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Dr. James Phelan

Research Fellow (Clinical Medicine)

 


  Angiogenesis, oncology, cardiovascular biology, inflammation   ANTI-CANCER DRUG DESIGN   ANTICANCER DRUGS   BACTERIAL INFECTION   BARRETTS ESOPHAGUS   BARRETTS-ESOPHAGUS   Biochemistry, metabolism   BOVINE TUBERCULOSIS   CANCER   CANCER CELL-LINE   CANCER PATIENTS   CANCER RISK   CANCER SUSCEPTIBILITY GENE   CANCER TREATMENT   CANCER-CELLS   CANCER-PATIENTS   CANCERS   Carbohydrates, Other Macromolecules Metabolism   CHEST INFECTIONS   CHRONIC INFLAMMATION   COINFECTION   Colorectal Cancer   Cytology and Cancerology   Development of novel anti-cancer drugs   Development of novel neo-adjuvant treatments for oesophageal and prostate cancer   DYSPLASIA   ELECTRON-TRANSPORT   ENERGY-METABOLISM   ESOPHAGEAL CANCER   FATTY ACID   FATTY ACID OXIDATION   FATTY-ACID SYNTHESIS   GASTROESOPHAGEAL REFLUX   GASTROESOPHAGEAL REFLUX DISEASE   GASTRO-OESOPHAGEAL REFLUX   Gastro-oesophageal reflux disease   GLUCOSE METABOLISM   GLUCOSE-METABOLISM   GLUTAMATE   GLUTAMINE   GLUTAMINE METABOLISM   GLUTAMINE SYNTHETASE   Glycolysis   HELICOBACTER PYLORI INFECTION   IMMUNOLOGY   Immunology, Immunotherapy   Immunometabolism   INFECTION   Inflammation   INFLAMMATION-INDUCED EXPRESSION   Innate immunology   INTESTINAL INFECTIONS   INTESTINAL INFLAMMATION   LACTATE AND ACETATE METABOLISM   L-GLUTAMINE   Lipid metabolism   LIPID-METABOLISM   L-TRYPTOPHAN   LUNG INFECTION   metabolism   Metabolism and metabolic diseases   Metabolism, Amino Acid   Metabolism, Lipid   Metabolism, Mineral   Metabolism, Nucleotide   Metabolism, Protein   Mitochondria   MITOCHONDRIAL   mitochondrial aspartate/glutamate   MITOCHONDRIAL COMPLEX I   MITOCHONDRIAL COMPLEX-I   MITOCHONDRIAL DNA   MITOCHONDRIAL DNA (MTDNA)   Mitochondrial fission & fusion mechanisms   Mitochondrial function   MITOCHONDRIAL INNER MEMBRANE   MITOCHONDRIAL MATRIX   MITOCHONDRIAL OUTER MEMBRANE   MITOCHONDRIAL OUTER-MEMBRANE   MITOCHONDRIAL RESPIRATION   MITOCHONDRIAL RESPIRATORY COMPLEX I   MITOCHONDRIAL RESPIRATORY-CHAIN   MITOCHONDRIAL UNCOUPLING PROTEIN   MITOCHONDRIAL-DNA   MITOCHONDRIAL-MEMBRANE POTENTIAL   Molecular Immunology   MYCOBACTERIUM INFECTION   Mycobacterium tuberculosis   MYCOBACTERIUM-TUBERCULOSIS   Oesophageal Cancer   OXIDATIVE INJURY   OXIDATIVE PHOSPHORYLATION   OXIDATIVE POTENTIAL   OXIDATIVE STRESS   OXIDATIVE-METABOLISM   OXIDATIVE-PHOSPHORYLATION   PENTOSE-PHOSPHATE PATHWAY   PREVENTION OF TUBERCULOSIS   PULMONARY TUBERCULOSIS   RESISTANT TUBERCULOSIS   RESPIRATORY INFECTION   TB immunology   TRIACYLGLYCEROL METABOLISM   TRYPTOPHAN   Tuberculosis   TUBERCULOSIS TRANSMISSION   Tumor Immunology   Tumour Biology/ Immunology   Tumour immunology and immunotherapy
 Evaluating the immunometabolic potential of desferrioxamine to augment antibiotic treatment against Mycobacterium tuberculosis

