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Professor Isabel Rozas

Professor (Chemistry)

Professor (Trinity Inst. of Neurosciences (TCIN))

Isabel Rozas was born in Madrid (Spain). After completing her BSc (hons) in Chemistry at the Universidad Complutense de Madrid in 1981, and her 'Licenciado de grado' research (similar to a MSc) in 1982, her PhD research was embarked upon at the Instituto de Quimica Medica in the National Council of Research (CSIC) in Madrid, and the degree achieved in 1987 at the Universidad Complutense de Madrid. Thereafter, she worked as a postdoctoral researcher at both the Department of Chemistry of the University of Saskatchewan (Canada) between 1989 and 1990, and the Department of Chemistry of Queen's University in Kingston (Canada) between 1993 and 1994. She worked as a researcher in the Medicinal Chemistry Institute (CSIC) until the year 2000, thereafter joining the School of Chemistry in TCD as a Lecturer. After being promoted to Senior Lecturer, and becoming a Fellow of TCD (2005), she became Associate Professor (later named Professor in) in 2011. She has supervised 17 PhD students and 4 MSc, earned approximately €2,000,000 in research income and published 159 peer-reviewed research papers. During 2009-2012 she served as External Examiner in Organic/Medicinal Chemistry at the School of Chemistry in NUI Maynooth and during 2012-2016 in the Department of Chemistry and Pharmaceutical Chemistry (serving the Schools of Pharmacy and Medicine) at the Royal College of Surgeons in Ireland. Additionally, she has held positions as Director of the Medicinal Chemistry Moderatorship, member of the Fellowship Central committee, Head of Organic, Medicinal and Biological Chemistry at the School of Chemistry, Director of Postgraduate Teaching and Learning, Director of Research and Director of Global Relationships at the School of Chemistry, Director of Dublin Chemistry postgraduate program, Tutor and served in numerous College committees and selection panels. Moreover, she has served in different scientific committees such as the Irish panel of the ERA-Chemistry panel, the Irish Centre of High-End Computing or the XXIII EFMC-International Symposium in Medicinal Chemistry held in Lisbon in September 2014, and the WATOC Theoretical Chemist conference to be held in Vancouver 2021. Additionally, she has organised the first Medicinal Chemistry Ireland conference in 2016 (TCD, Dublin) and co-organised the second and third editions (DCU-2018, NUI-Galway-2021). Since 2019 she is an Editor of the prestigious journal Bioorganic and Medicinal Chemistry Letters (Elsevier).
  Anticancer therapies   Chemistry of drug receptor interactions   Computational Biology   Computational chemistry and modelling   Computer assisted drug design   Depression   Design and synthesis of drugs   Drug development and evaluation   Drug discovery   Genitourinary, prostatic function and disease   Hetrocyclic chemistry   Hydrogen bonding   Malaria   Medicinal Chemistry   Molecular Biology   Neurodegeneration   Organic chemistry   Protein chemistry, structure and folding   Quantum chemistry   Structural Biology, Determination, Function   Synthesis and new molecules   Theoretical chemistry
 Blocking SARS-CoVid2 infection by inhibiting the TMPRSS2 protease
 Fluorescent probes to target nucleic acids
 Amidine-like derivatives targeting the Ras/Raf/MEK/ERK pathway
 Derivatives of guanidine-based DNA minor groove binders as antiprotozoal agents
 Rationally designed inhibitors of Staphylococcus aureus colonization

