radosław Pêkala, Przemysław Andrzej Pêkala, Iwona Maria Tomaszewska, Maria Jose Santos-Martinez, Marek Radomski, Mateusz Paweł Paziewski, Paweł Melchior Pasieka, Krzysztof Andrzej Tomaszewski., Aluminium Nanoparticles Released by Joint Implants‐Quartz Crystal Microbalance with Dissipation Analysis., The FASEB Journal, Experimental Biology (EB) 2020 meeting, , San Diego, 4th-7th April 2020, 34, (S1), 2020, Notes: [ ], Poster, PUBLISHED  URL
Justyna Hajtuch, Nadhim Hante, Ewelina Tomczyk, Michal Wojcik, Marek Witold Radomski, Maria Jose Santos-Martinez, Iwona Inkielewicz-Stepniak,

Effects of functionalized silver nanoparticles on aggregation of human blood platelets

, International Journal of Nanomedicine, Volume 14, 2019, p7399--7417 , Journal Article, PUBLISHED
Machado Cruz R, Santos-Martinez MJ, Tajber L., Impact of polyethylene glycol polymers on the physicochemical properties and mucoadhesivity of itraconazole nanoparticles., European Journal of Pharmaceutics and Biopharmaceutics, 144, 2019, p57 - 67, Journal Article, PUBLISHED  DOI
Hante NK, Medina C, Santos-Martinez MJ., Effect on Platelet Function of Metal-Based Nanoparticles Developed for Medical Applications., Frontiers in cardiovascular medicine., (6), 2019, p139-, Journal Article, PUBLISHED  TARA - Full Text  URL
Pharmacology of Haemostasis and Thrombosis in, Velazquez Farmacologia Basica y Clinica (19th Edition) , Ed. Medica Panamericana, 2018, [Santos-Martinez MJ; Radomski MW; Medina C.], Book Chapter, PUBLISHED
Umerska A, Paluch KJ, Santos-Martinez MJ, Corrigan OI, Medina C, Tajber L, 1. Freeze drying of polyelectrolyte complex nanoparticles: Effect of nanoparticle composition and cryoprotectant selection, International Journal of Pharmaceutics, 552, (1-2), 2018, p27 - 38, Journal Article, PUBLISHED  DOI
  

Page 1 of 6
Santos-Martinez, M.J., Medina, C., Radomska, A., Radomski, M.W., Clinician-scientist: a hobby for few, career prospects for some and training for all practicioners? , 2005, 17-19 , Report, PUBLISHED

  

Awards and Honours

Award Date
Dean's Research Initiatives Fund (Faculty of Health Sciences, TCD) 2015
Innovation Award CRANN 2010
Catalan Respiratory Medicine Association (FUCAP) 2003
Catalan Respiratory Medicine Association (SOCAP) 2003
Spanish Respiratory Medicine Association (SEPAR) 2002

Research Interests

Description Of Research Interests

Dr Santos-Martinez research interests are focused on blood platelets biology and pharmacology; nanoparticle-cell and nanoparticle-blood platelets interactions (Nanotoxicology/Biocompatibility of nanomaterials) and cancer. During her PhD studies she developed a novel method for measuring platelet aggregation using a Quartz Crystal Microbalance with Dissipation monitoring (QCM-D). This is a unique and extremely sensitive technology able to quantify and characterise surface-molecules-cells interactions at nanoscale. Her expertise on the use of QCM-D has been consolidated and she applies this technology for investigating 1) the effect of different compounds, nanomaterials and novel formulations on platelet function and 2) the interactions between nanoparticles developed for drug delivery, their targets and the potential barriers that they have to overcome to exert their action. In the field of cancer, her research is mainly focused on the contribution of platelets to cancer progression (tumor invasion, angiogenesis and blood metastasis).