Details Date
I have presented six posters at international conferences including the BSI (2017, Brighton), the 7th & 9th National Barrett's Symposium (2013 &2015, London), Keystone's Tumor Metabolism Conference (2014, Canada), at the European Association of Cancer Research (EACR23) (2014, Munich) and at Abcam's Cancer and Metabolism Conference (2013, Amsterdam).
Christina Cahill, Fiona O'Connell, Karl M Gogan, Donal J Cox, Sharee A Basdeo, Jacintha O'Sullivan, Stephen V Gordon , Joseph Keane, James J Phelan, The Iron Chelator Desferrioxamine Increases the Efficacy of Bedaquiline in Primary Human Macrophages Infected with BCG, International Journal of Molecular Sciences, 2021, Journal Article, PUBLISHED  TARA - Full Text  DOI  URL
Cilian Ó Maoldomhnaigh, Donal J Cox, James J Phelan, Fergal D Malone, Joseph Keane, Sharee A Basdeo, The Warburg Effect Occurs Rapidly in Stimulated Human Adult but Not Umbilical Cord Blood Derived Macrophages, Frontiers in Immunology, 2021, Journal Article, PUBLISHED  DOI  URL
Phelan JJ, O'Leary S, Keane J., Tuberculosis lymph node granulomas: using transcriptomics to discover immunopathology paradigms and guide host-directed therapy, The Journal of Clinical Investigation, 2021, Journal Article, PUBLISHED  DOI  URL
Noel E Donlon, Maria Davern, Andrew Sheppard, Robert Power, Fiona O'Connell, Aisling B Heeran, Ross King, Conall Hayes, Anshul Bhardwaj, James J Phelan, Margaret R Dunne, Narayanasamy Ravi, Claire L Donohoe, Jacintha O'Sullivan, John V Reynolds, Joanne Lysaght., The Prognostic Value of the Lymph Node in Oesophageal Adenocarcinoma; Incorporating Clinicopathological and Immunological Profiling, Cancers, 2021, Journal Article, PUBLISHED  DOI  URL
Abigail Keogan, Thi Nguyet Que Nguyen, James J. Phelan, Niamh Lynam-Lennon, C. Muldoon, A. A. Maguire, D. O'Toole, John V. Reynolds, Jacintha O'Sullivan, Aidan D Meade., Chemical imaging and machine learning for sub-classification of oesophageal tissue histology, Translational Biophotonics, 2021, Journal Article, IN_PRESS
James J. Phelan and Frederick J. Sheedy., Phagocyte metabolism: neutrophils have their cake but don't eat it., Trends in Immunology, 2021, Journal Article, IN_PRESS
Cilian Ó Maoldomhnaigh, Donal J Cox, James Joseph Phelan, Karl M. Gogan, Kate McQuaid, Amy Martina Coleman, Sharee Ann Basdeo and Joseph Keane., Lactate alters metabolism in human macrophages and improves their ability to kill Mycobacterium tuberculosis, Frontiers in Immunology, 2021, Journal Article, IN_PRESS
Petrasca A, Phelan J.J., Ansboro S, Veale D.J., Fearon U., Fletcher J.M., Targeting bioenergetics prevents CD4 T cell-mediated activation of synovial fibroblasts in rheumatoid arthritis., Rheumatology, 2020, Journal Article, PUBLISHED  DOI  URL
Dunne M.R.*, Phelan J.J.*, Michielsen A.J., Maguire A.A., Dunne C., Martin P., Noonan S., Tosetto M., Geraghty R., Fennelly D., Sheahan K., Ryan E.J., O'Sullivan J. (joint 1st author *), Characterising the prognostic potential of HLA-DR during colorectal cancer development., Cancer Immunology Immunotherapy, 2020, Journal Article, PUBLISHED  TARA - Full Text  DOI  URL
Phelan J.J., McQuaid, K., Kenny C., Gogan K.M., Cox D.J., Basdeo S.A., O'Leary S., Tazoll S.C., Ó Maoldomhnaigh C., O'Sullivan M.P., O'Neill LA, O'Sullivan M.J. & Keane J., Desferrioxamine supports metabolic function in primary human macrophages infected with Mycobacterium tuberculosis, Frontiers in Immunology, 2020, Journal Article, PUBLISHED  TARA - Full Text  DOI  URL
  

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Award Date
SFI/EI Technology Innovation Development Award (TIDA) (€127,349.00) 2019
British Society for Immunology - Travel Award (£1000) November 2018
Irish Research Council Government of Ireland Postdoctoral Fellowship (€91,970.00) 2020-2022