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Professor Paula Murphy

Professor (Zoology)

 Paula.Murphy@tcd.ie

 


Biography

Paula Murphy's research interests are in the genetic regulation of embryonic development, and she has been carrying out research in this field since starting postgraduate studies towards her doctoral degree in 1987. The relationship between gene expression patterns and gene function has been a prominent part of her work, and detailed expression analysis is one of her specialisations. She currently focuses this interest on development of the limbs and facial region of vertebrate embryos.

Research Tags

  3d Imaging   Developmental Biology   Embryology   Expression Analysis   Genetics   In Situ Hybridisation   Morphogenesis   Wnt Signalling Pathway
Murphy P., Armit C., Hill B., Venkataraman S., Frankel P., Baldock R. and Davidson D. , Integrated analysis of Wnt signalling system component gene expression, Development , 149, (16), 2022, pdoi: 10.1242/dev.200312. Epub , Notes: [Epub 2022 Aug 15 ], Journal Article, PUBLISHED  TARA - Full Text
Hill, Bill. Husz, Zost. Armit, Chris. Davidson, Duncan R. Murphy, Paula. Baldock, Richard A., WlzWarp: An Open-Source Tool for Complex Alignment of Spatial Data, 2022, Notes: [Preprint for open access through biorXiv ahead of peer review. posted Feb 14 2022], Journal Article, SUBMITTED  TARA - Full Text  DOI
Rolfe, RA. Shea, CA. and Murphy P., Geometric analysis of chondrogenic self-organisation of embryonic limb bud cells in micromass culture., Cell and Tissue Research , 2022, Notes: [doi: 10.1007/s00441-021-03564-y], Journal Article, PUBLISHED  TARA - Full Text
Rolfe, RA. Scanlon-O' Callaghan, D. and Murphy P., Joint development recovery on resumption of embryonic movement following paralysis, Disease Models and Mechanisms , 14, (4), 2021, phttps://doi.org/10.1242/dmm.04 , Journal Article, PUBLISHED  TARA - Full Text  URL
Shea, C.A. and Murphy, P , The Primary Cilium on Cells of Developing Skeletal Rudiments; Distribution, Characteristics and Response to Mechanical Stimulation, Frontiers in Cell and developmental Biology , 2021, phttps://doi.org/10.3389/fcell. , Journal Article, PUBLISHED  URL
Peterson BE., Rolfe RA., Kunselman A., Murphy P., and Szczesny S., Mechanical Stimulation via Muscle Activity is Necessary for the Maturation of Tendon Multiscale Mechanics during Embryonic Development, Frontiers in Cell and Developmental Biology , 2021, p10.3389/fcell.2021.725563 , Journal Article, PUBLISHED  TARA - Full Text  DOI  URL
Darker CD., Mullin M., Doyle L., Tanner M., McGrath D., Doherty L., Dreyer-Gibney K., Barret EM., Flynn D., Ivers J, Burke E, Ryan M., McCarron M., Murphy P., et alia, Developing a healthy university campus in Trinity College Dublin - overview and an outline process evaluation , Health Promotion International, 2021, Journal Article, PUBLISHED  DOI  URL
Shea C.A., Rolfe R.A., McNeill H., AND Murphy P., Localization of YAP activity in developing skeletal rudiments is responsive to mechanical stimulation, Developmental Dynamics , 249, (4), 2020, p523 - 542, Journal Article, PUBLISHED  TARA - Full Text  DOI  Other
V Sotiriou, RA Rolfe, P Murphy, NC Nowlan, Effects of abnormal muscle forces on prenatal joint morphogenesis in mice, Jounral of Orthopaedic Research, 37, (11), 2019, p2287 - 2296, Journal Article, PUBLISHED  TARA - Full Text  DOI  Other
Rolfe R., Shea C., Singh P., Bandyopadhyay A., Murphy P., Uncovering the mechanistic basis of biomechanical input controlling skeletal development: exploring the interplay with Wnt signalling at the joint, Philosophical Transactions B, 373, (1759), 2018, p1 - 12, Journal Article, PUBLISHED  DOI
  

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Hill, Bill. Husz, Zost. Armit, Chris. Davidson, Duncan R. Murphy, Paula. Baldock, Richard A., WlzWarp: An Open-Source Tool for Complex Alignment of Spatial Data, biorXiv , 2022, Notes: [Preprint for open access through biorXiv ahead of peer review. posted Feb 14 2022], Journal Article, APPROVED
Murphy, Paula. Summerhurst, Kristen. Brady, Gareth. Vendrell, Victor. Frankel, Patrick. Redmond, Martina. Maddock, Jessica. Killion-Connolly, Somantha. Armit, Chris. Hill, Bill. Venkatarman, Shanmugasundaram. Yiwen, Sun. Baldock, Richard. Davidson, Duncan. , Wnt Pathway Analysis mapped gene-expression data, University of Edinburgh (datashare) , 2021, Dataset, PUBLISHED
Murphy, Paula. Summerhurst, Kristen. Brady, Gareth. Vendrell, Victor. Frankel, Patrick. Redmond, Martina. Killion-Connolly, Somantha. Armit, Chris. Hill, Bill. Venkatarman, Shanmugasundaram. Yiwen, Sun. Baldock, Richard. Davidson, Duncan. Maddock, Jessica, Wnt Pathway Analysis mapped gene-expression point-cloud data, University of Edinburgh (datashare) , 2021, Dataset, PUBLISHED
Nowlan, N. C., P. Murphy & P. J. Prendergast. , The influence of mechanical forces in the growing embryonic limb. , Transactions of the 52nd Annual Meeting of the Orthopaedic Research Society, the 52nd Annual Meeting of the Orthopaedic Research Society, Chicago, Illinois, edited by Burr, D. B , 31, 2006, ppno. 123-, Conference Paper, PUBLISHED
Miller S.F., Runker A.E., Kerjan G., Friedel R.H., Murphy P., Mitchell K.J., TEM7R in the developing mammalian nervous system. , International Journal of Developmental Neuroscience , 24, 2006, p598 - 598, Journal Article, PUBLISHED

  

Awards and Honours

Award Date
Fellow of Trinity College Dublin 2008
Welcome Trust Research Grant 2010-2014
Science Foundation Ireland. Investigator Programme Grant September 2003 - September 2007
Norwegian Cancer Society (Den Norske Kreftforening) research grants 1996, 1997, 1998, 1999
Human Frontiers Science Program fellowship 1993
EMBO long term research fellowship 1991
Medical Research Council Studentship 1988