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Details Date
Editor of the Elsevier journal "Bioorganic and Medicinal Chemistry Letters" 2019-present
Member of the selection panel for the FWO (Belgium) 2017-2019
Member of the Science Council of the Irish Centre of High-End Computing (ICHEC) 2011-present
Member of the Irish panel for the ERA-Chemistry (EU calls) program 2009-2011
Member of the Molecular Medicine panel for the Health Research Board 2005-2008
External examiner in Organic/Medicinal Chemistry for the BSc-Chemistry & BSc-Pharmaceutical/Biomedical-Chemistry programs, School of Chemistry, NUI-Maynooth, Ireland 2009-2012
External examiner in Organic/Medicinal Chemistry for the Pharmacy degree and Chemistry modules of the Foundation-Year (Medicine & Physiotherapy degrees), Department of Pharmaceutical/Medicinal Chemistry, Royal College of Surgeons Ireland, Ireland 2012-2016
Project evaluator for funding agencies: National Science Foundation (USA), Association for International Cancer Research (UK), Wellcome Trust (UK). 2011-present
Reviewer for top-ranked international journals including: Journal of the American Chemical Society, Journal of Medicinal Chemistry, Journal of Physical Chemistry, ChemMedChem, Organic & Biomolecular Chemistry, European Journal of Medicinal Chemistry, New Journal of Chemistry, Physical Chemistry Chemical Physics. 2000-present
Language Skill Reading Skill Writing Skill Speaking
English Fluent Fluent Fluent
French Medium Basic Basic
Spanish Fluent Fluent Fluent
Details Date From Date To
Member of the American Chemical Society 2008 present
Member of the Royal Society of Chemistry 2005 present
World Association of Theoretical and Computational Chemists (WATOC) 1988 present
Spanish Society of Medicinal Chemistry 1987 2013
N. A. Al-Hadhrami, A. Ladwig, A. Rahman, I. Rozas, J. P. M. G. Malthouse, P. Evans, Synthesis of 2-Guanidinyl Pyridines and their Trypsin Inhibition, Bioorganic and Medicinal Chemistry, 2020, Notes: [DOI:10.1016/j.bmc.2020.115612], Journal Article, PUBLISHED
J. Grover, C. Trujillo, M. Saad, G. Emandi, N. Stipanicev, S. Bernhard, A. Guedin, J.-L. Mergny, M. O. Senge, I. Rozas, Dual-binding conjugates of diaromatic guanidines and porphyrins for recognition of G-quadruplexes, Organic and Biomolecular Chemistry, 2020, Notes: [DOI: 10.1039/D0OB01264E], Journal Article, PUBLISHED  TARA - Full Text  DOI
Ullah, H. and Previtali, V. and Mihigo, H.B. and Twamley, B. and Rauf, M.K. and Javed, F. and Waseem, A. and Baker, R.J. and Rozas, I., Structure-activity relationships of new Organotin(IV) anticancer agents and their cytotoxicity profile on HL-60, MCF-7 and HeLa human cancer cell lines, European Journal of Medicinal Chemistry, 181, (111544), 2019, Notes: [cited By 0], Journal Article, PUBLISHED  DOI
Trujillo, C. and Flood, A. and Sánchez-Sanz, G. and Twamley, B. and Rozas, I., Planarity or Nonplanarity: Modulating Guanidine Derivatives as α2-Adrenoceptors Ligands, Journal of Chemical Information and Modeling, 59, (5), 2019, p2479-2486 , Notes: [cited By 1], Journal Article, PUBLISHED  DOI
Rahman, A. and O'Sullivan, P. and Rozas, I., Recent developments in compounds acting in the DNA minor groove, MedChemComm, 10, (1), 2019, p26-40 , Notes: [cited By 1], Journal Article, PUBLISHED  DOI
Mahmood, K. and Hashmi, W. and Ismail, H. and Mirza, B. and Twamley, B. and Akhter, Z. and Rozas, I. and Baker, R.J., Synthesis, DNA binding and antibacterial activity of metal(II) complexes of a benzimidazole Schiff base, Polyhedron, 157, 2019, p326-334 , Notes: [cited By 5], Journal Article, PUBLISHED  DOI
C. Trujillo, I. Rozas, J. Elguero, I. Alkorta, G. Sánchez-Sanz, Modulating Intramolecular Chalcogen Bonds in Aromatic (thio)(seleno)phene-Based derivatives, Physical Chemistry Chemical Physics, 21, 2019, p23645-, Notes: [DOI:10.1039/C9CP03694F], Journal Article, PUBLISHED  DOI
R. Aggarwal, S. Sharma, M. Hooda, D. Sanz, R.M. Claramunt, B. Twamley, I. Rozas, Visible-light mediated regioselective approach towards synthesis of 7-aroyl-6-methyl-[1,2,4]triazolo[3,4-b][1,3,4]thiadiazines, Tetrahedron, 75, 2019, p130728-, Notes: [DOI:10.1016/j.tet.2019.130728], Journal Article, PUBLISHED
Previtali, V. and Trujillo, C. and Amet, R. and Zisterer, D.M. and Rozas, I., Effect of isouronium/guanidinium substitution on the efficacy of a series of novel anti-cancer agents, MedChemComm, 9, (4), 2018, p735-743 , Notes: [cited By 0], Journal Article, PUBLISHED  DOI
Trujillo, C. and Goya, P. and Rozas, I., Study of Meldrum's Acid Cyclization Reactions, Journal of Physical Chemistry A, 122, (9), 2018, p2535-2541 , Notes: [cited By 0], Journal Article, PUBLISHED  DOI

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Award Date
Fellow of the Trinity College Dublin 2005