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Dr. Eva Palsson Mcdermott

Research Fellow (Biochemistry)

Immunologist with a keen interest in clinical research, drug-discovery, scientific writing and developing novel therapeutics in immuno-oncology and immuno-inflammation. Currently based in the laboratory of Prof Luke O"Neill in Dublin whilst working as a Senior Scientific Investigator for Sitryx Therapeutics in Oxford, with a senior role in managing projects in immunology, target validation, immunometabolism and translational research.
Language Skill Reading Skill Writing Skill Speaking
English Fluent Fluent Fluent
French Medium Medium Basic
Swedish Fluent Fluent Fluent
Timmons GA, Carroll RG, O'Siorain JR, Cervantes-Silva MP, Fagan LE, Cox SL, Palsson-McDermott E, Finlay DK, Vincent EE, Jones N, Curtis AM, The Circadian Clock Protein BMAL1 Acts as a Metabolic Sensor In Macrophages to Control the Production of Pro IL-1β, Frontiers in Immunology, (12), 2021, Journal Article, PUBLISHED
PÃ¥lsson-McDermott, E.M. and O†Neill, L.A.J., Targeting immunometabolism as an anti-inflammatory strategy, Cell Research, 30, (4), 2020, p300-314 , Notes: [cited By 114], Journal Article, PUBLISHED  DOI
Zbigniew Zaslona, Ewelina Flis, Mieszko M Wilk, Richard G Carroll, Eva M Palsson-McDermott, Mark M Hughes, Ciana Diskin, Kathy Banahan, Dylan G Ryan, Alexander Hooftman, Alicja Misiak, Jay Kearney, Gunter Lochnit, Wilhelm Bertrams, Timm Greulich, Bernd Schmeck, Oliver J McElvaney, Kingston H G Mills, Ed C Lavelle, Małgorzata Wygrecka, Emma M Creagh, Luke A J O'Neill, Caspase-11 promotes allergic airway inflammation, Nature Communications, 2020, Journal Article, PUBLISHED
Angiari, S. and Runtsch, M.C. and Sutton, C.E. and Palsson-McDermott, E.M. and Kelly, B. and Rana, N. and Kane, H. and Papadopoulou, G. and Pearce, E.L. and Mills, K.H.G. and O'Neill, L.A.J., Pharmacological Activation of Pyruvate Kinase M2 Inhibits CD4+ T Cell Pathogenicity and Suppresses Autoimmunity, Cell Metabolism, 31, (2), 2020, p391-405.e8 , Notes: [cited By 11], Journal Article, PUBLISHED  TARA - Full Text  DOI
McElvaney, O.J. and Zaslona, Z. and Becker-Flegler, K. and Palsson-McDermott, E.M. and Boland, F. and Gunaratnam, C. and Gulbins, E. and O'Neill, L.A. and Reeves, E.P. and McElvaney, N.G., Specific inhibition of the NLRP3 inflammasome as an antiinflammatory strategy in cystic fibrosis, American Journal of Respiratory and Critical Care Medicine, 200, (11), 2019, p1381-1391 , Notes: [cited By 25], Journal Article, PUBLISHED  DOI
Hughes, M.M. and Hooftman, A. and Angiari, S. and Tummala, P. and Zaslona, Z. and Runtsch, M.C. and McGettrick, A.F. and Sutton, C.E. and Diskin, C. and Rooke, M. and Takahashi, S. and Sundararaj, S. and Casarotto, M.G. and Dahlstrom, J.E. and Palsson-McDermott, E.M. and Corr, S.C. and Mills, K.H.G. and Preston, R.J.S. and Neamati, N. and Xie, Y. and Baell, J.B. and Board, P.G. and O'Neill, L.A.J., Glutathione Transferase Omega-1 Regulates NLRP3 Inflammasome Activation through NEK7 Deglutathionylation, Cell Reports, 29, (1), 2019, p151-161.e5 , Notes: [cited By 0], Journal Article, PUBLISHED  TARA - Full Text  DOI
Galván-Peña, S., Carroll, R.G., Newman, C., (...), Modis, L.K., O'Neill, L.A., Malonylation of GAPDH is an inflammatory signal in macrophages, Nature Communications, 10, (1), 2019, p338-, Journal Article, PUBLISHED  TARA - Full Text  URL
Early JO, Menon D, Wyse CA, Cervantes-Silva MP, Zaslona Z, Carroll RG, Palsson-McDermott EM, Angiari S, Ryan DG, Corcoran SE, Timmons G, Geiger SS, Fitzpatrick DJ, O'Connell D, Xavier RJ, Hokamp K, O'Neill LAJ, Curtis AM., Circadian clock protein BMAL1 regulates IL-1ß in macrophages via NRF2., Proceedings of the National Academy of Sciences of the United States of America, 115, (36), 2018, pE8460-E8468 , Journal Article, PUBLISHED  DOI
Diskin C, Pålsson-McDermott EM., Metabolic Modulation in Macrophage Effector Function., Frontiers in immunology, 9, 2018, p270 , Journal Article, PUBLISHED  DOI
Palsson-McDermott, E.M. and Dyck, L. and Zaslona, Z. and Menon, D. and McGettrick, A.F. and Mills, K.H.G. and O'Neill, L.A., Pyruvate kinase M2 is required for the expression of the immune checkpoint PD-L1 in immune cells and tumors, Frontiers in Immunology, 8, (OCT), 2017, Notes: [cited By 0], Journal Article, PUBLISHED  DOI

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Immunometabolism, Innate Immunity, Drug Discovery